Incidental Mutation 'R6991:Brd10'
ID 543881
Institutional Source Beutler Lab
Gene Symbol Brd10
Ensembl Gene ENSMUSG00000046138
Gene Name bromodomain containing 10
Synonyms 9930021J03Rik, Gm9832
MMRRC Submission 045097-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.138) question?
Stock # R6991 (G1)
Quality Score 225.009
Status Not validated
Chromosome 19
Chromosomal Location 29691802-29783389 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 29696508 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Serine at position 995 (L995S)
Ref Sequence ENSEMBL: ENSMUSP00000135473 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000177155]
AlphaFold H3BKP8
Predicted Effect
Predicted Effect
SMART Domains Protein: ENSMUSP00000135031
Gene: ENSMUSG00000046138
AA Change: L294S

DomainStartEndE-ValueType
low complexity region 2 19 N/A INTRINSIC
low complexity region 379 393 N/A INTRINSIC
internal_repeat_1 397 526 2.65e-5 PROSPERO
low complexity region 528 537 N/A INTRINSIC
low complexity region 619 648 N/A INTRINSIC
low complexity region 701 716 N/A INTRINSIC
low complexity region 835 857 N/A INTRINSIC
low complexity region 880 896 N/A INTRINSIC
low complexity region 965 978 N/A INTRINSIC
internal_repeat_1 999 1143 2.65e-5 PROSPERO
low complexity region 1220 1226 N/A INTRINSIC
low complexity region 1246 1260 N/A INTRINSIC
low complexity region 1286 1304 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000176773
Predicted Effect possibly damaging
Transcript: ENSMUST00000177155
AA Change: L995S

PolyPhen 2 Score 0.861 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000135473
Gene: ENSMUSG00000046138
AA Change: L995S

DomainStartEndE-ValueType
low complexity region 4 66 N/A INTRINSIC
BROMO 75 198 1.22e-3 SMART
low complexity region 205 219 N/A INTRINSIC
low complexity region 280 298 N/A INTRINSIC
low complexity region 428 441 N/A INTRINSIC
coiled coil region 606 638 N/A INTRINSIC
low complexity region 655 689 N/A INTRINSIC
coiled coil region 697 729 N/A INTRINSIC
low complexity region 1079 1093 N/A INTRINSIC
internal_repeat_1 1097 1226 1.32e-7 PROSPERO
low complexity region 1228 1237 N/A INTRINSIC
low complexity region 1319 1348 N/A INTRINSIC
low complexity region 1401 1416 N/A INTRINSIC
low complexity region 1535 1557 N/A INTRINSIC
low complexity region 1580 1596 N/A INTRINSIC
low complexity region 1665 1678 N/A INTRINSIC
internal_repeat_1 1699 1843 1.32e-7 PROSPERO
low complexity region 1920 1926 N/A INTRINSIC
low complexity region 1946 1960 N/A INTRINSIC
low complexity region 1986 2004 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310022A10Rik T A 7: 27,279,871 (GRCm39) V278D probably damaging Het
Akap12 G T 10: 4,307,122 (GRCm39) E1311* probably null Het
Ankdd1a T A 9: 65,415,957 (GRCm39) D186V probably benign Het
Birc6 A G 17: 74,869,090 (GRCm39) E346G probably damaging Het
Ccr7 A C 11: 99,036,130 (GRCm39) V264G probably damaging Het
Col7a1 T C 9: 108,812,987 (GRCm39) probably null Het
Coq8a T C 1: 180,006,633 (GRCm39) T132A probably benign Het
Cplane1 A G 15: 8,281,690 (GRCm39) E2843G unknown Het
Cyp2b10 G A 7: 25,616,780 (GRCm39) S407N probably benign Het
