Incidental Mutation 'R6994:Vmn2r84'
ID |
544062 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r84
|
Ensembl Gene |
ENSMUSG00000070601 |
Gene Name |
vomeronasal 2, receptor 84 |
Synonyms |
EG625068 |
MMRRC Submission |
045100-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.070)
|
Stock # |
R6994 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
10 |
Chromosomal Location |
130221669-130230110 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
C to T
at 130226876 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Alanine to Threonine
at position 321
(A321T)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000092079
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094502]
|
AlphaFold |
D3YWE3 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000094502
AA Change: A321T
PolyPhen 2
Score 0.897 (Sensitivity: 0.82; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000092079 Gene: ENSMUSG00000070601 AA Change: A321T
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
77 |
448 |
1.3e-27 |
PFAM |
Pfam:NCD3G
|
508 |
561 |
6.9e-21 |
PFAM |
Pfam:7tm_3
|
594 |
830 |
4.6e-55 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
Validation Efficiency |
96% (82/85) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 84 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aadacl4 |
T |
G |
4: 144,349,849 (GRCm39) |
W369G |
probably damaging |
Het |
Abhd16b |
C |
T |
2: 181,135,461 (GRCm39) |
T121M |
possibly damaging |
Het |
Adam5 |
A |
T |
8: 25,276,262 (GRCm39) |
C468* |
probably null |
Het |
Aim2 |
C |
T |
1: 173,283,152 (GRCm39) |
A78V |
possibly damaging |
Het |
Alg9 |
G |
A |
9: 50,703,422 (GRCm39) |
W254* |
probably null |
Het |
Ankrd55 |
G |
C |
13: 112,504,834 (GRCm39) |
E499Q |
probably benign |
Het |
Atp6v0a2 |
T |
C |
5: 124,791,209 (GRCm39) |
F546S |
probably damaging |
Het |
Bean1 |
CT |
C |
8: 104,908,664 (GRCm39) |
|
probably null |
Het |
Bpi |
A |
T |
2: 158,100,164 (GRCm39) |
|
probably benign |
Het |
Bves |
A |
G |
10: 45,215,514 (GRCm39) |
H63R |
probably benign |
Het |
Ccdc183 |
T |
C |
2: 25,507,057 (GRCm39) |
M45V |
probably benign |
Het |
Cfhr4 |
T |
A |
1: 139,664,668 (GRCm39) |
I464L |
possibly damaging |
Het |
Cmklr1 |
T |
C |
5: 113,752,983 (GRCm39) |
Y6C |
probably damaging |
Het |
Colgalt1 |
C |
T |
8: 72,076,165 (GRCm39) |
R539C |
probably damaging |
Het |
Ctsm |
T |
A |
13: 61,687,698 (GRCm39) |
E53D |
probably damaging |
Het |
Cyp2a22 |
A |
G |
7: 26,638,606 (GRCm39) |
|
probably null |
Het |
Ddx10 |
A |
G |
9: 53,115,411 (GRCm39) |
V641A |
probably damaging |
Het |
Ddx6 |
T |
C |
9: 44,540,020 (GRCm39) |
V316A |
probably damaging |
Het |
Dhx34 |
T |
C |
7: 15,937,799 (GRCm39) |
D767G |
probably benign |
Het |
Dnaaf6rt |
T |
C |
1: 31,261,990 (GRCm39) |
|
probably benign |
Het |
Dtnbp1 |
T |
A |
13: 45,155,405 (GRCm39) |
D15V |
probably damaging |
Het |
Dtx3l |
C |
T |
16: 35,751,742 (GRCm39) |
|
probably null |
Het |
Entpd8 |
