Mutagenetix > Incidental Mutation

Incidental Mutation 'R7032:Dnah5'

546408

Institutional Source

Beutler Lab

Gene Symbol

Dnah5

Ensembl Gene

ENSMUSG00000022262

Gene Name

dynein, axonemal, heavy chain 5

Synonyms

Dnahc5, b2b3491Clo, b2b1154Clo, b2b1134Clo, b2b1565Clo, b2b1537Clo, Mdnah5

MMRRC Submission

045133-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.812) question?

Stock #

R7032 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

28203898-28472198 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 28326796 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Aspartic acid at position 2002 (N2002D)

Ref Sequence

ENSEMBL: ENSMUSP00000069751 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067048]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000067048
AA Change: N2002D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000069751
Gene: ENSMUSG00000022262
AA Change: N2002D

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	247	802	2.3e-163	PFAM
low complexity region	1077	1088	N/A	INTRINSIC
low complexity region	1113	1128	N/A	INTRINSIC
Pfam:DHC_N2	1399	1807	2.3e-134	PFAM
AAA	1972	2108	2e-3	SMART
AAA	2251	2424	4.3e-3	SMART
AAA	2579	2777	2.2e-3	SMART
low complexity region	2874	2889	N/A	INTRINSIC
Pfam:AAA_8	2914	3186	3.2e-70	PFAM
Pfam:MT	3198	3546	1e-44	PFAM
Pfam:AAA_9	3567	3792	1.4e-86	PFAM
low complexity region	3889	3899	N/A	INTRINSIC
Pfam:Dynein_heavy	3930	4618	4.4e-246	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.0%

Validation Efficiency

100% (67/67)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a dynein protein, which is part of a microtubule-associated motor protein complex consisting of heavy, light, and intermediate chains. This protein is an axonemal heavy chain dynein. It functions as a force-generating protein with ATPase activity, whereby the release of ADP is thought to produce the force-producing power stroke. Mutations in this gene cause primary ciliary dyskinesia type 3, as well as Kartagener syndrome, which are both diseases due to ciliary defects. [provided by RefSeq, Oct 2009]
PHENOTYPE: Mice homozygous for a disruption in this gene display postnatal lethality, hydrocephalus, respiratory infections, situs inversus and ciliary immotility. [provided by MGI curators]

Allele List at MGI

All alleles(11) : Targeted(2) Gene trapped(1) Transgenic(1) Chemically induced(7)

