Incidental Mutation 'R7000:Pcdhga8'
| ID |
544510 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pcdhga8
|
| Ensembl Gene |
ENSMUSG00000103897 |
| Gene Name |
protocadherin gamma subfamily A, 8 |
| Synonyms |
|
| MMRRC Submission |
045105-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.086)
|
| Stock # |
R7000 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
18 |
| Chromosomal Location |
37858759-37974926 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 37859946 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Lysine
at position 334
(I334K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000067728
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000066149]
[ENSMUST00000073447]
[ENSMUST00000115661]
[ENSMUST00000192511]
[ENSMUST00000192535]
[ENSMUST00000192931]
[ENSMUST00000193414]
[ENSMUST00000193869]
[ENSMUST00000194190]
[ENSMUST00000194418]
[ENSMUST00000194544]
[ENSMUST00000195112]
[ENSMUST00000195363]
[ENSMUST00000195823]
|
| AlphaFold |
Q91XY0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000066149
AA Change: I334K
PolyPhen 2
Score 0.106 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000067728
Gene: ENSMUSG00000103897
AA Change: I334K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
29 |
N/A |
INTRINSIC |
|
CA
|
31 |
131 |
4.84e-2 |
SMART |
|
CA
|
155 |
240 |
1.48e-22 |
SMART |
|
CA
|
264 |
345 |
1.14e-23 |
SMART |
|
CA
|
369 |
450 |
9.44e-21 |
SMART |
|
CA
|
474 |
560 |
1.03e-26 |
SMART |
|
CA
|
591 |
669 |
3.64e-13 |
SMART |
|
Pfam:Cadherin_C_2
|
688 |
772 |
3e-25 |
PFAM |
|
Pfam:Cadherin_tail
|
809 |
932 |
8.1e-38 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000073447
|
| SMART Domains |
Protein: ENSMUSP00000073150
Gene: ENSMUSG00000104346
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
CA
|
42 |
128 |
2.15e-2 |
SMART |
|
CA
|
152 |
237 |
4.8e-13 |
SMART |
|
CA
|
261 |
342 |
9.36e-25 |
SMART |
|
CA
|
366 |
447 |
6.62e-25 |
SMART |
|
CA
|
471 |
557 |
6.72e-26 |
SMART |
|
CA
|
588 |
666 |
2.15e-15 |
SMART |
|
Pfam:Cadherin_C_2
|
685 |
768 |
4.8e-24 |
PFAM |
|
Pfam:Cadherin_tail
|
805 |
928 |
8.1e-38 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115661
|
| SMART Domains |
Protein: ENSMUSP00000111325
Gene: ENSMUSG00000103458
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
20 |
131 |
5.3e-2 |
SMART |
|
CA
|
155 |
240 |
1.51e-19 |
SMART |
|
CA
|
264 |
348 |
7.6e-25 |
SMART |
|
CA
|
372 |
453 |
1.42e-24 |
SMART |
|
CA
|
477 |
563 |
1.42e-24 |
SMART |
|
CA
|
594 |
674 |
4.12e-12 |
SMART |
|
low complexity region
|
706 |
721 |
N/A |
INTRINSIC |
|
Pfam:Cadherin_tail
|
796 |
930 |
3.9e-58 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000192511
|
| SMART Domains |
Protein: ENSMUSP00000141704
Gene: ENSMUSG00000103472
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
47 |
133 |
1.57e-2 |
SMART |
|
CA
|
157 |
242 |
3.24e-19 |
SMART |
|
CA
|
266 |
347 |
3.21e-23 |
SMART |
|
CA
|
371 |
452 |
9.08e-23 |
SMART |
|
CA
|
476 |
562 |
1.32e-24 |
SMART |
|
CA
|
593 |
671 |
3.5e-15 |
SMART |
|
