Incidental Mutation 'R6987:Trav14-1'
ID 543048
Institutional Source Beutler Lab
Gene Symbol Trav14-1
Ensembl Gene ENSMUSG00000076840
Gene Name T cell receptor alpha variable 14-1
Synonyms Gm5770
MMRRC Submission 045094-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R6987 (G1)
Quality Score 225.009
Status Validated
Chromosome 14
Chromosomal Location 53791514-53792015 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 53791916 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 89 (R89*)
Ref Sequence ENSEMBL: ENSMUSP00000143077 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000198297]
AlphaFold A0A0G2JF94
Predicted Effect probably null
Transcript: ENSMUST00000198297
AA Change: R89*
SMART Domains Protein: ENSMUSP00000143077
Gene: ENSMUSG00000076840
AA Change: R89*

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
IGv 46 120 2.6e-13 SMART
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.8%
  • 10x: 99.0%
  • 20x: 96.9%
Validation Efficiency 100% (47/47)
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam10 A G 9: 70,629,978 (GRCm39) I137V probably benign Het
Agtr1b A C 3: 20,370,585 (GRCm39) I7S probably benign Het
Akt2 G T 7: 27,332,666 (GRCm39) V215L probably damaging Het
Ccdc148 C A 2: 58,872,926 (GRCm39) L294F probably damaging Het
Ccdc3 T A 2: 5,143,115 (GRCm39) V124E possibly damaging Het
Cldnd1 A G 16: 58,551,734 (GRCm39) D121G probably benign Het
Cnr1 A G 4: 33,944,739 (GRCm39) I376V probably benign Het
Cyp2c40 A G 19: 39,801,211 (GRCm39) probably benign Het
Dnah8 A G 17: 30,881,065 (GRCm39) I601V possibly damaging Het
Dnhd1 C A 7: 105,353,792 (GRCm39) H2982N probably damaging Het
Elavl4 A T 4: 110,108,602 (GRCm39) D55E possibly damaging Het
Enc1 T C 13: 97,382,144 (GRCm39) I218T probably benign Het
Fbln2 T A 6: 91,211,211 (GRCm39) V385D probably benign Het
Ffar2 A G 7: 30,519,108 (GRCm39) V144A possibly damaging Het
Fsip2 C T 2: 82,778,630 (GRCm39) Q159* probably null Het
Golga4 A G 9: 118,387,600 (GRCm39) H1574R probably benign Het
Herc2 G A 7: 55,756,201 (GRCm39) R747H possibly damaging Het
Lama4 A G 10: 38,950,275 (GRCm39) N985D probably benign Het
Lrp1 T C 10: 127,410,874 (GRCm39) N1438S probably damaging Het
Masp1 C A 16: 23,332,665 (GRCm39) V57F probably damaging Het
Mypn T C 10: 63,028,910 (GRCm39) E51G probably benign Het
Nos1 C T 5: 118,033,850 (GRCm39) T324M probably benign Het
Npas3 A G 12: 54,115,036 (GRCm39) K635E possibly damaging Het
Or5p4 C A 7: 107,680,338 (GRCm39) C112* probably null Het
Or8b12i A T 9: 20,082,130 (GRCm39) S246T probably benign Het
Osbp2 T C 11: 3,667,958 (GRCm39) E13G probably damaging Het
Pira12 A G 7: 3,900,660 (GRCm39) I30T probably damaging Het
Pkd1l1 A G 11: 8,852,575 (GRCm39) M636T probably benign Het
Pla2g4e C T 2: 120,016,861 (GRCm39) A227T probably benign Het
Prex2 C A 1: 11,240,976 (GRCm39) A1028E probably damaging Het
Prr14 A G 7: 127,072,977 (GRCm39) D49G possibly damaging Het
Slc9a9 A G 9: 94,552,043 (GRCm39) probably benign Het
Sptb A G 12: 76,660,021 (GRCm39) C960R probably benign Het
Taf15 C A 11: 83,375,521 (GRCm39) T31K possibly damaging Het
Tdrd9 C A 12: 111,992,027 (GRCm39) Q601K possibly damaging Het
Tes C A 6: 17,086,154 (GRCm39) Q16K probably benign Het
Ticam1 C T 17: 56,576,900 (GRCm39) E732K probably benign Het
Tmem168 T A 6: 13,591,476 (GRCm39) M63L possibly damaging Het
Trp53bp2 A T 1: 182,274,200 (GRCm39) Y615F probably damaging Het
Ttc27 T C 17: 75,084,736 (GRCm39) probably null Het
Usp25 T A 16: 76,874,068 (GRCm39) V548E probably damaging Het
Vmn1r124 A T 7: 20,993,743 (GRCm39) I267K probably benign Het
Vmn1r69 A G 7: 10,314,491 (GRCm39) M1T probably null Het
Zfp729a T A 13: 67,768,058 (GRCm39) K724* probably null Het
Zfp850 A T 7: 27,689,426 (GRCm39) C261S probably damaging Het
Zfp882 T A 8: 72,668,517 (GRCm39) V448E probably benign Het
Zzef1 A G 11: 72,746,340 (GRCm39) M881V possibly damaging Het
Other mutations in Trav14-1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02236:Trav14-1 APN 14 53,791,763 (GRCm39) missense possibly damaging 0.95
R5258:Trav14-1 UTSW 14 53,791,730 (GRCm39) missense probably benign 0.10
R6340:Trav14-1 UTSW 14 53,791,955 (GRCm39) missense probably damaging 1.00
R8838:Trav14-1 UTSW 14 53,792,009 (GRCm39) missense probably damaging 1.00
Z1177:Trav14-1 UTSW 14 53,791,836 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- GGTGAGACAAAGTCCCCAATC -3'
(R):5'- GCCTGAATGAGTCTAACCCC -3'

Sequencing Primer
(F):5'- CCAATCTCTGACAGTCTGGGAAG -3'
(R):5'- GCCTGAATGAGTCTAACCCCTATATC -3'
Posted On 2018-11-28