Other mutations in this stock

Total: 68 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310003L06Rik	T	A	5: 88,120,438 (GRCm39)	D398E	possibly damaging	Het
Adam34	T	C	8: 44,105,303 (GRCm39)	Y114C	probably damaging	Het
Akap9	T	A	5: 4,004,896 (GRCm39)	D156E	probably benign	Het
Apba1	T	A	19: 23,889,825 (GRCm39)	S408T	probably benign	Het
Asb14	C	T	14: 26,625,412 (GRCm39)	H256Y	probably benign	Het
Atf6	A	T	1: 170,627,181 (GRCm39)		probably null	Het
Atp6v1b2	T	A	8: 69,541,548 (GRCm39)	V35E	probably benign	Het
Atp8a2	T	C	14: 60,255,289 (GRCm39)		probably null	Het
Ccdc170	C	A	10: 4,432,597 (GRCm39)	P12Q	unknown	Het
Cdh23	C	T	10: 60,167,567 (GRCm39)	E1810K	probably damaging	Het
Cdo1	A	T	18: 46,853,475 (GRCm39)	F94L	probably damaging	Het
Cfap96	T	G	8: 46,409,474 (GRCm39)	S282R	probably damaging	Het
Chdh	C	T	14: 29,758,809 (GRCm39)	P585S	possibly damaging	Het
Clasp2	A	G	9: 113,683,391 (GRCm39)	N407S	probably benign	Het
Clca3a1	T	A	3: 144,453,329 (GRCm39)	S465C	probably benign	Het
Clip2	C	A	5: 134,551,484 (GRCm39)	V213L	probably damaging	Het
Col6a6	A	G	9: 105,644,707 (GRCm39)	S1194P	probably damaging	Het
Cyp7a1	T	C	4: 6,268,463 (GRCm39)	T421A	possibly damaging	Het
Dhh	C	T	15: 98,791,907 (GRCm39)	G367E	possibly damaging	Het
Epn2	T	A	11: 61,437,528 (GRCm39)	N15Y	probably damaging	Het
Evi5	A	C	5: 107,936,147 (GRCm39)	V647G	probably benign	Het
Eya1	T	C	1: 14,353,424 (GRCm39)		probably null	Het
Fam120a	A	G	13: 49,102,589 (GRCm39)	V222A	probably benign	Het
Fastkd5	A	T	2: 130,457,864 (GRCm39)	I242K	possibly damaging	Het
Hnrnpul1	A	G	7: 25,450,319 (GRCm39)	M131T	probably benign	Het
Ice1	T	C	13: 70,744,283 (GRCm39)	N2100S	probably damaging	Het
Ifi205	T	A	1: 173,855,916 (GRCm39)	D38V	possibly damaging	Het
Klhl9	G	A	4: 88,639,843 (GRCm39)	Q133*	probably null	Het
Krt84	T	C	15: 101,436,924 (GRCm39)	E370G	probably benign	Het
Lrrc4c	T	C	2: 97,459,410 (GRCm39)	I12T	probably benign	Het
Lrriq4	T	A	3: 30,709,850 (GRCm39)	L398*	probably null	Het
Ltf	G	A	9: 110,855,198 (GRCm39)		probably null	Het
Macf1	C	T	4: 123,366,101 (GRCm39)	V1322I	probably benign	Het
Mark2	T	A	19: 7,264,698 (GRCm39)	I112L	probably damaging	Het
Mettl25b	A	G	3: 87,831,649 (GRCm39)		probably null	Het
Mterf2	A	T	10: 84,956,527 (GRCm39)	C32*	probably null	Het
Myo3b	C	T	2: 69,925,608 (GRCm39)	T25I	probably damaging	Het
Nsun7	A	C	5: 66,421,378 (GRCm39)	I115L	probably benign	Het
Olfm3	G	A	3: 114,883,805 (GRCm39)	V36M	probably damaging	Het
Or1p1c	T	C	11: 74,160,428 (GRCm39)	I71T	possibly damaging	Het
Or5d44	T	C	2: 88,141,373 (GRCm39)	T256A	probably benign	Het
Or8b3	A	T	9: 38,314,965 (GRCm39)	Y262F	possibly damaging	Het
Or8g18	A	T	9: 39,148,983 (GRCm39)	S246T	possibly damaging	Het
Pcdhgb8	A	T	18: 37,896,962 (GRCm39)	R677S	probably benign	Het
Prrt4	A	C	6: 29,170,538 (GRCm39)	L638R	possibly damaging	Het
Ptk2	G	A	15: 73,093,658 (GRCm39)	P854S	possibly damaging	Het
Rab44	T	C	17: 29,359,438 (GRCm39)	F542S	unknown	Het
Rhobtb3	T	A	13: 76,020,513 (GRCm39)	E596D	probably benign	Het
Rpl36	T	C	17: 56,920,944 (GRCm39)	I44T	probably benign	Het
Rptor	A	G	11: 119,737,762 (GRCm39)	I112V	probably benign	Het
Rxfp2	T	C	5: 149,993,813 (GRCm39)	I611T	probably damaging	Het
Slc12a4	G	T	8: 106,675,865 (GRCm39)	N553K	probably damaging	Het
Spata31d1d	T	A	13: 59,876,046 (GRCm39)	R496S	probably benign	Het
Strbp	T	C	2: 37,493,125 (GRCm39)	D387G	possibly damaging	Het
Tas2r107	A	T	6: 131,636,153 (GRCm39)	C299S	possibly damaging	Het
Tbc1d21	A	T	9: 58,274,134 (GRCm39)		probably null	Het
Tdrd12	A	T	7: 35,180,471 (GRCm39)	Y847*	probably null	Het
Tlr2	A	T	3: 83,745,212 (GRCm39)	N290K	probably benign	Het
Tmppe	A	G	9: 114,234,858 (GRCm39)	T386A	probably damaging	Het
Tnks1bp1	C	A	2: 84,892,297 (GRCm39)	H741Q	probably benign	Het
Trpc6	G	A	9: 8,609,951 (GRCm39)	V140M	probably damaging	Het
Ttn	T	C	2: 76,641,932 (GRCm39)	D13427G	probably damaging	Het
Uba7	C	A	9: 107,853,371 (GRCm39)	L106I	possibly damaging	Het
Unc5b	T	G	10: 60,614,587 (GRCm39)	T237P	probably damaging	Het
Vit	A	C	17: 78,932,294 (GRCm39)	D467A	probably damaging	Het
Vmn1r103	T	C	7: 20,243,780 (GRCm39)	Y227C	possibly damaging	Het
Vmn1r77	T	A	7: 11,776,017 (GRCm39)	Y196*	probably null	Het
Zhx3	A	G	2: 160,622,898 (GRCm39)	V423A	probably damaging	Het

