Incidental Mutation 'R7011:Arhgap21'
| ID |
544995 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arhgap21
|
| Ensembl Gene |
ENSMUSG00000036591 |
| Gene Name |
Rho GTPase activating protein 21 |
| Synonyms |
ARHGAP10, 5530401C11Rik |
| MMRRC Submission |
045112-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.442)
|
| Stock # |
R7011 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
20852730-20973692 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 20853689 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Isoleucine
at position 1901
(T1901I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000122497
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000114594]
[ENSMUST00000141298]
[ENSMUST00000154230]
[ENSMUST00000173194]
[ENSMUST00000174584]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000114594
AA Change: T1895I
PolyPhen 2
Score 0.510 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000110241
Gene: ENSMUSG00000036591
AA Change: T1895I
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
58 |
159 |
1.03e-16 |
SMART |
|
low complexity region
|
351 |
362 |
N/A |
INTRINSIC |
|
low complexity region
|
445 |
459 |
N/A |
INTRINSIC |
|
low complexity region
|
625 |
635 |
N/A |
INTRINSIC |
|
low complexity region
|
911 |
925 |
N/A |
INTRINSIC |
|
PH
|
930 |
1040 |
2.09e-16 |
SMART |
|
RhoGAP
|
1157 |
1334 |
3.26e-62 |
SMART |
|
low complexity region
|
1381 |
1399 |
N/A |
INTRINSIC |
|
low complexity region
|
1448 |
1466 |
N/A |
INTRINSIC |
|
low complexity region
|
1533 |
1565 |
N/A |
INTRINSIC |
|
low complexity region
|
1573 |
1593 |
N/A |
INTRINSIC |
|
low complexity region
|
1891 |
1900 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000141298
AA Change: T1901I
PolyPhen 2
Score 0.650 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000120357
Gene: ENSMUSG00000036591
AA Change: T1901I
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
64 |
165 |
1.03e-16 |
SMART |
|
low complexity region
|
357 |
368 |
N/A |
INTRINSIC |
|
low complexity region
|
451 |
465 |
N/A |
INTRINSIC |
|
low complexity region
|
631 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
917 |
931 |
N/A |
INTRINSIC |
|
PH
|
936 |
1046 |
2.09e-16 |
SMART |
|
RhoGAP
|
1163 |
1340 |
3.26e-62 |
SMART |
|
low complexity region
|
1387 |
1405 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1472 |
N/A |
INTRINSIC |
|
low complexity region
|
1539 |
1571 |
N/A |
INTRINSIC |
|
low complexity region
|
1579 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1897 |
1906 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000154230
AA Change: T1901I
PolyPhen 2
Score 0.650 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000122497
Gene: ENSMUSG00000036591
AA Change: T1901I
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
64 |
165 |
1.03e-16 |
SMART |
|
low complexity region
|
357 |
368 |
N/A |
INTRINSIC |
|
low complexity region
|
451 |
465 |
N/A |
INTRINSIC |
|
low complexity region
|
631 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
917 |
931 |
N/A |
INTRINSIC |
|
PH
|
936 |
1046 |
2.09e-16 |
SMART |
|
RhoGAP
|
1163 |
1340 |
3.26e-62 |
SMART |
|
low complexity region
|
1387 |
1405 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1472 |
N/A |
INTRINSIC |
|
low complexity region
|
1539 |
1571 |
N/A |
INTRINSIC |
|
low complexity region
|
1579 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1897 |
1906 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000173194
AA Change: T1891I
PolyPhen 2
Score 0.510 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000133851
Gene: ENSMUSG00000036591
AA Change: T1891I
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
64 |
165 |
1.03e-16 |
SMART |
|
low complexity region
|
347 |
358 |
N/A |
INTRINSIC |
|
low complexity region
|
441 |
455 |
N/A |
INTRINSIC |
|
low complexity region
|
621 |
631 |
N/A |
INTRINSIC |
|