Ddi2 A G 4: 141,412,561 (GRCm39) V117A probably benign Het
Ddx42 G A 11: 106,129,970 (GRCm39) V421I probably damaging Het
Dip2c T A 13: 9,601,896 (GRCm39) L285* probably null Het
Dip2c C T 13: 9,684,868 (GRCm39) S1232F probably damaging Het
Dner T A 1: 84,454,123 (GRCm39) R402* probably null Het
Dpysl3 A T 18: 43,486,956 (GRCm39) I317N probably damaging Het
Dusp23 T A 1: 172,459,224 (GRCm39) Y146F probably benign Het
Eef1a2 C A 2: 180,790,421 (GRCm39) V412L possibly damaging Het
Epha7 C T 4: 28,821,489 (GRCm39) T218I probably damaging Het
Gigyf2 T A 1: 87,334,858 (GRCm39) C284S probably damaging Het
Golm1 ACTTCTTCT ACTTCT 13: 59,797,390 (GRCm39) probably benign Het
Hao2 T A 3: 98,784,068 (GRCm39) E327V probably damaging Het
Hdhd5 A G 6: 120,487,130 (GRCm39) V409A probably damaging Het
Kif9 T C 9: 110,323,690 (GRCm39) Y236H probably damaging Het
Kri1 T C 9: 21,199,050 (GRCm39) probably benign Het
Lig4 A T 8: 10,021,098 (GRCm39) V894E probably damaging Het
Lrriq1 T C 10: 103,023,319 (GRCm39) N982S probably damaging Het
Mapk8 T C 14: 33,132,841 (GRCm39) I32V possibly damaging Het
Mast4 C T 13: 102,941,155 (GRCm39) V301I probably damaging Het
Mstn T C 1: 53,101,100 (GRCm39) I59T probably benign Het
Mtrf1l T C 10: 5,763,384 (GRCm39) E315G probably damaging Het
Notch4 G T 17: 34,803,774 (GRCm39) E1515* probably null Het
Npw A C 17: 24,877,029 (GRCm39) V124G probably benign Het
Nxph3 A G 11: 95,402,244 (GRCm39) S57P probably damaging Het
Opn4 A T 14: 34,315,864 (GRCm39) L390M probably benign Het
Or12e10 G A 2: 87,640,787 (GRCm39) D208N possibly damaging Het
Or52e4 T C 7: 104,705,771 (GRCm39) I106T probably damaging Het
Or5b95 G T 19: 12,658,112 (GRCm39) L213F probably benign Het
Or5g23 T C 2: 85,438,592 (GRCm39) I221V possibly damaging Het
Or5p68 T A 7: 107,945,295 (GRCm39) N298Y possibly damaging Het
Pkd1l3 GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA 8: 110,350,827 (GRCm39) probably benign Het
Pla2g2e G A 4: 138,607,986 (GRCm39) C62Y probably damaging Het
Plcb4 G A 2: 135,752,114 (GRCm39) V107M probably damaging Het
Pramel33 T A 5: 93,632,233 (GRCm39) N107I probably damaging Het
Prorsd1 A C 11: 29,464,486 (GRCm39) probably benign Het
Prox2 A G 12: 85,134,165 (GRCm39) L587P probably benign Het
Prr22 A G 17: 57,078,345 (GRCm39) D166G possibly damaging Het
Ptprz1 G A 6: 23,002,686 (GRCm39) R1592Q probably benign Het
Rarg C G 15: 102,150,350 (GRCm39) R74P probably damaging Het
Rcan1 A G 16: 92,194,251 (GRCm39) V54A probably benign Het
Rmdn2 A G 17: 79,928,739 (GRCm39) probably benign Het
Sec16a G A 2: 26,320,498 (GRCm39) R1361C probably damaging Het
Serpina1a T C 12: 103,820,092 (GRCm39) T385A probably benign Het
Slc44a3 T C 3: 121,325,814 (GRCm39) Y12C probably benign Het
Smg1 C A 7: 117,767,091 (GRCm39) probably benign Het
Spock3 A G 8: 63,808,415 (GRCm39) *437W probably null Het
Sugct T A 13: 17,728,965 (GRCm39) Q220H probably benign Het
Tesk1 A G 4: 43,447,006 (GRCm39) T465A probably benign Het
Tnks C A 8: 35,301,647 (GRCm39) R1274I probably damaging Het
Trp53bp1 C T 2: 121,038,521 (GRCm39) R1439H probably damaging Het
Vmn1r16 G T 6: 57,299,869 (GRCm39) S251* probably null Het
