Incidental Mutation 'R6995:Cic'
| ID |
544124 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cic
|
| Ensembl Gene |
ENSMUSG00000005442 |
| Gene Name |
capicua transcriptional repressor |
| Synonyms |
1200010B10Rik |
| MMRRC Submission |
045101-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.949)
|
| Stock # |
R6995 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
24967129-24993584 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 24970736 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 156
(T156S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132351
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000169266]
[ENSMUST00000169392]
|
| AlphaFold |
Q924A2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000169266
AA Change: T156S
PolyPhen 2
Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000132351
Gene: ENSMUSG00000005442
AA Change: T156S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
9 |
23 |
N/A |
INTRINSIC |
|
low complexity region
|
33 |
73 |
N/A |
INTRINSIC |
|
low complexity region
|
151 |
165 |
N/A |
INTRINSIC |
|
Pfam:DUF4819
|
249 |
346 |
1.8e-23 |
PFAM |
|
low complexity region
|
351 |
367 |
N/A |
INTRINSIC |
|
low complexity region
|
403 |
427 |
N/A |
INTRINSIC |
|
low complexity region
|
445 |
457 |
N/A |
INTRINSIC |
|
low complexity region
|
462 |
475 |
N/A |
INTRINSIC |
|
low complexity region
|
618 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
673 |
685 |
N/A |
INTRINSIC |
|
low complexity region
|
724 |
734 |
N/A |
INTRINSIC |
|
low complexity region
|
740 |
751 |
N/A |
INTRINSIC |
|
low complexity region
|
779 |
786 |
N/A |
INTRINSIC |
|
low complexity region
|
858 |
883 |
N/A |
INTRINSIC |
|
low complexity region
|
898 |
911 |
N/A |
INTRINSIC |
|
PDB:4J2L|D
|
930 |
955 |
5e-10 |
PDB |
|
low complexity region
|
1013 |
1027 |
N/A |
INTRINSIC |
|
low complexity region
|
1031 |
1045 |
N/A |
INTRINSIC |
|
HMG
|
1106 |
1176 |
1.24e-17 |
SMART |
|
low complexity region
|
1322 |
1338 |
N/A |
INTRINSIC |
|
low complexity region
|
1380 |
1393 |
N/A |
INTRINSIC |
|
low complexity region
|
1415 |
1428 |
N/A |
INTRINSIC |
|
low complexity region
|
1432 |
1462 |
N/A |
INTRINSIC |
|
low complexity region
|
1474 |
1490 |
N/A |
INTRINSIC |
|
low complexity region
|
1552 |
1567 |
N/A |
INTRINSIC |
|
low complexity region
|
1636 |
1647 |
N/A |
INTRINSIC |
|
low complexity region
|
1689 |
1710 |
N/A |
INTRINSIC |
|
low complexity region
|
1744 |
1766 |
N/A |
INTRINSIC |
|
low complexity region
|
1846 |
1858 |
N/A |
INTRINSIC |
|
low complexity region
|
1971 |
1986 |
N/A |
INTRINSIC |
|
low complexity region
|
2024 |
2038 |
N/A |
INTRINSIC |
|
low complexity region
|
2041 |
2061 |
N/A |
INTRINSIC |
|
low complexity region
|
2129 |
2159 |
N/A |
INTRINSIC |
|
low complexity region
|
2186 |
2219 |
N/A |
INTRINSIC |
|
low complexity region
|
2311 |
2324 |
N/A |
INTRINSIC |
|
low complexity region
|
2389 |
2400 |
N/A |
INTRINSIC |
|
low complexity region
|
2430 |
2453 |
N/A |
INTRINSIC |
|
low complexity region
|
2474 |
2509 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000169392
|
| SMART Domains |
Protein: ENSMUSP00000131680
Gene: ENSMUSG00000005442
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
9 |
23 |
N/A |
INTRINSIC |
|
low complexity region
|
33 |
73 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit partial postnatal lethality, decreased body size, and severe lung alveolarization defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(61) : Targeted, other(4) Gene trapped(57)
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930433I11Rik |
A |
G |
7: 40,644,149 (GRCm39) |
Y606C |
probably benign |
Het |
| Acad9 |
A |
G |
3: 36,139,630 (GRCm39) |
Y410C |
probably damaging |
Het |
| Acot6 |
C |
T |
