Incidental Mutation 'IGL00335:Wee2'
ID |
5456 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Wee2
|
Ensembl Gene |
ENSMUSG00000037159 |
Gene Name |
WEE1 homolog 2 (S. pombe) |
Synonyms |
Wee1b, LOC381759 |
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
IGL00335
|
Quality Score |
|
Status
|
|
Chromosome |
6 |
Chromosomal Location |
40416022-40443747 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 40438995 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Phenylalanine
at position 373
(I373F)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000038754
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000038907]
|
AlphaFold |
Q66JT0 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000038907
AA Change: I373F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000038754 Gene: ENSMUSG00000037159 AA Change: I373F
Domain | Start | End | E-Value | Type |
low complexity region
|
117 |
128 |
N/A |
INTRINSIC |
Pfam:Pkinase
|
208 |
481 |
3.6e-51 |
PFAM |
Pfam:Pkinase_Tyr
|
209 |
478 |
9.6e-25 |
PFAM |
|
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 36 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1700048O20Rik |
C |
A |
9: 121,769,833 (GRCm39) |
|
noncoding transcript |
Het |
4930579F01Rik |
C |
A |
3: 137,891,959 (GRCm39) |
|
probably benign |
Het |
Aurkc |
T |
A |
7: 6,999,547 (GRCm39) |
I18N |
probably damaging |
Het |
Bace1 |
T |
C |
9: 45,750,588 (GRCm39) |
|
probably null |
Het |
Chrne |
C |
T |
11: 70,506,588 (GRCm39) |
V311I |
probably benign |
Het |
Cimip2b |
G |
A |
4: 43,428,158 (GRCm39) |
R100W |
possibly damaging |
Het |
Cyp2c70 |
C |
T |
19: 40,156,020 (GRCm39) |
V177M |
probably damaging |
Het |
Dusp10 |
A |
G |
1: 183,801,328 (GRCm39) |
E365G |
probably benign |
Het |
Fcgbp |
C |
A |
7: 27,785,560 (GRCm39) |
N332K |
possibly damaging |
Het |
Irx4 |
T |
C |
13: 73,416,810 (GRCm39) |
V402A |
probably benign |
Het |
Kcnq4 |
G |
A |
4: 120,555,213 (GRCm39) |
Q657* |
probably null |
Het |
Kif14 |
G |
A |
1: 136,396,756 (GRCm39) |
S354N |
probably benign |
Het |
Lama3 |
A |
G |
18: 12,582,645 (GRCm39) |
|
probably benign |
Het |
Lhfpl7 |
A |
G |
5: 113,383,869 (GRCm39) |
R96G |
probably benign |
Het |
Lrrc8b |
T |
C |
5: 105,628,365 (GRCm39) |
I237T |
probably damaging |
Het |
Mepe |
G |
T |
5: 104,485,843 (GRCm39) |
G328C |
probably damaging |
Het |
Numb |
A |
G |
12: 83,854,906 (GRCm39) |
I129T |
probably damaging |
Het |
Or5h25 |
T |
C |
16: 58,930,961 (GRCm39) |
D4G |
probably benign |
Het |
Or6c209 |
T |
C |
10: 129,483,306 (GRCm39) |
I103T |
probably benign |
Het |
Osmr |
T |
C |
15: 6,866,504 (GRCm39) |
D390G |
probably benign |
Het |
Pglyrp3 |
G |
A |
3: 91,929,986 (GRCm39) |
V51I |
probably damaging |
Het |
Phactr2 |
T |
C |
10: 13,121,279 (GRCm39) |
T470A |
probably damaging |
Het |
Psmg1 |
G |
A |
16: 95,781,268 (GRCm39) |
T259I |
possibly damaging |
Het |
Rtl3 |
T |
C |
X: 105,882,543 (GRCm39) |
T240A |
probably benign |
Het |
Ryr1 |
C |
T |
7: 28,824,385 (GRCm39) |
|
probably null |
Het |
Slc10a6 |
A |
G |
5: 103,756,991 (GRCm39) |
S258P |
probably benign |
Het |
Slc1a6 |
T |
C |
10: 78,637,647 (GRCm39) |
L391P |
probably damaging |
Het |
Slc6a7 |
C |
T |
18: 61,134,681 (GRCm39) |
V465M |
possibly damaging |
Het |
Sost |
T |
C |
