Incidental Mutation 'R7030:Or2g7'
ID 546287
Institutional Source Beutler Lab
Gene Symbol Or2g7
Ensembl Gene ENSMUSG00000094878
Gene Name olfactory receptor family 2 subfamily G member 7
Synonyms GA_x6K02T2PSCP-2515350-2516303, MOR256-19, Olfr130
MMRRC Submission 045131-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.119) question?
Stock # R7030 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 38378064-38379017 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 38378948 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 295 (D295E)
Ref Sequence ENSEMBL: ENSMUSP00000149601 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087129] [ENSMUST00000215726] [ENSMUST00000217390]
AlphaFold Q8VFC1
Predicted Effect probably benign
Transcript: ENSMUST00000087129
AA Change: D295E

PolyPhen 2 Score 0.131 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000084369
Gene: ENSMUSG00000094878
AA Change: D295E

DomainStartEndE-ValueType
Pfam:7tm_4 29 307 1.8e-44 PFAM
Pfam:7TM_GPCR_Srsx 34 223 1.9e-5 PFAM
Pfam:7tm_1 40 289 1.9e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215726
AA Change: D295E

PolyPhen 2 Score 0.131 (Sensitivity: 0.93; Specificity: 0.86)
Predicted Effect probably benign
Transcript: ENSMUST00000217390
AA Change: D295E