12: 84,156,149 (GRCm39) |
P366S |
probably damaging |
Het |
| Adrm1b |
T |
C |
3: 92,336,315 (GRCm39) |
|
probably benign |
Het |
| Anks1 |
G |
T |
17: 28,273,273 (GRCm39) |
G964V |
probably damaging |
Het |
| Apol7a |
A |
T |
15: 77,274,176 (GRCm39) |
|
probably benign |
Het |
| Arid3c |
G |
A |
4: 41,725,087 (GRCm39) |
A320V |
probably damaging |
Het |
| Bnip3l |
A |
T |
14: 67,237,101 (GRCm39) |
N50K |
probably benign |
Het |
| C1qtnf4 |
C |
A |
2: 90,720,297 (GRCm39) |
A190D |
probably benign |
Het |
| Calhm5 |
A |
T |
10: 33,972,189 (GRCm39) |
M82K |
probably benign |
Het |
| Cdcp3 |
G |
T |
7: 130,824,400 (GRCm39) |
W165L |
probably damaging |
Het |
| Cdh1 |
G |
T |
8: 107,387,545 (GRCm39) |
V482L |
probably benign |
Het |
| Cdrt4 |
A |
C |
11: 62,883,486 (GRCm39) |
I63L |
probably benign |
Het |
| Ckm |
A |
G |
7: 19,154,156 (GRCm39) |
N301S |
probably benign |
Het |
| Colgalt1 |
C |
T |
8: 72,076,165 (GRCm39) |
R539C |
probably damaging |
Het |
| Cop1 |
A |
G |
1: 159,134,154 (GRCm39) |
D132G |
probably damaging |
Het |
| Cpd |
G |
T |
11: 76,675,881 (GRCm39) |
N1257K |
probably benign |
Het |
| Cyp2c67 |
T |
C |
19: 39,604,123 (GRCm39) |
H411R |
probably damaging |
Het |
| Cyp2r1 |
A |
T |
7: 114,152,316 (GRCm39) |
F5I |
probably damaging |
Het |
| Dclk3 |
T |
A |
9: 111,296,768 (GRCm39) |
L104Q |
possibly damaging |
Het |
| Dnah7c |
A |
T |
1: 46,494,973 (GRCm39) |
Q67L |
probably benign |
Het |
| Dnm1l |
C |
A |
16: 16,147,671 (GRCm39) |
E365* |
probably null |
Het |
| Dst |
A |
T |
1: 34,205,315 (GRCm39) |
I502F |
probably damaging |
Het |
| Espl1 |
T |
C |
15: 102,212,535 (GRCm39) |
V547A |
possibly damaging |
Het |
| Foxa1 |
C |
T |
12: 57,589,264 (GRCm39) |
A319T |
probably benign |
Het |
| Frem1 |
G |
T |
4: 82,904,838 (GRCm39) |
H859N |
probably damaging |
Het |
| Frem3 |
T |
A |
8: 81,339,208 (GRCm39) |
D500E |
probably damaging |
Het |
| Gpatch2l |
G |
A |
12: 86,290,958 (GRCm39) |
R47H |
probably damaging |
Het |
| Grip1 |
A |
G |
10: 119,822,375 (GRCm39) |
D394G |
probably damaging |
Het |
| Gsap |
C |
A |
5: 21,476,235 (GRCm39) |
T589K |
possibly damaging |
Het |
| Gsg1l |
A |
G |
7: 125,522,658 (GRCm39) |
V190A |
probably damaging |
Het |
| Kcnmb1 |
A |
T |
11: 33,920,131 (GRCm39) |
T115S |
probably benign |
Het |
| Kirrel2 |
A |
C |
7: 30,154,604 (GRCm39) |
F169C |
probably damaging |
Het |
| L3mbtl1 |
C |
T |
2: 162,803,368 (GRCm39) |
T397M |
probably damaging |
Het |
| Lama1 |
G |
A |
17: 68,060,820 (GRCm39) |
C716Y |
|
Het |
| Lamc2 |
G |
A |
1: 153,012,508 (GRCm39) |
T722M |
probably benign |
Het |
| Lrig1 |
T |
C |
6: 94,588,610 (GRCm39) |
D513G |
possibly damaging |
Het |
| Lrrk1 |
T |
C |
7: 65,942,090 (GRCm39) |
D716G |
probably damaging |
Het |
| Matn4 |
G |
A |
2: 164,231,584 (GRCm39) |
R582* |
probably null |
Het |
| Mdn1 |
A |
T |
4: 32,733,374 (GRCm39) |
R3133W |
probably benign |
Het |
| Mmp7 |
A |
G |
9: 7,695,489 (GRCm39) |
D122G |
probably damaging |
Het |
| Naaladl1 |
A |
G |
19: 6,165,578 (GRCm39) |
D744G |
possibly damaging |
Het |
| Nampt |
T |
G |
12: 32,898,742 (GRCm39) |
Y453D |
probably benign |
Het |
| Nlrp12 |
A |
G |
7: 3,288,481 (GRCm39) |
V677A |
probably benign |
Het |
| Ntng2 |
T |
C |
2: 29,087,080 (GRCm39) |
N414S |
probably damaging |
Het |
| Or1e16 |
A |
G |
11: 73,286,410 (GRCm39) |
V146A |
probably benign |
Het |
| Or4g17 |
A |
G |
2: 111,209,708 (GRCm39) |
D121G |
probably damaging |
Het |
| Or5p52 |
A |
G |
7: 107,502,829 (GRCm39) |
R302G |
probably benign |
Het |
| Or9m1b |
A |
C |
2: 87,836,529 (GRCm39) |
F189V |
probably benign |
Het |
| Parp4 |
A |
C |
14: 56,851,196 (GRCm39) |
Q733P |
probably damaging |
Het |
| Pdcl3 |
G |
A |
1: 39,034,417 (GRCm39) |
V56I |
probably benign |
Het |
| Pepd |
A |
G |
