Incidental Mutation 'R7033:Dusp10'
ID 546423
Institutional Source Beutler Lab
Gene Symbol Dusp10
Ensembl Gene ENSMUSG00000039384
Gene Name dual specificity phosphatase 10
Synonyms MKP5, 2610306G15Rik, MKP-5
MMRRC Submission 045134-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.734) question?
Stock # R7033 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 183766575-183807833 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 183769802 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 256 (V256A)
Ref Sequence ENSEMBL: ENSMUSP00000045838 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048655] [ENSMUST00000050306] [ENSMUST00000139839]
AlphaFold Q9ESS0
Predicted Effect possibly damaging
Transcript: ENSMUST00000048655
AA Change: V256A

PolyPhen 2 Score 0.940 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000045838
Gene: ENSMUSG00000039384
AA Change: V256A

DomainStartEndE-ValueType
low complexity region 33 59 N/A INTRINSIC
low complexity region 92 111 N/A INTRINSIC
low complexity region 124 142 N/A INTRINSIC
RHOD 159 283 1.71e-11 SMART
DSPc 322 462 1.43e-54 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000050306
SMART Domains Protein: ENSMUSP00000055787
Gene: ENSMUSG00000044854

DomainStartEndE-ValueType
SCOP:d1howa_ 12 46 7e-3 SMART
low complexity region 81 115 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000139839
SMART Domains Protein: ENSMUSP00000121433
Gene: ENSMUSG00000039384

