Mutagenetix > Incidental Mutation

Incidental Mutation 'R6972:Trim29'

542305

Institutional Source

Beutler Lab

Gene Symbol

Trim29

Ensembl Gene

ENSMUSG00000032013

Gene Name

tripartite motif-containing 29

Synonyms

4732461M22Rik, 1110047J21Rik, 2810431N19Rik

MMRRC Submission

045082-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R6972 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

43222145-43247412 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 43238409 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 504 (N504K)

Ref Sequence

ENSEMBL: ENSMUSP00000034511 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000034511]

AlphaFold

Q8R2Q0

Predicted Effect

probably benign
Transcript: ENSMUST00000034511
AA Change: N504K

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)

SMART Domains

Protein: ENSMUSP00000034511
Gene: ENSMUSG00000032013
AA Change: N504K

Domain	Start	End	E-Value	Type
Blast:BBOX	168	216	3e-25	BLAST
BBOX	220	260	1.93e-11	SMART
low complexity region	399	410	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.0%
20x: 95.8%

Validation Efficiency

100% (41/41)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abhd2	A	G	7: 79,003,775 (GRCm39)	S285G	probably benign	Het
Afg1l	T	C	10: 42,354,370 (GRCm39)	T10A	probably benign	Het
Akap9	A	G	5: 4,096,699 (GRCm39)	N2525D	possibly damaging	Het
B3gnt7	G	A	1: 86,233,109 (GRCm39)	M1I	probably null	Het
Bdp1	T	C	13: 100,174,269 (GRCm39)	E2089G	probably null	Het
Calcrl	T	G	2: 84,198,922 (GRCm39)	I156L	probably benign	Het
Cd69	T	C	6: 129,246,543 (GRCm39)	S122G	probably benign	Het
Chek2	T	C	5: 111,003,705 (GRCm39)		probably null	Het
Ckap5	T	A	2: 91,436,658 (GRCm39)	I1586K	probably damaging	Het
Cyp4f14	C	T	17: 33,124,483 (GRCm39)	A523T	probably benign	Het
Dcaf1	T	A	9: 106,723,971 (GRCm39)	C466*	probably null	Het
Dcdc2a	A	T	13: 25,304,372 (GRCm39)		probably benign	Het
Eml5	T	C	12: 98,842,439 (GRCm39)	I220V	probably benign	Het
Etv2	T	C	7: 30,334,167 (GRCm39)	N189D	probably benign	Het
Fuz	T	C	7: 44,546,755 (GRCm39)		probably benign	Het
Git1	T	G	11: 77,390,347 (GRCm39)	V64G	probably damaging	Het
Gpr162	C	T	6: 124,838,272 (GRCm39)	R126H	probably damaging	Het
Grm5	T	C	7: 87,252,131 (GRCm39)	V127A	probably benign	Het
Iqsec1	T	C	6: 90,653,750 (GRCm39)	D665G	probably damaging	Het
Kcnh1	A	G	1: 191,959,144 (GRCm39)	I233V	probably damaging	Het
Lmcd1	C	T	6: 112,287,659 (GRCm39)	T115I	probably damaging	Het
Mybpc1	T	C	10: 88,396,223 (GRCm39)	E208G	possibly damaging	Het
Nfic	C	A	10: 81,256,191 (GRCm39)	A158S	probably benign	Het
Nos3	A	T	5: 24,585,241 (GRCm39)	I798L	probably benign	Het
Ntrk1	A	T	3: 87,691,288 (GRCm39)	L292Q	probably damaging	Het
Or2ag16	A	G	7: 106,351,906 (GRCm39)	S230P	possibly damaging	Het
Orc4	T	C	2: 48,817,196 (GRCm39)	Q164R	probably benign	Het
Pcdhb14	T	A	18: 37,582,745 (GRCm39)	V617E	probably damaging	Het
Pira1	C	G	7: 3,740,319 (GRCm39)	A301P	probably damaging	Het
Plscr3	G	A	11: 69,738,784 (GRCm39)	E149K	probably damaging	Het
Pltp	A	G	2: 164,688,512 (GRCm39)		probably null	Het
Pramel11	A	G	4: 143,623,472 (GRCm39)	L234P	probably damaging	Het
Prg2	G	A	2: 84,812,617 (GRCm39)	R109H	probably benign	Het
Ptprj	G	A	2: 90,410,747 (GRCm39)	S62F	possibly damaging	Het
Resf1	T	A	6: 149,227,607 (GRCm39)	Y218N	probably damaging	Het
Skint3	T	A	4: 112,116,089 (GRCm39)	S240T	probably damaging	Het
Smarca5	A	G	8: 81,431,380 (GRCm39)	Y946H	probably damaging	Het
Taf4b	T	C	18: 14,946,404 (GRCm39)	V409A	possibly damaging	Het
Tafa2	A	G	10: 123,540,278 (GRCm39)	T45A	probably benign	Het
Vmn2r77	T	C	7: 86,452,202 (GRCm39)	Y461H	probably damaging	Het
Zeb2	T	C	2: 44,887,330 (GRCm39)	K531E	probably damaging	Het
Zfp687	A	G	3: 94,916,688 (GRCm39)	S813P	possibly damaging	Het