low complexity region
|
907 |
921 |
N/A |
INTRINSIC |
|
PH
|
926 |
1036 |
2.09e-16 |
SMART |
|
RhoGAP
|
1153 |
1330 |
3.26e-62 |
SMART |
|
low complexity region
|
1377 |
1395 |
N/A |
INTRINSIC |
|
low complexity region
|
1444 |
1462 |
N/A |
INTRINSIC |
|
low complexity region
|
1529 |
1561 |
N/A |
INTRINSIC |
|
low complexity region
|
1569 |
1589 |
N/A |
INTRINSIC |
|
low complexity region
|
1887 |
1896 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174584
|
| SMART Domains |
Protein: ENSMUSP00000133347
Gene: ENSMUSG00000036591
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
186 |
197 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
294 |
N/A |
INTRINSIC |
|
low complexity region
|
460 |
470 |
N/A |
INTRINSIC |
|
low complexity region
|
746 |
760 |
N/A |
INTRINSIC |
|
PH
|
765 |
875 |
2.09e-16 |
SMART |
|
RhoGAP
|
992 |
1169 |
3.26e-62 |
SMART |
|
| Meta Mutation Damage Score |
0.0792 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
96% (66/69) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 68 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam19 |
C |
T |
11: 46,033,845 (GRCm39) |
P886S |
probably benign |
Het |
| Anapc1 |
C |
T |
2: 128,490,601 (GRCm39) |
|
probably null |
Het |
| Ankrd34c |
C |
A |
9: 89,611,001 (GRCm39) |
G447* |
probably null |
Het |
| Apbb1ip |
A |
T |
2: 22,725,943 (GRCm39) |
E238D |
probably damaging |
Het |
| Arfgap1 |
T |
C |
2: 180,613,935 (GRCm39) |
L110P |
probably damaging |
Het |
| Brpf1 |
C |
A |
6: 113,295,427 (GRCm39) |
Q679K |
probably benign |
Het |
| Btnl2 |
A |
G |
17: 34,582,487 (GRCm39) |
E351G |
probably damaging |
Het |
| Cd209f |
T |
A |
8: 4,154,859 (GRCm39) |
T80S |
probably benign |
Het |
| Cdc16 |
A |
G |
8: 13,819,451 (GRCm39) |
E349G |
probably damaging |
Het |
| Cfap53 |
A |
T |
18: 74,462,564 (GRCm39) |
D436V |
probably benign |
Het |
| Crhr2 |
A |
T |
6: 55,076,195 (GRCm39) |
|
probably null |
Het |
| Cux1 |
T |
C |
5: 136,388,887 (GRCm39) |
K226E |
probably damaging |
Het |
| Ddr2 |
A |
T |
1: 169,809,672 (GRCm39) |
D768E |
probably damaging |
Het |
| Dhx8 |
T |
C |
11: 101,632,346 (GRCm39) |
L435P |
probably damaging |
Het |
| Dnah11 |
AGGCC |
AGGCCGGCC |
12: 117,885,753 (GRCm39) |
|
probably null |
Het |
| Eif4ebp1 |
G |
A |
8: 27,763,372 (GRCm39) |
R55Q |
probably damaging |
Het |
| Fbh1 |
T |
A |
2: 11,767,774 (GRCm39) |
D358V |
probably damaging |
Het |
| Fra10ac1 |
T |
A |
19: 38,177,242 (GRCm39) |
E304D |
probably benign |
Het |
| Gabrb2 |
T |
C |
11: 42,517,488 (GRCm39) |
S399P |
possibly damaging |
Het |
| Gpatch2l |
G |
A |
12: 86,290,958 (GRCm39) |
R47H |
probably damaging |
Het |
| Gprin2 |
G |
T |
14: 33,917,393 (GRCm39) |
H126N |
probably null |
Het |
| Gucy1a1 |
A |
G |
3: 82,016,422 (GRCm39) |
S189P |
probably damaging |
Het |
| Htr1d |
T |
C |
4: 136,170,317 (GRCm39) |
M182T |
probably benign |
Het |
| Lipc |
A |
G |
9: 70,726,236 (GRCm39) |
F73L |
probably benign |
Het |
| Liph |
A |
G |
16: 21,802,847 (GRCm39) |
I74T |
probably damaging |
Het |
| Lrif1 |
T |
G |
3: 106,639,601 (GRCm39) |
Y229D |
probably damaging |
Het |
| Magel2 |
C |
T |
7: 62,028,281 (GRCm39) |
T395I |
possibly damaging |
Het |
| Magi3 |
T |
C |
3: 104,013,070 (GRCm39) |
N139S |
probably damaging |
Het |
| Man2c1 |
T |
A |
9: 57,045,117 (GRCm39) |
V336E |
probably damaging |
Het |
| Mapk12 |
A |
T |
15: 89,019,803 (GRCm39) |
Y135N |
probably damaging |
Het |
| Mapkapk3 |
C |
T |
9: 107,166,595 (GRCm39) |
|
probably benign |
Het |
| Mast1 |
A |
T |
8: 85,638,574 (GRCm39) |
Y653* |
probably null |
Het |
| Muc16 |
T |
A |
9: 18,548,747 (GRCm39) |
I5849F |
probably benign |
Het |
| Muc16 |
T |
A |
9: 18,548,839 (GRCm39) |
H5818L |
probably benign |
Het |
| Ndufa10 |
A |
G |
1: 92,398,581 (GRCm39) |
S68P |
probably damaging |
Het |
| Nedd1 |
C |
A |
10: 92,526,635 (GRCm39) |
L503F |
probably benign |
Het |
| Nr1i3 |
A |
G |
1: 171,041,927 (GRCm39) |