PolyPhen 2 Score 0.131 (Sensitivity: 0.93; Specificity: 0.86)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 98% (92/94)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 93 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AAdacl4fm3 G T 4: 144,430,173 (GRCm39) A272D possibly damaging Het
Abr A T 11: 76,350,038 (GRCm39) I347N probably damaging Het
Acbd4 T A 11: 102,994,985 (GRCm39) L50Q probably damaging Het
Acsl5 T G 19: 55,261,251 (GRCm39) Y69* probably null Het
Agtpbp1 G A 13: 59,652,108 (GRCm39) T401I probably damaging Het
Ap3m2 C T 8: 23,289,807 (GRCm39) E99K probably damaging Het
Arhgef28 A T 13: 98,124,769 (GRCm39) S504R possibly damaging Het
Arsj T A 3: 126,232,752 (GRCm39) D499E probably damaging Het
Bach1 G A 16: 87,516,179 (GRCm39) R240Q probably benign Het
Camk2b T C 11: 5,939,575 (GRCm39) D232G probably damaging Het
Casc3 C T 11: 98,713,359 (GRCm39) P258S possibly damaging Het
Catspere2 T A 1: 177,845,280 (GRCm39) I100N probably damaging Het
Ccdc80 T A 16: 44,943,252 (GRCm39) N787K possibly damaging Het
Celsr1 C A 15: 85,789,679 (GRCm39) C2653F probably damaging Het
Cep170 T C 1: 176,584,051 (GRCm39) E11G probably damaging Het
Chia1 A C 3: 106,022,641 (GRCm39) N12H probably damaging Het
Chrna4 T C 2: 180,671,334 (GRCm39) T141A probably damaging Het
Col25a1 T C 3: 130,272,671 (GRCm39) probably null Het
Dcstamp A T 15: 39,622,929 (GRCm39) I417F probably damaging Het
Dnah5 A G 15: 28,238,738 (GRCm39) I427V probably benign Het
Dnah5 A G 15: 28,333,208 (GRCm39) E2203G probably benign Het
Dnmt3c A T 2: 153,559,345 (GRCm39) S409C probably damaging Het
Dock6 A T 9: 21,724,375 (GRCm39) M1541K probably damaging Het
Dzip1l C T 9: 99,547,888 (GRCm39) T714I probably benign Het
Exoc6b T C 6: 84,825,807 (GRCm39) R535G probably damaging Het
Fam83h A G 15: 75,876,588 (GRCm39) S250P probably benign Het
Fat4 C T 3: 39,036,107 (GRCm39) T3253I probably damaging Het
Fer1l6 T A 15: 58,501,227 (GRCm39) F1302I probably damaging Het
Fmnl1 T G 11: 103,085,600 (GRCm39) probably benign Het
Gckr C A 5: 31,459,554 (GRCm39) F201L possibly damaging Het
Gm10036 A G 18: 15,966,292 (GRCm39) T148A probably benign Het
Gm5142 G A 14: 59,415,909 (GRCm39) S83F probably benign Het
Gpr37 A T 6: 25,689,004 (GRCm39) V31D possibly damaging Het
Gramd2b A T 18: 56,618,321 (GRCm39) Y207F probably damaging Het
Hr T C 14: 70,801,124 (GRCm39) probably null Het
Igf2r A G 17: 12,952,753 (GRCm39) L231P probably damaging Het
Ighv1-66 A T 12: 115,557,157 (GRCm39) W3R probably damaging Het
Insyn2b T A 11: 34,352,030 (GRCm39) V24E probably damaging Het
Kcnu1 T C 8: 26,408,491 (GRCm39) S101P probably benign Het
Klhl23 T G 2: 69,664,310 (GRCm39) V553G probably damaging Het
Lrp1 T C 10: 127,388,745 (GRCm39) I3235V probably damaging Het
Mb A T 15: 76,900,256 (GRCm39) I57N probably damaging Het
Micu1 T C 10: 59,624,843 (GRCm39) I295T possibly damaging Het
Mink1 G A 11: 70,498,601 (GRCm39) V589I possibly damaging Het
Mndal T C 1: 173,703,160 (GRCm39) K82E probably damaging Het
Mroh1 A C 15: 76,321,517 (GRCm39) K1066T probably benign Het
Muc5b T A 7: 141,396,192 (GRCm39) N149K unknown Het
Myo7b G T 18: 32,104,626 (GRCm39) L1404I probably damaging Het
Nlrc4 A G 17: 74,753,001 (GRCm39) S461P probably damaging Het
Nudt12 A T 17: 59,310,348 (GRCm39) D418E probably benign Het
Or5g27 G T 2: 85,409,746 (GRCm39) R54S possibly damaging Het
Pcdha1 A G 18: 37,292,326 (GRCm39) H817R probably damaging Het
Pcdha4 A G 18: 37,087,080 (GRCm39) Y421C probably damaging Het
Pcf11 T C 7: 92,306,886 (GRCm39) D1094G probably benign Het
Pck2 A T 14: 55,785,223 (GRCm39) D427V probably damaging Het
Pclo A G 5: 14,726,421 (GRCm39) T1760A probably benign Het
Pdzk1ip1 T A 4: 114,950,188 (GRCm39) Y83N probably damaging Het
Pgs1 T C 11: 117,893,312 (GRCm39) I213T probably damaging Het
Plin4 T A 17: 56,410,969 (GRCm39) T1021S probably damaging Het
Plxnb1 T A 9: 108,941,375 (GRCm39) I1677N probably damaging Het
