Incidental Mutation 'R7010:Nrros'
ID 544982
Institutional Source Beutler Lab
Gene Symbol Nrros
Ensembl Gene ENSMUSG00000052384
Gene Name negative regulator of reactive oxygen species
Synonyms E430025L02Rik, Lrrc33
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7010 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 31961603-31984412 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 31962398 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 540 (T540A)
Ref Sequence ENSEMBL: ENSMUSP00000110817 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099991] [ENSMUST00000115163] [ENSMUST00000115165] [ENSMUST00000126869] [ENSMUST00000130410] [ENSMUST00000143682] [ENSMUST00000144345] [ENSMUST00000231836]
AlphaFold Q8BMT4
Predicted Effect possibly damaging
Transcript: ENSMUST00000099991
AA Change: T512A

PolyPhen 2 Score 0.644 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000097571
Gene: ENSMUSG00000052384
AA Change: T512A

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
LRRNT 31 61 1.05e1 SMART
LRR 80 103 1.01e2 SMART
LRR 131 155 5.27e1 SMART
LRR 156 179 4.05e-1 SMART
LRR_TYP 180 203 7.67e-2 SMART
LRR 204 227 1.49e1 SMART
LRR_TYP 327 350 1.67e-2 SMART
LRR 376 400 3.27e1 SMART
LRR_TYP 401 424 1.79e-2 SMART
LRR 461 484 1.45e1 SMART
LRR 535 556 1.76e1 SMART
LRR 559 580 3.36e1 SMART
transmembrane domain 653 675 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000115163
AA Change: T540A

PolyPhen 2 Score 0.962 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000110817
Gene: ENSMUSG00000052384
AA Change: T540A

DomainStartEndE-ValueType
LRRNT 59 89 1.05e1 SMART
LRR 108 131 1.01e2 SMART
LRR 159 183 5.27e1 SMART
LRR 184 207 4.05e-1 SMART
LRR_TYP 208 231 7.67e-2 SMART
LRR 232 255 1.49e1 SMART
LRR_TYP 355 378 1.67e-2 SMART
LRR 404 428 3.27e1 SMART
LRR_TYP 429 452 1.79e-2 SMART
LRR 489 512 1.45e1 SMART
LRR 563 584 1.76e1 SMART
LRR 587 608 3.36e1 SMART
transmembrane domain 681 703 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000115165
AA Change: T488A

PolyPhen 2 Score 0.758 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000110819
Gene: ENSMUSG00000052384
AA Change: T488A

DomainStartEndE-ValueType
Blast:LRRNT 8 37 5e-8 BLAST
LRR 56 79 1.01e2 SMART
LRR 107 131 5.27e1 SMART
LRR 132 155 4.05e-1 SMART
LRR_TYP 156 179 7.67e-2 SMART
LRR 180 203 1.49e1 SMART
LRR_TYP 303 326 1.67e-2 SMART
LRR 352 376 3.27e1 SMART
LRR_TYP 377 400 1.79e-2 SMART
LRR 437 460 1.45e1 SMART
LRR 511 532 1.76e1 SMART
LRR 535 556 3.36e1 SMART
transmembrane domain 629 651 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000126869
AA Change: T512A

PolyPhen 2 Score 0.644 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000116388
Gene: ENSMUSG00000052384
AA Change: T512A

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
LRRNT 31 61 1.05e1 SMART
LRR 80 103 1.01e2 SMART
LRR 131 155 5.27e1 SMART
LRR 156 179 4.05e-1 SMART
LRR_TYP 180 203 7.67e-2 SMART
LRR 204 227 1.49e1 SMART
LRR_TYP 327 350 1.67e-2 SMART
LRR 376 400 3.27e1 SMART
LRR_TYP 401 424 1.79e-2 SMART
LRR 461 484 1.45e1 SMART
LRR 535 556 1.76e1 SMART
LRR 559 580 3.36e1 SMART
transmembrane domain 653 675 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000130410
SMART Domains Protein: ENSMUSP00000122290
Gene: ENSMUSG00000052384

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
LRRNT 31 61 1.05e1 SMART
Pfam:LRR_7 81 97 1.9e-2 PFAM
Pfam:LRR_7 105 121 6.8e-2 PFAM
Pfam:LRR_7 133 144 2e-1 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000143682
AA Change: T512A