7: 34,721,144 (GRCm39) |
Y256C |
probably damaging |
Het |
| Plg |
G |
T |
17: 12,637,938 (GRCm39) |
R788L |
probably benign |
Het |
| Plod1 |
A |
T |
4: 148,000,675 (GRCm39) |
|
probably benign |
Het |
| Ptprc |
A |
G |
1: 138,016,482 (GRCm39) |
V513A |
probably damaging |
Het |
| Pxdn |
T |
C |
12: 30,045,370 (GRCm39) |
I373T |
possibly damaging |
Het |
| Qrfprl |
A |
T |
6: 65,418,285 (GRCm39) |
K151I |
probably damaging |
Het |
| Rbbp8 |
G |
A |
18: 11,851,965 (GRCm39) |
G262E |
probably damaging |
Het |
| Rfc2 |
T |
A |
5: 134,623,104 (GRCm39) |
Y240* |
probably null |
Het |
| Rps15 |
A |
G |
10: 80,129,598 (GRCm39) |
E71G |
possibly damaging |
Het |
| Rsrc1 |
C |
T |
3: 66,901,982 (GRCm39) |
P44L |
unknown |
Het |
| Ryr1 |
A |
C |
7: 28,793,607 (GRCm39) |
M1287R |
probably damaging |
Het |
| Scart2 |
G |
A |
7: 139,841,514 (GRCm39) |
D273N |
probably benign |
Het |
| Serpina9 |
A |
G |
12: 103,967,495 (GRCm39) |
L300P |
probably damaging |
Het |
| Sh3rf2 |
G |
A |
18: 42,234,606 (GRCm39) |
A130T |
probably damaging |
Het |
| Slc12a8 |
G |
A |
16: 33,355,263 (GRCm39) |
W26* |
probably null |
Het |
| Snx18 |
A |
T |
13: 113,731,265 (GRCm39) |
H576Q |
probably damaging |
Het |
| Tagln3 |
G |
A |
16: 45,543,321 (GRCm39) |
T107I |
probably benign |
Het |
| Thap1 |
C |
A |
8: 26,652,679 (GRCm39) |
T139K |
probably damaging |
Het |
| Tle4 |
T |
A |
19: 14,541,817 (GRCm39) |
|
probably null |
Het |
| Tmem87a |
A |
T |
2: 120,193,409 (GRCm39) |
M502K |
possibly damaging |
Het |
| Tpcn2 |
A |
T |
7: 144,810,522 (GRCm39) |
V605E |
probably benign |
Het |
| Trgj1 |
C |
A |
13: 19,394,529 (GRCm39) |
|
probably benign |
Het |
| Tsc2 |
A |
T |
17: 24,847,028 (GRCm39) |
V179E |
probably damaging |
Het |
| Ubap2l |
T |
C |
3: 89,916,548 (GRCm39) |
T909A |
probably damaging |
Het |
| Ubl4b |
T |
G |
3: 107,462,140 (GRCm39) |
Q40P |
probably damaging |
Het |
| Vmn1r229 |
A |
G |
17: 21,035,277 (GRCm39) |
D174G |
probably damaging |
Het |
| Vmn2r50 |
A |
T |
7: 9,779,964 (GRCm39) |
Y472* |
probably null |
Het |
| Vmn2r74 |
T |
A |
7: 85,601,943 (GRCm39) |
D565V |
probably benign |
Het |
| Vmn2r74 |
T |
A |
7: 85,606,860 (GRCm39) |
|
probably null |
Het |
| Vmn2r82 |
T |
A |
10: 79,232,377 (GRCm39) |
V792E |
probably damaging |
Het |
| Zfp335 |
G |
A |
2: 164,735,210 (GRCm39) |
Q1179* |
probably null |
Het |
| Zmynd12 |
A |
C |
4: 119,310,772 (GRCm39) |
K327Q |
probably benign |
Het |
| Zwilch |
G |
A |
9: 64,072,731 (GRCm39) |
Q27* |
probably null |
Het |
|
| Other mutations in Cic |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00092:Cic
|
APN |
7 |
24,991,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01668:Cic
|
APN |
7 |
24,990,629 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL02229:Cic
|
APN |
7 |
24,990,375 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02506:Cic
|
APN |
7 |
24,990,282 (GRCm39) |
missense |
probably benign |
|
|
IGL02794:Cic
|
APN |
7 |
24,985,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03065:Cic
|
APN |
7 |
24,985,246 (GRCm39) |
splice site |
probably benign |
|
|
IGL03304:Cic
|
APN |
7 |
24,984,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Capuccino
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Cassock
|
UTSW |
7 |
24,988,338 (GRCm39) |
nonsense |
probably null |
|
|
Monkey
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4850_Cic_466
|
UTSW |
7 |
24,972,327 (GRCm39) |
missense |
probably damaging |
0.98 |
|
1mM(1):Cic
|
UTSW |
7 |
24,990,214 (GRCm39) |
splice site |
probably benign |
|
|
IGL03046:Cic
|
UTSW |
7 |
