Incidental Mutation 'R7029:Brox'
ID 546168
Institutional Source Beutler Lab
Gene Symbol Brox
Ensembl Gene ENSMUSG00000046836
Gene Name BRO1 domain and CAAX motif containing
Synonyms 0610010K06Rik
MMRRC Submission 045130-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.100) question?
Stock # R7029 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 183057916-183078813 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 183065750 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Leucine at position 206 (P206L)
Ref Sequence ENSEMBL: ENSMUSP00000132333 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057062] [ENSMUST00000163528] [ENSMUST00000194327] [ENSMUST00000195054]
AlphaFold Q8K2Q7
Predicted Effect possibly damaging
Transcript: ENSMUST00000057062
AA Change: P206L

PolyPhen 2 Score 0.920 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000061345
Gene: ENSMUSG00000046836
AA Change: P206L

DomainStartEndE-ValueType
BRO1 4 384 1.74e-92 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000163528
AA Change: P206L

PolyPhen 2 Score 0.920 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000132333
Gene: ENSMUSG00000046836
AA Change: P206L

DomainStartEndE-ValueType
PDB:3ZXP|C 1 101 5e-63 PDB
Blast:BRO1 4 101 1e-67 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000194327
Predicted Effect probably benign
Transcript: ENSMUST00000195054
Meta Mutation Damage Score 0.4238 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700034J05Rik T C 6: 146,853,841 (GRCm39) Q271R probably benign Het
Abhd4 T A 14: 54,500,164 (GRCm39) W63R probably damaging Het
Adcy5 A G 16: 35,120,018 (GRCm39) M1176V probably null Het
Bach1 G A 16: 87,516,179 (GRCm39) R240Q probably benign Het
Ccn3 A G 15: 54,611,171 (GRCm39) D102G possibly damaging Het
Def6 A G 17: 28,444,943 (GRCm39) K447R probably benign Het
Dna2 T C 10: 62,799,773 (GRCm39) S726P probably damaging Het
Ell G A 8: 71,031,879 (GRCm39) V15I probably damaging Het
Entrep2 T A 7: 64,409,075 (GRCm39) T440S probably benign Het
Epha3 T A 16: 63,593,698 (GRCm39) D130V probably benign Het
Gys1 A G 7: 45,089,008 (GRCm39) T200A possibly damaging Het
Habp4 A T 13: 64,309,939 (GRCm39) H47L probably benign Het
Iqcn G T 8: 71,161,511 (GRCm39) V235L possibly damaging Het
Kcnj10 C A 1: 172,196,563 (GRCm39) R26S probably benign Het
Klhl1 T A 14: 96,755,632 (GRCm39) D41V probably benign Het
Lyn A G 4: 3,782,996 (GRCm39) T410A probably damaging Het
Mga A G 2: 119,754,031 (GRCm39) T847A probably damaging Het
Mrgpra3 G T 7: 47,239,290 (GRCm39) T212N probably benign Het
Myh4 T C 11: 67,137,251 (GRCm39) F491L probably benign Het
Neurl4 T A 11: 69,801,562 (GRCm39) I1206N probably damaging Het
Pcdhb15 T A 18: 37,608,621 (GRCm39) W618R possibly damaging Het
Pomc A G 12: 4,010,146 (GRCm39) H129R probably damaging Het
Ppm1l C A 3: 69,460,399 (GRCm39) H325Q probably benign Het
Psme4 A G 11: 30,722,474 (GRCm39) probably benign Het
Reep2 A G 18: 34,978,342 (GRCm39) I74V probably null Het
Robo2 T G 16: 73,745,225 (GRCm39) E850A probably damaging Het
Scrn2 T A 11: 96,921,262 (GRCm39) probably benign Het
Sfpq G A 4: 126,923,675 (GRCm39) R673K probably benign Het
Sh2d3c T C 2: 32,644,581 (GRCm39) *703R probably null Het
Spp1 A G 5: 104,587,167 (GRCm39) M85V probably benign Het
Srebf1 T C 11: 60,097,810 (GRCm39) E98G probably damaging Het
Srrm4 T A 5: 116,582,851 (GRCm39) probably benign Het
Ticam1 A T 17: 56,578,154 (GRCm39) S314T possibly damaging Het
Tie1 T C 4: 118,341,823 (GRCm39) I209V possibly damaging Het
Vapa G A 17: 65,889,586 (GRCm39) R194* probably null Het
Vcan C T 13: 89,838,360 (GRCm39) D2395N probably damaging Het
Whamm A G 7: 81,241,574 (GRCm39) H295R probably benign Het
Zdhhc14 A G 17: 5,698,186 (GRCm39) Y85C probably damaging Het
Zfp35 T A 18: 24,136,583 (GRCm39) F309Y probably damaging Het
Zfp423 C A 8: 88,414,694 (GRCm39) C1187F probably damaging Het
Zfp874b T C 13: 67,622,392 (GRCm39) Y302C probably damaging Het
Other mutations in Brox
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0854:Brox UTSW 1 183,069,322 (GRCm39) missense possibly damaging 0.50
R1086:Brox UTSW 1 183,064,052 (GRCm39) missense probably damaging 1.00
R4488:Brox UTSW 1 183,062,514 (GRCm39) missense probably benign 0.01
R4524:Brox UTSW 1 183,074,045 (GRCm39) missense possibly damaging 0.95
R5112:Brox UTSW 1 183,073,541 (GRCm39) missense probably benign
R5559:Brox UTSW 1 183,073,552 (GRCm39) missense possibly damaging 0.83
R5951:Brox UTSW 1 183,064,072 (GRCm39) missense probably damaging 1.00
R7027:Brox UTSW 1 183,065,750 (GRCm39) missense possibly damaging 0.92
R7229:Brox UTSW 1 183,073,523 (GRCm39) nonsense probably null
R7629:Brox UTSW 1 183,074,068 (GRCm39) missense probably damaging 0.97
R7935:Brox UTSW 1 183,062,484 (GRCm39) missense probably damaging 0.98
R8140:Brox UTSW 1 183,075,437 (GRCm39) splice site probably null
R8164:Brox UTSW 1 183,062,491 (GRCm39) missense possibly damaging 0.95
R9430:Brox UTSW 1 183,069,353 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTGAGAGGAGCATGCACATGTG -3'
(R):5'- TCAAAATCAGTGTCCTCTTTCTGTG -3'

Sequencing Primer
(F):5'- CTGGATGGTGAGCAAGCCAC -3'
(R):5'- TGTCCTCTTTCTGTGTTTATATTTGC -3'
Posted On 2019-05-13