Incidental Mutation 'R6966:Ly6c1'
ID 542021
Institutional Source Beutler Lab
Gene Symbol Ly6c1
Ensembl Gene ENSMUSG00000079018
Gene Name lymphocyte antigen 6 family member C1
Synonyms Ly6c, Ly-6C
MMRRC Submission 045076-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R6966 (G1)
Quality Score 210.009
Status Not validated
Chromosome 15
Chromosomal Location 74915867-74920679 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to T at 74917289 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000140722 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065408] [ENSMUST00000179762] [ENSMUST00000185200] [ENSMUST00000185372] [ENSMUST00000187347] [ENSMUST00000188845] [ENSMUST00000191216]
AlphaFold P0CW02
Predicted Effect unknown
Transcript: ENSMUST00000065408
AA Change: F120I
SMART Domains Protein: ENSMUSP00000066954
Gene: ENSMUSG00000079018
AA Change: F120I

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
LU 27 115 1.62e-32 SMART
low complexity region 117 131 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000179762
AA Change: F120I
SMART Domains Protein: ENSMUSP00000137401
Gene: ENSMUSG00000079018
AA Change: F120I

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
LU 27 115 1.62e-32 SMART
low complexity region 117 131 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000185200
SMART Domains Protein: ENSMUSP00000140622
Gene: ENSMUSG00000079018

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Pfam:UPAR_LY6 29 77 2.3e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000185372
SMART Domains Protein: ENSMUSP00000139948
Gene: ENSMUSG00000079018

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Pfam:UPAR_LY6 29 77 6.3e-6 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000187347
AA Change: F120I
SMART Domains Protein: ENSMUSP00000139799
Gene: ENSMUSG00000079018
AA Change: F120I

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
LU 27 115 1.62e-32 SMART
low complexity region 117 131 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000188845
SMART Domains Protein: ENSMUSP00000139559
Gene: ENSMUSG00000079018

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
LU 27 115 1.52e-28 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000191216
SMART Domains Protein: ENSMUSP00000140722
Gene: ENSMUSG00000079018

