Incidental Mutation 'R6984:Ticam1'
ID 542873
Institutional Source Beutler Lab
Gene Symbol Ticam1
Ensembl Gene ENSMUSG00000047123
Gene Name TIR domain containing adaptor molecule 1
Synonyms Trif, TICAM-1
MMRRC Submission 045091-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6984 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 56576462-56583767 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 56576900 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Lysine at position 732 (E732K)
Ref Sequence ENSEMBL: ENSMUSP00000055104 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058136]
AlphaFold Q80UF7
Predicted Effect probably benign
Transcript: ENSMUST00000058136
AA Change: E732K

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000055104
Gene: ENSMUSG00000047123
AA Change: E732K

DomainStartEndE-ValueType
PDB:4BSX|D 5 153 3e-52 PDB
low complexity region 345 384 N/A INTRINSIC
SCOP:d1fyva_ 386 491 8e-3 SMART
PDB:2M1X|A 391 547 1e-74 PDB
Pfam:RHIM 610 698 4.7e-13 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.1%
  • 20x: 96.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012]
PHENOTYPE: Homozygous null mice are viable but exhibit abnormalities of the innate immune system. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik A G 14: 32,383,937 (GRCm39) V676A probably benign Het
Abcb5 A G 12: 118,891,012 (GRCm39) M495T possibly damaging Het
Aktip A T 8: 91,853,346 (GRCm39) F124I probably damaging Het
Alpk2 C A 18: 65,438,749 (GRCm39) Q1348H possibly damaging Het
Apol11b T C 15: 77,519,546 (GRCm39) D178G probably benign Het
Asb15 A T 6: 24,566,336 (GRCm39) I430F probably benign Het
Chd2 A C 7: 73,134,159 (GRCm39) Y729* probably null Het
Cpb2 T C 14: 75,502,898 (GRCm39) V159A possibly damaging Het
Csf2rb A G 15: 78,229,719 (GRCm39) S429G probably damaging Het
Ctsw C T 19: 5,516,646 (GRCm39) R133H probably damaging Het
Dhx30 A G 9: 109,920,485 (GRCm39) probably null Het
Dnah8 G A 17: 30,958,712 (GRCm39) G2185R probably damaging Het
Ell2 C A 13: 75,910,006 (GRCm39) L119M probably damaging Het
Enthd1 A T 15: 80,444,309 (GRCm39) I82N probably damaging Het
Epx T A 11: 87,759,424 (GRCm39) D555V probably damaging Het
Fhdc1 T G 3: 84,351,823 (GRCm39) D1134A possibly damaging Het
Fip1l1 T A 5: 74,702,734 (GRCm39) V82D probably damaging Het
Fn1 A T 1: 71,665,238 (GRCm39) F960I probably damaging Het
Gsdmc2 A T 15: 63,696,898 (GRCm39) Y424* probably null Het
Hsd3b7 T A 7: 127,400,717 (GRCm39) I57N probably damaging Het
Ighv10-1 A T 12: 114,442,702 (GRCm39) D94E possibly damaging Het
Ighv3-3 A G 12: 114,160,350 (GRCm39) V20A possibly damaging Het
Kcnh3 G T 15: 99,126,433 (GRCm39) C220F probably benign Het
Kctd16 G A 18: 40,390,101 (GRCm39) probably benign Het
L3mbtl3 T C 10: 26,158,753 (GRCm39) K632E unknown Het
Lama1 G A 17: 68,086,107 (GRCm39) V1449M Het
