Incidental Mutation 'R6982:Or8g32'
ID 542737
Institutional Source Beutler Lab
Gene Symbol Or8g32
Ensembl Gene ENSMUSG00000094269
Gene Name olfactory receptor family 8 subfamily G member 32
Synonyms GA_x6K02T2PVTD-33090395-33091330, MOR171-33P, MOR171-49, Olfr951
MMRRC Submission 045383-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R6982 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 39305089-39306033 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 39305618 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 174 (I174T)
Ref Sequence ENSEMBL: ENSMUSP00000150976 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078531] [ENSMUST00000216107]
AlphaFold Q9EQ94
Predicted Effect probably damaging
Transcript: ENSMUST00000078531
AA Change: I177T

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000077615
Gene: ENSMUSG00000094269
AA Change: I177T

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 2.5e-52 PFAM
Pfam:7tm_1 44 293 5e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216107
AA Change: I174T

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 96.7%
Validation Efficiency 98% (55/56)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts16 T A 13: 70,916,639 (GRCm39) probably null Het
Adamtsl3 C A 7: 82,164,271 (GRCm39) P362H probably damaging Het
Ambra1 G A 2: 91,747,818 (GRCm39) V1065I probably damaging Het
Ankrd66 T C 17: 43,849,926 (GRCm39) T79A probably damaging Het
Ano2 G A 6: 125,969,856 (GRCm39) R724H probably benign Het
Bmp8a A G 4: 123,218,934 (GRCm39) L158P probably damaging Het
C1ra G A 6: 124,494,684 (GRCm39) E316K probably benign Het
Cilp T C 9: 65,187,087 (GRCm39) Y1061H probably damaging Het
Clybl G A 14: 122,639,359 (GRCm39) G308R probably damaging Het
Cntnap5c C T 17: 58,399,247 (GRCm39) P367S possibly damaging Het
Col20a1 T C 2: 180,638,499 (GRCm39) V371A probably benign Het
Col24a1 G T 3: 145,020,807 (GRCm39) G393* probably null Het
Dnah12 A G 14: 26,521,033 (GRCm39) probably null Het
Dnah8 T A 17: 30,986,899 (GRCm39) S3183T probably benign Het
Dph2 A T 4: 117,746,993 (GRCm39) I435N probably benign Het
Fam3c G T 6: 22,322,300 (GRCm39) A107D probably damaging Het
Fezf2 G T 14: 12,343,645 (GRCm38) Q367K probably damaging Het
Gbp2 A G 3: 142,335,846 (GRCm39) D182G probably damaging Het
Gpr162 T A 6: 124,837,919 (GRCm39) I244F probably damaging Het
Jakmip1 A T 5: 37,282,285 (GRCm39) N159I probably damaging Het
Jkampl A T 6: 73,446,527 (GRCm39) Y7* probably null Het
Kdm4a A T 4: 118,010,636 (GRCm39) probably null Het
Klf5 A G 14: 99,550,671 (GRCm39) H416R probably damaging Het
Lrrc63 A G 14: 75,322,211 (GRCm39) V631A probably benign Het
Man1a T C 10: 53,950,819 (GRCm39) E101G possibly damaging Het
Msantd4 T A 9: 4,384,061 (GRCm39) N127K possibly damaging Het
Myo3b A T 2: 70,256,409 (GRCm39) E1248D probably benign Het
Ncapd2 A T 6: 125,153,699 (GRCm39) I672N probably damaging Het
Nfic T C 10: 81,256,634 (GRCm39) probably null Het
Nr1h3 A G 2: 91,021,104 (GRCm39) S228P probably damaging Het
Pccb A T 9: 100,905,349 (GRCm39) probably null Het
Pcmtd1 T G 1: 7,217,906 (GRCm39) V118G probably damaging Het
Pkhd1l1 A T 15: 44,429,664 (GRCm39) N3294I probably damaging Het
Plscr4 A G 9: 92,364,796 (GRCm39) T74A probably benign Het
Rasa2 A T 9: 96,442,803 (GRCm39) I540N probably damaging Het