M4V |
probably benign |
Het |
| Or12e9 |
G |
A |
2: 87,202,604 (GRCm39) |
A243T |
possibly damaging |
Het |
| Or2av9 |
T |
A |
11: 58,380,970 (GRCm39) |
I204F |
possibly damaging |
Het |
| Or4f14b |
A |
T |
2: 111,775,031 (GRCm39) |
F257I |
probably benign |
Het |
| Or9i2 |
T |
C |
19: 13,816,403 (GRCm39) |
I45V |
probably benign |
Het |
| Pcdh18 |
A |
T |
3: 49,709,231 (GRCm39) |
S695T |
probably benign |
Het |
| Pcdha1 |
T |
C |
18: 37,063,588 (GRCm39) |
I84T |
probably damaging |
Het |
| Plek |
T |
A |
11: 16,944,760 (GRCm39) |
D90V |
possibly damaging |
Het |
| Ppp6r1 |
A |
G |
7: 4,649,825 (GRCm39) |
C47R |
probably damaging |
Het |
| Psg27 |
G |
C |
7: 18,290,798 (GRCm39) |
N468K |
probably benign |
Het |
| Ptchd4 |
G |
A |
17: 42,814,759 (GRCm39) |
E887K |
probably benign |
Het |
| Rabgap1 |
C |
T |
2: 37,430,492 (GRCm39) |
L678F |
probably damaging |
Het |
| Rmdn3 |
T |
C |
2: 118,968,904 (GRCm39) |
Y429C |
probably damaging |
Het |
| Ros1 |
A |
T |
10: 52,056,272 (GRCm39) |
C73S |
probably damaging |
Het |
| Rtkn2 |
G |
A |
10: 67,815,495 (GRCm39) |
|
probably benign |
Het |
| Slc25a42 |
A |
G |
8: 70,639,352 (GRCm39) |
S242P |
probably damaging |
Het |
| Smtnl1 |
T |
A |
2: 84,648,753 (GRCm39) |
D167V |
probably benign |
Het |
| Smurf2 |
A |
G |
11: 106,724,610 (GRCm39) |
L511P |
probably benign |
Het |
| Stbd1 |
A |
T |
5: 92,752,977 (GRCm39) |
K156* |
probably null |
Het |
| Tenm4 |
G |
T |
7: 96,545,342 (GRCm39) |
G2453* |
probably null |
Het |
| Tent4a |
C |
T |
13: 69,648,199 (GRCm39) |
G489S |
probably damaging |
Het |
| Tpr |
A |
G |
1: 150,309,523 (GRCm39) |
K1760E |
probably damaging |
Het |
| Triobp |
T |
A |
15: 78,862,923 (GRCm39) |
L1427Q |
probably damaging |
Het |
| Uaca |
A |
G |
9: 60,777,650 (GRCm39) |
E679G |
probably damaging |
Het |
| Ucn3 |
T |
G |
13: 3,991,421 (GRCm39) |
H77P |
possibly damaging |
Het |
| Wnk2 |
T |
A |
13: 49,224,567 (GRCm39) |
D998V |
probably damaging |
Het |
| Xrcc3 |
A |
G |
12: 111,770,969 (GRCm39) |
V320A |
probably damaging |
Het |
| Zdbf2 |
A |
G |
1: 63,345,925 (GRCm39) |
T1435A |
possibly damaging |
Het |
| Zfp36l2 |
G |
T |
17: 84,493,861 (GRCm39) |
H259N |
possibly damaging |
Het |
| Zfp619 |
A |
T |
7: 39,187,186 (GRCm39) |
H1072L |
probably damaging |
Het |
| Zfy2 |
T |
A |
Y: 2,107,127 (GRCm39) |
E502D |
possibly damaging |
Het |
| Zfyve16 |
G |
A |
13: 92,658,495 (GRCm39) |
P472L |
probably benign |
Het |
|
| Other mutations in Arhgap21 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01382:Arhgap21
|
APN |
2 |
20,860,511 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01472:Arhgap21
|
APN |
2 |
20,854,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01634:Arhgap21
|
APN |
2 |
20,919,455 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01766:Arhgap21
|
APN |
2 |
20,854,448 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02097:Arhgap21
|
APN |
2 |
20,884,813 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL02197:Arhgap21
|
APN |
2 |
20,885,117 (GRCm39) |
missense |
probably benign |
|
|
IGL02264:Arhgap21
|
APN |
2 |
20,864,850 (GRCm39) |
splice site |
probably null |
|
|
IGL02346:Arhgap21
|
APN |
2 |
20,884,762 (GRCm39) |
splice site |
probably benign |
|
|
IGL02418:Arhgap21
|
APN |
2 |
20,885,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02605:Arhgap21
|
APN |
2 |
20,860,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02701:Arhgap21
|
APN |
2 |
20,896,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03019:Arhgap21
|
APN |
2 |
20,865,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03085:Arhgap21
|
APN |
2 |
20,919,532 (GRCm39) |
missense |
probably benign |
|
|
IGL03265:Arhgap21
|
APN |
2 |
20,854,439 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL03379:Arhgap21
|
APN |
2 |
20,885,500 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0304:Arhgap21
|
UTSW |
2 |