T |
C |
2: 24,973,321 (GRCm39) |
I162T |
probably damaging |
Het |
Fam186a |
G |
T |
15: 99,840,347 (GRCm39) |
Q1966K |
probably benign |
Het |
Fbxo27 |
A |
C |
7: 28,392,785 (GRCm39) |
D22A |
probably damaging |
Het |
Fermt3 |
A |
T |
19: 6,977,095 (GRCm39) |
I577N |
probably damaging |
Het |
Frmd8 |
A |
T |
19: 5,923,209 (GRCm39) |
S81T |
probably damaging |
Het |
Gm5108 |
T |
A |
5: 68,102,012 (GRCm39) |
|
probably benign |
Het |
Gm9195 |
T |
C |
14: 72,718,271 (GRCm39) |
Y135C |
probably damaging |
Het |
Gpatch2l |
G |
A |
12: 86,290,958 (GRCm39) |
R47H |
probably damaging |
Het |
Kcnh8 |
A |
T |
17: 53,284,723 (GRCm39) |
I898F |
probably benign |
Het |
Kri1 |
C |
T |
9: 21,199,083 (GRCm39) |
|
probably benign |
Het |
Krt32 |
T |
A |
11: 99,977,271 (GRCm39) |
I210F |
probably damaging |
Het |
Lama1 |
G |
A |
17: 68,060,820 (GRCm39) |
C716Y |
|
Het |
Lamc2 |
G |
A |
1: 153,012,508 (GRCm39) |
T722M |
probably benign |
Het |
Lpin3 |
C |
T |
2: 160,746,803 (GRCm39) |
P766L |
probably damaging |
Het |
Macroh2a1 |
T |
C |
13: 56,237,643 (GRCm39) |
N206D |
probably benign |
Het |
Marf1 |
T |
C |
16: 13,946,721 (GRCm39) |
T1169A |
probably damaging |
Het |
Morc1 |
G |
A |
16: 48,385,984 (GRCm39) |
V536M |
probably benign |
Het |
Morc1 |
A |
T |
16: 48,438,909 (GRCm39) |
H768L |
probably benign |
Het |
Mpped2 |
T |
A |
2: 106,529,878 (GRCm39) |
H42Q |
possibly damaging |
Het |
Nfatc1 |
G |
T |
18: 80,696,779 (GRCm39) |
|
probably null |
Het |
Nfkbid |
G |
A |
7: 30,125,192 (GRCm39) |
S263N |
probably benign |
Het |
Npas3 |
C |
A |
12: 54,115,576 (GRCm39) |
Q802K |
probably damaging |
Het |
Or52s1b |
T |
C |
7: 102,822,119 (GRCm39) |
T242A |
probably damaging |
Het |
Or5ac20 |
T |
G |
16: 59,104,453 (GRCm39) |
M136L |
possibly damaging |
Het |
Or5p67 |
T |
A |
7: 107,922,101 (GRCm39) |
I261F |
possibly damaging |
Het |
Pabpc4l |
C |
A |
3: 46,401,345 (GRCm39) |
V100L |
possibly damaging |
Het |
Pagr1a |
A |
G |
7: 126,615,613 (GRCm39) |
|
probably null |
Het |
Pcdh1 |
A |
T |
18: 38,331,553 (GRCm39) |
N483K |
probably damaging |
Het |
Pikfyve |
C |
A |
1: 65,291,689 (GRCm39) |
P1303T |
probably damaging |
Het |
Plekhh3 |
T |
A |
11: 101,056,519 (GRCm39) |
|
probably null |
Het |
Pnkd |
T |
A |
1: 74,332,335 (GRCm39) |
|
probably null |
Het |
Pparg |
A |
T |
6: 115,428,011 (GRCm39) |
Q166L |
probably benign |
Het |
Psenen |
A |
G |
7: 30,262,932 (GRCm39) |
|
probably null |
Het |
Rab4a |
T |
C |
8: 124,557,105 (GRCm39) |
S142P |
probably damaging |
Het |
Reg3a |
T |
C |
6: 78,358,132 (GRCm39) |
V21A |
probably benign |
Het |
Relt |
A |
C |
7: 100,502,321 (GRCm39) |
|
probably benign |
Het |
Rftn1 |
T |
A |
17: 50,344,019 (GRCm39) |
T90S |
possibly damaging |
Het |
Ripor3 |
T |
G |
2: 167,839,186 (GRCm39) |
D105A |
probably damaging |
Het |
Rnase10 |
T |
A |
14: 51,247,138 (GRCm39) |
I135N |
probably damaging |
Het |
Rsrc1 |
C |
T |
3: 66,901,982 (GRCm39) |
P44L |
unknown |
Het |