Serpina3j C A 12: 104,283,556 (GRCm39) T218K probably benign Het
Slc16a4 A G 3: 107,206,589 (GRCm39) D173G probably benign Het
Slc19a2 T C 1: 164,084,428 (GRCm39) L106P possibly damaging Het
Slc22a19 C T 19: 7,660,334 (GRCm39) V359M probably benign Het
Slc22a7 T A 17: 46,745,563 (GRCm39) M323L probably benign Het
Spata21 A T 4: 140,824,184 (GRCm39) N149I possibly damaging Het
Spink5 G A 18: 44,110,792 (GRCm39) G121D probably damaging Het
Spink5 T C 18: 44,143,109 (GRCm39) probably null Het
Ssbp4 T C 8: 71,060,815 (GRCm39) S6G possibly damaging Het
Sytl2 T C 7: 90,045,772 (GRCm39) S641P probably damaging Het
Tcf3 A T 10: 80,253,384 (GRCm39) F215I probably damaging Het
Tmem150c C A 5: 100,240,680 (GRCm39) D61Y probably benign Het
Ttc7 T A 17: 87,614,437 (GRCm39) F201I probably damaging Het
Tyw3 T C 3: 154,285,867 (GRCm39) I208V probably benign Het
Vmn1r202 T C 13: 22,685,917 (GRCm39) T167A probably benign Het
Vmn1r83 A T 7: 12,055,763 (GRCm39) L98Q probably damaging Het
Vmn2r95 T C 17: 18,672,323 (GRCm39) Y687H probably damaging Het
Wdr59 A T 8: 112,187,445 (GRCm39) F783L probably benign Het
Zfhx4 A G 3: 5,468,890 (GRCm39) Y3016C probably damaging Het
Zfp518b T C 5: 38,830,248 (GRCm39) T586A probably benign Het
Other mutations in Or8g32
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01527:Or8g32 APN 9 39,305,114 (GRCm39) missense probably benign 0.01
IGL01650:Or8g32 APN 9 39,305,252 (GRCm39) missense probably damaging 0.99
IGL02134:Or8g32 APN 9 39,305,830 (GRCm39) missense probably damaging 0.99
IGL03113:Or8g32 APN 9 39,305,981 (GRCm39) missense probably damaging 1.00
R0127:Or8g32 UTSW 9 39,305,238 (GRCm39) missense probably benign 0.16
R1730:Or8g32 UTSW 9 39,305,518 (GRCm39) missense probably benign 0.01
R1783:Or8g32 UTSW 9 39,305,518 (GRCm39) missense probably benign 0.01
R1924:Or8g32 UTSW 9 39,305,163 (GRCm39) missense possibly damaging 0.93
R3785:Or8g32 UTSW 9 39,305,678 (GRCm39) missense probably benign 0.07
R3787:Or8g32 UTSW 9 39,305,678 (GRCm39) missense probably benign 0.07
R4607:Or8g32 UTSW 9 39,306,031 (GRCm39) makesense probably null
R4803:Or8g32 UTSW 9 39,305,932 (GRCm39) missense probably benign 0.26
R5314:Or8g32 UTSW 9 39,305,785 (GRCm39) missense probably damaging 1.00
R5338:Or8g32 UTSW 9 39,305,371 (GRCm39) missense probably damaging 1.00
R5360:Or8g32 UTSW 9 39,305,698 (GRCm39) missense probably benign 0.00
R5468:Or8g32 UTSW 9 39,305,257 (GRCm39) missense probably benign 0.33
R6590:Or8g32 UTSW 9 39,305,845 (GRCm39) missense probably benign 0.00
R6690:Or8g32 UTSW 9 39,305,845 (GRCm39) missense probably benign 0.00
R6925:Or8g32 UTSW 9 39,305,157 (GRCm39) missense probably benign 0.01
R6925:Or8g32 UTSW 9 39,305,156 (GRCm39) missense probably benign 0.32
R7662:Or8g32 UTSW 9 39,305,389 (GRCm39) missense probably benign 0.01
R8074:Or8g32 UTSW 9 39,305,242 (GRCm39) missense probably damaging 1.00
R8389:Or8g32 UTSW 9 39,305,912 (GRCm39) missense probably damaging 1.00
R9444:Or8g32 UTSW 9 39,305,365 (GRCm39) missense probably benign 0.19
R9642:Or8g32 UTSW 9 39,305,857 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTTTGGCACTGCAGAGAGC -3'
(R):5'- TGCTGAAGGCTTTGGACCTG -3'

Sequencing Primer
(F):5'- TTGGCACTGCAGAGAGCTACAC -3'
(R):5'- TGCCCTCCCTAGAGTGAATG -3'
Posted On 2018-11-28