Incidental Mutation 'R6713:Meis3'
ID 543581
Institutional Source Beutler Lab
Gene Symbol Meis3
Ensembl Gene ENSMUSG00000041420
Gene Name Meis homeobox 3
Synonyms Mrg2
MMRRC Submission 044831-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.105) question?
Stock # R6713 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 15909015-15920429 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 15916255 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Stop codon at position 72 (G72*)
Ref Sequence ENSEMBL: ENSMUSP00000134855 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000002495] [ENSMUST00000176446] [ENSMUST00000176506] [ENSMUST00000177156]
AlphaFold P97368
Predicted Effect silent
Transcript: ENSMUST00000002495
SMART Domains Protein: ENSMUSP00000002495
Gene: ENSMUSG00000041420

DomainStartEndE-ValueType
low complexity region 88 101 N/A INTRINSIC
low complexity region 230 244 N/A INTRINSIC
HOX 265 330 9.15e-12 SMART
Predicted Effect probably null
Transcript: ENSMUST00000176446
AA Change: G72*
Predicted Effect silent
Transcript: ENSMUST00000176506
SMART Domains Protein: ENSMUSP00000134918
Gene: ENSMUSG00000041420

DomainStartEndE-ValueType
low complexity region 88 101 N/A INTRINSIC
low complexity region 213 227 N/A INTRINSIC
HOX 248 313 9.15e-12 SMART
Predicted Effect silent
Transcript: ENSMUST00000177156
SMART Domains Protein: ENSMUSP00000135103
Gene: ENSMUSG00000041420

