Incidental Mutation 'IGL00329:Vmn1r21'
| ID |
5442 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r21
|
| Ensembl Gene |
ENSMUSG00000115343 |
| Gene Name |
vomeronasal 1 receptor 21 |
| Synonyms |
V1rc28 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.121)
|
| Stock # |
IGL00329
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
57820549-57821442 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 57821049 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Threonine
at position 132
(S132T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154295
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000081186]
[ENSMUST00000203310]
[ENSMUST00000203488]
[ENSMUST00000226191]
|
| AlphaFold |
Q8R2C6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000081186
AA Change: S132T
PolyPhen 2
Score 0.048 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000079950
Gene: ENSMUSG00000058588
AA Change: S132T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
293 |
5.9e-52 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000203270
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000203310
AA Change: S132T
PolyPhen 2
Score 0.048 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000145398
Gene: ENSMUSG00000115343
AA Change: S132T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
27 |
107 |
1.8e-14 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000203488
AA Change: S132T
PolyPhen 2
Score 0.048 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000144978
Gene: ENSMUSG00000115343
AA Change: S132T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
105 |
2e-13 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226191
AA Change: S132T
PolyPhen 2
Score 0.048 (Sensitivity: 0.94; Specificity: 0.83)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 30 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acad9 |
A |
G |
3: 36,123,911 (GRCm39) |
N72S |
probably benign |
Het |
| Aopep |
T |
A |
13: 63,338,977 (GRCm39) |
I623N |
probably damaging |
Het |
| Apba3 |
C |
T |
10: 81,108,901 (GRCm39) |
P555S |
probably damaging |
Het |
| Arcn1 |
C |
A |
9: 44,670,333 (GRCm39) |
E98* |
probably null |
Het |
| Cimip2b |
G |
A |
4: 43,428,158 (GRCm39) |
R100W |
possibly damaging |
Het |
| Col28a1 |
G |
T |
6: 8,175,425 (GRCm39) |
T141K |
probably damaging |
Het |
| Dna2 |
T |
C |
10: 62,802,222 (GRCm39) |
F811S |
probably damaging |
Het |
| Dusp19 |
T |
A |
2: 80,461,269 (GRCm39) |
I186K |
probably damaging |
Het |
| Dync2li1 |
A |
G |
17: 84,952,154 (GRCm39) |
D195G |
possibly damaging |
Het |
| Epm2aip1 |
T |
C |
9: 111,101,855 (GRCm39) |
V276A |
possibly damaging |
Het |
| Extl3 |
T |
C |
14: 65,313,070 (GRCm39) |
E704G |
probably benign |
Het |
| Gle1 |
T |
C |
2: 29,829,301 (GRCm39) |
|
probably benign |
Het |
| Gm2178 |
C |
A |
14: 26,235,767 (GRCm39) |
|
probably benign |
Het |
| Gm4553 |
T |
C |
7: 141,718,964 (GRCm39) |
S155G |
unknown |
Het |
| Herc2 |
T |
A |
7: 55,774,047 (GRCm39) |
L1166Q |
probably damaging |
Het |
| Hsd11b2 |
A |
G |
8: 106,249,759 (GRCm39) |
E290G |
probably benign |
Het |
| Inpp5d |
T |
C |
1: 87,595,725 (GRCm39) |
V157A |
probably benign |
Het |
| Krt72 |
T |
A |
15: 101,693,434 (GRCm39) |
Q160L |
probably damaging |
Het |
| Lrrd1 |
A |
G |
5: 3,900,081 (GRCm39) |
K129E |
possibly damaging |
Het |
| Mapk13 |
A |
G |
17: 28,995,379 (GRCm39) |
Y200C |
probably damaging |
Het |
| Mme |
G |
A |
3: 63,287,749 (GRCm39) |
W750* |
probably null |
Het |
| Nat8l |
C |
T |
5: 34,155,761 (GRCm39) |
P139L |
probably damaging |
Het |
| Nrtn |
C |
A |
17: 57,058,569 (GRCm39) |
R144L |
probably benign |
Het |
| Or52h9 |
C |
A |
7: 104,202,299 (GRCm39) |
P58T |
probably benign |
Het |
| Pate12 |
G |
A |
9: 36,344,198 (GRCm39) |
|
probably benign |
Het |
| Pdgfa |
T |
A |
5: 138,974,216 (GRCm39) |
|
probably benign |
Het |
| Rtp3 |
A |
G |
9: 110,815,666 (GRCm39) |
V233A |
probably benign |
Het |
| Syne2 |
A |
G |
12: 76,078,474 (GRCm39) |
|
probably benign |
Het |
| Trappc10 |
A |
T |
10: 78,039,711 (GRCm39) |
|
probably benign |
Het |
| Usp24 |
A |
G |
4: 106,216,288 (GRCm39) |
T380A |
probably benign |
Het |
|
| Other mutations in Vmn1r21 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01366:Vmn1r21
|
APN |
6 |
57,820,799 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01660:Vmn1r21
|
APN |
6 |
57,821,222 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02864:Vmn1r21
|
APN |
6 |
57,820,661 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02961:Vmn1r21
|
APN |
6 |
57,820,974 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03170:Vmn1r21
|
APN |
6 |
57,820,847 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4453001:Vmn1r21
|
UTSW |
6 |
57,821,307 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1800:Vmn1r21
|
UTSW |
6 |
57,820,799 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1928:Vmn1r21
|
UTSW |
6 |
57,821,077 (GRCm39) |
nonsense |
probably null |
|
|
R3407:Vmn1r21
|
UTSW |
6 |
57,820,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5566:Vmn1r21
|
UTSW |
6 |
57,821,079 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6012:Vmn1r21
|
UTSW |
6 |
57,820,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6293:Vmn1r21
|
UTSW |
6 |
57,821,255 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6473:Vmn1r21
|
UTSW |
6 |
57,820,583 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7128:Vmn1r21
|
UTSW |
6 |
57,820,936 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7489:Vmn1r21
|
UTSW |
6 |
57,820,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7559:Vmn1r21
|
UTSW |
6 |
57,821,227 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8002:Vmn1r21
|
UTSW |
6 |
57,821,199 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8218:Vmn1r21
|
UTSW |
6 |
57,820,910 (GRCm39) |
missense |
noncoding transcript |
|
|
R8467:Vmn1r21
|
UTSW |
6 |
57,821,441 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R8922:Vmn1r21
|
UTSW |
6 |
57,820,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8930:Vmn1r21
|
UTSW |
6 |
57,820,998 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8932:Vmn1r21
|
UTSW |
6 |
57,820,998 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8961:Vmn1r21
|
UTSW |
6 |
57,820,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9154:Vmn1r21
|
UTSW |
6 |
57,821,348 (GRCm39) |
missense |
probably benign |
0.36 |
|
Z1176:Vmn1r21
|
UTSW |
6 |
57,820,563 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Posted On |
2012-04-20 |
Incidental Mutation