Incidental Mutation 'R6661:Ankrd9'
ID 543527
Institutional Source Beutler Lab
Gene Symbol Ankrd9
Ensembl Gene ENSMUSG00000037904
Gene Name ankyrin repeat domain 9
Synonyms 2500003O20Rik
MMRRC Submission 044781-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6661 (G1)
Quality Score 44.0073
Status Validated
Chromosome 12
Chromosomal Location 110942854-110945516 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) C to A at 110944202 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000123239 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043459] [ENSMUST00000128353] [ENSMUST00000135131] [ENSMUST00000140788] [ENSMUST00000142012] [ENSMUST00000148765]
AlphaFold Q8BH83
Predicted Effect probably benign
Transcript: ENSMUST00000043459
SMART Domains Protein: ENSMUSP00000048823
Gene: ENSMUSG00000037904

DomainStartEndE-ValueType
Blast:ANK 70 99 1e-6 BLAST
Blast:ANK 111 139 3e-6 BLAST
ANK 157 186 1.42e0 SMART
low complexity region 213 233 N/A INTRINSIC
low complexity region 238 246 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000128353
SMART Domains Protein: ENSMUSP00000120816
Gene: ENSMUSG00000037904

DomainStartEndE-ValueType
Blast:ANK 70 99 1e-6 BLAST
Blast:ANK 111 139 3e-6 BLAST
ANK 157 186 1.42e0 SMART
low complexity region 213 233 N/A INTRINSIC
low complexity region 238 246 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000135131
SMART Domains Protein: ENSMUSP00000119339
Gene: ENSMUSG00000037904

DomainStartEndE-ValueType
Blast:ANK 70 99 1e-6 BLAST
Blast:ANK 111 139 3e-6 BLAST
ANK 157 186 1.42e0 SMART
low complexity region 213 233 N/A INTRINSIC
low complexity region 238 246 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000140788
SMART Domains Protein: ENSMUSP00000121279
Gene: ENSMUSG00000037904

DomainStartEndE-ValueType
Blast:ANK 70 99 1e-6 BLAST
Blast:ANK 111 139 3e-6 BLAST
ANK 157 186 1.42e0 SMART
low complexity region 213 233 N/A INTRINSIC
low complexity region 238 246 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000142012
SMART Domains Protein: ENSMUSP00000121536
Gene: ENSMUSG00000037904

DomainStartEndE-ValueType
Blast:ANK 103 132 1e-6 BLAST
Blast:ANK 144 172 2e-6 BLAST
ANK 190 219 1.42e0 SMART
low complexity region 246 266 N/A INTRINSIC
low complexity region 271 279 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000148765
SMART Domains Protein: ENSMUSP00000123239
Gene: ENSMUSG00000037904