Other mutations in Trim29

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02364:Trim29	APN	9	43,222,599 (GRCm39)	missense	probably benign	0.05
IGL02387:Trim29	APN	9	43,236,149 (GRCm39)	missense	probably benign	0.02
R1770:Trim29	UTSW	9	43,243,673 (GRCm39)	missense	probably damaging	1.00
R1883:Trim29	UTSW	9	43,222,702 (GRCm39)	missense	probably damaging	1.00
R1962:Trim29	UTSW	9	43,222,615 (GRCm39)	missense	probably benign
R4198:Trim29	UTSW	9	43,222,677 (GRCm39)	nonsense	probably null
R4200:Trim29	UTSW	9	43,222,677 (GRCm39)	nonsense	probably null
R4303:Trim29	UTSW	9	43,222,419 (GRCm39)	missense	probably damaging	1.00
R4863:Trim29	UTSW	9	43,240,872 (GRCm39)	missense	possibly damaging	0.89
R4934:Trim29	UTSW	9	43,222,265 (GRCm39)	missense	probably benign	0.36
R6171:Trim29	UTSW	9	43,230,674 (GRCm39)	missense	probably damaging	1.00
R6737:Trim29	UTSW	9	43,230,681 (GRCm39)	missense	probably benign	0.01
R7191:Trim29	UTSW	9	43,222,906 (GRCm39)	missense	probably damaging	1.00
R7434:Trim29	UTSW	9	43,246,428 (GRCm39)	missense	probably damaging	1.00
R7588:Trim29	UTSW	9	43,246,425 (GRCm39)	missense	probably damaging	1.00
R7590:Trim29	UTSW	9	43,222,788 (GRCm39)	missense	probably damaging	1.00
R8781:Trim29	UTSW	9	43,222,615 (GRCm39)	missense	probably benign	0.27
R8866:Trim29	UTSW	9	43,222,945 (GRCm39)	missense	probably damaging	1.00
R8922:Trim29	UTSW	9	43,233,636 (GRCm39)	missense	possibly damaging	0.80
R9336:Trim29	UTSW	9	43,238,350 (GRCm39)	missense	possibly damaging	0.59
R9709:Trim29	UTSW	9	43,231,797 (GRCm39)	missense	probably benign	0.12
X0065:Trim29	UTSW	9	43,233,621 (GRCm39)	missense	probably benign	0.06

Predicted Primers

PCR Primer
(F):5'- TGGAAGAGTTCAAAGGGCTC -3'
(R):5'- AGTTCTGCATAAGCCAGTGC -3'

Sequencing Primer
(F):5'- AGTTCAAAGGGCTCTGGGG -3'
(R):5'- TGCATAAGCCAGTGCAGTTC -3'

Posted On

2018-11-28