Other mutations in Dnah5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00226:Dnah5	APN	15	28,272,488 (GRCm39)	missense	probably benign
IGL00331:Dnah5	APN	15	28,421,766 (GRCm39)	missense	probably damaging	1.00
IGL00519:Dnah5	APN	15	28,444,364 (GRCm39)	missense	probably benign	0.10
IGL00537:Dnah5	APN	15	28,458,848 (GRCm39)	critical splice donor site	probably null
IGL01102:Dnah5	APN	15	28,410,149 (GRCm39)	critical splice donor site	probably null
IGL01126:Dnah5	APN	15	28,302,545 (GRCm39)	missense	possibly damaging	0.85
IGL01154:Dnah5	APN	15	28,458,802 (GRCm39)	missense	possibly damaging	0.75
IGL01349:Dnah5	APN	15	28,295,059 (GRCm39)	splice site	probably benign
IGL01353:Dnah5	APN	15	28,233,418 (GRCm39)	missense	probably benign	0.00
IGL01372:Dnah5	APN	15	28,230,636 (GRCm39)	missense	probably benign	0.00
IGL01390:Dnah5	APN	15	28,411,686 (GRCm39)	missense	probably benign	0.00
IGL01446:Dnah5	APN	15	28,326,815 (GRCm39)	missense	probably damaging	1.00
IGL01472:Dnah5	APN	15	28,331,872 (GRCm39)	missense	probably damaging	1.00
IGL01485:Dnah5	APN	15	28,331,872 (GRCm39)	missense	probably damaging	1.00
IGL01568:Dnah5	APN	15	28,229,798 (GRCm39)	missense	probably benign	0.01
IGL01592:Dnah5	APN	15	28,236,783 (GRCm39)	missense	probably benign	0.01
IGL01594:Dnah5	APN	15	28,311,480 (GRCm39)	missense	possibly damaging	0.87
IGL01677:Dnah5	APN	15	28,367,928 (GRCm39)	missense	probably damaging	1.00
IGL01845:Dnah5	APN	15	28,449,315 (GRCm39)	missense	probably benign	0.06
IGL01904:Dnah5	APN	15	28,307,510 (GRCm39)	missense	probably benign	0.09
IGL01913:Dnah5	APN	15	28,313,899 (GRCm39)	missense	possibly damaging	0.50
IGL01950:Dnah5	APN	15	28,290,435 (GRCm39)	missense	probably null	1.00
IGL01963:Dnah5	APN	15	28,370,682 (GRCm39)	missense	probably benign	0.12
IGL02008:Dnah5	APN	15	28,343,698 (GRCm39)	missense	probably damaging	0.98
IGL02088:Dnah5	APN	15	28,459,264 (GRCm39)	critical splice acceptor site	probably null
IGL02090:Dnah5	APN	15	28,240,187 (GRCm39)	splice site	probably benign
IGL02114:Dnah5	APN	15	28,397,270 (GRCm39)	missense	probably damaging	0.97
IGL02135:Dnah5	APN	15	28,248,031 (GRCm39)	missense	possibly damaging	0.50
IGL02232:Dnah5	APN	15	28,299,386 (GRCm39)	missense	probably damaging	1.00
IGL02386:Dnah5	APN	15	28,340,527 (GRCm39)	missense	probably damaging	1.00
IGL02475:Dnah5	APN	15	28,219,296 (GRCm39)	missense	probably benign	0.09
IGL02626:Dnah5	APN	15	28,307,422 (GRCm39)	missense	possibly damaging	0.94
IGL02650:Dnah5	APN	15	28,289,193 (GRCm39)	splice site	probably benign
IGL02651:Dnah5	APN	15	28,350,768 (GRCm39)	missense	probably benign	0.05
IGL02652:Dnah5	APN	15	28,366,333 (GRCm39)	missense	probably damaging	0.99
IGL02670:Dnah5	APN	15	28,409,442 (GRCm39)	missense	probably damaging	1.00
IGL02697:Dnah5	APN	15	28,445,289 (GRCm39)	missense	probably benign	0.00
IGL02721:Dnah5	APN	15	28,234,389 (GRCm39)	critical splice acceptor site	probably null
IGL02858:Dnah5	APN	15	28,453,358 (GRCm39)	missense	possibly damaging	0.65
IGL02859:Dnah5	APN	15	28,383,771 (GRCm39)	missense	probably benign	0.01
IGL02945:Dnah5	APN	15	28,270,572 (GRCm39)	missense	probably benign	0.00
IGL02949:Dnah5	APN	15	28,272,331 (GRCm39)	missense	probably benign	0.32
IGL02971:Dnah5	APN	15	28,384,607 (GRCm39)	missense	probably damaging	1.00
IGL03017:Dnah5	APN	15	28,340,471 (GRCm39)	missense	possibly damaging	0.93
IGL03177:Dnah5	APN	15	28,295,545 (GRCm39)	missense	probably damaging	0.97
IGL03212:Dnah5	APN	15	28,290,309 (GRCm39)	missense	probably benign	0.08
IGL03224:Dnah5	APN	15	28,459,300 (GRCm39)	missense	probably damaging	1.00
IGL03231:Dnah5	APN	15	28,311,294 (GRCm39)	missense	probably damaging	1.00
IGL03273:Dnah5	APN	15	28,458,795 (GRCm39)	missense	probably damaging	0.98
IGL03294:Dnah5	APN	15	28,233,441 (GRCm39)	critical splice donor site	probably null
IGL03331:Dnah5	APN	15	28,420,086 (GRCm39)	missense	probably damaging	1.00
