Incidental Mutation 'R6979:Mroh5'
ID 542634
Institutional Source Beutler Lab
Gene Symbol Mroh5
Ensembl Gene ENSMUSG00000072487
Gene Name maestro heat-like repeat family member 5
Synonyms Gm628, LOC268816
MMRRC Submission 045087-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R6979 (G1)
Quality Score 225.009
Status Not validated
Chromosome 15
Chromosomal Location 73658785-73711520 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 73664978 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Arginine at position 264 (K264R)
Ref Sequence ENSEMBL: ENSMUSP00000118236 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071419] [ENSMUST00000110021] [ENSMUST00000151999]
AlphaFold A0A571BEG0
Predicted Effect probably benign
Transcript: ENSMUST00000071419
SMART Domains Protein: ENSMUSP00000071366
Gene: ENSMUSG00000072487

DomainStartEndE-ValueType
low complexity region 173 184 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000110021
AA Change: K99R

PolyPhen 2 Score 0.075 (Sensitivity: 0.93; Specificity: 0.85)
Predicted Effect probably benign
Transcript: ENSMUST00000151999
AA Change: K264R

PolyPhen 2 Score 0.159 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000118236
Gene: ENSMUSG00000072487
AA Change: K264R

DomainStartEndE-ValueType
low complexity region 5 16 N/A INTRINSIC
SCOP:d1gw5a_ 294 635 1e-2 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 97.2%
Validation Efficiency 100% (50/50)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadac C T 3: 59,947,424 (GRCm39) T374M probably benign Het
Aspg A G 12: 112,087,378 (GRCm39) D278G possibly damaging Het
Aspm C A 1: 139,408,223 (GRCm39) A2370E probably damaging Het
Ccnt2 T C 1: 127,702,873 (GRCm39) M65T probably damaging Het
Cd163 A G 6: 124,294,945 (GRCm39) T670A probably benign Het
Cpne3 G A 4: 19,533,098 (GRCm39) T279I probably benign Het
Ctdspl G A 9: 118,869,598 (GRCm39) V227M probably damaging Het
Ctnnd2 A G 15: 30,619,376 (GRCm39) E99G probably damaging Het
Dapk1 T C 13: 60,896,095 (GRCm39) S728P probably damaging Het
Dmxl2 A G 9: 54,358,163 (GRCm39) I512T possibly damaging Het
Dop1a A T 9: 86,403,695 (GRCm39) T1630S possibly damaging Het
Dqx1 A G 6: 83,037,992 (GRCm39) D460G probably damaging Het
Foxg1 T C 12: 49,431,567 (GRCm39) probably benign Het
H2-Q2 T A 17: 35,564,623 (GRCm39) probably null Het
Hes6 T C 1: 91,340,810 (GRCm39) E17G possibly damaging Het
Ighv1-42 T C 12: 114,900,848 (GRCm39) Y79C possibly damaging Het
Itfg2 T C 6: 128,388,554 (GRCm39) D311G probably damaging Het
Itgb5 T A 16: 33,740,356 (GRCm39) C489S probably damaging Het
Map4k5 A T 12: 69,869,622 (GRCm39) C488S probably damaging Het
Mark1 C T 1: 184,644,825 (GRCm39) G377D possibly damaging Het
Mat2a A G 6: 72,412,096 (GRCm39) V318A probably damaging Het
Mpp7 T G 18: 7,355,049 (GRCm39) N459T possibly damaging Het
Mrc2 C A 11: 105,239,461 (GRCm39) N1348K probably damaging Het
Mtor A G 4: 148,608,930 (GRCm39) M1529V possibly damaging Het
Mtrr C T 13: 68,718,122 (GRCm39) probably null Het
Nwd1 C T 8: 73,394,288 (GRCm39) P517L probably damaging Het
Or4a27 T A 2: 88,559,528 (GRCm39) R138S probably benign Het
Or8h10 A G 2: 86,808,577 (GRCm39) S188P probably damaging Het
Polr1c A G 17: 46,557,095 (GRCm39) F63L probably damaging Het
Polrmt C T 10: 79,582,400 (GRCm39) probably null Het
Pomt2 T C 12: 87,177,125 (GRCm39) I287M probably damaging Het
Prkar2a T A 9: 108,610,342 (GRCm39) N190K possibly damaging Het
Prl3d3 T A 13: 27,341,545 (GRCm39) Y59N possibly damaging Het
Prl5a1 T A 13: 28,335,189 (GRCm39) F199L probably benign Het
Prpf38b A G 3: 108,818,640 (GRCm39) V40A probably benign Het
Ptchd1 T A X: 154,357,708 (GRCm39) Y499F probably damaging Het
Ptgs1 A G 2: 36,141,311 (GRCm39) D586G probably benign Het