11: 101,857,705 (GRCm39) |
D32G |
probably damaging |
Het |
Sox4 |
C |
A |
13: 29,136,956 (GRCm39) |
G17W |
probably damaging |
Het |
Tifab |
A |
G |
13: 56,324,282 (GRCm39) |
S54P |
probably damaging |
Het |
Tnrc6a |
T |
A |
7: 122,770,003 (GRCm39) |
S598T |
probably benign |
Het |
Vmn2r1 |
T |
A |
3: 64,012,809 (GRCm39) |
I890N |
probably damaging |
Het |
Wapl |
A |
G |
14: 34,414,593 (GRCm39) |
D485G |
probably benign |
Het |
Xkr6 |
A |
G |
14: 64,056,664 (GRCm39) |
T192A |
probably damaging |
Het |
Zfp638 |
A |
G |
6: 83,956,700 (GRCm39) |
D1769G |
probably damaging |
Het |
|
Other mutations in Wee2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01096:Wee2
|
APN |
6 |
40,440,187 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01978:Wee2
|
APN |
6 |
40,432,087 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03026:Wee2
|
APN |
6 |
40,438,915 (GRCm39) |
missense |
probably benign |
0.00 |
IGL03091:Wee2
|
APN |
6 |
40,438,968 (GRCm39) |
missense |
probably benign |
0.02 |
IGL03350:Wee2
|
APN |
6 |
40,426,665 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03352:Wee2
|
APN |
6 |
40,429,589 (GRCm39) |
critical splice donor site |
probably null |
|
R0420:Wee2
|
UTSW |
6 |
40,433,929 (GRCm39) |
missense |
probably benign |
0.04 |
R0506:Wee2
|
UTSW |
6 |
40,440,187 (GRCm39) |
missense |
probably benign |
0.04 |
R1205:Wee2
|
UTSW |
6 |
40,420,875 (GRCm39) |
start gained |
probably benign |
|
R1702:Wee2
|
UTSW |
6 |
40,441,135 (GRCm39) |
missense |
probably benign |
0.04 |
R3982:Wee2
|
UTSW |
6 |
40,432,175 (GRCm39) |
missense |
possibly damaging |
0.86 |
R3983:Wee2
|
UTSW |
6 |
40,432,175 (GRCm39) |
missense |
possibly damaging |
0.86 |
R5946:Wee2
|
UTSW |
6 |
40,440,146 (GRCm39) |
missense |
probably null |
1.00 |
R6020:Wee2
|
UTSW |
6 |
40,426,554 (GRCm39) |
splice site |
probably null |
|
R6127:Wee2
|
UTSW |
6 |
40,426,701 (GRCm39) |
missense |
probably damaging |
1.00 |
R6189:Wee2
|
UTSW |
6 |
40,426,617 (GRCm39) |
missense |
probably damaging |
1.00 |
R6342:Wee2
|
UTSW |
6 |
40,421,189 (GRCm39) |
missense |
probably benign |
0.05 |
R6347:Wee2
|
UTSW |
6 |
40,432,039 (GRCm39) |
missense |
probably damaging |
1.00 |
R6350:Wee2
|
UTSW |
6 |
40,432,039 (GRCm39) |
missense |
probably damaging |
1.00 |
R6513:Wee2
|
UTSW |
6 |
40,429,553 (GRCm39) |
missense |
probably benign |
0.00 |
R7091:Wee2
|
UTSW |
6 |
40,438,936 (GRCm39) |
missense |
probably benign |
0.00 |
R8258:Wee2
|
UTSW |
6 |
40,421,114 (GRCm39) |
missense |
probably benign |
0.00 |
R8259:Wee2
|
UTSW |
6 |
40,421,114 (GRCm39) |
missense |
probably benign |
0.00 |
R8463:Wee2
|
UTSW |
6 |
40,420,914 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
R8853:Wee2
|
UTSW |
6 |
40,441,200 (GRCm39) |
missense |
probably benign |
0.07 |
R9028:Wee2
|
UTSW |
6 |
40,421,189 (GRCm39) |
missense |
probably benign |
|
R9170:Wee2
|
UTSW |
6 |
40,437,977 (GRCm39) |
missense |
probably benign |
0.07 |
R9231:Wee2
|
UTSW |
6 |
40,440,089 (GRCm39) |
missense |
probably damaging |
1.00 |
R9394:Wee2
|
UTSW |
6 |
40,433,878 (GRCm39) |
missense |
probably damaging |
0.96 |
R9474:Wee2
|
UTSW |
6 |
40,432,044 (GRCm39) |
nonsense |
probably null |
|
R9493:Wee2
|
UTSW |
6 |
40,421,057 (GRCm39) |
missense |
probably benign |
0.39 |
|
Posted On |
2012-04-20 |