IGL03337:Dnah5	APN	15	28,290,287 (GRCm39)	missense	probably benign	0.10
IGL03367:Dnah5	APN	15	28,234,473 (GRCm39)	missense	possibly damaging	0.95
Firtel	UTSW	15	28,448,513 (GRCm39)	missense	possibly damaging	0.95
lowbar	UTSW	15	28,311,279 (GRCm39)	splice site	probably null
notherone	UTSW	15	28,340,552 (GRCm39)	missense	probably benign	0.13
scheffler	UTSW	15	28,438,237 (GRCm39)	splice site	probably benign
IGL02837:Dnah5	UTSW	15	28,269,546 (GRCm39)	missense	probably benign
P0008:Dnah5	UTSW	15	28,302,533 (GRCm39)	missense	probably damaging	1.00
P0014:Dnah5	UTSW	15	28,403,619 (GRCm39)	missense	probably damaging	1.00
PIT4687001:Dnah5	UTSW	15	28,383,723 (GRCm39)	missense	probably damaging	0.98
R0030:Dnah5	UTSW	15	28,451,663 (GRCm39)	missense	probably benign	0.34
R0087:Dnah5	UTSW	15	28,350,759 (GRCm39)	missense	probably damaging	1.00
R0099:Dnah5	UTSW	15	28,240,080 (GRCm39)	missense	probably damaging	1.00
R0102:Dnah5	UTSW	15	28,245,897 (GRCm39)	splice site	probably benign
R0102:Dnah5	UTSW	15	28,245,897 (GRCm39)	splice site	probably benign
R0104:Dnah5	UTSW	15	28,453,499 (GRCm39)	missense	possibly damaging	0.88
R0112:Dnah5	UTSW	15	28,263,825 (GRCm39)	missense	probably benign	0.00
R0122:Dnah5	UTSW	15	28,378,509 (GRCm39)	missense	probably damaging	1.00
R0126:Dnah5	UTSW	15	28,246,465 (GRCm39)	missense	probably benign	0.00
R0127:Dnah5	UTSW	15	28,295,071 (GRCm39)	missense	probably damaging	1.00
R0233:Dnah5	UTSW	15	28,333,216 (GRCm39)	missense	probably damaging	1.00
R0310:Dnah5	UTSW	15	28,299,256 (GRCm39)	missense	probably benign	0.19
R0386:Dnah5	UTSW	15	28,383,727 (GRCm39)	missense	probably damaging	1.00
R0421:Dnah5	UTSW	15	28,229,687 (GRCm39)	missense	possibly damaging	0.79
R0481:Dnah5	UTSW	15	28,383,745 (GRCm39)	missense	probably benign	0.31
R0514:Dnah5	UTSW	15	28,366,467 (GRCm39)	missense	probably damaging	1.00
R0609:Dnah5	UTSW	15	28,327,925 (GRCm39)	missense	probably benign
R0720:Dnah5	UTSW	15	28,314,007 (GRCm39)	missense	probably null	0.98
R0731:Dnah5	UTSW	15	28,311,289 (GRCm39)	missense	possibly damaging	0.78
R0747:Dnah5	UTSW	15	28,444,333 (GRCm39)	missense	possibly damaging	0.64
R0747:Dnah5	UTSW	15	28,444,332 (GRCm39)	missense	probably damaging	0.99
R0766:Dnah5	UTSW	15	28,448,633 (GRCm39)	missense	probably null	0.89
R0849:Dnah5	UTSW	15	28,263,745 (GRCm39)	missense	probably damaging	0.96
R1034:Dnah5	UTSW	15	28,302,617 (GRCm39)	missense	probably damaging	1.00
R1084:Dnah5	UTSW	15	28,343,598 (GRCm39)	missense	probably benign	0.01
R1148:Dnah5	UTSW	15	28,421,836 (GRCm39)	missense	probably damaging	1.00
R1148:Dnah5	UTSW	15	28,421,836 (GRCm39)	missense	probably damaging	1.00
R1200:Dnah5	UTSW	15	28,246,403 (GRCm39)	missense	possibly damaging	0.88
R1208:Dnah5	UTSW	15	28,327,877 (GRCm39)	missense	probably damaging	1.00
R1208:Dnah5	UTSW	15	28,327,877 (GRCm39)	missense	probably damaging	1.00
R1269:Dnah5	UTSW	15	28,238,657 (GRCm39)	missense	probably damaging	1.00
R1373:Dnah5	UTSW	15	28,314,064 (GRCm39)	splice site	probably benign
R1401:Dnah5	UTSW	15	28,402,059 (GRCm39)	missense	probably damaging	1.00
R1413:Dnah5	UTSW	15	28,370,555 (GRCm39)	missense	probably benign
R1430:Dnah5	UTSW	15	28,346,003 (GRCm39)	missense	probably benign	0.37
R1457:Dnah5	UTSW	15	28,403,688 (GRCm39)	critical splice donor site	probably null
R1468:Dnah5	UTSW	15	28,230,609 (GRCm39)	nonsense	probably null
R1468:Dnah5	UTSW	15	28,230,609 (GRCm39)	nonsense	probably null
R1560:Dnah5	UTSW	15	28,420,149 (GRCm39)	missense	probably damaging	1.00
R1568:Dnah5	UTSW	15	28,409,323 (GRCm39)	missense	probably damaging	0.98
R1574:Dnah5	UTSW	15	28,252,569 (GRCm39)	missense	probably benign	0.00
R1574:Dnah5	UTSW	15	28,252,569 (GRCm39)	missense	probably benign	0.00
R1603:Dnah5	UTSW	15	28,449,326 (GRCm39)	missense	probably benign	0.09
R1603:Dnah5	UTSW	15	28,295,131 (GRCm39)	splice site	probably benign
R1673:Dnah5	UTSW	15	28,290,294 (GRCm39)	missense	probably benign