transmembrane domain
|
694 |
716 |
N/A |
INTRINSIC |
|
low complexity region
|
916 |
935 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000192535
|
| SMART Domains |
Protein: ENSMUSP00000142010
Gene: ENSMUSG00000103749
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
17 |
25 |
N/A |
INTRINSIC |
|
CA
|
56 |
131 |
8e-3 |
SMART |
|
CA
|
155 |
240 |
2.49e-20 |
SMART |
|
CA
|
264 |
341 |
4.97e-29 |
SMART |
|
CA
|
365 |
446 |
1.09e-25 |
SMART |
|
CA
|
470 |
556 |
1.75e-24 |
SMART |
|
CA
|
587 |
668 |
9.18e-10 |
SMART |
|
transmembrane domain
|
687 |
709 |
N/A |
INTRINSIC |
|
low complexity region
|
907 |
926 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000192931
|
| SMART Domains |
Protein: ENSMUSP00000141348
Gene: ENSMUSG00000103037
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
36 |
119 |
8e-3 |
SMART |
|
CA
|
143 |
228 |
1.34e-20 |
SMART |
|
CA
|
252 |
333 |
1.52e-24 |
SMART |
|
CA
|
357 |
438 |
9.22e-24 |
SMART |
|
CA
|
462 |
548 |
1.24e-24 |
SMART |
|
CA
|
579 |
660 |
1.3e-9 |
SMART |
|
transmembrane domain
|
679 |
701 |
N/A |
INTRINSIC |
|
low complexity region
|
899 |
918 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193414
|
| SMART Domains |
Protein: ENSMUSP00000141893
Gene: ENSMUSG00000103567
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
45 |
131 |
2.45e-1 |
SMART |
|
CA
|
155 |
240 |
1.05e-18 |
SMART |
|
CA
|
264 |
345 |
6.52e-24 |
SMART |
|
CA
|
369 |
450 |
5.99e-23 |
SMART |
|
CA
|
474 |
560 |
6.99e-24 |
SMART |
|
CA
|
591 |
669 |
5.31e-15 |
SMART |
|
transmembrane domain
|
692 |
714 |
N/A |
INTRINSIC |
|
low complexity region
|
913 |
932 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193869
|
| SMART Domains |
Protein: ENSMUSP00000141482
Gene: ENSMUSG00000103332
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
28 |
N/A |
INTRINSIC |
|
CA
|
45 |
131 |
1.64e-2 |
SMART |
|
CA
|
155 |
240 |
6.42e-23 |
SMART |
|
CA
|
264 |
345 |
1.76e-20 |
SMART |
|
CA
|
369 |
450 |
2.27e-23 |
SMART |
|
CA
|
474 |
560 |
1.5e-23 |
SMART |
|
CA
|
591 |
669 |
1.17e-16 |
SMART |
|
transmembrane domain
|
692 |
714 |
N/A |
INTRINSIC |
|
low complexity region
|
912 |
931 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193984
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000194190
|
| SMART Domains |
Protein: ENSMUSP00000142062
Gene: ENSMUSG00000103144
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
28 |
N/A |
INTRINSIC |
|
CA
|
31 |
131 |
3.16e-2 |
SMART |
|
CA
|
155 |
240 |
5.39e-16 |
SMART |
|
CA
|
264 |
345 |
6.72e-26 |
SMART |
|
CA
|
369 |
450 |
1.32e-24 |
SMART |
|
CA
|
474 |
560 |
4.17e-22 |
SMART |
|
CA
|
591 |
669 |
4.48e-13 |
SMART |
|
transmembrane domain
|
692 |
714 |
N/A |
INTRINSIC |
|
low complexity region
|
912 |
931 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000194418
|
| SMART Domains |
Protein: ENSMUSP00000142140
Gene: ENSMUSG00000103677
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
44 |
130 |
1.64e-2 |
SMART |
|
CA
|
154 |
239 |
3.93e-18 |
SMART |
|
CA
|
263 |
344 |
5.22e-23 |
SMART |
|
CA
|
