Incidental Mutation 'R7006:Or8h10'
ID 544707
Institutional Source Beutler Lab
Gene Symbol Or8h10
Ensembl Gene ENSMUSG00000070875
Gene Name olfactory receptor family 8 subfamily H member 10
Synonyms Olfr1100, GA_x6K02T2Q125-48465387-48464422, MOR206-4
MMRRC Submission 045011-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # R7006 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 86808173-86809138 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 86808303 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 279 (T279I)
Ref Sequence ENSEMBL: ENSMUSP00000151088 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094913] [ENSMUST00000117211]
AlphaFold Q8VFM1
Predicted Effect probably damaging
Transcript: ENSMUST00000094913
AA Change: T279I

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000092517
Gene: ENSMUSG00000070875
AA Change: T279I

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.7e-51 PFAM
Pfam:7tm_1 41 314 2.3e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000117211
AA Change: T279I

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AAdacl4fm3 A G 4: 144,447,853 (GRCm39) V41A probably benign Het
Adcy2 G A 13: 69,036,139 (GRCm39) T174M probably damaging Het
Ankfy1 T A 11: 72,631,290 (GRCm39) I412N probably benign Het
AW146154 T C 7: 41,130,648 (GRCm39) E156G possibly damaging Het
B4galnt1 T C 10: 127,005,700 (GRCm39) L267P probably benign Het
Bod1l T C 5: 41,989,895 (GRCm39) E276G probably damaging Het
Ccdc187 T C 2: 26,171,102 (GRCm39) T459A probably benign Het
Ccdc196 T A 12: 78,255,702 (GRCm39) *177R probably null Het
Cep72 G A 13: 74,198,427 (GRCm39) Q311* probably null Het
Cir1 T C 2: 73,140,834 (GRCm39) Q45R probably damaging Het
Ciz1 T C 2: 32,261,127 (GRCm39) probably null Het
Crtap G T 9: 114,215,391 (GRCm39) A166E probably damaging Het
Dipk1a A G 5: 108,058,027 (GRCm39) V132A probably benign Het
Dmp1 A G 5: 104,360,188 (GRCm39) D288G probably benign Het
Fhad1 CGG CG 4: 141,645,602 (GRCm39) probably null Het
Fmnl2 C A 2: 52,998,266 (GRCm39) Q544K probably benign Het
Gpsm1 T C 2: 26,212,572 (GRCm39) L72P probably damaging Het
Gys1 G A 7: 45,089,437 (GRCm39) A199T probably damaging Het
Kcnq3 A C 15: 65,892,165 (GRCm39) Y403* probably null Het
Kcp A C 6: 29,499,169 (GRCm39) Y298D probably damaging Het
Kif5c T C 2: 49,625,526 (GRCm39) S599P probably damaging Het
Krt20 A T 11: 99,328,587 (GRCm39) Y113N probably benign Het
Mcm8 T G 2: 132,665,181 (GRCm39) V191G probably damaging Het
Msr1 T A 8: 40,042,423 (GRCm39) D384V probably damaging Het
Mtpap A C 18: 4,380,873 (GRCm39) S184R possibly damaging Het
Npc1l1 G A 11: 6,167,731 (GRCm39) T1020M probably benign Het
Nphp4 A G 4: 152,573,259 (GRCm39) T66A probably benign Het
Or1o3 T A 17: 37,573,625 (GRCm39) *310L probably null Het
Or4f14 C A 2: 111,742,601 (GRCm39) V225L probably benign Het
Or8k18 T A 2: 86,085,572 (GRCm39) Q155L probably benign Het
Phf11d G T 14: 59,590,823 (GRCm39) T178K probably benign Het
Ppm1d A G 11: 85,227,977 (GRCm39) K298E possibly damaging Het
Rab2b A T 14: 52,503,690 (GRCm39) I144K probably benign Het
