Incidental Mutation 'R6532:Adal'
ID 543437
Institutional Source Beutler Lab
Gene Symbol Adal
Ensembl Gene ENSMUSG00000027259
Gene Name adenosine deaminase-like
Synonyms 4930578F03Rik
MMRRC Submission 044658-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6532 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 120970909-120987161 bp(+) (GRCm39)
Type of Mutation splice site (3 bp from exon)
DNA Base Change (assembly) A to G at 120976604 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000113052 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028702] [ENSMUST00000066155] [ENSMUST00000110662] [ENSMUST00000119031]
AlphaFold Q80SY6
Predicted Effect probably null
Transcript: ENSMUST00000028702
SMART Domains Protein: ENSMUSP00000028702
Gene: ENSMUSG00000027259

DomainStartEndE-ValueType
Pfam:A_deaminase 1 276 1.8e-37 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000066155
SMART Domains Protein: ENSMUSP00000067133
Gene: ENSMUSG00000027259

DomainStartEndE-ValueType
Pfam:A_deaminase 16 343 1.6e-36 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000110662
SMART Domains Protein: ENSMUSP00000106290
Gene: ENSMUSG00000027259

DomainStartEndE-ValueType
Pfam:A_deaminase 2 200 1.1e-28 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000119031
SMART Domains Protein: ENSMUSP00000113052
Gene: ENSMUSG00000027259

DomainStartEndE-ValueType
Pfam:A_deaminase 16 343 3e-44 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.4%
  • 10x: 97.2%
  • 20x: 91.1%
Validation Efficiency 100% (34/34)
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 A G 7: 45,626,803 (GRCm39) L1418P probably damaging Het
Atr T A 9: 95,790,461 (GRCm39) N1600K probably benign Het
Cubn T C 2: 13,463,813 (GRCm39) T631A probably benign Het
Dpp9 C T 17: 56,512,854 (GRCm39) G118D possibly damaging Het
Ear1 C T 14: 44,056,709 (GRCm39) R53H probably benign Het
Exoc1 T C 5: 76,685,684 (GRCm39) V132A probably damaging Het
Fam227a C T 15: 79,520,921 (GRCm39) R301Q probably benign Het
Garnl3 A T 2: 32,921,131 (GRCm39) M298K possibly damaging Het
Glb1l3 T C 9: 26,729,738 (GRCm39) D619G probably benign Het
Haspin A T 11: 73,028,377 (GRCm39) C237* probably null Het
Hook1 T G 4: 95,907,993 (GRCm39) probably null Het
Hoxa7 A G 6: 52,194,295 (GRCm39) F31L probably benign Het
Hoxb7 C A 11: 96,177,714 (GRCm39) S54* probably null Het
Idh3b AG AGCACCACAACTG 2: 130,121,593 (GRCm39) probably null Het
Ifi207 A G 1: 173,557,211 (GRCm39) V516A possibly damaging Het
Inca1 T C 11: 70,586,733 (GRCm39) M1V probably null Het
Kcnt2 A G 1: 140,511,844 (GRCm39) T933A probably damaging Het
Lama4 G A 10: 38,924,073 (GRCm39) D494N possibly damaging Het
Lrp1 A C 10: 127,377,551 (GRCm39) H4133Q probably damaging Het
Lrp1 A G 10: 127,385,276 (GRCm39) F3542L probably damaging Het
Myo1f A G 17: 33,794,820 (GRCm39) D20G probably damaging Het
Nlk G T 11: 78,586,881 (GRCm39) A71E probably damaging Het
Nvl G A 1: 180,971,708 (GRCm39) probably null Het
Or9m1 A T 2: 87,733,546 (GRCm39) I158N probably damaging Het
Pakap T C 4: 57,855,174 (GRCm39) F168L probably benign Het
Pcnx1 C A 12: 82,027,738 (GRCm39) H1601N probably damaging Het
Pnkp T A 7: 44,506,829 (GRCm39) M1K probably null Het
Skic2 G A 17: 35,063,719 (GRCm39) R575C probably damaging Het
Slc25a54 A G 3: 109,019,368 (GRCm39) Y324C probably damaging Het
Tdrd3 A G 14: 87,743,252 (GRCm39) E400G probably damaging Het
Unc5b A G 10: 60,614,607 (GRCm39) I230T possibly damaging Het
Wfdc2 A G 2: 164,405,296 (GRCm39) T50A probably benign Het
Zfp563 A G 17: 33,324,672 (GRCm39) I422M probably benign Het
Other mutations in Adal
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00815:Adal APN 2 120,981,699 (GRCm39) splice site probably benign
IGL01917:Adal APN 2 120,973,035 (GRCm39) missense possibly damaging 0.88
IGL02487:Adal APN 2 120,985,877 (GRCm39) missense probably benign 0.12
R0004:Adal UTSW 2 120,982,966 (GRCm39) missense probably damaging 1.00
R0234:Adal UTSW 2 120,978,798 (GRCm39) missense probably benign 0.01
R0234:Adal UTSW 2 120,978,798 (GRCm39) missense probably benign 0.01
R1376:Adal UTSW 2 120,983,011 (GRCm39) missense probably damaging 1.00
R1376:Adal UTSW 2 120,983,011 (GRCm39) missense probably damaging 1.00
R4989:Adal UTSW 2 120,986,030 (GRCm39) utr 3 prime probably benign
R6606:Adal UTSW 2 120,980,769 (GRCm39) missense probably damaging 1.00
R6750:Adal UTSW 2 120,973,130 (GRCm39) missense probably damaging 1.00
R6819:Adal UTSW 2 120,978,794 (GRCm39) missense probably damaging 0.99
R7035:Adal UTSW 2 120,985,942 (GRCm39) missense probably benign 0.00
R8210:Adal UTSW 2 120,985,236 (GRCm39) missense possibly damaging 0.91
R9373:Adal UTSW 2 120,980,703 (GRCm39) missense probably benign 0.21
R9446:Adal UTSW 2 120,976,530 (GRCm39) missense probably null 0.99
Predicted Primers PCR Primer
(F):5'- CTGTAGCACTTGGCCGGTC -3'
(R):5'- CTGTGTGGAGGCCAGAGAAC -3'

Sequencing Primer
(F):5'- TAGCACTTGGCCGGTCCATTG -3'
(R):5'- TGTGTGAAATGCCCCCTAAG -3'
Posted On 2018-12-12