Incidental Mutation 'R7022:Or51g2'
ID 545692
Institutional Source Beutler Lab
Gene Symbol Or51g2
Ensembl Gene ENSMUSG00000043354
Gene Name olfactory receptor family 51 subfamily G member 2
Synonyms Olfr577, GA_x6K02T2PBJ9-5685322-5684384, MOR7-2
MMRRC Submission 045123-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.132) question?
Stock # R7022 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 102622259-102623197 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 102623175 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 8 (N8I)
Ref Sequence ENSEMBL: ENSMUSP00000150712 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051505] [ENSMUST00000185326] [ENSMUST00000214080] [ENSMUST00000215237]
AlphaFold Q8VH11
Predicted Effect possibly damaging
Transcript: ENSMUST00000051505
AA Change: N8I

PolyPhen 2 Score 0.461 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000059586
Gene: ENSMUSG00000043354
AA Change: N8I

DomainStartEndE-ValueType
Pfam:7tm_4 34 312 3.3e-140 PFAM
Pfam:7TM_GPCR_Srsx 38 310 1.2e-6 PFAM
Pfam:7tm_1 44 295 7.5e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000185326
SMART Domains Protein: ENSMUSP00000142459
Gene: ENSMUSG00000073962

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 35 300 9.7e-12 PFAM
Pfam:7tm_1 41 291 1.8e-29 PFAM
Pfam:7tm_4 140 284 2.6e-28 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214080
AA Change: N8I

PolyPhen 2 Score 0.461 (Sensitivity: 0.89; Specificity: 0.90)
Predicted Effect possibly damaging
Transcript: ENSMUST00000215237
AA Change: N8I

