Mutagenetix > Incidental Mutation

Incidental Mutation 'R6984:Or10v5'

542879

Institutional Source

Beutler Lab

Gene Symbol

Or10v5

Ensembl Gene

ENSMUSG00000048292

Gene Name

olfactory receptor family 10 subfamily V member 5

Synonyms

MOR266-2, GA_x6K02T2RE5P-2172809-2171862, Olfr1417

MMRRC Submission

045091-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.071) question?

Stock #

R6984 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

11805441-11806388 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 11805668 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 241 (T241S)

Ref Sequence

ENSEMBL: ENSMUSP00000149141 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061235] [ENSMUST00000214887]

AlphaFold

Q8VGJ6

Predicted Effect

probably damaging
Transcript: ENSMUST00000061235
AA Change: T241S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000062542
Gene: ENSMUSG00000048292
AA Change: T241S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	309	3.3e-53	PFAM
Pfam:7tm_1	41	291	3.1e-22	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000214887
AA Change: T241S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.1%
20x: 96.4%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3425401B19Rik	A	G	14: 32,383,937 (GRCm39)	V676A	probably benign	Het
Abcb5	A	G	12: 118,891,012 (GRCm39)	M495T	possibly damaging	Het
Aktip	A	T	8: 91,853,346 (GRCm39)	F124I	probably damaging	Het
Alpk2	C	A	18: 65,438,749 (GRCm39)	Q1348H	possibly damaging	Het
Apol11b	T	C	15: 77,519,546 (GRCm39)	D178G	probably benign	Het
Asb15	A	T	6: 24,566,336 (GRCm39)	I430F	probably benign	Het
Chd2	A	C	7: 73,134,159 (GRCm39)	Y729*	probably null	Het
Cpb2	T	C	14: 75,502,898 (GRCm39)	V159A	possibly damaging	Het
Csf2rb	A	G	15: 78,229,719 (GRCm39)	S429G	probably damaging	Het
Ctsw	C	T	19: 5,516,646 (GRCm39)	R133H	probably damaging	Het
Dhx30	A	G	9: 109,920,485 (GRCm39)		probably null	Het
Dnah8	G	A	17: 30,958,712 (GRCm39)	G2185R	probably damaging	Het
Ell2	C	A	13: 75,910,006 (GRCm39)	L119M	probably damaging	Het
Enthd1	A	T	15: 80,444,309 (GRCm39)	I82N	probably damaging	Het
Epx	T	A	11: 87,759,424 (GRCm39)	D555V	probably damaging	Het
Fhdc1	T	G	3: 84,351,823 (GRCm39)	D1134A	possibly damaging	Het
Fip1l1	T	A	5: 74,702,734 (GRCm39)	V82D	probably damaging	Het
Fn1	A	T	1: 71,665,238 (GRCm39)	F960I	probably damaging	Het
Gsdmc2	A	T	15: 63,696,898 (GRCm39)	Y424*	probably null	Het
Hsd3b7	T	A	7: 127,400,717 (GRCm39)	I57N	probably damaging	Het
Ighv10-1	A	T	12: 114,442,702 (GRCm39)	D94E	possibly damaging	Het
Ighv3-3	A	G	12: 114,160,350 (GRCm39)	V20A	possibly damaging	Het
Kcnh3	G	T	15: 99,126,433 (GRCm39)	C220F	probably benign	Het
Kctd16	G	A	18: 40,390,101 (GRCm39)		probably benign	Het
L3mbtl3	T	C	10: 26,158,753 (GRCm39)	K632E	unknown	Het
Lama1	G	A	17: 68,086,107 (GRCm39)	V1449M		Het
Lgr6	A	G	1: 134,915,740 (GRCm39)	I336T	possibly damaging	Het
Lrp1b	A	C	2: 40,712,640 (GRCm39)	D3117E	probably damaging	Het
Lrrc4b	A	T	7: 44,110,722 (GRCm39)	E198V	possibly damaging	Het
Map2	A	T	1: 66,454,395 (GRCm39)	D1095V	possibly damaging	Het
Mapk8ip1	A	T	2: 92,217,072 (GRCm39)	S417T	probably damaging	Het
Med24	A	G	11: 98,609,368 (GRCm39)	V94A	possibly damaging	Het
Megf11	A	G	9: 64,593,734 (GRCm39)	I637V	probably benign	Het
Mpp7	C	T	18: 7,441,623 (GRCm39)	G182D	probably damaging	Het
Myh15	G	A	16: 48,930,775 (GRCm39)	G583D	probably damaging	Het
Naa15	A	G	3: 51,380,021 (GRCm39)	T750A	probably benign	Het
Or10d5b	C	T	9: 39,886,030 (GRCm39)	V30I	unknown	Het
Or1e30	G	A	11: 73,678,603 (GRCm39)	V280M	possibly damaging	Het
Pgm1	A	T	4: 99,786,851 (GRCm39)	Q30L	probably benign	Het
Pi4kb	C	T	3: 94,904,245 (GRCm39)	R238C	probably damaging	Het
Plec	T	C	15: 76,059,527 (GRCm39)	E3497G	probably damaging	Het
Plpp4	C	T	7: 128,992,616 (GRCm39)	A218V	possibly damaging	Het
Plxnc1	G	A	10: 94,667,392 (GRCm39)	A1094V	probably damaging	Het
Pom121l2	A	T	13: 22,166,191 (GRCm39)	D154V	probably benign	Het
Prrt4	G	T	6: 29,171,429 (GRCm39)	P341Q	probably benign	Het
Psd3	A	G	8: 68,270,697 (GRCm39)	V21A	possibly damaging	Het
Rhot1	T	A	11: 80,124,310 (GRCm39)	C157*	probably null	Het
Rnase9	C	T	14: 51,276,673 (GRCm39)	V102M	probably benign	Het
Rpgrip1l	A	C	8: 91,987,426 (GRCm39)	M877R	probably benign	Het
Ryr3	T	C	2: 112,705,436 (GRCm39)	Y806C	probably damaging	Het
Smox	C	T	2: 131,364,031 (GRCm39)	A45V	possibly damaging	Het
Sympk	A	G	7: 18,771,968 (GRCm39)	D344G	probably benign	Het
Tcf12	G	A	9: 71,914,041 (GRCm39)	Q76*	probably null	Het
Ticam1	C	T	17: 56,576,900 (GRCm39)	E732K	probably benign	Het
Trgv6	G	T	13: 19,374,814 (GRCm39)	G40W	possibly damaging	Het
Ttc19	A	G	11: 62,204,863 (GRCm39)	Y318C	probably damaging	Het
Vmn2r17	T	A	5: 109,600,533 (GRCm39)	D610E	probably benign	Het
Wdr24	A	G	17: 26,047,209 (GRCm39)	T701A	possibly damaging	Het
Zfp268	T	C	4: 145,347,186 (GRCm39)	L30P	probably damaging	Het