Vmn2r15 T A 5: 109,441,180 (GRCm39) Q226L probably damaging Het
Vmn2r67 T G 7: 84,804,953 (GRCm39) Y53S possibly damaging Het
Vmn2r99 A G 17: 19,598,372 (GRCm39) N132S probably benign Het
Wdr73 T G 7: 80,541,604 (GRCm39) T313P probably benign Het
Zfp65 C T 13: 67,856,640 (GRCm39) R213Q probably damaging Het
Other mutations in Brd10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01311:Brd10 APN 19 29,731,420 (GRCm39) missense probably benign 0.33
IGL01535:Brd10 APN 19 29,731,212 (GRCm39) missense possibly damaging 0.53
IGL02019:Brd10 APN 19 29,694,463 (GRCm39) missense probably benign 0.28
IGL02034:Brd10 APN 19 29,694,259 (GRCm39) missense possibly damaging 0.73
IGL03114:Brd10 APN 19 29,694,532 (GRCm39) missense probably benign 0.18
IGL03382:Brd10 APN 19 29,694,676 (GRCm39) missense probably damaging 1.00
R0020:Brd10 UTSW 19 29,693,597 (GRCm39) missense probably damaging 0.98
R0020:Brd10 UTSW 19 29,693,597 (GRCm39) missense probably damaging 0.98
R0142:Brd10 UTSW 19 29,695,654 (GRCm39) missense possibly damaging 0.93
R0178:Brd10 UTSW 19 29,732,188 (GRCm39) missense probably damaging 1.00
R0453:Brd10 UTSW 19 29,731,068 (GRCm39) missense probably damaging 1.00
R0730:Brd10 UTSW 19 29,695,381 (GRCm39) missense probably benign 0.00
R0735:Brd10 UTSW 19 29,695,038 (GRCm39) missense possibly damaging 0.92
R0891:Brd10 UTSW 19 29,695,053 (GRCm39) missense probably damaging 1.00
R0894:Brd10 UTSW 19 29,697,974 (GRCm39) splice site probably benign
R1289:Brd10 UTSW 19 29,700,852 (GRCm39) missense probably benign 0.07
R1368:Brd10 UTSW 19 29,693,796 (GRCm39) missense probably damaging 0.97
R1387:Brd10 UTSW 19 29,700,853 (GRCm39) missense probably benign 0.15
R1483:Brd10 UTSW 19 29,696,745 (GRCm39) missense possibly damaging 0.93
R1526:Brd10 UTSW 19 29,712,545 (GRCm39) missense probably damaging 1.00
R1612:Brd10 UTSW 19 29,695,245 (GRCm39) missense possibly damaging 0.86
R1721:Brd10 UTSW 19 29,720,998 (GRCm39) missense probably damaging 0.99
R1764:Brd10 UTSW 19 29,696,560 (GRCm39) missense possibly damaging 0.53
R1822:Brd10 UTSW 19 29,693,814 (GRCm39) missense probably damaging 0.99
R1824:Brd10 UTSW 19 29,693,814 (GRCm39) missense probably damaging 0.99
R1859:Brd10 UTSW 19 29,732,323 (GRCm39) missense possibly damaging 0.53
R1868:Brd10 UTSW 19 29,720,998 (GRCm39) missense probably damaging 0.99
R1880:Brd10 UTSW 19 29,695,523 (GRCm39) missense probably benign 0.06
R1898:Brd10 UTSW 19 29,712,532 (GRCm39) missense possibly damaging 0.74
R1936:Brd10 UTSW 19 29,731,077 (GRCm39) missense possibly damaging 0.87
R1939:Brd10 UTSW 19 29,731,077 (GRCm39) missense possibly damaging 0.87
R1969:Brd10 UTSW 19 29,694,075 (GRCm39) missense possibly damaging 0.95
R2153:Brd10 UTSW 19 29,694,229 (GRCm39) missense probably benign 0.01
R2366:Brd10 UTSW 19 29,731,035 (GRCm39) missense probably damaging 0.99
R2379:Brd10 UTSW 19 29,696,275 (GRCm39) missense probably benign 0.01
R3107:Brd10 UTSW 19 29,700,847 (GRCm39) missense probably damaging 1.00
R4012:Brd10 UTSW 19 29,720,990 (GRCm39) missense probably damaging 1.00
R4222:Brd10 UTSW 19 29,696,149 (GRCm39) missense probably benign 0.18