PolyPhen 2 Score 0.461 (Sensitivity: 0.89; Specificity: 0.90)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (75/75)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a A T 11: 109,974,326 (GRCm39) S203T probably damaging Het
Adat1 A T 8: 112,716,494 (GRCm39) M76K probably damaging Het
Ankrd33 G C 15: 101,014,780 (GRCm39) V56L probably benign Het
Ascc3 T A 10: 50,592,725 (GRCm39) L1134I possibly damaging Het
C3 T G 17: 57,524,286 (GRCm39) D948A probably damaging Het
Ccdc121rt3 A C 5: 112,503,395 (GRCm39) M103R probably benign Het
Ccdc40 A G 11: 119,122,612 (GRCm39) E138G possibly damaging Het
Cd80 A G 16: 38,306,866 (GRCm39) probably null Het
Cdca7 T A 2: 72,309,873 (GRCm39) probably null Het
Chit1 A G 1: 134,079,030 (GRCm39) S447G probably benign Het
Cmya5 C T 13: 93,205,786 (GRCm39) probably null Het
Cnnm2 A T 19: 46,750,989 (GRCm39) I260F probably damaging Het
Cnnm2 T A 19: 46,847,379 (GRCm39) probably null Het
Col1a2 T C 6: 4,534,639 (GRCm39) L881P unknown Het
Crebbp A T 16: 3,935,187 (GRCm39) S901T probably damaging Het
Dcun1d2 T C 8: 13,321,637 (GRCm39) Y158C probably damaging Het
Dnhd1 C T 7: 105,370,005 (GRCm39) P4477S probably benign Het
Donson A G 16: 91,478,218 (GRCm39) Y428H probably damaging Het
Dsp G T 13: 38,375,716 (GRCm39) W1167L probably benign Het
Elmo2 C T 2: 165,136,961 (GRCm39) V592M probably damaging Het
Enpp3 T A 10: 24,702,093 (GRCm39) E60D probably damaging Het
Erfl A T 7: 24,631,089 (GRCm39) probably null Het
Fam83b TAAGA T 9: 76,409,394 (GRCm39) probably null Het
Fbxo38 A G 18: 62,669,295 (GRCm39) C52R probably damaging Het
Gm10912 T C 2: 103,897,055 (GRCm39) W65R probably damaging Het
Gm43518 A T 5: 124,074,490 (GRCm39) M44L probably benign Het
Gnb1 T A 4: 155,637,913 (GRCm39) D212E probably damaging Het
Gnl1 A G 17: 36,299,620 (GRCm39) N597S probably damaging Het
Gprin1 T G 13: 54,886,855 (GRCm39) E473A probably benign Het
Ighv1-69 T A 12: 115,586,834 (GRCm39) M100L probably benign Het
Igkv14-100 T C 6: 68,496,193 (GRCm39) S29P probably damaging Het
Ints6 A G 14: 62,951,786 (GRCm39) V232A probably damaging Het
Jup A G 11: 100,270,379 (GRCm39) L376P probably damaging Het
Kdr A T 5: 76,132,920 (GRCm39) Y119* probably null Het
Kif1a T G 1: 92,993,820 (GRCm39) T377P probably benign Het
Lama5 C A 2: 179,822,524 (GRCm39) V2850L probably damaging Het
Lrp2 T C 2: 69,313,552 (GRCm39) Y2393C probably damaging Het
Mfsd13a C T 19: 46,356,763 (GRCm39) Q255* probably null Het
Msh3 A C 13: 92,372,096 (GRCm39) D891E probably damaging Het
Msl2 A G 9: 100,957,335 (GRCm39) N2D possibly damaging Het
Myo19 T C 11: 84,791,373 (GRCm39) L476P probably damaging Het
Nbeal2 G A 9: 110,467,686 (GRCm39) R501W probably damaging Het
Nfasc C A 1: 132,548,787 (GRCm39) K293N probably damaging Het
Npbwr1 A T 1: 5,987,319 (GRCm39) L65Q probably damaging Het
Nrbp1 T A 5: 31,401,825 (GRCm39) D34E probably damaging Het
Nup205 T A 6: 35,220,871 (GRCm39) V1891D probably benign Het
Or5g29 T A 2: 85,420,942 (GRCm39) D19E probably benign Het
Or5k1b T C 16: 58,581,482 (GRCm39) N19S probably benign Het
Or8g22 G T 9: 38,958,379 (GRCm39) C156* probably null Het
Oscp1 G A 4: 125,976,783 (GRCm39) probably null Het
Pcdhgb7 A G 18: 37,886,086 (GRCm39) T419A probably damaging Het
Pdzph1 T C 17: 59,281,121 (GRCm39) D387G probably benign Het
Phc1 A G 6: 122,311,990 (GRCm39) F56S probably damaging Het
Pik3c2g A G 6: 139,599,061 (GRCm39) E59G possibly damaging Het
Prickle1 G T 15: 93,398,752 (GRCm39) T692K possibly damaging Het
Rbm45 T A 2: 76,206,738 (GRCm39) L250Q probably damaging Het
Ror1 T A 4: 100,265,108 (GRCm39) M194K probably damaging Het
Rrbp1 T A 2: 143,799,722 (GRCm39) probably null Het
Rundc3b T C 5: 8,562,348 (GRCm39) K340R probably null Het
Scn1a T A 2: 66,148,243 (GRCm39) T1101S probably damaging Het
Sdk1 C G 5: 142,080,412 (GRCm39) probably null Het
Skic2 A G 17: 35,064,183 (GRCm39) F501S possibly damaging Het
Slc20a1 T A 2: 129,041,979 (GRCm39) M114K probably damaging Het
Sorl1 A C 9: 41,881,047 (GRCm39) I2158S probably benign Het
Strip1 A T 3: 107,534,111 (GRCm39) F174L probably benign Het
Sucnr1 A T 3: 59,993,699 (GRCm39) I76L probably benign Het
Syt17 C T 7: 118,007,242 (GRCm39) V412I probably benign Het
Tie1 T A 4: 118,346,850 (GRCm39) H18L probably benign Het
Tpp1 T G 7: 105,398,129 (GRCm39) K345Q probably damaging Het
Trcg1 G A 9: 57,148,852 (GRCm39) M141I possibly damaging Het
Trpc4ap T C 2: 155,499,742 (GRCm39) N260S probably benign Het
Vps41 C A 13: 19,026,438 (GRCm39) T512K possibly damaging Het
Vps52 A T 17: 34,178,293 (GRCm39) M147L probably benign Het
Ywhaq A G 12: 21,441,752 (GRCm39) probably benign Het
Zfp619 A G 7: 39,184,387 (GRCm39) N139S probably benign Het
Other mutations in Or51g2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02246:Or51g2 APN 7 102,622,951 (GRCm39) missense possibly damaging 0.62
IGL03111:Or51g2 APN 7 102,622,738 (GRCm39) missense probably damaging 1.00
R1529:Or51g2 UTSW 7 102,623,086 (GRCm39) missense probably damaging 1.00
R1753:Or51g2 UTSW 7 102,622,263 (GRCm39) missense probably benign
R3005:Or51g2 UTSW 7 102,622,465 (GRCm39) missense possibly damaging 0.56
R4457:Or51g2 UTSW 7 102,622,734 (GRCm39) missense probably damaging 1.00
R4675:Or51g2 UTSW 7 102,623,013 (GRCm39) missense probably damaging 0.99
R4808:Or51g2 UTSW 7 102,623,118 (GRCm39) missense probably damaging 0.99
R4891:Or51g2 UTSW 7 102,622,759 (GRCm39) missense probably benign 0.12
R4917:Or51g2 UTSW 7 102,622,614 (GRCm39) missense possibly damaging 0.93
R4918:Or51g2 UTSW 7 102,622,614 (GRCm39) missense possibly damaging 0.93
R5328:Or51g2 UTSW 7 102,623,175 (GRCm39) missense possibly damaging 0.46
R6375:Or51g2 UTSW 7 102,622,960 (GRCm39) missense probably damaging 1.00
R6683:Or51g2 UTSW 7 102,622,920 (GRCm39) missense probably benign 0.05
R6958:Or51g2 UTSW 7 102,623,091 (GRCm39) missense possibly damaging 0.67
R7429:Or51g2 UTSW 7 102,622,969 (GRCm39) missense probably damaging 1.00
R7430:Or51g2 UTSW 7 102,622,969 (GRCm39) missense probably damaging 1.00
R7490:Or51g2 UTSW 7 102,623,017 (GRCm39) missense probably damaging 1.00
R7808:Or51g2 UTSW 7 102,622,317 (GRCm39) missense possibly damaging 0.56
R8169:Or51g2 UTSW 7 102,622,545 (GRCm39) missense probably damaging 0.99
R8544:Or51g2 UTSW 7 102,622,938 (GRCm39) missense probably damaging 1.00
R9027:Or51g2 UTSW 7 102,622,560 (GRCm39) missense probably damaging 1.00
R9265:Or51g2 UTSW 7 102,623,112 (GRCm39) nonsense probably null
X0027:Or51g2 UTSW 7 102,622,893 (GRCm39) missense probably benign 0.05
Z1176:Or51g2 UTSW 7 102,622,516 (GRCm39) missense not run
Z1177:Or51g2 UTSW 7 102,622,516 (GRCm39) missense not run
Predicted Primers PCR Primer
(F):5'- TAGCACTGTAGGGAGGGTAC -3'
(R):5'- TCTCTTCAGAGACTATACAGGCTTAG -3'

Sequencing Primer
(F):5'- TCAGTCAGAGCGAGCATGGAC -3'
(R):5'- GACTATACAGGCTTAGGATTATTTGG -3'
Posted On 2019-05-13