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
LU 27 111 5.2e-27 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 97.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam26b G A 8: 43,974,472 (GRCm39) R177C possibly damaging Het
Adgrb2 CG C 4: 129,908,155 (GRCm39) probably null Het
Bahcc1 G A 11: 120,173,985 (GRCm39) V1582M probably damaging Het
Baiap2 A T 11: 119,897,231 (GRCm39) R529* probably null Het
Bcl9l C T 9: 44,420,685 (GRCm39) Q1327* probably null Het
Brsk2 T A 7: 141,538,270 (GRCm39) C139S possibly damaging Het
Catsper3 T A 13: 55,946,672 (GRCm39) I123N probably damaging Het
Cd84 A G 1: 171,713,976 (GRCm39) N325D possibly damaging Het
Chid1 T A 7: 141,076,297 (GRCm39) Y357F possibly damaging Het
Clstn2 A T 9: 97,408,459 (GRCm39) Y416* probably null Het
Cnot1 A T 8: 96,451,160 (GRCm39) L2189Q probably damaging Het
Csnk2b T A 17: 35,336,758 (GRCm39) I170L probably benign Het
Dnah3 T C 7: 119,631,977 (GRCm39) Q1326R probably damaging Het
Drd1 T C 13: 54,207,564 (GRCm39) I210V probably damaging Het
Eef1d G T 15: 75,775,558 (GRCm39) Q34K probably benign Het
Fam184a T C 10: 53,531,095 (GRCm39) T760A probably benign Het
Fnip1 G T 11: 54,373,385 (GRCm39) V199F probably benign Het
Glyatl3 T C 17: 41,215,829 (GRCm39) K226E probably damaging Het
Gm19410 C T 8: 36,285,127 (GRCm39) T2093I possibly damaging Het
Herc1 A T 9: 66,318,347 (GRCm39) E1206D probably benign Het
Hs6st1 G A 1: 36,143,299 (GRCm39) W411* probably null Het
Hsf2 C A 10: 57,372,080 (GRCm39) S60R probably damaging Het
Hyal5 C A 6: 24,891,291 (GRCm39) N368K probably damaging Het
Itgb2l A T 16: 96,231,843 (GRCm39) F308I probably benign Het
Kdm7a G A 6: 39,129,773 (GRCm39) L468F probably damaging Het
Lamp3 A T 16: 19,518,403 (GRCm39) L278* probably null Het
Mark3 A G 12: 111,606,458 (GRCm39) N524D probably damaging Het
Met T G 6: 17,531,531 (GRCm39) L603R possibly damaging Het
Mical1 A T 10: 41,355,750 (GRCm39) Q198L probably damaging Het
Nacad T A 11: 6,552,634 (GRCm39) I186F possibly damaging Het
Nt5c3b A T 11: 100,320,750 (GRCm39) M257K probably benign Het
Nuak2 T C 1: 132,252,770 (GRCm39) M108T possibly damaging Het
Nub1 T A 5: 24,894,470 (GRCm39) Y51N probably damaging Het
Nxpe5 T C 5: 138,237,679 (GRCm39) S68P probably damaging Het
Or10ag58 C T 2: 87,265,623 (GRCm39) T264I probably damaging Het
Or5d44 A G 2: 88,141,835 (GRCm39) S102P probably benign Het
Or6c66 A G 10: 129,461,633 (GRCm39) V99A probably benign Het
Pias3 A G 3: 96,609,511 (GRCm39) D276G probably damaging Het
Setd7 A G 3: 51,437,605 (GRCm39) Y217H probably damaging Het
Slc23a1 A T 18: 35,758,114 (GRCm39) I142N probably damaging Het
Slx4ip T C 2: 136,910,144 (GRCm39) S310P probably damaging Het
Tcp11l2 G A 10: 84,427,133 (GRCm39) R199Q possibly damaging Het
Tgm4 T A 9: 122,880,207 (GRCm39) D226E possibly damaging Het
Tspyl4 C A 10: 34,173,673 (GRCm39) A55E probably benign Het
Uap1l1 A G 2: 25,254,950 (GRCm39) I146T probably damaging Het
Ush2a G A 1: 188,308,441 (GRCm39) G2030D probably damaging Het
Uts2r G A 11: 121,052,213 (GRCm39) G359D possibly damaging Het
Vwa7 T C 17: 35,236,072 (GRCm39) S9P probably benign Het
Zbtb16 A G 9: 48,568,654 (GRCm39) C604R probably damaging Het
Zfp804b A G 5: 6,821,615 (GRCm39) S483P probably damaging Het
Zfpm1 G A 8: 123,058,904 (GRCm39) A175T probably damaging Het
Other mutations in Ly6c1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R2002:Ly6c1 UTSW 15 74,920,342 (GRCm39) missense possibly damaging 0.62
R3881:Ly6c1 UTSW 15 74,917,436 (GRCm39) missense probably benign 0.07
R5986:Ly6c1 UTSW 15 74,917,457 (GRCm39) missense probably damaging 1.00
R6462:Ly6c1 UTSW 15 74,916,178 (GRCm39) unclassified probably benign
R7169:Ly6c1 UTSW 15 74,916,495 (GRCm39) missense probably benign 0.00
R7355:Ly6c1 UTSW 15 74,919,256 (GRCm39) missense possibly damaging 0.78
R7583:Ly6c1 UTSW 15 74,920,346 (GRCm39) missense probably damaging 1.00
R9037:Ly6c1 UTSW 15 74,917,300 (GRCm39) missense probably damaging 1.00
R9038:Ly6c1 UTSW 15 74,917,300 (GRCm39) missense probably damaging 1.00
R9039:Ly6c1 UTSW 15 74,917,300 (GRCm39) missense probably damaging 1.00
R9224:Ly6c1 UTSW 15 74,916,465 (GRCm39) missense probably benign 0.00
R9354:Ly6c1 UTSW 15 74,916,471 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TAGAGAGGAGTCGGGCACTTAC -3'
(R):5'- AAGTGAGTCACTCCCTGATTTC -3'

Sequencing Primer
(F):5'- GCTATAAAGGTGAAACAGGGTGTTCC -3'
(R):5'- TCTTGCAGACTCTCAAAGAAGG -3'
Posted On 2018-11-28