Other mutations in Or10v5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0530:Or10v5	UTSW	19	11,805,556 (GRCm39)	missense	probably benign	0.26
R1532:Or10v5	UTSW	19	11,805,983 (GRCm39)	missense	probably benign	0.00
R1730:Or10v5	UTSW	19	11,805,445 (GRCm39)	missense	probably benign	0.06
R2032:Or10v5	UTSW	19	11,805,664 (GRCm39)	missense	probably damaging	1.00
R2237:Or10v5	UTSW	19	11,805,814 (GRCm39)	missense	probably damaging	1.00
R2238:Or10v5	UTSW	19	11,805,814 (GRCm39)	missense	probably damaging	1.00
R2239:Or10v5	UTSW	19	11,805,814 (GRCm39)	missense	probably damaging	1.00
R4959:Or10v5	UTSW	19	11,806,300 (GRCm39)	missense	probably benign
R4973:Or10v5	UTSW	19	11,806,300 (GRCm39)	missense	probably benign
R5015:Or10v5	UTSW	19	11,805,482 (GRCm39)	missense	probably benign	0.00
R6799:Or10v5	UTSW	19	11,806,178 (GRCm39)	missense	possibly damaging	0.91
R7063:Or10v5	UTSW	19	11,805,548 (GRCm39)	missense	probably damaging	1.00
R7222:Or10v5	UTSW	19	11,806,021 (GRCm39)	missense	probably damaging	0.99
R8021:Or10v5	UTSW	19	11,806,256 (GRCm39)	missense	probably benign	0.39
R8748:Or10v5	UTSW	19	11,805,596 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCCCAGTGTCTGAGAGGATC -3'
(R):5'- CATGAGACTGGCATGTGCAG -3'

Sequencing Primer
(F):5'- CATTGTTTTTCAAGCAGGAGGAAGC -3'
(R):5'- AGACTGGCATGTGCAGACACC -3'

Posted On

2018-11-28