PolyPhen 2 Score 0.644 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000119349
Gene: ENSMUSG00000052384
AA Change: T512A

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
LRRNT 31 61 1.05e1 SMART
LRR 80 103 1.01e2 SMART
LRR 131 155 5.27e1 SMART
LRR 156 179 4.05e-1 SMART
LRR_TYP 180 203 7.67e-2 SMART
LRR 204 227 1.49e1 SMART
LRR_TYP 327 350 1.67e-2 SMART
LRR 376 400 3.27e1 SMART
LRR_TYP 401 424 1.79e-2 SMART
LRR 461 484 1.45e1 SMART
LRR 535 556 1.76e1 SMART
LRR 559 580 3.36e1 SMART
transmembrane domain 653 675 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000144345
SMART Domains Protein: ENSMUSP00000121492
Gene: ENSMUSG00000052384

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
LRRNT 31 61 1.05e1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000231836
AA Change: T504A

PolyPhen 2 Score 0.316 (Sensitivity: 0.90; Specificity: 0.89)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous knockout leads to increased oxidative stress and susceptibility to experimental autoimmune encephalomyelitis, but to reduced susceptibility to bacterial infections. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AL592187.3 A T 15: 77,486,797 (GRCm39) Y58F probably benign Het
Ano10 T C 9: 122,082,190 (GRCm39) T494A probably damaging Het
Asah2 A T 19: 32,031,954 (GRCm39) F72I probably benign Het
Atat1 T C 17: 36,219,522 (GRCm39) D114G probably damaging Het
Atp6v1e2 C T 17: 87,251,773 (GRCm39) M208I probably benign Het
Bicd1 A G 6: 149,396,113 (GRCm39) Y161C probably damaging Het
Camk2g T C 14: 20,791,512 (GRCm39) S410G probably benign Het
Car2 C T 3: 14,965,113 (GRCm39) P249L possibly damaging Het
Cdh23 T G 10: 60,366,770 (GRCm39) I237L probably benign Het
Dlat T A 9: 50,569,274 (GRCm39) K176N probably damaging Het
Dnajc12 T A 10: 63,233,059 (GRCm39) C67S probably benign Het
Fat1 G T 8: 45,406,386 (GRCm39) E1046* probably null Het
Gmip G A 8: 70,264,050 (GRCm39) A137T probably damaging Het
Gpatch2l G A 12: 86,290,958 (GRCm39) R47H probably damaging Het
Grk6 A G 13: 55,598,113 (GRCm39) I62V possibly damaging Het
Hook1 G T 4: 95,903,048 (GRCm39) L512F probably damaging Het
Ighe T C 12: 113,236,761 (GRCm39) T36A Het
Il17rc A G 6: 113,456,249 (GRCm39) N338S possibly damaging Het
Itgb6 T C 2: 60,480,322 (GRCm39) Y338C probably damaging Het
Kcnd2 A G 6: 21,216,707 (GRCm39) Y137C probably damaging Het
L3mbtl3 T A 10: 26,158,759 (GRCm39) probably null Het
Lcn3 T C 2: 25,656,068 (GRCm39) F41S probably damaging Het
Map3k8 T C 18: 4,334,060 (GRCm39) H344R probably damaging Het
Marf1 A T 16: 13,954,865 (GRCm39) I884N probably damaging Het
Nalcn G A 14: 123,530,877 (GRCm39) T1387I probably damaging Het
Or5p63 A T 7: 107,811,349 (GRCm39) I129N probably damaging Het
Pank2 T C 2: 131,122,293 (GRCm39) Y273H probably benign Het
Pgrmc2 A G 3: 41,037,068 (GRCm39) V121A probably damaging Het
Phldb2 C T 16: 45,571,868 (GRCm39) V1175M probably damaging Het
Prss3b A C 6: 41,009,247 (GRCm39) S196A probably benign Het
Ranbp2 A G 10: 58,290,393 (GRCm39) probably null Het
Rsrc1 C T 3: 66,901,982 (GRCm39) P44L unknown Het
Syt7 A G 19: 10,395,354 (GRCm39) T55A probably benign Het