R1755:Dnah5	UTSW	15	28,326,782 (GRCm39)	missense	probably damaging	0.99
R1785:Dnah5	UTSW	15	28,313,932 (GRCm39)	missense	probably damaging	1.00
R1786:Dnah5	UTSW	15	28,313,932 (GRCm39)	missense	probably damaging	1.00
R1789:Dnah5	UTSW	15	28,270,572 (GRCm39)	missense	probably benign	0.00
R1817:Dnah5	UTSW	15	28,246,546 (GRCm39)	nonsense	probably null
R1819:Dnah5	UTSW	15	28,246,546 (GRCm39)	nonsense	probably null
R1834:Dnah5	UTSW	15	28,409,270 (GRCm39)	missense	probably benign	0.00
R1855:Dnah5	UTSW	15	28,411,815 (GRCm39)	missense	possibly damaging	0.88
R1870:Dnah5	UTSW	15	28,331,859 (GRCm39)	nonsense	probably null
R1871:Dnah5	UTSW	15	28,331,859 (GRCm39)	nonsense	probably null
R1987:Dnah5	UTSW	15	28,343,737 (GRCm39)	missense	probably damaging	0.99
R1988:Dnah5	UTSW	15	28,343,737 (GRCm39)	missense	probably damaging	0.99
R1989:Dnah5	UTSW	15	28,343,737 (GRCm39)	missense	probably damaging	0.99
R2062:Dnah5	UTSW	15	28,366,416 (GRCm39)	missense	probably damaging	1.00
R2069:Dnah5	UTSW	15	28,312,534 (GRCm39)	splice site	probably null
R2121:Dnah5	UTSW	15	28,297,151 (GRCm39)	splice site	probably benign
R2128:Dnah5	UTSW	15	28,408,467 (GRCm39)	missense	probably benign	0.00
R2129:Dnah5	UTSW	15	28,408,467 (GRCm39)	missense	probably benign	0.00
R2151:Dnah5	UTSW	15	28,444,237 (GRCm39)	missense	probably damaging	1.00
R2159:Dnah5	UTSW	15	28,252,691 (GRCm39)	missense	probably benign	0.00
R2207:Dnah5	UTSW	15	28,343,817 (GRCm39)	missense	probably benign	0.11
R2231:Dnah5	UTSW	15	28,408,563 (GRCm39)	critical splice donor site	probably null
R2232:Dnah5	UTSW	15	28,408,563 (GRCm39)	critical splice donor site	probably null
R2282:Dnah5	UTSW	15	28,327,448 (GRCm39)	missense	probably damaging	0.99
R2305:Dnah5	UTSW	15	28,387,913 (GRCm39)	missense	probably benign	0.25
R2339:Dnah5	UTSW	15	28,314,028 (GRCm39)	missense	probably benign	0.00
R2437:Dnah5	UTSW	15	28,307,537 (GRCm39)	critical splice donor site	probably null
R2696:Dnah5	UTSW	15	28,278,722 (GRCm39)	missense	probably benign	0.00
R3156:Dnah5	UTSW	15	28,438,237 (GRCm39)	splice site	probably benign
R3431:Dnah5	UTSW	15	28,295,413 (GRCm39)	missense	probably benign	0.20
R3700:Dnah5	UTSW	15	28,387,937 (GRCm39)	missense	possibly damaging	0.72
R3724:Dnah5	UTSW	15	28,270,566 (GRCm39)	missense	probably benign	0.08
R3732:Dnah5	UTSW	15	28,409,268 (GRCm39)	missense	possibly damaging	0.64
R3872:Dnah5	UTSW	15	28,411,656 (GRCm39)	missense	possibly damaging	0.50
R4063:Dnah5	UTSW	15	28,421,144 (GRCm39)	missense	probably damaging	0.98
R4072:Dnah5	UTSW	15	28,340,444 (GRCm39)	nonsense	probably null
R4075:Dnah5	UTSW	15	28,293,937 (GRCm39)	missense	probably benign
R4245:Dnah5	UTSW	15	28,219,335 (GRCm39)	missense	probably benign
R4254:Dnah5	UTSW	15	28,438,248 (GRCm39)	missense	probably benign	0.07
R4255:Dnah5	UTSW	15	28,438,248 (GRCm39)	missense	probably benign	0.07
R4392:Dnah5	UTSW	15	28,289,375 (GRCm39)	missense	probably benign	0.19
R4552:Dnah5	UTSW	15	28,397,300 (GRCm39)	missense	probably benign	0.19
R4574:Dnah5	UTSW	15	28,367,909 (GRCm39)	missense	probably benign	0.05
R4577:Dnah5	UTSW	15	28,289,396 (GRCm39)	missense	probably benign	0.06
R4587:Dnah5	UTSW	15	28,304,745 (GRCm39)	missense	probably damaging	1.00
R4631:Dnah5	UTSW	15	28,420,140 (GRCm39)	missense	probably damaging	1.00
R4631:Dnah5	UTSW	15	28,402,099 (GRCm39)	missense	probably damaging	1.00
R4676:Dnah5	UTSW	15	28,295,406 (GRCm39)	missense	possibly damaging	0.65
R4707:Dnah5	UTSW	15	28,372,521 (GRCm39)	missense	probably damaging	0.97
R4754:Dnah5	UTSW	15	28,421,101 (GRCm39)	splice site	probably null
R4767:Dnah5	UTSW	15	28,270,620 (GRCm39)	missense	probably benign	0.02
R4857:Dnah5	UTSW	15	28,345,953 (GRCm39)	missense	probably benign	0.00
R4883:Dnah5	UTSW	15	28,343,784 (GRCm39)	missense	probably benign	0.00
R4889:Dnah5	UTSW	15	28,235,938 (GRCm39)	missense	probably benign	0.01
R4946:Dnah5	UTSW	15	28,388,050 (GRCm39)	missense	probably damaging	1.00