Rttn |
A |
G |
18: 89,047,023 (GRCm39) |
E895G |
probably damaging |
Het |
Serpina3a |
G |
A |
12: 104,079,089 (GRCm39) |
|
probably null |
Het |
Slco5a1 |
C |
T |
1: 12,951,617 (GRCm39) |
C562Y |
probably damaging |
Het |
Spen |
T |
C |
4: 141,220,770 (GRCm39) |
T396A |
unknown |
Het |
Tgfbr3 |
A |
G |
5: 107,280,892 (GRCm39) |
S623P |
probably damaging |
Het |
Tmem8b |
A |
G |
4: 43,690,192 (GRCm39) |
I876V |
probably damaging |
Het |
Tmod3 |
T |
C |
9: 75,416,669 (GRCm39) |
K221R |
probably damaging |
Het |
Tomm40 |
G |
T |
7: 19,436,831 (GRCm39) |
D40E |
probably damaging |
Het |
Trav6d-4 |
G |
T |
14: 52,991,048 (GRCm39) |
G28V |
probably damaging |
Het |
Trav8d-2 |
G |
T |
14: 53,279,933 (GRCm39) |
A17S |
probably benign |
Het |
Triml2 |
T |
C |
8: 43,643,115 (GRCm39) |
C158R |
possibly damaging |
Het |
Trip10 |
A |
G |
17: 57,562,331 (GRCm39) |
E283G |
probably damaging |
Het |
Tubb2b |
T |
C |
13: 34,311,518 (GRCm39) |
Y425C |
probably damaging |
Het |
Ubr1 |
T |
C |
2: 120,794,074 (GRCm39) |
T37A |
probably benign |
Het |
Unc13b |
A |
G |
4: 43,171,403 (GRCm39) |
|
probably benign |
Het |
Unc13b |
A |
G |
4: 43,173,203 (GRCm39) |
|
probably benign |
Het |
Vcan |
A |
T |
13: 89,841,526 (GRCm39) |
D379E |
possibly damaging |
Het |
Vmn1r44 |
T |
A |
6: 89,871,140 (GRCm39) |
H295Q |
probably benign |
Het |
Vmn2r16 |
A |
T |
5: 109,487,969 (GRCm39) |
S281C |
probably damaging |
Het |
Vsig10l |
A |
T |
7: 43,114,491 (GRCm39) |
H271L |
possibly damaging |
Het |
Vwa8 |
A |
T |
14: 79,145,596 (GRCm39) |
H91L |
possibly damaging |
Het |
Zfp957 |
T |
A |
14: 79,451,130 (GRCm39) |
E223V |
probably damaging |
Het |
|
Other mutations in Vmn2r84 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01461:Vmn2r84
|
APN |
10 |
130,227,094 (GRCm39) |
missense |
possibly damaging |
0.65 |
IGL01590:Vmn2r84
|
APN |
10 |
130,221,964 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01639:Vmn2r84
|
APN |
10 |
130,225,141 (GRCm39) |
nonsense |
probably null |
|
IGL01843:Vmn2r84
|
APN |
10 |
130,222,148 (GRCm39) |
missense |
probably benign |
|
IGL01911:Vmn2r84
|
APN |
10 |
130,222,277 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01937:Vmn2r84
|
APN |
10 |
130,221,755 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01977:Vmn2r84
|
APN |
10 |
130,229,935 (GRCm39) |
missense |
probably benign |
0.11 |
IGL02177:Vmn2r84
|
APN |
10 |
130,227,881 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02291:Vmn2r84
|
APN |
10 |
130,226,617 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02590:Vmn2r84
|
APN |
10 |
130,227,356 (GRCm39) |
splice site |
probably benign |
|
IGL02727:Vmn2r84
|
APN |
10 |
130,229,995 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL02900:Vmn2r84
|
APN |
10 |
130,223,861 (GRCm39) |
splice site |
probably benign |
|
IGL03383:Vmn2r84
|
APN |
10 |
130,222,556 (GRCm39) |
missense |
probably damaging |
1.00 |
PIT4378001:Vmn2r84
|
UTSW |
10 |
130,221,784 (GRCm39) |