20,864,612 (GRCm39) |
splice site |
probably benign |
|
|
R0363:Arhgap21
|
UTSW |
2 |
20,885,944 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0498:Arhgap21
|
UTSW |
2 |
20,867,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0539:Arhgap21
|
UTSW |
2 |
20,919,610 (GRCm39) |
nonsense |
probably null |
|
|
R0633:Arhgap21
|
UTSW |
2 |
20,860,198 (GRCm39) |
nonsense |
probably null |
|
|
R0905:Arhgap21
|
UTSW |
2 |
20,854,745 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1550:Arhgap21
|
UTSW |
2 |
20,886,576 (GRCm39) |
nonsense |
probably null |
|
|
R1570:Arhgap21
|
UTSW |
2 |
20,885,651 (GRCm39) |
missense |
probably benign |
|
|
R1686:Arhgap21
|
UTSW |
2 |
20,886,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1746:Arhgap21
|
UTSW |
2 |
20,865,910 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1864:Arhgap21
|
UTSW |
2 |
20,866,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1865:Arhgap21
|
UTSW |
2 |
20,866,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2209:Arhgap21
|
UTSW |
2 |
20,854,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2211:Arhgap21
|
UTSW |
2 |
20,886,451 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R2276:Arhgap21
|
UTSW |
2 |
20,868,037 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2277:Arhgap21
|
UTSW |
2 |
20,868,037 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2279:Arhgap21
|
UTSW |
2 |
20,868,037 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2336:Arhgap21
|
UTSW |
2 |
20,884,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2516:Arhgap21
|
UTSW |
2 |
20,859,809 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3722:Arhgap21
|
UTSW |
2 |
20,855,102 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3877:Arhgap21
|
UTSW |
2 |
20,864,717 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4017:Arhgap21
|
UTSW |
2 |
20,896,915 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4232:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4233:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4234:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4235:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4236:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4434:Arhgap21
|
UTSW |
2 |
20,972,146 (GRCm39) |
missense |
probably benign |
|
|
R4686:Arhgap21
|
UTSW |
2 |
20,868,033 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4817:Arhgap21
|
UTSW |
2 |
20,854,967 (GRCm39) |
missense |
probably benign |
|
|
R4834:Arhgap21
|
UTSW |
2 |
20,870,130 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4845:Arhgap21
|
UTSW |
2 |
20,885,998 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4889:Arhgap21
|
UTSW |
2 |
20,885,279 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4904:Arhgap21
|
UTSW |
2 |
20,854,872 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4911:Arhgap21
|
UTSW |
2 |
20,863,800 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4994:Arhgap21
|
UTSW |
2 |
20,854,701 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5067:Arhgap21
|
UTSW |
2 |
20,884,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5086:Arhgap21
|
UTSW |
2 |
20,853,645 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5281:Arhgap21
|
UTSW |
2 |
20,854,127 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5364:Arhgap21
|
UTSW |
2 |
20,854,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5420:Arhgap21
|
UTSW |
2 |
20,885,897 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5476:Arhgap21
|
UTSW |
2 |
20,885,497 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5831:Arhgap21
|
UTSW |
2 |
20,868,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5949:Arhgap21
|
UTSW |
2 |
20,853,852 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5994:Arhgap21
|
UTSW |
2 |
20,886,187 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R6014:Arhgap21
|
UTSW |
2 |