R4946:Dnah5	UTSW	15	28,326,703 (GRCm39)	missense	probably damaging	0.96
R4947:Dnah5	UTSW	15	28,272,518 (GRCm39)	missense	probably benign
R5033:Dnah5	UTSW	15	28,421,824 (GRCm39)	missense	probably damaging	0.96
R5164:Dnah5	UTSW	15	28,408,438 (GRCm39)	missense	probably benign	0.00
R5175:Dnah5	UTSW	15	28,448,550 (GRCm39)	missense	probably damaging	1.00
R5182:Dnah5	UTSW	15	28,311,424 (GRCm39)	missense	probably damaging	0.99
R5187:Dnah5	UTSW	15	28,272,318 (GRCm39)	missense	probably benign	0.41
R5272:Dnah5	UTSW	15	28,350,811 (GRCm39)	missense	probably benign
R5308:Dnah5	UTSW	15	28,229,797 (GRCm39)	missense	possibly damaging	0.80
R5310:Dnah5	UTSW	15	28,311,474 (GRCm39)	missense	probably damaging	1.00
R5322:Dnah5	UTSW	15	28,384,390 (GRCm39)	missense	probably benign	0.41
R5398:Dnah5	UTSW	15	28,293,872 (GRCm39)	missense	probably benign
R5596:Dnah5	UTSW	15	28,343,754 (GRCm39)	missense	probably damaging	1.00
R5603:Dnah5	UTSW	15	28,420,078 (GRCm39)	missense	probably damaging	1.00
R5619:Dnah5	UTSW	15	28,302,581 (GRCm39)	missense	probably damaging	1.00
R5656:Dnah5	UTSW	15	28,421,210 (GRCm39)	missense	probably benign	0.03
R5741:Dnah5	UTSW	15	28,246,513 (GRCm39)	missense	probably benign	0.11
R5754:Dnah5	UTSW	15	28,402,014 (GRCm39)	missense	probably benign	0.01
R5763:Dnah5	UTSW	15	28,311,298 (GRCm39)	missense	probably damaging	1.00
R5824:Dnah5	UTSW	15	28,313,967 (GRCm39)	missense	probably benign	0.00
R5836:Dnah5	UTSW	15	28,383,738 (GRCm39)	missense	probably damaging	1.00
R5838:Dnah5	UTSW	15	28,290,341 (GRCm39)	missense	probably benign	0.00
R5864:Dnah5	UTSW	15	28,297,159 (GRCm39)	missense	possibly damaging	0.83
R5895:Dnah5	UTSW	15	28,234,599 (GRCm39)	splice site	probably null
R5896:Dnah5	UTSW	15	28,272,206 (GRCm39)	missense	probably benign
R5899:Dnah5	UTSW	15	28,448,513 (GRCm39)	missense	possibly damaging	0.95
R5905:Dnah5	UTSW	15	28,387,979 (GRCm39)	missense	probably damaging	1.00
R5924:Dnah5	UTSW	15	28,307,473 (GRCm39)	missense	probably benign	0.41
R5927:Dnah5	UTSW	15	28,335,864 (GRCm39)	missense	probably benign	0.00
R5929:Dnah5	UTSW	15	28,311,354 (GRCm39)	missense	probably damaging	1.00
R5929:Dnah5	UTSW	15	28,311,353 (GRCm39)	missense	probably benign	0.01
R5931:Dnah5	UTSW	15	28,453,425 (GRCm39)	missense	probably damaging	0.99
R5964:Dnah5	UTSW	15	28,458,730 (GRCm39)	missense	possibly damaging	0.49
R5975:Dnah5	UTSW	15	28,234,428 (GRCm39)	missense	probably damaging	1.00
R5993:Dnah5	UTSW	15	28,299,372 (GRCm39)	missense	probably benign	0.09
R6016:Dnah5	UTSW	15	28,328,030 (GRCm39)	missense	probably damaging	1.00
R6028:Dnah5	UTSW	15	28,387,979 (GRCm39)	missense	probably damaging	1.00
R6065:Dnah5	UTSW	15	28,230,614 (GRCm39)	missense	possibly damaging	0.47
R6117:Dnah5	UTSW	15	28,270,566 (GRCm39)	missense	probably damaging	0.99
R6143:Dnah5	UTSW	15	28,233,377 (GRCm39)	missense	probably benign	0.05
R6146:Dnah5	UTSW	15	28,459,331 (GRCm39)	missense	probably benign
R6154:Dnah5	UTSW	15	28,204,177 (GRCm39)	missense	probably benign	0.15
R6164:Dnah5	UTSW	15	28,378,489 (GRCm39)	missense	probably benign	0.08
R6266:Dnah5	UTSW	15	28,335,773 (GRCm39)	missense	possibly damaging	0.67
R6321:Dnah5	UTSW	15	28,372,557 (GRCm39)	missense	probably damaging	0.99
R6349:Dnah5	UTSW	15	28,238,657 (GRCm39)	missense	probably damaging	1.00
R6431:Dnah5	UTSW	15	28,349,970 (GRCm39)	missense	possibly damaging	0.52
R6467:Dnah5	UTSW	15	28,438,329 (GRCm39)	missense	probably benign	0.10
R6564:Dnah5	UTSW	15	28,367,891 (GRCm39)	missense	probably benign
R6607:Dnah5	UTSW	15	28,445,346 (GRCm39)	missense	possibly damaging	0.95
R6619:Dnah5	UTSW	15	28,409,266 (GRCm39)	missense	probably benign	0.03
R6633:Dnah5	UTSW	15	28,293,933 (GRCm39)	missense	probably benign	0.27
R6647:Dnah5	UTSW	15	28,403,633 (GRCm39)	missense	probably benign	0.02
R6782:Dnah5	UTSW	15	28,449,302 (GRCm39)	missense	possibly damaging	0.89
R6797:Dnah5	UTSW	15	28,233,384 (GRCm39)	nonsense	probably null
R6797:Dnah5	UTSW	15	28,451,609 (GRCm39)	missense	probably damaging	1.00
