Incidental Mutation 'R6975:Or51a24'
ID 542419
Institutional Source Beutler Lab
Gene Symbol Or51a24
Ensembl Gene ENSMUSG00000051340
Gene Name olfactory receptor family 51 subfamily A member 24
Synonyms GA_x6K02T2PBJ9-6819097-6818150, MOR13-5, Olfr645
MMRRC Submission 045085-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R6975 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 103733338-103734285 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 103734002 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 95 (N95S)
Ref Sequence ENSEMBL: ENSMUSP00000062821 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057104] [ENSMUST00000138055]
AlphaFold Q7TRQ1
Predicted Effect probably benign
Transcript: ENSMUST00000057104
AA Change: N95S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000062821
Gene: ENSMUSG00000051340
AA Change: N95S

DomainStartEndE-ValueType
Pfam:7tm_4 33 313 5.4e-113 PFAM
Pfam:7TM_GPCR_Srsx 37 256 8e-8 PFAM
Pfam:7tm_1 43 295 5.4e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000138055
SMART Domains Protein: ENSMUSP00000139240
Gene: ENSMUSG00000109824

DomainStartEndE-ValueType
transmembrane domain 29 51 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 96.9%
Validation Efficiency 100% (46/46)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010315B03Rik T A 9: 124,056,687 (GRCm39) H100L probably benign Het
Apaf1 A T 10: 90,856,596 (GRCm39) H870Q probably damaging Het
Aplf T C 6: 87,623,068 (GRCm39) D358G probably damaging Het
Atp10a A T 7: 58,423,733 (GRCm39) S233C probably damaging Het
Ccdc158 A T 5: 92,814,579 (GRCm39) Y82* probably null Het
Clba1 C T 12: 112,773,217 (GRCm39) P70L possibly damaging Het
Cubn T C 2: 13,491,600 (GRCm39) D149G probably damaging Het
Cyp4f14 T C 17: 33,133,608 (GRCm39) T83A probably benign Het
Endog A G 2: 30,061,648 (GRCm39) probably benign Het
Extl3 T C 14: 65,304,246 (GRCm39) E721G probably benign Het
Gatad1 T C 5: 3,693,540 (GRCm39) R210G probably benign Het
Gcn1 A G 5: 115,751,518 (GRCm39) H2033R probably damaging Het
Gm12830 T C 4: 114,702,246 (GRCm39) M136T Het
Gm6871 T C 7: 41,196,202 (GRCm39) silent Het
Hoxc4 T C 15: 102,944,098 (GRCm39) S159P probably damaging Het
Ift70a2 T C 2: 75,806,752 (GRCm39) R587G probably damaging Het
Ift70a2 A T 2: 75,808,004 (GRCm39) Y169* probably null Het
Igf2bp2 T A 16: 21,880,611 (GRCm39) Q494L probably null Het
Igfn1 T A 1: 135,896,183 (GRCm39) N1461I probably damaging Het
Il23r C A 6: 67,400,352 (GRCm39) K659N probably damaging Het
Map3k11 A G 19: 5,740,755 (GRCm39) S161G possibly damaging Het
Naip6 T A 13: 100,452,773 (GRCm39) Q96L probably damaging Het
Nup133 T C 8: 124,642,057 (GRCm39) E802G probably damaging Het
Nutm1 G A 2: 112,086,563 (GRCm39) S56F probably damaging Het
Or10x4 T A 1: 174,219,243 (GRCm39) S203T probably benign Het
Otop2 A T 11: 115,220,152 (GRCm39) S331C possibly damaging Het
Pira1 C G 7: 3,740,319 (GRCm39) A301P probably damaging Het
Pkd1l3 A G 8: 110,387,539 (GRCm39) R1818G possibly damaging Het
Pms1 A T 1: 53,228,590 (GRCm39) I886N probably damaging Het
Pnpla6 A G 8: 3,588,068 (GRCm39) Y1107C probably damaging Het
Ppp3ca A G 3: 136,611,062 (GRCm39) T362A probably damaging Het
Rarb A G 14: 16,574,942 (GRCm38) S25P possibly damaging Het
Rnf121 A T 7: 101,673,218 (GRCm39) probably null Het
Sae1 T C 7: 16,070,712 (GRCm39) Y266C probably damaging Het
Scpep1 A T 11: 88,838,031 (GRCm39) F85L probably damaging Het
Shank1 T A 7: 43,962,530 (GRCm39) probably null Het
Slc40a1 T C 1: 45,948,652 (GRCm39) K543E probably benign Het
Slc9a9 A G 9: 94,842,499 (GRCm39) Y350C probably damaging Het
Sun2 G T 15: 79,618,420 (GRCm39) Y246* probably null Het
Tas1r2 T A 4: 139,397,031 (GRCm39) I790N probably damaging Het
Tmtc2 T C 10: 105,158,863 (GRCm39) T577A probably benign Het
Trim24 T G 6: 37,896,427 (GRCm39) probably null Het
Ttc12 A G 9: 49,349,718 (GRCm39) V693A probably benign Het
Zbtb22 A C 17: 34,136,938 (GRCm39) D361A probably damaging Het
Zfp276 T A 8: 123,983,570 (GRCm39) C324* probably null Het
Zfp536 A G 7: 37,267,952 (GRCm39) L488P probably damaging Het
Other mutations in Or51a24
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1303:Or51a24 UTSW 7 103,733,948 (GRCm39) missense probably damaging 1.00
R1488:Or51a24 UTSW 7 103,733,859 (GRCm39) missense probably benign
R1556:Or51a24 UTSW 7 103,733,468 (GRCm39) missense probably benign
R2158:Or51a24 UTSW 7 103,734,033 (GRCm39) missense probably benign
R2987:Or51a24 UTSW 7 103,734,077 (GRCm39) missense probably benign 0.01
R4437:Or51a24 UTSW 7 103,734,128 (GRCm39) missense possibly damaging 0.88
R4773:Or51a24 UTSW 7 103,733,502 (GRCm39) missense probably damaging 1.00
R5285:Or51a24 UTSW 7 103,733,340 (GRCm39) makesense probably null
R5396:Or51a24 UTSW 7 103,734,098 (GRCm39) missense probably benign 0.08
R5516:Or51a24 UTSW 7 103,733,444 (GRCm39) missense possibly damaging 0.53
R5761:Or51a24 UTSW 7 103,733,376 (GRCm39) missense probably benign 0.01
R5793:Or51a24 UTSW 7 103,734,237 (GRCm39) missense probably benign 0.10
R5960:Or51a24 UTSW 7 103,733,560 (GRCm39) missense probably damaging 1.00
R6242:Or51a24 UTSW 7 103,733,771 (GRCm39) missense possibly damaging 0.82
R6676:Or51a24 UTSW 7 103,733,661 (GRCm39) missense probably benign 0.02
R8202:Or51a24 UTSW 7 103,734,198 (GRCm39) missense probably benign 0.20
R9402:Or51a24 UTSW 7 103,733,610 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AAAGCTACGGAGGACTGTTCCC -3'
(R):5'- AATGGAAGCCATGGAACCCTG -3'

Sequencing Primer
(F):5'- GACTGTTCCCAGGCCCATTG -3'
(R):5'- ATGGAACCCTGGCTGTCTC -3'
Posted On 2018-11-28