R4328:Brd10 UTSW 19 29,720,961 (GRCm39) missense probably benign 0.00
R4329:Brd10 UTSW 19 29,720,961 (GRCm39) missense probably benign 0.00
R4387:Brd10 UTSW 19 29,782,715 (GRCm39) unclassified probably benign
R4688:Brd10 UTSW 19 29,694,501 (GRCm39) missense probably benign 0.33
R4796:Brd10 UTSW 19 29,731,018 (GRCm39) missense probably benign 0.33
R4820:Brd10 UTSW 19 29,695,809 (GRCm39) missense possibly damaging 0.53
R4832:Brd10 UTSW 19 29,694,616 (GRCm39) missense possibly damaging 0.53
R5056:Brd10 UTSW 19 29,694,759 (GRCm39) missense probably benign
R5150:Brd10 UTSW 19 29,782,950 (GRCm39) missense probably damaging 0.96
R5224:Brd10 UTSW 19 29,696,450 (GRCm39) missense possibly damaging 0.73
R5306:Brd10 UTSW 19 29,707,230 (GRCm39) intron probably benign
R5460:Brd10 UTSW 19 29,732,250 (GRCm39) missense probably damaging 0.98
R5477:Brd10 UTSW 19 29,731,518 (GRCm39) missense probably benign 0.33
R5531:Brd10 UTSW 19 29,731,072 (GRCm39) missense possibly damaging 0.73
R5559:Brd10 UTSW 19 29,694,363 (GRCm39) missense possibly damaging 0.91
R5647:Brd10 UTSW 19 29,731,210 (GRCm39) missense possibly damaging 0.73
R5886:Brd10 UTSW 19 29,696,677 (GRCm39) missense probably benign 0.03
R6029:Brd10 UTSW 19 29,732,367 (GRCm39) unclassified probably benign
R6240:Brd10 UTSW 19 29,694,640 (GRCm39) missense probably benign 0.18
R6331:Brd10 UTSW 19 29,695,147 (GRCm39) missense probably benign 0.33
R6456:Brd10 UTSW 19 29,693,914 (GRCm39) missense possibly damaging 0.93
R6584:Brd10 UTSW 19 29,696,128 (GRCm39) missense possibly damaging 0.53
R6661:Brd10 UTSW 19 29,700,864 (GRCm39) missense possibly damaging 0.53
R7059:Brd10 UTSW 19 29,696,945 (GRCm39) missense probably benign 0.33
R7128:Brd10 UTSW 19 29,693,881 (GRCm39) missense possibly damaging 0.53
R7211:Brd10 UTSW 19 29,763,712 (GRCm39) missense
R7471:Brd10 UTSW 19 29,707,139 (GRCm39) splice site probably null
R7686:Brd10 UTSW 19 29,694,870 (GRCm39) missense probably benign 0.34
R8012:Brd10 UTSW 19 29,695,534 (GRCm39) missense possibly damaging 0.73
R8203:Brd10 UTSW 19 29,693,443 (GRCm39) missense probably benign 0.18
R8353:Brd10 UTSW 19 29,731,242 (GRCm39) missense possibly damaging 0.53
R8672:Brd10 UTSW 19 29,731,564 (GRCm39) missense probably benign
R8755:Brd10 UTSW 19 29,693,890 (GRCm39) missense probably benign 0.03
R8918:Brd10 UTSW 19 29,696,841 (GRCm39) missense possibly damaging 0.53
R8954:Brd10 UTSW 19 29,696,126 (GRCm39) missense possibly damaging 0.72
R9038:Brd10 UTSW 19 29,731,900 (GRCm39) missense possibly damaging 0.86
R9195:Brd10 UTSW 19 29,763,703 (GRCm39) missense
R9204:Brd10 UTSW 19 29,696,938 (GRCm39) missense possibly damaging 0.73
R9518:Brd10 UTSW 19 29,731,541 (GRCm39) missense possibly damaging 0.53
R9743:Brd10 UTSW 19 29,694,261 (GRCm39) missense probably benign
R9747:Brd10 UTSW 19 29,731,911 (GRCm39) missense possibly damaging 0.73
RF011:Brd10 UTSW 19 29,721,009 (GRCm39) missense possibly damaging 0.53
X0027:Brd10 UTSW 19 29,712,599 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGCTGAGGTGCTGCTATCTC -3'
(R):5'- GTGTCTACTCTCCAGAAAGGG -3'

Sequencing Primer
(F):5'- GAGGTGCTGCTATCTCTTTTTCAAC -3'
(R):5'- AGAAAGGGACCAAACCTATTCAG -3'
Posted On 2019-05-13