missense |
probably damaging |
1.00 |
R0076:Vmn2r84
|
UTSW |
10 |
130,230,062 (GRCm39) |
missense |
probably damaging |
1.00 |
R0089:Vmn2r84
|
UTSW |
10 |
130,222,588 (GRCm39) |
splice site |
probably benign |
|
R0153:Vmn2r84
|
UTSW |
10 |
130,227,877 (GRCm39) |
missense |
probably benign |
0.06 |
R0611:Vmn2r84
|
UTSW |
10 |
130,221,991 (GRCm39) |
missense |
probably damaging |
1.00 |
R0883:Vmn2r84
|
UTSW |
10 |
130,226,984 (GRCm39) |
missense |
probably damaging |
0.99 |
R1237:Vmn2r84
|
UTSW |
10 |
130,223,725 (GRCm39) |
splice site |
probably null |
|
R1295:Vmn2r84
|
UTSW |
10 |
130,225,008 (GRCm39) |
missense |
probably benign |
0.12 |
R1401:Vmn2r84
|
UTSW |
10 |
130,227,859 (GRCm39) |
missense |
possibly damaging |
0.89 |
R1521:Vmn2r84
|
UTSW |
10 |
130,225,137 (GRCm39) |
missense |
probably benign |
0.10 |
R1590:Vmn2r84
|
UTSW |
10 |
130,227,349 (GRCm39) |
critical splice acceptor site |
probably null |
|
R1710:Vmn2r84
|
UTSW |
10 |
130,226,968 (GRCm39) |
missense |
probably benign |
0.02 |
R1891:Vmn2r84
|
UTSW |
10 |
130,221,938 (GRCm39) |
missense |
possibly damaging |
0.78 |
R1956:Vmn2r84
|
UTSW |
10 |
130,226,677 (GRCm39) |
missense |
probably benign |
0.01 |
R1957:Vmn2r84
|
UTSW |
10 |
130,226,677 (GRCm39) |
missense |
probably benign |
0.01 |
R1962:Vmn2r84
|
UTSW |
10 |
130,226,591 (GRCm39) |
missense |
probably damaging |
0.99 |
R1994:Vmn2r84
|
UTSW |
10 |
130,221,878 (GRCm39) |
missense |
probably damaging |
1.00 |
R2124:Vmn2r84
|
UTSW |
10 |
130,227,100 (GRCm39) |
missense |
probably damaging |
0.99 |
R2409:Vmn2r84
|
UTSW |
10 |
130,227,940 (GRCm39) |
missense |
probably damaging |
0.99 |
R2474:Vmn2r84
|
UTSW |
10 |
130,222,392 (GRCm39) |
missense |
possibly damaging |
0.50 |
R2851:Vmn2r84
|
UTSW |
10 |
130,230,036 (GRCm39) |
missense |
probably benign |
0.05 |
R3508:Vmn2r84
|
UTSW |
10 |
130,226,777 (GRCm39) |
missense |
probably damaging |
1.00 |
R3792:Vmn2r84
|
UTSW |
10 |
130,221,669 (GRCm39) |
makesense |
probably null |
|
R4051:Vmn2r84
|
UTSW |
10 |
130,226,767 (GRCm39) |
missense |
probably damaging |
1.00 |
R4061:Vmn2r84
|
UTSW |
10 |
130,221,898 (GRCm39) |
missense |
probably damaging |
1.00 |
R4091:Vmn2r84
|
UTSW |
10 |
130,227,238 (GRCm39) |
missense |
probably damaging |
1.00 |
R4190:Vmn2r84
|
UTSW |
10 |
130,227,163 (GRCm39) |
nonsense |
probably null |
|
R4520:Vmn2r84
|
UTSW |
10 |
130,222,391 (GRCm39) |
missense |
probably damaging |
1.00 |
R4584:Vmn2r84
|
UTSW |
10 |
130,226,582 (GRCm39) |
missense |
probably benign |
0.00 |
R4588:Vmn2r84
|
UTSW |
10 |
130,221,809 (GRCm39) |
missense |
probably damaging |
0.98 |
R4655:Vmn2r84
|
UTSW |
10 |
130,229,973 (GRCm39) |
nonsense |
probably null |
|
R4860:Vmn2r84
|
UTSW |
10 |
130,221,712 (GRCm39) |
missense |
probably damaging |
0.99 |
R4860:Vmn2r84
|
UTSW |
10 |
130,221,712 (GRCm39) |
missense |
probably damaging |
0.99 |
R5022:Vmn2r84
|
UTSW |
10 |
130,222,417 (GRCm39) |
missense |
probably damaging |