Lgr6 A G 1: 134,915,740 (GRCm39) I336T possibly damaging Het
Lrp1b A C 2: 40,712,640 (GRCm39) D3117E probably damaging Het
Lrrc4b A T 7: 44,110,722 (GRCm39) E198V possibly damaging Het
Map2 A T 1: 66,454,395 (GRCm39) D1095V possibly damaging Het
Mapk8ip1 A T 2: 92,217,072 (GRCm39) S417T probably damaging Het
Med24 A G 11: 98,609,368 (GRCm39) V94A possibly damaging Het
Megf11 A G 9: 64,593,734 (GRCm39) I637V probably benign Het
Mpp7 C T 18: 7,441,623 (GRCm39) G182D probably damaging Het
Myh15 G A 16: 48,930,775 (GRCm39) G583D probably damaging Het
Naa15 A G 3: 51,380,021 (GRCm39) T750A probably benign Het
Or10d5b C T 9: 39,886,030 (GRCm39) V30I unknown Het
Or10v5 T A 19: 11,805,668 (GRCm39) T241S probably damaging Het
Or1e30 G A 11: 73,678,603 (GRCm39) V280M possibly damaging Het
Pgm1 A T 4: 99,786,851 (GRCm39) Q30L probably benign Het
Pi4kb C T 3: 94,904,245 (GRCm39) R238C probably damaging Het
Plec T C 15: 76,059,527 (GRCm39) E3497G probably damaging Het
Plpp4 C T 7: 128,992,616 (GRCm39) A218V possibly damaging Het
Plxnc1 G A 10: 94,667,392 (GRCm39) A1094V probably damaging Het
Pom121l2 A T 13: 22,166,191 (GRCm39) D154V probably benign Het
Prrt4 G T 6: 29,171,429 (GRCm39) P341Q probably benign Het
Psd3 A G 8: 68,270,697 (GRCm39) V21A possibly damaging Het
Rhot1 T A 11: 80,124,310 (GRCm39) C157* probably null Het
Rnase9 C T 14: 51,276,673 (GRCm39) V102M probably benign Het
Rpgrip1l A C 8: 91,987,426 (GRCm39) M877R probably benign Het
Ryr3 T C 2: 112,705,436 (GRCm39) Y806C probably damaging Het
Smox C T 2: 131,364,031 (GRCm39) A45V possibly damaging Het
Sympk A G 7: 18,771,968 (GRCm39) D344G probably benign Het
Tcf12 G A 9: 71,914,041 (GRCm39) Q76* probably null Het
Trgv6 G T 13: 19,374,814 (GRCm39) G40W possibly damaging Het
Ttc19 A G 11: 62,204,863 (GRCm39) Y318C probably damaging Het
Vmn2r17 T A 5: 109,600,533 (GRCm39) D610E probably benign Het
Wdr24 A G 17: 26,047,209 (GRCm39) T701A possibly damaging Het
Zfp268 T C 4: 145,347,186 (GRCm39) L30P probably damaging Het
Other mutations in Ticam1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02160:Ticam1 APN 17 56,577,560 (GRCm39) missense possibly damaging 0.80
IGL02164:Ticam1 APN 17 56,577,019 (GRCm39) missense unknown
Lps2 UTSW 17 56,576,969 (GRCm39) frame shift probably null
Pangu UTSW 17 56,276,693 (GRCm38) critical splice donor site probably benign
Yue UTSW 17 56,578,339 (GRCm39) missense probably benign 0.06
R0930:Ticam1 UTSW 17 56,578,687 (GRCm39) missense probably damaging 1.00
R0930:Ticam1 UTSW 17 56,577,226 (GRCm39) missense unknown
R1509:Ticam1 UTSW 17 56,578,113 (GRCm39) missense probably benign 0.43
R1837:Ticam1 UTSW 17 56,577,799 (GRCm39) missense possibly damaging 0.87
R1863:Ticam1 UTSW 17 56,578,436 (GRCm39) missense probably damaging 1.00