368 |
449 |
5.02e-25 |
SMART |
|
CA
|
473 |
559 |
2.07e-26 |
SMART |
|
CA
|
590 |
668 |
6.84e-18 |
SMART |
|
transmembrane domain
|
690 |
712 |
N/A |
INTRINSIC |
|
low complexity region
|
911 |
930 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000194544
|
| SMART Domains |
Protein: ENSMUSP00000141847
Gene: ENSMUSG00000102836
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:CA
|
18 |
66 |
5e-20 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000195112
|
| SMART Domains |
Protein: ENSMUSP00000141449
Gene: ENSMUSG00000102748
| Domain | Start | End | E-Value | Type |
|---|
|
CA
|
24 |
130 |
8.18e-3 |
SMART |
|
CA
|
154 |
239 |
1.39e-18 |
SMART |
|
CA
|
263 |
344 |
7.91e-23 |
SMART |
|
CA
|
368 |
449 |
2.27e-23 |
SMART |
|
CA
|
473 |
559 |
1.24e-24 |
SMART |
|
CA
|
590 |
671 |
1.3e-9 |
SMART |
|
transmembrane domain
|
690 |
712 |
N/A |
INTRINSIC |
|
low complexity region
|
909 |
928 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000195363
|
| SMART Domains |
Protein: ENSMUSP00000142227
Gene: ENSMUSG00000103585
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
17 |
25 |
N/A |
INTRINSIC |
|
CA
|
56 |
131 |
1.47e-2 |
SMART |
|
CA
|
155 |
240 |
1.23e-19 |
SMART |
|
CA
|
264 |
343 |
5.54e-27 |
SMART |
|
CA
|
367 |
448 |
5.09e-26 |
SMART |
|
CA
|
472 |
558 |
1.98e-23 |
SMART |
|
CA
|
589 |
670 |
1.3e-9 |
SMART |
|
transmembrane domain
|
689 |
711 |
N/A |
INTRINSIC |
|
low complexity region
|
893 |
912 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000195823
|
| SMART Domains |
Protein: ENSMUSP00000141803
Gene: ENSMUSG00000103793
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
13 |
24 |
N/A |
INTRINSIC |
|
CA
|
45 |
131 |
2.41e-2 |
SMART |
|
CA
|
155 |
240 |
5.77e-16 |
SMART |
|
CA
|
264 |
345 |
1.1e-21 |
SMART |
|
CA
|
369 |
450 |
2.75e-22 |
SMART |
|
low complexity region
|
453 |
462 |
N/A |
INTRINSIC |
|
CA
|
474 |
560 |
9.22e-24 |
SMART |
|
CA
|
591 |
669 |
2.4e-13 |
SMART |
|
transmembrane domain
|
692 |
714 |
N/A |
INTRINSIC |
|
low complexity region
|
913 |
932 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb1a |
G |
A |
5: 8,752,823 (GRCm39) |
A525T |
probably benign |
Het |
| Abcc6 |
A |
G |
7: 45,654,946 (GRCm39) |
I515T |
possibly damaging |
Het |
| Abi1 |
G |
A |
2: 22,832,053 (GRCm39) |
A420V |
probably damaging |
Het |
| Abtb2 |
A |
T |
2: 103,542,787 (GRCm39) |
I887F |
possibly damaging |
Het |
| Acap3 |
G |
A |
4: 155,988,306 (GRCm39) |
G602S |
possibly damaging |
Het |
| Auts2 |
T |
A |
5: 131,469,056 (GRCm39) |
T754S |
probably benign |
Het |
| AW551984 |
T |
C |
9: 39,512,085 (GRCm39) |
R12G |
probably benign |
Het |
| Bcan |
G |
A |
3: 87,895,686 (GRCm39) |
R817* |
probably null |
Het |
| Bmp10 |
A |
G |
6: 87,411,175 (GRCm39) |
T323A |
probably benign |
Het |
| Bpnt1 |
T |
C |
1: 185,082,053 (GRCm39) |
L165P |
probably damaging |
Het |
| Casz1 |
G |
A |
4: 149,013,693 (GRCm39) |
A86T |
probably damaging |
Het |
| Ccn3 |
A |
T |
15: 54,615,743 (GRCm39) |
T303S |
probably damaging |
Het |
| Cd1d2 |
T |
C |
3: 86,895,080 (GRCm39) |
