Mutagenetix > Incidental Mutation

Incidental Mutation 'R6698:Or13m2-ps1'

543592

Institutional Source

Beutler Lab

Gene Symbol

Or13m2-ps1

Ensembl Gene

Gene Name

olfactory receptor family 13 subfamily M member 2, pseudogene 1

Synonyms

Olfr451-ps1, MOR257-6, GA_x6K02T2P3E9-4759141-4758206

MMRRC Submission

044816-MU

Accession Numbers

Essential gene?

Not available question?

Stock #

R6698 (G1)

Quality Score

61.0073

Status

Validated

Chromosome

Chromosomal Location

42777677-42778609 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 42778136 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 154 (T154S)

Ref Sequence

ENSEMBL: ENSMUSP00000144800 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000205127]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000205127
AA Change: T154S

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000144800
Gene: ENSMUSG00000108058
AA Change: T154S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	306	2.1e-46	PFAM
Pfam:7tm_1	41	288	1.4e-16	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.0%
20x: 94.0%

Validation Efficiency

95% (40/42)

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Brca2	T	C	5: 150,455,859 (GRCm39)	V200A	probably damaging	Het
Camk2g	T	A	14: 20,792,776 (GRCm39)	K393*	probably null	Het
Catsperb	T	A	12: 101,475,466 (GRCm39)	F337I	probably damaging	Het
Cdk17	T	C	10: 93,064,540 (GRCm39)	Y270H	probably damaging	Het
Col5a3	C	T	9: 20,690,329 (GRCm39)	G1162R	probably damaging	Het
Col6a5	T	A	9: 105,811,374 (GRCm39)	N715I	unknown	Het
Fancg	A	G	4: 43,007,034 (GRCm39)	S248P	probably benign	Het
Flvcr1	T	C	1: 190,757,929 (GRCm39)	Y79C	probably damaging	Het
Gabrp	A	G	11: 33,507,017 (GRCm39)	S198P	probably damaging	Het
Gask1b	A	G	3: 79,843,902 (GRCm39)	I10V	probably damaging	Het
Glp1r	A	G	17: 31,155,375 (GRCm39)	Y454C	probably damaging	Het
Gpr158	A	C	2: 21,831,921 (GRCm39)	D1007A	probably damaging	Het
Gsdmc3	A	G	15: 63,732,120 (GRCm39)	F302S	possibly damaging	Het
Gsdmc4	T	A	15: 63,765,613 (GRCm39)	D312V	probably benign	Het
Itga5	T	C	15: 103,259,808 (GRCm39)	Y663C	probably benign	Het
Kif1b	A	T	4: 149,359,413 (GRCm39)	M108K	probably damaging	Het
Klf11	T	G	12: 24,703,618 (GRCm39)	S18A	probably damaging	Het
Lmtk2	T	C	5: 144,111,737 (GRCm39)	V819A	probably benign	Het
Lrba	A	G	3: 86,211,732 (GRCm39)	M451V	probably damaging	Het
Lrp1b	T	C	2: 41,192,958 (GRCm39)	D488G	probably damaging	Het
Mark4	T	C	7: 19,163,362 (GRCm39)	N589S	probably benign	Het
Mis12	T	C	11: 70,916,012 (GRCm39)	F15S	probably damaging	Het
Nif3l1	A	G	1: 58,489,648 (GRCm39)	D179G	probably benign	Het
Nlrx1	A	G	9: 44,177,104 (GRCm39)	W3R	probably damaging	Het
Nup210l	G	A	3: 90,089,815 (GRCm39)	S1194N	possibly damaging	Het
Or5d20-ps1	A	G	2: 87,931,561 (GRCm39)	F257L	unknown	Het
Pnkd	T	A	1: 74,389,836 (GRCm39)	L320Q	probably damaging	Het
Prkn	A	G	17: 11,286,183 (GRCm39)		probably null	Het
Rcc2	G	A	4: 140,429,586 (GRCm39)	C40Y	probably benign	Homo
Rilpl2	C	T	5: 124,607,843 (GRCm39)	E126K	probably damaging	Het
Rpn2	T	C	2: 157,139,330 (GRCm39)	I208T	possibly damaging	Het
Skint4	G	T	4: 111,977,096 (GRCm39)	C170F	probably damaging	Het
Synj1	C	G	16: 90,757,340 (GRCm39)	V877L	probably damaging	Het
Tcp11	A	T	17: 28,290,804 (GRCm39)	I106N	possibly damaging	Het
Tg	A	G	15: 66,711,211 (GRCm39)	Y991C	probably damaging	Het
Trib3	A	G	2: 152,180,339 (GRCm39)	S285P	probably damaging	Het
Wdr49	A	T	3: 75,336,673 (GRCm39)	W345R	probably benign	Het
Wnt5a	A	G	14: 28,240,420 (GRCm39)	Y190C	possibly damaging	Het
Xpo1	A	G	11: 23,244,040 (GRCm39)	E955G	probably benign	Het

Other mutations in Or13m2-ps1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R6285:Or13m2-ps1	UTSW	6	42,777,843 (GRCm39)	missense	probably benign	0.44
R7890:Or13m2-ps1	UTSW	6	42,778,426 (GRCm39)	nonsense	probably null
R8272:Or13m2-ps1	UTSW	6	42,778,038 (GRCm39)	missense	probably damaging	1.00
R9321:Or13m2-ps1	UTSW	6	42,777,792 (GRCm39)	missense	possibly damaging	0.69

Predicted Primers

PCR Primer
(F):5'- AGTCCATCCCGTTTCACAG -3'
(R):5'- ATGGCAGCAACAATGTGAGC -3'

Sequencing Primer
(F):5'- CAGTTGTGTGATGCAGCTGTATATC -3'
(R):5'- TGTGAGCATAGGAAAACAGCACC -3'

Posted On

2019-03-21