Incidental Mutation 'R7012:Or5t16'
ID 545061
Institutional Source Beutler Lab
Gene Symbol Or5t16
Ensembl Gene ENSMUSG00000075167
Gene Name olfactory receptor family 5 subfamily T member 16
Synonyms GA_x6K02T2Q125-48475870-48474938, MOR179-3, Olfr1101
MMRRC Submission 045113-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # R7012 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 86818586-86819518 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 86819051 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Glutamine at position 156 (H156Q)
Ref Sequence ENSEMBL: ENSMUSP00000151171 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099870] [ENSMUST00000214411]
AlphaFold Q7TR59
Predicted Effect possibly damaging
Transcript: ENSMUST00000099870
AA Change: H156Q

PolyPhen 2 Score 0.497 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000097455
Gene: ENSMUSG00000075167
AA Change: H156Q

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 1.7e-51 PFAM
Pfam:7tm_1 38 287 5.1e-19 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214411
AA Change: H156Q

PolyPhen 2 Score 0.497 (Sensitivity: 0.88; Specificity: 0.90)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (49/49)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acox3 T C 5: 35,769,431 (GRCm39) F686L probably benign Het
Adcy4 C T 14: 56,017,376 (GRCm39) V266I possibly damaging Het
Adgrb1 A G 15: 74,401,750 (GRCm39) T249A probably damaging Het
Adss1 A G 12: 112,600,670 (GRCm39) D213G probably benign Het
Ap1b1 T G 11: 4,980,963 (GRCm39) V453G probably damaging Het
Apold1 G A 6: 134,961,007 (GRCm39) G154R probably damaging Het
Birc5 A G 11: 117,740,262 (GRCm39) E29G probably benign Het
Clcn1 G A 6: 42,267,542 (GRCm39) R75H probably benign Het
Cngb1 T A 8: 95,984,583 (GRCm39) I868F possibly damaging Het
Cntn6 T A 6: 104,703,223 (GRCm39) V215E probably damaging Het
Cntn6 A G 6: 104,751,441 (GRCm39) I294V probably benign Het
Col6a2 A T 10: 76,450,511 (GRCm39) I140N possibly damaging Het
Cops5 A G 1: 10,100,890 (GRCm39) *147Q probably null Het
Dbr1 T A 9: 99,465,374 (GRCm39) Y317* probably null Het
Dock5 A C 14: 68,060,035 (GRCm39) V468G probably damaging Het
F13b A G 1: 139,444,096 (GRCm39) I477V probably benign Het
Fhad1 CGG CG 4: 141,645,602 (GRCm39) probably null Het
Git1 T C 11: 77,390,606 (GRCm39) L114P probably damaging Het
Greb1l G T 18: 10,529,707 (GRCm39) probably null Het
Itih4 A G 14: 30,612,706 (GRCm39) N244S probably benign Het
Lin28a A G 4: 133,746,040 (GRCm39) S5P probably damaging Het
Lipt1 T C 1: 37,915,060 (GRCm39) I372T probably benign Het
Lysmd4 A G 7: 66,875,765 (GRCm39) T143A probably benign Het
Muc16 T C 9: 18,406,914 (GRCm39) probably null Het
Or13c9 A G 4: 52,936,193 (GRCm39) L30P probably damaging Het
Or2y1g A T 11: 49,171,823 (GRCm39) M283L probably benign Het
Or6e1 A G 14: 54,519,674 (GRCm39) I226T possibly damaging Het
Pclo G A 5: 14,800,493 (GRCm39) G4438D unknown Het
Phlpp2 T A 8: 110,603,486 (GRCm39) F51I possibly damaging Het
Rab5c G A 11: 100,610,789 (GRCm39) R40C probably damaging Het
Rxfp2 T C 5: 150,004,659 (GRCm39) V711A probably benign Het
Sbno2 A T 10: 79,905,352 (GRCm39) probably benign Het
Setd2 T A 9: 110,376,751 (GRCm39) S189T probably damaging Het
Sez6 A G 11: 77,868,621 (GRCm39) N965S probably benign Het
Sh3d19 A G 3: 85,992,320 (GRCm39) N116S probably benign Het
Slc43a3 T C 2: 84,777,313 (GRCm39) Y221H probably damaging Het
Slco1a6 T C 6: 142,032,287 (GRCm39) I613V probably benign Het
Stag3 T A 5: 138,295,871 (GRCm39) probably null Het
Ston1 T C 17: 88,943,413 (GRCm39) M273T probably damaging Het
Tbc1d32 A T 10: 56,100,820 (GRCm39) Y53N probably damaging Het
Tmem132b T A 5: 125,775,654 (GRCm39) L376Q probably damaging Het
Trim60 A G 8: 65,453,043 (GRCm39) V402A possibly damaging Het
Tssk5 A C 15: 76,257,745 (GRCm39) N178K probably damaging Het
Ttll9 T C 2: 152,844,982 (GRCm39) I450T possibly damaging Het
Tyw1 T G 5: 130,306,571 (GRCm39) probably null Het
Usp16 T C 16: 87,255,632 (GRCm39) probably null Het
Vmn2r97 T C 17: 19,167,756 (GRCm39) V670A probably damaging Het
Vmn2r98 A G 17: 19,286,530 (GRCm39) N343D probably benign Het
Zfp472 T G 17: 33,196,220 (GRCm39) N98K probably benign Het
Other mutations in Or5t16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01288:Or5t16 APN 2 86,818,598 (GRCm39) missense probably benign
IGL03018:Or5t16 APN 2 86,819,349 (GRCm39) missense probably damaging 1.00
IGL03265:Or5t16 APN 2 86,819,424 (GRCm39) missense probably damaging 1.00
R0627:Or5t16 UTSW 2 86,819,358 (GRCm39) missense probably benign 0.21
R2871:Or5t16 UTSW 2 86,819,192 (GRCm39) nonsense probably null
R2871:Or5t16 UTSW 2 86,819,192 (GRCm39) nonsense probably null
R7144:Or5t16 UTSW 2 86,819,164 (GRCm39) missense probably damaging 1.00
R7151:Or5t16 UTSW 2 86,819,385 (GRCm39) missense probably benign 0.16
R7521:Or5t16 UTSW 2 86,818,954 (GRCm39) missense probably damaging 1.00
R7672:Or5t16 UTSW 2 86,818,663 (GRCm39) missense possibly damaging 0.93
R7725:Or5t16 UTSW 2 86,819,323 (GRCm39) missense probably benign 0.00
R7863:Or5t16 UTSW 2 86,819,424 (GRCm39) missense probably damaging 1.00
R7965:Or5t16 UTSW 2 86,818,707 (GRCm39) missense probably benign 0.12
R8447:Or5t16 UTSW 2 86,818,885 (GRCm39) missense probably benign 0.01
R8500:Or5t16 UTSW 2 86,818,822 (GRCm39) missense probably damaging 1.00
R8899:Or5t16 UTSW 2 86,818,710 (GRCm39) missense probably benign 0.03
R9776:Or5t16 UTSW 2 86,819,055 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- GCAGAATGCATCTTCAAGATAGC -3'
(R):5'- GTAGCACAGATGTTTCTTGCTG -3'

Sequencing Primer
(F):5'- TGCATCTTCAAGATAGCAAACAGG -3'
(R):5'- GCTGTTAGCTGTGGAACCAC -3'
Posted On 2019-05-13