F189L |
probably benign |
Het |
| Cep72 |
A |
G |
13: 74,206,444 (GRCm39) |
M126T |
probably damaging |
Het |
| Cep85l |
T |
A |
10: 53,174,295 (GRCm39) |
T483S |
probably damaging |
Het |
| Cfi |
C |
A |
3: 129,666,522 (GRCm39) |
T415K |
probably damaging |
Het |
| Chrna7 |
A |
G |
7: 62,755,787 (GRCm39) |
L253S |
probably damaging |
Het |
| Col4a4 |
T |
C |
1: 82,475,051 (GRCm39) |
H596R |
unknown |
Het |
| Cplx3 |
G |
C |
9: 57,523,231 (GRCm39) |
Q109E |
probably benign |
Het |
| Cyp2j8 |
A |
T |
4: 96,335,588 (GRCm39) |
M402K |
probably benign |
Het |
| Cyp3a16 |
T |
A |
5: 145,399,980 (GRCm39) |
|
probably null |
Het |
| Dhdh |
T |
C |
7: 45,124,698 (GRCm39) |
K332E |
possibly damaging |
Het |
| Dnah11 |
C |
A |
12: 117,981,396 (GRCm39) |
C2590F |
probably damaging |
Het |
| Dnah17 |
T |
C |
11: 117,916,528 (GRCm39) |
|
probably null |
Het |
| Dtx1 |
A |
G |
5: 120,833,148 (GRCm39) |
Y97H |
probably damaging |
Het |
| Duxf1 |
T |
C |
10: 58,058,814 (GRCm39) |
T647A |
possibly damaging |
Het |
| Elf1 |
A |
G |
14: 79,808,208 (GRCm39) |
D183G |
probably damaging |
Het |
| Esyt3 |
A |
C |
9: 99,204,206 (GRCm39) |
L94R |
probably damaging |
Het |
| Exoc3 |
A |
G |
13: 74,330,285 (GRCm39) |
Y521H |
probably benign |
Het |
| F5 |
C |
T |
1: 164,007,075 (GRCm39) |
T293M |
probably damaging |
Het |
| Fam118b |
A |
T |
9: 35,146,560 (GRCm39) |
H102Q |
probably damaging |
Het |
| Flad1 |
T |
C |
3: 89,309,549 (GRCm39) |
|
probably benign |
Het |
| Flrt3 |
G |
A |
2: 140,502,804 (GRCm39) |
R275* |
probably null |
Het |
| Fndc7 |
G |
A |
3: 108,783,964 (GRCm39) |
A215V |
probably benign |
Het |
| Fscn1 |
T |
A |
5: 142,946,382 (GRCm39) |
V60E |
probably damaging |
Het |
| Gm17175 |
A |
T |
14: 51,811,418 (GRCm39) |
M1K |
probably null |
Het |
| Gpatch2l |
G |
A |
12: 86,290,958 (GRCm39) |
R47H |
probably damaging |
Het |
| Gprc6a |
T |
C |
10: 51,491,143 (GRCm39) |
S694G |
probably benign |
Het |
| Iglon5 |
A |
T |
7: 43,126,254 (GRCm39) |
|
probably null |
Het |
| Iqch |
T |
C |
9: 63,361,892 (GRCm39) |
T874A |
probably benign |
Het |
| Lamc2 |
T |
A |
1: 153,041,873 (GRCm39) |
H87L |
possibly damaging |
Het |
| Ldlrad1 |
T |
A |
4: 107,066,777 (GRCm39) |
D37E |
probably benign |
Het |
| Loxhd1 |
T |
C |
18: 77,460,129 (GRCm39) |
|
probably null |
Het |
| Lxn |
T |
G |
3: 67,369,704 (GRCm39) |
E60D |
probably benign |
Het |
| Man2b2 |
A |
G |
5: 36,979,213 (GRCm39) |
W276R |
probably damaging |
Het |
| Mast1 |
T |
C |
8: 85,655,598 (GRCm39) |
Y182C |
probably damaging |
Het |
| Mroh8 |
C |
T |
2: 157,058,897 (GRCm39) |
R923Q |
probably benign |
Het |
| Obscn |
A |
G |
11: 59,026,864 (GRCm39) |
L113P |
probably damaging |
Het |
| Ocln |
C |
T |
13: 100,671,470 (GRCm39) |
|
probably null |
Het |
| Oog2 |
A |
T |
4: 143,921,897 (GRCm39) |
Q269L |
probably damaging |
Het |
| Or52e8 |
G |
A |
7: 104,624,338 (GRCm39) |
P285S |
probably damaging |
Het |
| Or5b113 |
A |
G |
19: 13,341,987 (GRCm39) |
|
probably benign |
Het |
| Osbpl3 |
A |
G |
6: 50,274,137 (GRCm39) |