Stoml1 A G 9: 58,167,523 (GRCm39) D5G probably damaging Het
Styxl2 T C 1: 165,926,663 (GRCm39) N983S probably benign Het
Tanc1 T C 2: 59,626,188 (GRCm39) V515A probably damaging Het
Tas1r3 A G 4: 155,947,361 (GRCm39) V108A possibly damaging Het
Tifab T C 13: 56,324,059 (GRCm39) Y128C probably benign Het
Tmc6 G T 11: 117,665,083 (GRCm39) R397S probably damaging Het
Tnpo3 C T 6: 29,589,162 (GRCm39) A63T probably damaging Het
Trgc4 T A 13: 19,528,995 (GRCm39) probably benign Het
Usp16 G T 16: 87,268,724 (GRCm39) C284F probably damaging Het
Wipf1 T C 2: 73,267,441 (GRCm39) D319G probably damaging Het
Xpnpep3 T A 15: 81,326,649 (GRCm39) W347R probably damaging Het
Zfp180 G T 7: 23,804,537 (GRCm39) E319* probably null Het
Other mutations in Or8h10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02387:Or8h10 APN 2 86,808,193 (GRCm39) nonsense probably null
R0102:Or8h10 UTSW 2 86,808,549 (GRCm39) missense possibly damaging 0.90
R0477:Or8h10 UTSW 2 86,808,567 (GRCm39) missense probably damaging 0.99
R0586:Or8h10 UTSW 2 86,809,126 (GRCm39) missense probably damaging 0.99
R0743:Or8h10 UTSW 2 86,808,843 (GRCm39) missense probably benign 0.12
R1163:Or8h10 UTSW 2 86,809,020 (GRCm39) missense probably damaging 1.00
R1640:Or8h10 UTSW 2 86,808,963 (GRCm39) missense probably damaging 1.00
R2865:Or8h10 UTSW 2 86,808,805 (GRCm39) missense possibly damaging 0.56
R4478:Or8h10 UTSW 2 86,808,562 (GRCm39) missense probably benign
R4548:Or8h10 UTSW 2 86,809,014 (GRCm39) missense probably damaging 0.98
R4618:Or8h10 UTSW 2 86,808,618 (GRCm39) missense possibly damaging 0.87
R4829:Or8h10 UTSW 2 86,808,918 (GRCm39) missense probably damaging 0.99
R4858:Or8h10 UTSW 2 86,808,693 (GRCm39) missense probably damaging 1.00
R5071:Or8h10 UTSW 2 86,808,666 (GRCm39) missense possibly damaging 0.88
R5072:Or8h10 UTSW 2 86,808,666 (GRCm39) missense possibly damaging 0.88
R5073:Or8h10 UTSW 2 86,808,666 (GRCm39) missense possibly damaging 0.88
R5074:Or8h10 UTSW 2 86,808,666 (GRCm39) missense possibly damaging 0.88
R5574:Or8h10 UTSW 2 86,808,867 (GRCm39) missense probably benign 0.00
R5735:Or8h10 UTSW 2 86,809,044 (GRCm39) missense probably benign 0.08
R5874:Or8h10 UTSW 2 86,808,786 (GRCm39) missense probably damaging 0.99
R6228:Or8h10 UTSW 2 86,809,035 (GRCm39) missense probably damaging 1.00
R6689:Or8h10 UTSW 2 86,808,498 (GRCm39) missense probably benign 0.36
R6979:Or8h10 UTSW 2 86,808,577 (GRCm39) missense probably damaging 1.00
R7274:Or8h10 UTSW 2 86,808,867 (GRCm39) missense probably benign 0.00
R7399:Or8h10 UTSW 2 86,808,501 (GRCm39) missense probably benign 0.19
R7560:Or8h10 UTSW 2 86,809,122 (GRCm39) missense probably benign 0.00
R7765:Or8h10 UTSW 2 86,808,538 (GRCm39) missense probably damaging 0.98
R8381:Or8h10 UTSW 2 86,808,373 (GRCm39) missense probably benign 0.36
R8390:Or8h10 UTSW 2 86,808,501 (GRCm39) missense probably benign 0.19
R8694:Or8h10 UTSW 2 86,808,591 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CATGTTGCCTGGTACATTTAGAG -3'
(R):5'- CACAATATCTGCATCCTATGTGTC -3'

Sequencing Primer
(F):5'- ATATTTGAAGATTACACCACCACTC -3'
(R):5'- ATCTGCATCCTATGTGTCTATTCTC -3'
Posted On 2019-05-13