24,990,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0012:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0012:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0027:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0027:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0038:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0038:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0063:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0063:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0064:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0064:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0118:Cic
|
UTSW |
7 |
24,985,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0193:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0193:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0241:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0241:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0377:Cic
|
UTSW |
7 |
24,985,224 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0462:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0462:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0800:Cic
|
UTSW |
7 |
24,984,662 (GRCm39) |
missense |
probably benign |
|
|
R1253:Cic
|
UTSW |
7 |
24,990,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1458:Cic
|
UTSW |
7 |
24,979,162 (GRCm39) |
intron |
probably benign |
|
|
R1462:Cic
|
UTSW |
7 |
24,971,032 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1462:Cic
|
UTSW |
7 |
24,971,032 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1519:Cic
|
UTSW |
7 |
24,993,235 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1586:Cic
|
UTSW |
7 |
24,985,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1824:Cic
|
UTSW |
7 |
24,987,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1908:Cic
|
UTSW |
7 |
24,986,265 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2045:Cic
|
UTSW |
7 |
24,970,961 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R2063:Cic
|
UTSW |
7 |
24,972,876 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2161:Cic
|
UTSW |
7 |
24,987,559 (GRCm39) |
splice site |
probably null |
|
|
R2495:Cic
|
UTSW |
7 |
24,991,201 (GRCm39) |
splice site |
probably benign |
|
|
R2865:Cic
|
UTSW |
7 |
24,972,646 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3692:Cic
|
UTSW |
7 |
24,988,338 (GRCm39) |
nonsense |
probably null |
|
|
R3709:Cic
|
UTSW |
7 |
24,986,406 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3710:Cic
|
UTSW |
7 |
24,986,406 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3872:Cic
|
UTSW |
7 |
24,971,124 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R3946:Cic
|
UTSW |
7 |
24,971,771 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4199:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
frame shift |
probably null |
|
|
R4426:Cic
|
UTSW |
7 |
24,993,433 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4502:Cic
|
UTSW |
7 |
24,987,892 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4585:Cic
|
UTSW |
7 |
24,972,203 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4586:Cic
|
UTSW |
7 |
24,972,203 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4614:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
frame shift |
probably null |
|
|
R4664:Cic
|
UTSW |
7 |
24,990,099 (GRCm39) |
small deletion |
probably benign |
|
|
R4688:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
frame shift |
probably null |
|
|
R4695:Cic
|
UTSW |
7 |
24,973,013 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R4696:Cic
|
UTSW |
7 |
24,987,908 (GRCm39) |
missense |
probably benign |
|
|
R4746:Cic
|
UTSW |
7 |
24,987,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4758:Cic
|
UTSW |
7 |
24,991,636 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R4767:Cic
|
UTSW |
7 |
24,971,025 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4776:Cic
|
UTSW |
7 |
24,982,308 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4820:Cic