1.00 |
R5146:Vmn2r84
|
UTSW |
10 |
130,221,971 (GRCm39) |
missense |
probably damaging |
1.00 |
R5237:Vmn2r84
|
UTSW |
10 |
130,221,863 (GRCm39) |
missense |
probably damaging |
0.99 |
R5695:Vmn2r84
|
UTSW |
10 |
130,225,064 (GRCm39) |
missense |
probably benign |
0.12 |
R5793:Vmn2r84
|
UTSW |
10 |
130,221,754 (GRCm39) |
missense |
probably damaging |
0.99 |
R6210:Vmn2r84
|
UTSW |
10 |
130,222,114 (GRCm39) |
missense |
probably damaging |
1.00 |
R6286:Vmn2r84
|
UTSW |
10 |
130,226,737 (GRCm39) |
missense |
possibly damaging |
0.65 |
R6580:Vmn2r84
|
UTSW |
10 |
130,225,110 (GRCm39) |
missense |
possibly damaging |
0.93 |
R6607:Vmn2r84
|
UTSW |
10 |
130,226,731 (GRCm39) |
missense |
possibly damaging |
0.87 |
R6818:Vmn2r84
|
UTSW |
10 |
130,222,147 (GRCm39) |
missense |
probably benign |
0.09 |
R6956:Vmn2r84
|
UTSW |
10 |
130,225,136 (GRCm39) |
missense |
probably damaging |
0.98 |
R7075:Vmn2r84
|
UTSW |
10 |
130,226,941 (GRCm39) |
missense |
probably damaging |
0.99 |
R7225:Vmn2r84
|
UTSW |
10 |
130,222,552 (GRCm39) |
missense |
probably damaging |
0.99 |
R7252:Vmn2r84
|
UTSW |
10 |
130,222,279 (GRCm39) |
missense |
probably damaging |
1.00 |
R7263:Vmn2r84
|
UTSW |
10 |
130,225,077 (GRCm39) |
missense |
probably damaging |
1.00 |
R7297:Vmn2r84
|
UTSW |
10 |
130,227,119 (GRCm39) |
missense |
probably benign |
0.19 |
R7439:Vmn2r84
|
UTSW |
10 |
130,227,982 (GRCm39) |
missense |
possibly damaging |
0.90 |
R7441:Vmn2r84
|
UTSW |
10 |
130,227,982 (GRCm39) |
missense |
possibly damaging |
0.90 |
R7857:Vmn2r84
|
UTSW |
10 |
130,226,738 (GRCm39) |
missense |
probably benign |
0.00 |
R8263:Vmn2r84
|
UTSW |
10 |
130,227,037 (GRCm39) |
missense |
probably damaging |
1.00 |
R8555:Vmn2r84
|
UTSW |
10 |
130,230,100 (GRCm39) |
missense |
probably benign |
0.28 |
R8766:Vmn2r84
|
UTSW |
10 |
130,222,241 (GRCm39) |
missense |
probably damaging |
0.98 |
R8821:Vmn2r84
|
UTSW |
10 |
130,226,968 (GRCm39) |
missense |
probably benign |
0.02 |
R8831:Vmn2r84
|
UTSW |
10 |
130,226,968 (GRCm39) |
missense |
probably benign |
0.02 |
R8970:Vmn2r84
|
UTSW |
10 |
130,222,244 (GRCm39) |
missense |
probably damaging |
0.98 |
R9164:Vmn2r84
|
UTSW |
10 |
130,221,669 (GRCm39) |
makesense |
probably null |
|
R9190:Vmn2r84
|
UTSW |
10 |
130,226,843 (GRCm39) |
missense |
probably benign |
0.03 |
R9261:Vmn2r84
|
UTSW |
10 |
130,229,976 (GRCm39) |
missense |
probably benign |
0.00 |
R9310:Vmn2r84
|
UTSW |
10 |
130,227,993 (GRCm39) |
missense |
possibly damaging |
0.81 |
R9434:Vmn2r84
|
UTSW |
10 |
130,221,745 (GRCm39) |
missense |
possibly damaging |
0.65 |
R9613:Vmn2r84
|
UTSW |
10 |
130,226,591 (GRCm39) |
missense |
probably damaging |
0.99 |
Z1177:Vmn2r84
|
UTSW |
10 |
130,227,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- GCAGTGCTGTCAATTCTAATGG -3'
(R):5'- TGTGATCCCAGAAACCATGAAG -3'
Sequencing Primer
(F):5'- GGTTTTCGCATGTGAAATGATCC -3'
(R):5'- TATGACATCTTCAGCAAAGGTTG -3'
|
Posted On |
2019-05-13 |