20,886,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6739:Arhgap21
|
UTSW |
2 |
20,885,543 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6817:Arhgap21
|
UTSW |
2 |
20,885,107 (GRCm39) |
missense |
probably benign |
0.23 |
|
R6821:Arhgap21
|
UTSW |
2 |
20,853,659 (GRCm39) |
missense |
probably benign |
|
|
R6844:Arhgap21
|
UTSW |
2 |
20,886,116 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6870:Arhgap21
|
UTSW |
2 |
20,885,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6891:Arhgap21
|
UTSW |
2 |
20,855,142 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7144:Arhgap21
|
UTSW |
2 |
20,870,198 (GRCm39) |
missense |
probably benign |
|
|
R7237:Arhgap21
|
UTSW |
2 |
20,854,783 (GRCm39) |
nonsense |
probably null |
|
|
R7261:Arhgap21
|
UTSW |
2 |
20,885,177 (GRCm39) |
missense |
probably benign |
|
|
R7558:Arhgap21
|
UTSW |
2 |
20,860,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7566:Arhgap21
|
UTSW |
2 |
20,917,102 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7738:Arhgap21
|
UTSW |
2 |
20,855,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7738:Arhgap21
|
UTSW |
2 |
20,854,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7820:Arhgap21
|
UTSW |
2 |
20,867,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7822:Arhgap21
|
UTSW |
2 |
20,885,524 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7965:Arhgap21
|
UTSW |
2 |
20,854,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7986:Arhgap21
|
UTSW |
2 |
20,867,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8028:Arhgap21
|
UTSW |
2 |
20,885,216 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8209:Arhgap21
|
UTSW |
2 |
20,876,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8226:Arhgap21
|
UTSW |
2 |
20,876,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8251:Arhgap21
|
UTSW |
2 |
20,854,221 (GRCm39) |
missense |
probably benign |
|
|
R8486:Arhgap21
|
UTSW |
2 |
20,865,236 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8487:Arhgap21
|
UTSW |
2 |
20,886,116 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8508:Arhgap21
|
UTSW |
2 |
20,858,991 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8835:Arhgap21
|
UTSW |
2 |
20,972,144 (GRCm39) |
nonsense |
probably null |
|
|
R9140:Arhgap21
|
UTSW |
2 |
20,886,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9190:Arhgap21
|
UTSW |
2 |
20,858,983 (GRCm39) |
missense |
probably null |
0.04 |
|
R9204:Arhgap21
|
UTSW |
2 |
20,885,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9227:Arhgap21
|
UTSW |
2 |
20,860,469 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9230:Arhgap21
|
UTSW |
2 |
20,860,469 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9308:Arhgap21
|
UTSW |
2 |
20,854,061 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9374:Arhgap21
|
UTSW |
2 |
20,886,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9449:Arhgap21
|
UTSW |
2 |
20,885,464 (GRCm39) |
missense |
probably benign |
|
|
R9454:Arhgap21
|
UTSW |
2 |
20,870,153 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9499:Arhgap21
|
UTSW |
2 |
20,886,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9544:Arhgap21
|
UTSW |
2 |
20,858,938 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9552:Arhgap21
|
UTSW |
2 |
20,886,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9567:Arhgap21
|
UTSW |
2 |
20,896,953 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9588:Arhgap21
|
UTSW |
2 |
20,858,938 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9749:Arhgap21
|
UTSW |
2 |
20,854,026 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1191:Arhgap21
|
UTSW |
2 |
20,886,283 (GRCm39) |
missense |
probably benign |
0.30 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGACCCAGCTTAAAGTCAGGG -3'
(R):5'- ACTTTCGGCTGTGAATCGG -3'
Sequencing Primer
(F):5'- CTTAAAGTCAGGGAGGAGTCTC -3'
(R):5'- TCGGCTGTGAATCGGTTAAAACC -3'
|
| Posted On |
2019-05-13 |
Incidental Mutation