Tfcp2l1 T C 1: 118,581,457 (GRCm39) S137P probably damaging Het
Tom1 T A 8: 75,778,603 (GRCm39) V140D probably damaging Het
Ttc23l T G 15: 10,515,224 (GRCm39) I385L probably damaging Het
Vmn1r122 A G 7: 20,867,896 (GRCm39) V53A probably damaging Het
Vmn2r1 C T 3: 64,012,146 (GRCm39) T669I probably benign Het
Vmn2r86 A G 10: 130,291,726 (GRCm39) L13P probably benign Het
Zfp958 T C 8: 4,678,377 (GRCm39) I134T probably benign Het
Other mutations in Nrros
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00920:Nrros APN 16 31,966,438 (GRCm39) missense probably benign 0.06
IGL01097:Nrros APN 16 31,963,003 (GRCm39) missense possibly damaging 0.71
IGL02065:Nrros APN 16 31,963,492 (GRCm39) missense possibly damaging 0.84
IGL03372:Nrros APN 16 31,963,588 (GRCm39) missense probably damaging 1.00
R0615:Nrros UTSW 16 31,962,903 (GRCm39) missense probably damaging 1.00
R0669:Nrros UTSW 16 31,962,241 (GRCm39) missense probably damaging 1.00
R0840:Nrros UTSW 16 31,962,241 (GRCm39) missense probably damaging 1.00
R1398:Nrros UTSW 16 31,961,962 (GRCm39) missense probably damaging 0.98
R1796:Nrros UTSW 16 31,962,329 (GRCm39) missense probably damaging 1.00
R2031:Nrros UTSW 16 31,962,975 (GRCm39) nonsense probably null
R2033:Nrros UTSW 16 31,962,975 (GRCm39) nonsense probably null
R2034:Nrros UTSW 16 31,962,975 (GRCm39) nonsense probably null
R2087:Nrros UTSW 16 31,962,975 (GRCm39) nonsense probably null
R2089:Nrros UTSW 16 31,962,975 (GRCm39) nonsense probably null
R2090:Nrros UTSW 16 31,962,975 (GRCm39) nonsense probably null
R2091:Nrros UTSW 16 31,962,975 (GRCm39) nonsense probably null
R2091:Nrros UTSW 16 31,962,975 (GRCm39) nonsense probably null
R2151:Nrros UTSW 16 31,962,076 (GRCm39) missense probably benign 0.11
R2438:Nrros UTSW 16 31,963,117 (GRCm39) missense probably benign 0.25
R2438:Nrros UTSW 16 31,962,929 (GRCm39) splice site probably null
R5474:Nrros UTSW 16 31,963,170 (GRCm39) missense probably benign 0.00
R5527:Nrros UTSW 16 31,963,288 (GRCm39) missense probably damaging 1.00
R5629:Nrros UTSW 16 31,963,223 (GRCm39) missense probably damaging 1.00
R5888:Nrros UTSW 16 31,961,905 (GRCm39) missense probably benign 0.15
R5939:Nrros UTSW 16 31,962,272 (GRCm39) missense probably benign 0.01
R5982:Nrros UTSW 16 31,963,411 (GRCm39) missense probably damaging 0.96
R6869:Nrros UTSW 16 31,963,249 (GRCm39) missense probably damaging 1.00
R6912:Nrros UTSW 16 31,981,057 (GRCm39) missense probably null 0.01
R7469:Nrros UTSW 16 31,963,030 (GRCm39) missense probably benign 0.14
R7673:Nrros UTSW 16 31,981,099 (GRCm39) missense unknown
R7770:Nrros UTSW 16 31,962,346 (GRCm39) missense probably benign 0.01
R7948:Nrros UTSW 16 31,981,076 (GRCm39) missense unknown
R8375:Nrros UTSW 16 31,966,456 (GRCm39) missense probably damaging 1.00
R8702:Nrros UTSW 16 31,966,589 (GRCm39) intron probably benign
R9740:Nrros UTSW 16 31,963,667 (GRCm39) missense possibly damaging 0.95
X0022:Nrros UTSW 16 31,961,858 (GRCm39) missense possibly damaging 0.71
Predicted Primers PCR Primer
(F):5'- AGAGAGTTTCTGCGGAGGTC -3'
(R):5'- GTCACAATCAGATCTCACTTTGTC -3'

Sequencing Primer
(F):5'- TCTGCGGAGGTCGAGAGTC -3'
(R):5'- TCAGATGGTGCCCGTAGACTG -3'
Posted On 2019-05-13