Slx4 T C 16: 3,802,879 (GRCm39) K1312E probably damaging Het
Smok3c A G 5: 138,062,987 (GRCm39) D158G probably benign Het
Spen A T 4: 141,205,374 (GRCm39) D1084E unknown Het
Tcp11l1 C T 2: 104,536,784 (GRCm39) G27D probably benign Het
Tep1 A G 14: 51,076,094 (GRCm39) S1679P possibly damaging Het
Tmem259 C T 10: 79,814,391 (GRCm39) V322I possibly damaging Het
Tmpo A T 10: 90,988,359 (GRCm39) probably null Het
Ttn C A 2: 76,555,137 (GRCm39) A30623S probably damaging Het
Ube2l3 G A 16: 16,977,841 (GRCm39) probably benign Het
Unkl A G 17: 25,418,890 (GRCm39) D146G probably damaging Het
Vmn1r51 A T 6: 90,106,186 (GRCm39) H34L possibly damaging Het
Vmn2r17 A G 5: 109,576,265 (GRCm39) T379A possibly damaging Het
Zfp35 G T 18: 24,136,927 (GRCm39) G424C probably benign Het
Zfp420 T A 7: 29,575,446 (GRCm39) H555Q probably damaging Het
Other mutations in Mroh5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00420:Mroh5 APN 15 73,664,638 (GRCm39) splice site probably benign
IGL00466:Mroh5 APN 15 73,664,638 (GRCm39) splice site probably benign
IGL02937:Mroh5 APN 15 73,661,827 (GRCm39) missense probably damaging 1.00
R0102:Mroh5 UTSW 15 73,691,199 (GRCm39) missense probably benign 0.07
R0321:Mroh5 UTSW 15 73,661,892 (GRCm39) missense probably damaging 1.00
R0433:Mroh5 UTSW 15 73,662,657 (GRCm39) missense probably damaging 1.00
R0433:Mroh5 UTSW 15 73,661,877 (GRCm39) missense probably benign 0.01
R0707:Mroh5 UTSW 15 73,662,588 (GRCm39) missense possibly damaging 0.48
R1666:Mroh5 UTSW 15 73,659,754 (GRCm39) missense probably benign 0.43
R1668:Mroh5 UTSW 15 73,659,754 (GRCm39) missense probably benign 0.43
R2139:Mroh5 UTSW 15 73,661,940 (GRCm39) missense probably damaging 1.00
R2269:Mroh5 UTSW 15 73,664,997 (GRCm39) missense probably benign 0.02
R4078:Mroh5 UTSW 15 73,657,889 (GRCm39) missense possibly damaging 0.79
R4420:Mroh5 UTSW 15 73,654,923 (GRCm39) small deletion probably benign
R4460:Mroh5 UTSW 15 73,663,645 (GRCm39) missense probably damaging 0.97
R4585:Mroh5 UTSW 15 73,661,120 (GRCm39) missense probably benign 0.38
R5285:Mroh5 UTSW 15 73,654,923 (GRCm39) small deletion probably benign
R5287:Mroh5 UTSW 15 73,654,923 (GRCm39) small deletion probably benign
R5437:Mroh5 UTSW 15 73,659,818 (GRCm39) missense probably benign 0.02
R5760:Mroh5 UTSW 15 73,693,356 (GRCm39) missense probably damaging 0.98
R5972:Mroh5 UTSW 15 73,662,568 (GRCm39) critical splice donor site probably null
R6192:Mroh5 UTSW 15 73,662,630 (GRCm39) missense probably damaging 1.00
R6457:Mroh5 UTSW 15 73,662,691 (GRCm39) missense probably damaging 1.00
R6477:Mroh5 UTSW 15 73,662,604 (GRCm39) missense probably damaging 1.00
R6776:Mroh5 UTSW 15 73,661,817 (GRCm39) critical splice donor site probably null
R7238:Mroh5 UTSW 15 73,663,278 (GRCm39) critical splice acceptor site probably null
R7406:Mroh5 UTSW 15 73,659,583 (GRCm39) missense probably benign 0.38
R7853:Mroh5 UTSW 15 73,663,189 (GRCm39) missense probably benign 0.00
R7973:Mroh5 UTSW 15 73,664,614 (GRCm39) nonsense probably null
R8215:Mroh5 UTSW 15 73,691,139 (GRCm39) missense probably damaging 0.96
R8251:Mroh5 UTSW 15 73,655,002 (GRCm39) missense probably benign 0.01
R8771:Mroh5 UTSW 15 73,693,203 (GRCm39) missense possibly damaging 0.92
R9032:Mroh5 UTSW 15 73,655,302 (GRCm39) missense probably benign 0.00
R9070:Mroh5 UTSW 15 73,656,688 (GRCm39) missense probably damaging 1.00
R9238:Mroh5 UTSW 15 73,663,586 (GRCm39) missense probably benign 0.05
R9321:Mroh5 UTSW 15 73,661,113 (GRCm39) missense probably benign 0.00
X0024:Mroh5 UTSW 15 73,659,570 (GRCm39) missense probably benign 0.01
Z1088:Mroh5 UTSW 15 73,659,880 (GRCm39) missense possibly damaging 0.85
Predicted Primers
Posted On 2018-11-28