S826P |
probably damaging |
Het |
| Otogl |
T |
C |
10: 107,615,692 (GRCm39) |
N1869S |
probably benign |
Het |
| Pamr1 |
G |
A |
2: 102,441,968 (GRCm39) |
D186N |
probably damaging |
Het |
| Pde7b |
A |
G |
10: 20,319,038 (GRCm39) |
S95P |
probably damaging |
Het |
| Pik3cg |
A |
T |
12: 32,242,128 (GRCm39) |
V994E |
probably damaging |
Het |
| Pkp1 |
T |
C |
1: 135,817,692 (GRCm39) |
M148V |
probably benign |
Het |
| Plbd1 |
T |
G |
6: 136,589,836 (GRCm39) |
K461Q |
probably benign |
Het |
| Pmfbp1 |
A |
G |
8: 110,257,221 (GRCm39) |
E594G |
possibly damaging |
Het |
| Pold3 |
A |
T |
7: 99,755,865 (GRCm39) |
H60Q |
probably damaging |
Het |
| Polr3gl |
C |
T |
3: 96,487,783 (GRCm39) |
R52Q |
possibly damaging |
Het |
| Ptgds |
A |
G |
2: 25,357,828 (GRCm39) |
|
probably null |
Het |
| Scarb2 |
T |
C |
5: 92,601,934 (GRCm39) |
D320G |
probably benign |
Het |
| Sdk2 |
T |
C |
11: 113,693,995 (GRCm39) |
Y1812C |
probably damaging |
Het |
| Skint8 |
C |
A |
4: 111,794,222 (GRCm39) |
T204N |
probably benign |
Het |
| Slc23a2 |
T |
C |
2: 131,936,123 (GRCm39) |
Q49R |
possibly damaging |
Het |
| Slc26a7 |
T |
C |
4: 14,552,476 (GRCm39) |
Q227R |
probably benign |
Het |
| Sntn |
C |
T |
14: 13,679,108 (GRCm38) |
T94I |
probably damaging |
Het |
| Spem2 |
C |
T |
11: 69,708,582 (GRCm39) |
G128S |
probably benign |
Het |
| Supt16 |
A |
T |
14: 52,408,907 (GRCm39) |
S822R |
probably damaging |
Het |
| Syn3 |
T |
C |
10: 85,916,116 (GRCm39) |
Y290C |
probably damaging |
Het |
| Tdrd6 |
C |
G |
17: 43,938,599 (GRCm39) |
E816D |
probably benign |
Het |
| Tln1 |
A |
T |
4: 43,556,302 (GRCm39) |
M72K |
probably damaging |
Het |
| Tlnrd1 |
A |
G |
7: 83,531,987 (GRCm39) |
V148A |
probably damaging |
Het |
| Trim24 |
C |
A |
6: 37,935,613 (GRCm39) |
T832K |
probably benign |
Het |
| Ubr4 |
C |
T |
4: 139,141,715 (GRCm39) |
A1267V |
probably damaging |
Het |
| Usp17lb |
A |
T |
7: 104,490,492 (GRCm39) |
M145K |
probably damaging |
Het |
| Vmn1r178 |
T |
A |
7: 23,593,762 (GRCm39) |
M270K |
probably benign |
Het |
| Vmn2r70 |
A |
T |
7: 85,208,819 (GRCm39) |
C553S |
probably damaging |
Het |
| Vps37c |
G |
T |
19: 10,687,693 (GRCm39) |
E51D |
probably damaging |
Het |
| Zfp62 |
T |
G |
11: 49,107,206 (GRCm39) |
Y432* |
probably null |
Het |
|
| Other mutations in Pcdhga8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
G1patch:Pcdhga8
|
UTSW |
18 |
37,860,315 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4017:Pcdhga8
|
UTSW |
18 |
37,948,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4182:Pcdhga8
|
UTSW |
18 |
37,860,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4504:Pcdhga8
|
UTSW |
18 |
37,949,816 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4506:Pcdhga8
|
UTSW |
18 |
37,949,816 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4850:Pcdhga8
|
UTSW |
18 |
37,860,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4851:Pcdhga8
|
UTSW |
18 |
37,949,457 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4857:Pcdhga8
|
UTSW |
18 |