|
UTSW |
7 |
24,971,157 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4850:Cic
|
UTSW |
7 |
24,972,327 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4851:Cic
|
UTSW |
7 |
24,972,327 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4922:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
small insertion |
probably benign |
|
|
R4989:Cic
|
UTSW |
7 |
24,986,535 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5131:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
small insertion |
probably benign |
|
|
R5718:Cic
|
UTSW |
7 |
24,972,203 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5801:Cic
|
UTSW |
7 |
24,970,863 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5949:Cic
|
UTSW |
7 |
24,971,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6000:Cic
|
UTSW |
7 |
24,971,423 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6246:Cic
|
UTSW |
7 |
24,971,067 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6283:Cic
|
UTSW |
7 |
24,985,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6364:Cic
|
UTSW |
7 |
24,972,248 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R6481:Cic
|
UTSW |
7 |
24,987,706 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R6919:Cic
|
UTSW |
7 |
24,971,202 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6920:Cic
|
UTSW |
7 |
24,990,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7002:Cic
|
UTSW |
7 |
24,971,621 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7113:Cic
|
UTSW |
7 |
24,972,869 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7560:Cic
|
UTSW |
7 |
24,972,278 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7680:Cic
|
UTSW |
7 |
24,991,856 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7698:Cic
|
UTSW |
7 |
24,972,597 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7746:Cic
|
UTSW |
7 |
24,988,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7841:Cic
|
UTSW |
7 |
24,985,192 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7879:Cic
|
UTSW |
7 |
24,984,551 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7916:Cic
|
UTSW |
7 |
24,987,715 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7920:Cic
|
UTSW |
7 |
24,971,384 (GRCm39) |
missense |
probably benign |
|
|
R8056:Cic
|
UTSW |
7 |
24,990,366 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8226:Cic
|
UTSW |
7 |
24,987,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8281:Cic
|
UTSW |
7 |
24,971,249 (GRCm39) |
missense |
probably benign |
|
|
R8847:Cic
|
UTSW |
7 |
24,970,631 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8991:Cic
|
UTSW |
7 |
24,988,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9083:Cic
|
UTSW |
7 |
24,985,470 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9140:Cic
|
UTSW |
7 |
24,985,165 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9200:Cic
|
UTSW |
7 |
24,971,940 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9208:Cic
|
UTSW |
7 |
24,987,502 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9301:Cic
|
UTSW |
7 |
24,991,117 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9408:Cic
|
UTSW |
7 |
24,971,414 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R9569:Cic
|
UTSW |
7 |
24,972,120 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9752:Cic
|
UTSW |
7 |
24,971,403 (GRCm39) |
missense |
probably damaging |
0.96 |
|
V7732:Cic
|
UTSW |
7 |
24,991,670 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Cic
|
UTSW |
7 |
24,970,444 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
| Predicted Primers |
PCR Primer
(F):5'- GATCCTACTCCAGGCCTAACTG -3'
(R):5'- AGAAAGTCAAGGCACGGTCC -3'
Sequencing Primer
(F):5'- GGATGGGGAGGCAGGCC -3'
(R):5'- TGCACACCCAAGTCCTGG -3'
|
| Posted On |
2019-05-13 |
Incidental Mutation