R6831:Dnah5	UTSW	15	28,411,661 (GRCm39)	missense	possibly damaging	0.88
R6849:Dnah5	UTSW	15	28,278,770 (GRCm39)	missense	probably benign	0.14
R6871:Dnah5	UTSW	15	28,229,786 (GRCm39)	missense	probably benign	0.32
R6936:Dnah5	UTSW	15	28,409,414 (GRCm39)	missense	probably damaging	1.00
R6943:Dnah5	UTSW	15	28,235,866 (GRCm39)	missense	probably damaging	1.00
R7030:Dnah5	UTSW	15	28,333,208 (GRCm39)	missense	probably benign	0.00
R7030:Dnah5	UTSW	15	28,238,738 (GRCm39)	missense	probably benign
R7063:Dnah5	UTSW	15	28,233,394 (GRCm39)	missense	probably benign	0.00
R7094:Dnah5	UTSW	15	28,453,482 (GRCm39)	missense	probably damaging	0.98
R7097:Dnah5	UTSW	15	28,453,410 (GRCm39)	missense	probably benign	0.00
R7126:Dnah5	UTSW	15	28,349,983 (GRCm39)	missense	probably benign	0.03
R7153:Dnah5	UTSW	15	28,365,668 (GRCm39)	splice site	probably null
R7209:Dnah5	UTSW	15	28,459,371 (GRCm39)	missense	possibly damaging	0.71
R7276:Dnah5	UTSW	15	28,367,984 (GRCm39)	missense	probably damaging	1.00
R7320:Dnah5	UTSW	15	28,270,616 (GRCm39)	missense	probably null	0.33
R7350:Dnah5	UTSW	15	28,235,965 (GRCm39)	critical splice donor site	probably null
R7380:Dnah5	UTSW	15	28,370,524 (GRCm39)	missense	probably damaging	1.00
R7438:Dnah5	UTSW	15	28,347,098 (GRCm39)	missense	probably damaging	0.99
R7499:Dnah5	UTSW	15	28,302,596 (GRCm39)	missense	probably damaging	1.00
R7513:Dnah5	UTSW	15	28,370,561 (GRCm39)	missense	probably benign
R7519:Dnah5	UTSW	15	28,390,629 (GRCm39)	missense	probably damaging	0.98
R7524:Dnah5	UTSW	15	28,297,212 (GRCm39)	missense	possibly damaging	0.50
R7556:Dnah5	UTSW	15	28,290,389 (GRCm39)	missense	probably null	0.43
R7570:Dnah5	UTSW	15	28,347,098 (GRCm39)	missense	probably damaging	1.00
R7585:Dnah5	UTSW	15	28,402,014 (GRCm39)	missense	probably benign	0.09
R7642:Dnah5	UTSW	15	28,248,125 (GRCm39)	critical splice donor site	probably null
R7670:Dnah5	UTSW	15	28,246,378 (GRCm39)	splice site	probably null
R7763:Dnah5	UTSW	15	28,314,001 (GRCm39)	missense	probably damaging	1.00
R7821:Dnah5	UTSW	15	28,411,678 (GRCm39)	missense	possibly damaging	0.89
R7826:Dnah5	UTSW	15	28,367,958 (GRCm39)	missense	probably damaging	1.00
R7872:Dnah5	UTSW	15	28,245,830 (GRCm39)	missense	probably damaging	0.99
R7889:Dnah5	UTSW	15	28,448,560 (GRCm39)	nonsense	probably null
R7919:Dnah5	UTSW	15	28,350,742 (GRCm39)	missense	probably damaging	1.00
R7920:Dnah5	UTSW	15	28,453,368 (GRCm39)	missense	probably benign	0.00
R7936:Dnah5	UTSW	15	28,345,983 (GRCm39)	missense	possibly damaging	0.64
R7996:Dnah5	UTSW	15	28,409,323 (GRCm39)	missense	probably damaging	0.98
R8063:Dnah5	UTSW	15	28,230,729 (GRCm39)	missense	probably benign
R8084:Dnah5	UTSW	15	28,388,099 (GRCm39)	missense	probably damaging	1.00
R8105:Dnah5	UTSW	15	28,372,548 (GRCm39)	missense	probably benign
R8114:Dnah5	UTSW	15	28,240,122 (GRCm39)	missense	probably benign	0.01
R8142:Dnah5	UTSW	15	28,384,519 (GRCm39)	missense	probably benign	0.36
R8153:Dnah5	UTSW	15	28,384,576 (GRCm39)	missense	probably damaging	1.00
R8161:Dnah5	UTSW	15	28,350,850 (GRCm39)	missense	possibly damaging	0.79
R8174:Dnah5	UTSW	15	28,311,279 (GRCm39)	splice site	probably null
R8187:Dnah5	UTSW	15	28,384,355 (GRCm39)	missense	probably damaging	1.00
R8194:Dnah5	UTSW	15	28,453,414 (GRCm39)	missense	probably damaging	0.99
R8280:Dnah5	UTSW	15	28,408,538 (GRCm39)	missense	probably benign	0.01
R8291:Dnah5	UTSW	15	28,263,743 (GRCm39)	missense	probably benign	0.03
R8324:Dnah5	UTSW	15	28,347,011 (GRCm39)	missense	probably damaging	1.00
R8347:Dnah5	UTSW	15	28,236,812 (GRCm39)	missense	possibly damaging	0.90
R8356:Dnah5	UTSW	15	28,444,313 (GRCm39)	missense	probably benign	0.03
R8356:Dnah5	UTSW	15	28,444,469 (GRCm39)	missense	probably null	0.02
R8361:Dnah5	UTSW	15	28,331,956 (GRCm39)	missense	probably damaging	0.98
R8375:Dnah5	UTSW	15	28,327,489 (GRCm39)	missense	probably benign	0.00
