Incidental Mutation 'R6665:Rab32'
ID 543598
Institutional Source Beutler Lab
Gene Symbol Rab32
Ensembl Gene ENSMUSG00000019832
Gene Name RAB32, member RAS oncogene family
Synonyms 2810011A17Rik
MMRRC Submission 044785-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.213) question?
Stock # R6665 (G1)
Quality Score 64.0073
Status Validated
Chromosome 10
Chromosomal Location 10420783-10433951 bp(-) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) T to C at 10433846 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000152210 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019974] [ENSMUST00000220018]
AlphaFold Q9CZE3
Predicted Effect probably benign
Transcript: ENSMUST00000019974
SMART Domains Protein: ENSMUSP00000019974
Gene: ENSMUSG00000019832

DomainStartEndE-ValueType
RAB 24 193 3.44e-59 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000220018
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.7%
  • 20x: 93.0%
Validation Efficiency 100% (34/34)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene anchors the type II regulatory subunit of protein kinase A to the mitochondrion and aids in mitochondrial fission. The encoded protein also appears to be involved in autophagy and melanosome secretion. Variations in this gene may be linked to leprosy. [provided by RefSeq, Dec 2015]
Allele List at MGI

All alleles(2) : Targeted, other(2)
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts15 A G 9: 30,815,775 (GRCm39) probably null Het
Adamts16 T G 13: 70,927,689 (GRCm39) K517Q probably damaging Het
Atp9b A C 18: 80,960,950 (GRCm39) V87G probably benign Het
Avil A G 10: 126,856,394 (GRCm39) K808E probably damaging Het
Bin2 T C 15: 100,554,676 (GRCm39) E49G probably damaging Het
Ccdc146 T C 5: 21,508,092 (GRCm39) Y652C probably damaging Het
Cd6 T C 19: 10,768,367 (GRCm39) N541D probably benign Het
Col28a1 A G 6: 8,062,277 (GRCm39) V671A probably benign Het
Dock6 C T 9: 21,751,208 (GRCm39) C355Y probably damaging Het
Dsc2 A G 18: 20,183,205 (GRCm39) F71S probably damaging Het
Dusp8 G A 7: 141,643,842 (GRCm39) P24S probably damaging Het
Dysf A G 6: 84,107,098 (GRCm39) Y1151C probably benign Het
Fhip2b A T 14: 70,823,078 (GRCm39) L659Q probably damaging Het
Frem2 T C 3: 53,562,077 (GRCm39) Y810C probably damaging Het
Gpat2 G C 2: 127,273,838 (GRCm39) G294R possibly damaging Het
Hexb T C 13: 97,315,893 (GRCm39) N380D probably benign Het
Ice1 T C 13: 70,751,592 (GRCm39) E1498G possibly damaging Het
Lrif1 T A 3: 106,642,659 (GRCm39) probably null Het
Myo9a G T 9: 59,779,155 (GRCm39) G1637V probably benign Het
Myod1 A T 7: 46,026,281 (GRCm39) H62L probably damaging Het
Myoz3 A C 18: 60,709,495 (GRCm39) L222R probably damaging Het
Naca T A 10: 127,884,227 (GRCm39) N2180K probably damaging Het
Or6c76 T C 10: 129,612,116 (GRCm39) F111S probably damaging Het
Pik3cb A G 9: 98,955,702 (GRCm39) V405A probably benign Het
Prkdc T C 16: 15,603,914 (GRCm39) probably null Het
Serpinb10 A C 1: 107,474,597 (GRCm39) N253T possibly damaging Het
Slc13a5 C T 11: 72,151,186 (GRCm39) V131I probably damaging Het
Slc25a40 A G 5: 8,502,788 (GRCm39) N290S probably benign Het
Slc6a6 T C 6: 91,703,020 (GRCm39) V131A probably benign Het
Spef2 A T 15: 9,600,604 (GRCm39) probably null Het
Stxbp2 A G 8: 3,691,998 (GRCm39) M547V probably benign Het
Tmem247 A T 17: 87,225,998 (GRCm39) Q146L probably benign Het
Vmn2r67 T C 7: 84,785,900 (GRCm39) I702V probably benign Het
Zmynd15 T C 11: 70,355,636 (GRCm39) S436P probably benign Het
Other mutations in Rab32
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00789:Rab32 APN 10 10,426,556 (GRCm39) missense probably benign 0.07
IGL01061:Rab32 APN 10 10,433,618 (GRCm39) missense probably damaging 0.99
IGL01071:Rab32 APN 10 10,433,591 (GRCm39) missense probably damaging 1.00
IGL02193:Rab32 APN 10 10,422,199 (GRCm39) splice site probably benign
IGL02814:Rab32 APN 10 10,422,171 (GRCm39) missense probably benign
IGL03233:Rab32 APN 10 10,422,057 (GRCm39) nonsense probably null
A5278:Rab32 UTSW 10 10,433,717 (GRCm39) missense possibly damaging 0.94
R0135:Rab32 UTSW 10 10,426,584 (GRCm39) missense probably damaging 1.00
R0514:Rab32 UTSW 10 10,426,640 (GRCm39) missense probably damaging 1.00
R0826:Rab32 UTSW 10 10,426,611 (GRCm39) missense possibly damaging 0.95
R1406:Rab32 UTSW 10 10,426,637 (GRCm39) missense probably damaging 1.00
R1406:Rab32 UTSW 10 10,426,637 (GRCm39) missense probably damaging 1.00
R2045:Rab32 UTSW 10 10,426,577 (GRCm39) missense probably damaging 1.00
R4701:Rab32 UTSW 10 10,426,598 (GRCm39) missense probably benign 0.04
R7880:Rab32 UTSW 10 10,422,159 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGTTGAGAACTTTGAGGGCG -3'
(R):5'- ACTTGACATCATGGACCAGCC -3'

Sequencing Primer
(F):5'- AAGTCCACGCCAATGGTG -3'
(R):5'- TTGTCTAAGGCCAGCAGGG -3'
Posted On 2019-03-22