DomainStartEndE-ValueType
low complexity region 88 101 N/A INTRINSIC
low complexity region 230 244 N/A INTRINSIC
Pfam:Homeobox_KN 283 313 2e-12 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.9%
Validation Efficiency 100% (39/39)
MGI Phenotype FUNCTION: The protein encoding this gene belongs to the three amino acid loop extension family of homeodomain transcription factors, which play essential roles in many embryonic processes. These proteins are characterized by an atypical homeodomain containing a three amino acid loop extension between helices 1 and 2. Expression of this gene begins during the compaction stage of embryogenesis and continues into the blastocyst stage. This gene is also expressed in pancreatic islet cells and beta-cells and regulates beta-cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apol10a C T 15: 77,373,051 (GRCm39) T229M possibly damaging Het
Cdh16 G A 8: 105,346,617 (GRCm39) Q226* probably null Het
Cemip A T 7: 83,592,845 (GRCm39) N1227K probably benign Het
Dusp13b A G 14: 21,798,541 (GRCm39) V41A probably damaging Het
F3 C T 3: 121,525,323 (GRCm39) T53I possibly damaging Het
Fan1 T A 7: 64,022,234 (GRCm39) N340Y probably damaging Het
Fyb2 T A 4: 104,847,432 (GRCm39) M484K probably benign Het
Glb1l A T 1: 75,179,061 (GRCm39) H253Q probably benign Het
Grm8 T C 6: 27,363,190 (GRCm39) E775G probably damaging Het
Hipk3 C T 2: 104,276,916 (GRCm39) V388M probably damaging Het
Ighe T C 12: 113,232,908 (GRCm39) probably benign Het
Kif14 A G 1: 136,453,544 (GRCm39) T1491A probably benign Het
Klre1 A G 6: 129,559,229 (GRCm39) probably null Het
Kpna6 A T 4: 129,547,777 (GRCm39) L257M probably damaging Het
Ldhc G A 7: 46,515,955 (GRCm39) probably null Het
Lekr1 C A 3: 65,591,380 (GRCm39) A39D probably benign Het
Lins1 A G 7: 66,358,230 (GRCm39) T122A probably benign Het
Lrrc40 G A 3: 157,769,350 (GRCm39) R516Q probably benign Het
Mpo A G 11: 87,686,194 (GRCm39) T115A probably damaging Het
Mrgprb5 A G 7: 47,818,537 (GRCm39) V66A probably damaging Het
Myo1c C T 11: 75,562,461 (GRCm39) P918S probably benign Het
Nags C A 11: 102,037,347 (GRCm39) A146E probably benign Het
Nkain4 C T 2: 180,585,970 (GRCm39) G31D probably damaging Het
Or2y1 T G 11: 49,385,784 (GRCm39) C141W probably damaging Het
Or4k1 T A 14: 50,377,181 (GRCm39) H305L probably benign Het
Or5ak24 A C 2: 85,260,883 (GRCm39) C97G probably damaging Het
Or8a1 A G 9: 37,641,560 (GRCm39) C240R probably damaging Het
Otud6b C T 4: 14,822,739 (GRCm39) V122I probably benign Het
Ovca2 C T 11: 75,069,569 (GRCm39) S18N possibly damaging Het
Pax2 A G 19: 44,823,916 (GRCm39) S370G unknown Het
Pias2 G A 18: 77,153,416 (GRCm39) probably null Het
Slc2a10 T C 2: 165,357,128 (GRCm39) F263L probably damaging Het
Slc6a17 T G 3: 107,378,703 (GRCm39) M660L probably benign Het
Smarcc2 A G 10: 128,323,638 (GRCm39) probably null Het
Srcap A G 7: 127,134,089 (GRCm39) T937A probably benign Het
Ssh2 C A 11: 77,340,259 (GRCm39) D470E possibly damaging Het
St8sia1 A T 6: 142,775,008 (GRCm39) probably null Het
Supt20 T A 3: 54,606,022 (GRCm39) I36K possibly damaging Het
Tor1aip2 T A 1: 155,941,155 (GRCm39) L487Q probably damaging Het
Zfp619 G T 7: 39,187,322 (GRCm39) K1117N probably damaging Het
Other mutations in Meis3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01014:Meis3 APN 7 15,912,872 (GRCm39) critical splice acceptor site probably benign 0.00
IGL02508:Meis3 APN 7 15,912,722 (GRCm39) splice site probably null
IGL03125:Meis3 APN 7 15,912,695 (GRCm39) missense probably damaging 1.00
IGL03383:Meis3 APN 7 15,917,744 (GRCm39) missense probably damaging 1.00
R0032:Meis3 UTSW 7 15,916,210 (GRCm39) unclassified probably benign
R1147:Meis3 UTSW 7 15,917,701 (GRCm39) unclassified probably benign
R1471:Meis3 UTSW 7 15,911,496 (GRCm39) nonsense probably null
R3054:Meis3 UTSW 7 15,916,378 (GRCm39) missense probably damaging 1.00
R3927:Meis3 UTSW 7 15,911,419 (GRCm39) missense probably benign 0.06
R5314:Meis3 UTSW 7 15,917,989 (GRCm39) missense probably damaging 0.99
R6847:Meis3 UTSW 7 15,917,789 (GRCm39) missense probably damaging 1.00
R7218:Meis3 UTSW 7 15,918,626 (GRCm39) missense probably benign
R7517:Meis3 UTSW 7 15,911,743 (GRCm39) missense probably damaging 1.00
R7540:Meis3 UTSW 7 15,911,418 (GRCm39) nonsense probably null
R7699:Meis3 UTSW 7 15,911,481 (GRCm39) missense probably benign
R7700:Meis3 UTSW 7 15,911,481 (GRCm39) missense probably benign
R7790:Meis3 UTSW 7 15,916,322 (GRCm39) missense probably benign 0.37
R8902:Meis3 UTSW 7 15,911,887 (GRCm39) missense probably benign 0.17
R8909:Meis3 UTSW 7 15,919,385 (GRCm39) missense possibly damaging 0.83
R9095:Meis3 UTSW 7 15,917,764 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAACTCAAGTGACCAAGGTGAG -3'
(R):5'- CTCTGGGTGGCTCATAGATG -3'

Sequencing Primer
(F):5'- CAAGTGACCAAGGTGAGAAACTTAAG -3'
(R):5'- TTTGGGACAGTGACCTCCC -3'
Posted On 2019-03-13