37,859,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4902:Pcdhga8
|
UTSW |
18 |
37,948,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5235:Pcdhga8
|
UTSW |
18 |
37,860,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5254:Pcdhga8
|
UTSW |
18 |
37,859,673 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5646:Pcdhga8
|
UTSW |
18 |
37,859,823 (GRCm39) |
missense |
probably benign |
|
|
R5943:Pcdhga8
|
UTSW |
18 |
37,949,565 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6115:Pcdhga8
|
UTSW |
18 |
37,860,596 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R6130:Pcdhga8
|
UTSW |
18 |
37,860,580 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6631:Pcdhga8
|
UTSW |
18 |
37,860,109 (GRCm39) |
missense |
probably benign |
|
|
R6725:Pcdhga8
|
UTSW |
18 |
37,860,315 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6915:Pcdhga8
|
UTSW |
18 |
37,858,998 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7027:Pcdhga8
|
UTSW |
18 |
37,860,164 (GRCm39) |
missense |
probably benign |
|
|
R7406:Pcdhga8
|
UTSW |
18 |
37,859,238 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7481:Pcdhga8
|
UTSW |
18 |
37,860,990 (GRCm39) |
missense |
probably benign |
|
|
R7491:Pcdhga8
|
UTSW |
18 |
37,860,483 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7625:Pcdhga8
|
UTSW |
18 |
37,859,954 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7712:Pcdhga8
|
UTSW |
18 |
37,860,102 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7740:Pcdhga8
|
UTSW |
18 |
37,860,470 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7912:Pcdhga8
|
UTSW |
18 |
37,859,896 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7917:Pcdhga8
|
UTSW |
18 |
37,860,669 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8017:Pcdhga8
|
UTSW |
18 |
37,860,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8037:Pcdhga8
|
UTSW |
18 |
37,860,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8066:Pcdhga8
|
UTSW |
18 |
37,859,435 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8228:Pcdhga8
|
UTSW |
18 |
37,861,236 (GRCm39) |
missense |
probably benign |
|
|
R8744:Pcdhga8
|
UTSW |
18 |
37,860,827 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8938:Pcdhga8
|
UTSW |
18 |
37,859,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9013:Pcdhga8
|
UTSW |
18 |
37,858,997 (GRCm39) |
missense |
probably benign |
|
|
R9160:Pcdhga8
|
UTSW |
18 |
37,860,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9178:Pcdhga8
|
UTSW |
18 |
37,860,892 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9192:Pcdhga8
|
UTSW |
18 |
37,859,163 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9360:Pcdhga8
|
UTSW |
18 |
37,859,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9650:Pcdhga8
|
UTSW |
18 |
37,860,519 (GRCm39) |
missense |
probably benign |
0.31 |
|
| Predicted Primers |
PCR Primer
(F):5'- CGTCAATGGGAAGGTGACATAC -3'
(R):5'- CGGTCCAAGTATTTCCATGTTAC -3'
Sequencing Primer
(F):5'- TGGGAAGGTGACATACAAATTCC -3'
(R):5'- GTCCAAGTATTTCCATGTTACCAATC -3'
|
| Posted On |
2019-05-13 |
Incidental Mutation