R8474:Dnah5	UTSW	15	28,247,978 (GRCm39)	missense	probably benign	0.00
R8481:Dnah5	UTSW	15	28,419,941 (GRCm39)	missense	probably benign	0.00
R8494:Dnah5	UTSW	15	28,345,977 (GRCm39)	missense	probably benign	0.32
R8495:Dnah5	UTSW	15	28,409,414 (GRCm39)	missense	probably damaging	0.97
R8519:Dnah5	UTSW	15	28,299,245 (GRCm39)	missense	probably benign	0.07
R8683:Dnah5	UTSW	15	28,289,367 (GRCm39)	missense	probably benign	0.00
R8739:Dnah5	UTSW	15	28,346,006 (GRCm39)	missense	probably benign	0.01
R8752:Dnah5	UTSW	15	28,290,365 (GRCm39)	missense	probably benign	0.00
R8784:Dnah5	UTSW	15	28,388,097 (GRCm39)	missense	probably benign	0.16
R8813:Dnah5	UTSW	15	28,229,719 (GRCm39)	missense	probably damaging	1.00
R8862:Dnah5	UTSW	15	28,459,502 (GRCm39)	splice site	probably benign
R8873:Dnah5	UTSW	15	28,219,334 (GRCm39)	missense	probably benign
R8885:Dnah5	UTSW	15	28,327,886 (GRCm39)	missense	probably damaging	1.00
R8901:Dnah5	UTSW	15	28,365,715 (GRCm39)	missense	possibly damaging	0.76
R9025:Dnah5	UTSW	15	28,409,412 (GRCm39)	missense	probably damaging	1.00
R9037:Dnah5	UTSW	15	28,248,104 (GRCm39)	missense	probably benign	0.05
R9057:Dnah5	UTSW	15	28,391,014 (GRCm39)	missense	probably damaging	1.00
R9059:Dnah5	UTSW	15	28,245,812 (GRCm39)	missense	probably benign
R9065:Dnah5	UTSW	15	28,293,936 (GRCm39)	missense	probably benign	0.09
R9098:Dnah5	UTSW	15	28,420,107 (GRCm39)	missense
R9118:Dnah5	UTSW	15	28,401,994 (GRCm39)	frame shift	probably null
R9149:Dnah5	UTSW	15	28,387,914 (GRCm39)	missense	probably benign	0.00
R9184:Dnah5	UTSW	15	28,340,552 (GRCm39)	missense	probably benign	0.13
R9205:Dnah5	UTSW	15	28,448,480 (GRCm39)	missense	possibly damaging	0.88
R9297:Dnah5	UTSW	15	28,204,054 (GRCm39)	start gained	probably benign
R9302:Dnah5	UTSW	15	28,240,032 (GRCm39)	missense	probably benign	0.03
R9310:Dnah5	UTSW	15	28,448,579 (GRCm39)	missense	probably damaging	1.00
R9318:Dnah5	UTSW	15	28,204,054 (GRCm39)	start gained	probably benign
R9405:Dnah5	UTSW	15	28,272,306 (GRCm39)	missense	probably benign
R9424:Dnah5	UTSW	15	28,272,286 (GRCm39)	missense	probably benign	0.01
R9467:Dnah5	UTSW	15	28,366,293 (GRCm39)	missense	possibly damaging	0.94
R9469:Dnah5	UTSW	15	28,421,146 (GRCm39)	missense	probably benign	0.06
R9548:Dnah5	UTSW	15	28,328,025 (GRCm39)	missense	possibly damaging	0.79
R9564:Dnah5	UTSW	15	28,290,422 (GRCm39)	missense	probably benign	0.04
R9576:Dnah5	UTSW	15	28,272,286 (GRCm39)	missense	probably benign	0.01
R9593:Dnah5	UTSW	15	28,236,774 (GRCm39)	missense	probably benign
R9644:Dnah5	UTSW	15	28,230,650 (GRCm39)	missense	probably damaging	0.98
R9655:Dnah5	UTSW	15	28,242,900 (GRCm39)	missense	probably benign
R9657:Dnah5	UTSW	15	28,410,089 (GRCm39)	missense	probably damaging	1.00
R9704:Dnah5	UTSW	15	28,247,965 (GRCm39)	missense	probably benign	0.00
R9797:Dnah5	UTSW	15	28,233,316 (GRCm39)	missense	probably benign	0.34
RF009:Dnah5	UTSW	15	28,204,165 (GRCm39)	missense	probably benign	0.00
X0011:Dnah5	UTSW	15	28,408,527 (GRCm39)	missense	probably benign	0.16
X0018:Dnah5	UTSW	15	28,269,500 (GRCm39)	missense	probably benign	0.00
X0022:Dnah5	UTSW	15	28,270,557 (GRCm39)	missense	probably benign	0.01
X0023:Dnah5	UTSW	15	28,384,454 (GRCm39)	missense	probably damaging	0.99
X0028:Dnah5	UTSW	15	28,470,623 (GRCm39)	missense	probably damaging	1.00
Z1088:Dnah5	UTSW	15	28,366,503 (GRCm39)	missense	probably null	0.10
Z1088:Dnah5	UTSW	15	28,384,376 (GRCm39)	missense	probably damaging	1.00
Z1177:Dnah5	UTSW	15	28,295,457 (GRCm39)	missense	probably damaging	0.98
Z1177:Dnah5	UTSW	15	28,270,549 (GRCm39)	missense	probably benign	0.00
Z1177:Dnah5	UTSW	15	28,270,500 (GRCm39)	missense	probably benign	0.32
Z1177:Dnah5	UTSW	15	28,387,909 (GRCm39)	missense	possibly damaging	0.72

Predicted Primers

PCR Primer
(F):5'- TCTGCATCACCAACAAGTTTG -3'
(R):5'- TGCAGACTGAATCAAATTGCCC -3'

Sequencing Primer
(F):5'- AGTGCCTTTGGGATGCCC -3'
(R):5'- AATTGCCCTGTAGCCTAAGCATG -3'

Posted On

2019-05-13