DomainStartEndE-ValueType
Blast:ANK 70 99 1e-6 BLAST
Blast:ANK 111 139 3e-6 BLAST
ANK 157 186 1.42e0 SMART
low complexity region 213 233 N/A INTRINSIC
low complexity region 238 246 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.8%
  • 20x: 93.8%
Validation Efficiency 93% (38/41)
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Amy2a1 T C 3: 113,325,363 (GRCm39) Y77C probably damaging Het
Arhgap28 C A 17: 68,152,746 (GRCm39) W675L probably damaging Het
Arhgap44 A G 11: 64,900,834 (GRCm39) S595P probably damaging Het
Brd10 A T 19: 29,700,864 (GRCm39) H741Q possibly damaging Het
Cacna1d C A 14: 29,811,832 (GRCm39) D1273Y probably damaging Het
Ccr4 T C 9: 114,325,031 (GRCm39) probably benign Het
Celsr1 A G 15: 85,803,135 (GRCm39) V2468A probably damaging Het
Chd2 T C 7: 73,140,230 (GRCm39) E666G possibly damaging Het
Ctnnd1 C A 2: 84,439,986 (GRCm39) V775L probably damaging Het
Cux2 C A 5: 122,007,360 (GRCm39) R767L probably benign Het
Decr2 A G 17: 26,302,561 (GRCm39) L217S possibly damaging Het
Dennd4c T A 4: 86,717,626 (GRCm39) M541K possibly damaging Het
Dnah7a T C 1: 53,662,609 (GRCm39) R651G probably benign Het
Fbrsl1 A T 5: 110,525,963 (GRCm39) F80I probably damaging Het
Fmnl2 C A 2: 52,998,297 (GRCm39) P554Q probably damaging Het
Gapvd1 C T 2: 34,618,450 (GRCm39) D308N probably damaging Het
Gatb A G 3: 85,559,726 (GRCm39) probably null Het
Jcad G A 18: 4,675,256 (GRCm39) G1006D probably damaging Het
Krt1c A G 15: 101,724,398 (GRCm39) Y289H probably damaging Het
Lrrc52 A G 1: 167,293,922 (GRCm39) F121S probably damaging Het
Lrrc63 G A 14: 75,362,633 (GRCm39) T299I unknown Het
Magi1 T C 6: 93,920,289 (GRCm39) N109S probably benign Het
Mbd4 C A 6: 115,826,116 (GRCm39) E271* probably null Het
Meis2 T A 2: 115,694,751 (GRCm39) D457V probably damaging Het
Mroh8 A G 2: 157,067,547 (GRCm39) V604A probably benign Het
Nedd4 T A 9: 72,593,377 (GRCm39) V150E probably damaging Het
Nes A G 3: 87,884,243 (GRCm39) E790G probably damaging Het
Or8h8 T C 2: 86,753,492 (GRCm39) N128S probably benign Het
Pik3c2a T C 7: 115,967,993 (GRCm39) I834V possibly damaging Het
Plxnb1 T C 9: 108,933,367 (GRCm39) C666R possibly damaging Het
Prg2 T C 2: 84,813,620 (GRCm39) probably null Het
Selenbp2 A G 3: 94,609,821 (GRCm39) D257G probably damaging Het
Slf1 T C 13: 77,191,964 (GRCm39) R957G probably damaging Het
Smim10l1 T A 6: 133,082,513 (GRCm39) M46K possibly damaging Het
Sptbn5 T C 2: 119,902,856 (GRCm39) Y50C possibly damaging Het
Tcea1 A G 1: 4,928,652 (GRCm39) probably benign Het
Tex14 A G 11: 87,385,842 (GRCm39) E234G probably damaging Het
Tmbim4 T C 10: 120,060,556 (GRCm39) V181A probably benign Het
Trappc9 A G 15: 72,461,993 (GRCm39) S1091P possibly damaging Het
Txnrd3 T A 6: 89,631,134 (GRCm39) C143* probably null Het
Ushbp1 C T 8: 71,843,305 (GRCm39) C314Y unknown Het
Other mutations in Ankrd9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01722:Ankrd9 APN 12 110,943,797 (GRCm39) missense probably damaging 1.00
IGL02220:Ankrd9 APN 12 110,943,933 (GRCm39) start codon destroyed probably null 0.99
IGL02327:Ankrd9 APN 12 110,943,849 (GRCm39) missense probably damaging 1.00
IGL03148:Ankrd9 APN 12 110,943,293 (GRCm39) missense probably benign
R4321:Ankrd9 UTSW 12 110,943,074 (GRCm39) missense probably damaging 1.00
R4807:Ankrd9 UTSW 12 110,943,669 (GRCm39) missense probably benign 0.25
R5918:Ankrd9 UTSW 12 110,943,200 (GRCm39) missense probably benign
R6233:Ankrd9 UTSW 12 110,943,554 (GRCm39) missense probably damaging 1.00
R6695:Ankrd9 UTSW 12 110,943,497 (GRCm39) missense probably benign 0.03
R7672:Ankrd9 UTSW 12 110,943,180 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- CAGACCAACCTGTGAGACGAAG -3'
(R):5'- TCTAAGTGAATAATCTCCACGACCC -3'

Sequencing Primer
(F):5'- AATGAATCGGGTCTGCCAGTC -3'
(R):5'- CGACCCTCCTGGAAAGAAGTTTG -3'
Posted On 2019-02-15