Pm20d2 T C 4: 33,174,752 (GRCm39) E378G possibly damaging Het
Prkcq T G 2: 11,231,661 (GRCm39) probably null Het
Psmd2 C T 16: 20,480,883 (GRCm39) P780L probably damaging Het
Pvr A G 7: 19,639,105 (GRCm39) S392P possibly damaging Het
Rad51ap2 G C 12: 11,507,432 (GRCm39) L451F possibly damaging Het
Rbm20 A G 19: 53,823,197 (GRCm39) E598G probably damaging Het
Rho A T 6: 115,912,504 (GRCm39) N123Y possibly damaging Het
Rictor T C 15: 6,737,934 (GRCm39) probably null Het
Rilpl2 T G 5: 124,606,656 (GRCm39) K186T probably damaging Het
Rps6ka4 A C 19: 6,816,992 (GRCm39) L61R probably damaging Het
Sds C A 5: 120,618,890 (GRCm39) Q118K probably benign Het
Septin1 C T 7: 126,816,157 (GRCm39) R91K probably benign Het
Sf3a3 A G 4: 124,616,673 (GRCm39) Y185C probably damaging Het
Shtn1 T C 19: 58,998,266 (GRCm39) M376V possibly damaging Het
Slc6a9 A G 4: 117,714,633 (GRCm39) T189A possibly damaging Het
Slc7a6 T G 8: 106,922,606 (GRCm39) V464G possibly damaging Het
Smg8 T A 11: 86,975,919 (GRCm39) D554V probably damaging Het
Sox8 A G 17: 25,789,082 (GRCm39) probably null Het
Spata31e4 G T 13: 50,857,019 (GRCm39) V886L possibly damaging Het
Spats2l T A 1: 57,918,689 (GRCm39) V41D probably damaging Het
Sult2a3 A T 7: 13,801,493 (GRCm39) F282Y probably damaging Het
Svs3a T G 2: 164,132,091 (GRCm39) Y220D probably damaging Het
Teddm1a T A 1: 153,768,369 (GRCm39) Y278N probably damaging Het
Tlk1 T C 2: 70,552,272 (GRCm39) Y526C probably damaging Het
Tmc3 T A 7: 83,266,025 (GRCm39) probably null Het
Ttn T A 2: 76,596,583 (GRCm39) E20110V probably damaging Het
Tulp4 A G 17: 6,264,941 (GRCm39) D235G probably damaging Het
Usp50 T C 2: 126,622,395 (GRCm39) Y55C possibly damaging Het
Vmn1r224 T C 17: 20,639,789 (GRCm39) L122P probably benign Het
Vmn2r62 A G 7: 42,438,473 (GRCm39) L121P possibly damaging Het
Whrn G T 4: 63,413,368 (GRCm39) probably benign Het
Zer1 G T 2: 30,001,033 (GRCm39) H129Q probably benign Het
Zfand4 G A 6: 116,282,618 (GRCm39) A64T probably benign Het
Other mutations in Or2g7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01527:Or2g7 APN 17 38,378,986 (GRCm39) missense probably benign
IGL02158:Or2g7 APN 17 38,378,158 (GRCm39) missense probably damaging 0.97
IGL03172:Or2g7 APN 17 38,378,275 (GRCm39) missense probably damaging 0.99
R0389:Or2g7 UTSW 17 38,378,562 (GRCm39) missense possibly damaging 0.58
R0448:Or2g7 UTSW 17 38,378,563 (GRCm39) missense probably benign 0.00
R0616:Or2g7 UTSW 17 38,378,131 (GRCm39) missense probably damaging 1.00
R0961:Or2g7 UTSW 17 38,378,814 (GRCm39) missense probably damaging 1.00
R1789:Or2g7 UTSW 17 38,378,839 (GRCm39) missense probably damaging 1.00
R2108:Or2g7 UTSW 17 38,378,746 (GRCm39) missense possibly damaging 0.82
R4600:Or2g7 UTSW 17 38,378,853 (GRCm39) missense probably damaging 0.99
R4977:Or2g7 UTSW 17 38,378,638 (GRCm39) missense possibly damaging 0.67
R5120:Or2g7 UTSW 17 38,378,157 (GRCm39) missense probably damaging 0.97
R5930:Or2g7 UTSW 17 38,378,641 (GRCm39) missense probably benign 0.11
R6273:Or2g7 UTSW 17 38,378,686 (GRCm39) missense probably damaging 1.00
R6636:Or2g7 UTSW 17 38,378,115 (GRCm39) missense probably damaging 0.98
R6637:Or2g7 UTSW 17 38,378,115 (GRCm39) missense probably damaging 0.98
R7045:Or2g7 UTSW 17 38,378,862 (GRCm39) missense probably benign 0.01
R7175:Or2g7 UTSW 17 38,378,370 (GRCm39) missense probably damaging 0.96
R7359:Or2g7 UTSW 17 38,378,506 (GRCm39) nonsense probably null
R7762:Or2g7 UTSW 17 38,378,566 (GRCm39) missense probably damaging 1.00
R7980:Or2g7 UTSW 17 38,378,412 (GRCm39) missense possibly damaging 0.64
R8050:Or2g7 UTSW 17 38,378,370 (GRCm39) missense probably damaging 1.00
R9035:Or2g7 UTSW 17 38,378,179 (GRCm39) missense probably benign 0.00
X0019:Or2g7 UTSW 17 38,378,613 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CTGATGAGGTTACGGTCAGC -3'
(R):5'- TAGCACTCTAGAGAAGCCGGTG -3'

Sequencing Primer
(F):5'- ATGAGGTTACGGTCAGCTCTAACC -3'
(R):5'- CACTCTAGAGAAGCCGGTGAGTTTAG -3'
Posted On 2019-05-13