R1867:Ticam1 UTSW 17 56,578,718 (GRCm39) missense probably benign 0.01
R1872:Ticam1 UTSW 17 56,578,897 (GRCm39) missense probably benign 0.00
R1893:Ticam1 UTSW 17 56,578,894 (GRCm39) missense probably benign 0.36
R1980:Ticam1 UTSW 17 56,578,555 (GRCm39) missense probably damaging 0.99
R1981:Ticam1 UTSW 17 56,578,555 (GRCm39) missense probably damaging 0.99
R1982:Ticam1 UTSW 17 56,578,555 (GRCm39) missense probably damaging 0.99
R2263:Ticam1 UTSW 17 56,578,888 (GRCm39) missense possibly damaging 0.95
R2513:Ticam1 UTSW 17 56,578,612 (GRCm39) missense possibly damaging 0.61
R4294:Ticam1 UTSW 17 56,578,339 (GRCm39) missense probably benign 0.06
R4888:Ticam1 UTSW 17 56,578,642 (GRCm39) missense probably damaging 0.98
R4982:Ticam1 UTSW 17 56,579,020 (GRCm39) missense probably benign 0.10
R5396:Ticam1 UTSW 17 56,578,117 (GRCm39) missense probably benign 0.02
R5604:Ticam1 UTSW 17 56,578,756 (GRCm39) missense probably benign 0.13
R5641:Ticam1 UTSW 17 56,577,629 (GRCm39) frame shift probably null
R5647:Ticam1 UTSW 17 56,577,629 (GRCm39) frame shift probably null
R5648:Ticam1 UTSW 17 56,577,629 (GRCm39) frame shift probably null
R5657:Ticam1 UTSW 17 56,577,629 (GRCm39) frame shift probably null
R5770:Ticam1 UTSW 17 56,577,629 (GRCm39) frame shift probably null
R5771:Ticam1 UTSW 17 56,577,629 (GRCm39) frame shift probably null
R5964:Ticam1 UTSW 17 56,578,703 (GRCm39) missense probably damaging 0.99
R5974:Ticam1 UTSW 17 56,578,178 (GRCm39) missense probably benign
R6217:Ticam1 UTSW 17 56,577,730 (GRCm39) missense probably damaging 1.00
R6983:Ticam1 UTSW 17 56,576,900 (GRCm39) missense probably benign 0.00
R6985:Ticam1 UTSW 17 56,576,900 (GRCm39) missense probably benign 0.00
R6986:Ticam1 UTSW 17 56,576,900 (GRCm39) missense probably benign 0.00
R6987:Ticam1 UTSW 17 56,576,900 (GRCm39) missense probably benign 0.00
R6988:Ticam1 UTSW 17 56,576,900 (GRCm39) missense probably benign 0.00
R6989:Ticam1 UTSW 17 56,576,900 (GRCm39) missense probably benign 0.00
R7029:Ticam1 UTSW 17 56,578,154 (GRCm39) missense possibly damaging 0.51
R7684:Ticam1 UTSW 17 56,576,984 (GRCm39) missense unknown
R7755:Ticam1 UTSW 17 56,577,182 (GRCm39) missense unknown
R7885:Ticam1 UTSW 17 56,578,067 (GRCm39) missense probably benign 0.04
R8021:Ticam1 UTSW 17 56,577,089 (GRCm39) missense unknown
R8414:Ticam1 UTSW 17 56,578,340 (GRCm39) missense probably benign 0.00
R8822:Ticam1 UTSW 17 56,578,444 (GRCm39) missense probably damaging 1.00
R9442:Ticam1 UTSW 17 56,577,428 (GRCm39) missense probably benign 0.00
R9521:Ticam1 UTSW 17 56,578,388 (GRCm39) missense probably benign 0.07
V8831:Ticam1 UTSW 17 56,576,969 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- GGTCTCAAGCTGGGTCCAAC -3'
(R):5'- TCCTCAGGGTGGTACTCCAG -3'

Sequencing Primer
(F):5'- TGGGTCCAACTAATAGCCACTGTG -3'
(R):5'- CAGGGTGGTACTCCAGTTTTCC -3'
Posted On 2018-11-28