DomainStartEndE-ValueType
low complexity region 33 59 N/A INTRINSIC
low complexity region 92 111 N/A INTRINSIC
low complexity region 124 142 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.8%
Validation Efficiency 96% (70/73)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
PHENOTYPE: Mice homozygous for a knock-out allele display alterations in both innate and adaptive immune responses. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700024B05Rik A G 14: 41,819,374 (GRCm39) Y105C probably damaging Het
Acr T C 15: 89,453,703 (GRCm39) S81P probably benign Het
Akr1c14 T C 13: 4,129,178 (GRCm39) probably null Het
Ank2 C A 3: 126,738,499 (GRCm39) E2375* probably null Het
Avpi1 A G 19: 42,113,416 (GRCm39) W14R probably damaging Het
Brd4 A G 17: 32,417,989 (GRCm39) V55A probably benign Het
Casp8ap2 A G 4: 32,639,392 (GRCm39) N149D probably damaging Het
Ccl25 A T 8: 4,399,641 (GRCm39) probably benign Het
Celf5 A G 10: 81,298,548 (GRCm39) L299P probably damaging Het
Cfap418 A G 4: 10,898,014 (GRCm39) T199A probably benign Het
Cfap57 T G 4: 118,470,323 (GRCm39) T186P possibly damaging Het
Chrm4 A G 2: 91,758,692 (GRCm39) M367V probably benign Het
Col1a2 A T 6: 4,516,904 (GRCm39) probably benign Het
Crybg3 G A 16: 59,374,528 (GRCm39) P2242L probably damaging Het
Cspg4 T C 9: 56,795,358 (GRCm39) V1031A probably damaging Het
Dbnl C A 11: 5,748,102 (GRCm39) P313T probably benign Het
Dnah1 A G 14: 30,986,882 (GRCm39) F3637L probably damaging Het
Dnah7a A T 1: 53,518,820 (GRCm39) I2979N probably damaging Het
Dync2i1 T C 12: 116,175,511 (GRCm39) M889V probably benign Het
Erlin2 T C 8: 27,521,792 (GRCm39) V164A probably benign Het
Fam110a T C 2: 151,812,131 (GRCm39) D213G probably damaging Het
Fkbp1a T C 2: 151,399,420 (GRCm39) probably null Het
Foxg1 G A 12: 49,431,503 (GRCm39) probably benign Het
Gm12185 T C 11: 48,806,826 (GRCm39) S122G probably benign Het
Gm2042 A T 12: 87,927,051 (GRCm39) D456V probably damaging Het
Grin2b A G 6: 135,900,036 (GRCm39) Y282H probably damaging Het
Gys2 T C 6: 142,418,448 (GRCm39) D27G probably benign Het
H2-DMa T A 17: 34,355,971 (GRCm39) probably null Het
Hectd4 T A 5: 121,502,631 (GRCm39) I4245N possibly damaging Het
Incenp A G 19: 9,870,736 (GRCm39) Y298H unknown Het
Ints2 C T 11: 86,123,911 (GRCm39) G626R probably damaging Het
Kifc1 A T 17: 34,102,671 (GRCm39) V314E probably damaging Het
Lurap1l C T 4: 80,829,604 (GRCm39) P5S probably benign Het
Mtmr11 A G 3: 96,077,262 (GRCm39) Y540C probably damaging Het
Muc4 C A 16: 32,576,698 (GRCm39) probably benign Het
Myh13 A G 11: 67,260,142 (GRCm39) E1860G possibly damaging Het
Myl10 G C 5: 136,726,825 (GRCm39) V70L probably benign Het
Nbeal1 G A 1: 60,350,106 (GRCm39) G2385D probably damaging Het
Ncaph2 G A 15: 89,255,559 (GRCm39) A578T probably benign Het
Ncr1 T C 7: 4,341,144 (GRCm39) V8A possibly damaging Het
Nutm1 T C 2: 112,086,513 (GRCm39) T73A probably damaging Het
Olfm1 G A 2: 28,119,348 (GRCm39) D313N probably damaging Het
Or11h4 A G 14: 50,974,164 (GRCm39) F152L possibly damaging Het
Or13f5 A G 4: 52,826,089 (GRCm39) M231V probably benign Het
Or4a66 T A 2: 88,531,164 (GRCm39) N170Y probably damaging Het
Otog T A 7: 45,916,822 (GRCm39) probably null Het
Peak1 G T 9: 56,166,991 (GRCm39) D312E probably damaging Het
Plekhg1 T C 10: 3,890,251 (GRCm39) I331T probably damaging Het
Polr1b T C 2: 128,957,562 (GRCm39) V539A possibly damaging Het
Polr2a A T 11: 69,638,039 (GRCm39) H143Q possibly damaging Het
Ppargc1b G T 18: 61,440,785 (GRCm39) A711D probably damaging Het
Prnd T A 2: 131,795,362 (GRCm39) C161S possibly damaging Het
Prrt4 A G 6: 29,171,147 (GRCm39) L435P possibly damaging Het
Psen2 C T 1: 180,055,085 (GRCm39) probably null Het
Psg23 T C 7: 18,348,669 (GRCm39) E46G possibly damaging Het
Rasgef1b C T 5: 99,380,195 (GRCm39) R350H probably damaging Het
Rfxank G C 8: 70,590,820 (GRCm39) P16A probably benign Het
Sema6a A G 18: 47,381,637 (GRCm39) I944T probably damaging Het
Serpinc1 A G 1: 160,825,091 (GRCm39) T313A probably benign Het
Slc27a4 T C 2: 29,694,283 (GRCm39) S36P possibly damaging Het
Slc36a1 C A 11: 55,114,563 (GRCm39) R214S probably benign Het
Sorl1 C T 9: 41,942,279 (GRCm39) S982N possibly damaging Het
Speer1k G T 5: 11,000,518 (GRCm39) probably null Het
Syt1 A C 10: 108,526,797 (GRCm39) D37E probably benign Het
Tcl1b5 A T 12: 105,142,750 (GRCm39) D26V probably damaging Het
Tenm4 A T 7: 96,544,430 (GRCm39) K2149* probably null Het
Ubc T A 5: 125,465,238 (GRCm39) I30F probably damaging Het
Ugt1a7c A T 1: 88,023,250 (GRCm39) E136D possibly damaging Het
Utp20 A G 10: 88,590,337 (GRCm39) probably null Het
Vmn1r159 C T 7: 22,542,289 (GRCm39) V248I probably damaging Het
Vmn2r105 T C 17: 20,428,874 (GRCm39) H734R probably damaging Het
Xrcc2 T G 5: 25,897,707 (GRCm39) I81L possibly damaging Het
Zfat A C 15: 68,052,864 (GRCm39) I310S probably damaging Het
Zfp119a A G 17: 56,173,009 (GRCm39) V278A probably benign Het
Zfp53 A G 17: 21,720,508 (GRCm39) K33E probably benign Het
Zfp866 G T 8: 70,218,491 (GRCm39) H376Q probably damaging Het
Other mutations in Dusp10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00335:Dusp10 APN 1 183,801,328 (GRCm39) missense probably benign 0.00
IGL01094:Dusp10 APN 1 183,769,697 (GRCm39) splice site probably null
IGL01380:Dusp10 APN 1 183,801,211 (GRCm39) missense possibly damaging 0.93
FR4449:Dusp10 UTSW 1 183,769,253 (GRCm39) missense probably damaging 1.00
FR4548:Dusp10 UTSW 1 183,769,253 (GRCm39) missense probably damaging 1.00
FR4737:Dusp10 UTSW 1 183,769,253 (GRCm39) missense probably damaging 1.00
FR4976:Dusp10 UTSW 1 183,769,253 (GRCm39) missense probably damaging 1.00
LCD18:Dusp10 UTSW 1 183,769,253 (GRCm39) missense probably damaging 1.00
R0369:Dusp10 UTSW 1 183,801,253 (GRCm39) missense probably damaging 1.00
R0433:Dusp10 UTSW 1 183,801,393 (GRCm39) missense probably damaging 1.00
R0464:Dusp10 UTSW 1 183,801,273 (GRCm39) missense probably benign 0.01
R1112:Dusp10 UTSW 1 183,769,097 (GRCm39) missense probably damaging 0.98
R1474:Dusp10 UTSW 1 183,769,645 (GRCm39) splice site probably null
R1667:Dusp10 UTSW 1 183,769,055 (GRCm39) missense probably damaging 1.00
R1719:Dusp10 UTSW 1 183,769,422 (GRCm39) missense probably benign 0.22
R1899:Dusp10 UTSW 1 183,801,377 (GRCm39) missense possibly damaging 0.64
R5238:Dusp10 UTSW 1 183,769,210 (GRCm39) missense possibly damaging 0.94
R5277:Dusp10 UTSW 1 183,769,204 (GRCm39) missense possibly damaging 0.94
R5742:Dusp10 UTSW 1 183,769,853 (GRCm39) splice site probably null
R5948:Dusp10 UTSW 1 183,801,073 (GRCm39) missense probably benign
R6890:Dusp10 UTSW 1 183,801,393 (GRCm39) missense probably damaging 1.00
R6969:Dusp10 UTSW 1 183,801,085 (GRCm39) missense probably damaging 1.00
R7007:Dusp10 UTSW 1 183,769,414 (GRCm39) missense probably benign 0.22
R7436:Dusp10 UTSW 1 183,801,418 (GRCm39) missense probably damaging 1.00
R7447:Dusp10 UTSW 1 183,801,153 (GRCm39) missense probably benign
R7479:Dusp10 UTSW 1 183,769,617 (GRCm39) missense probably damaging 0.99
R7572:Dusp10 UTSW 1 183,806,506 (GRCm39) missense probably damaging 1.00
R8191:Dusp10 UTSW 1 183,769,749 (GRCm39) missense possibly damaging 0.89
R8201:Dusp10 UTSW 1 183,769,202 (GRCm39) missense possibly damaging 0.51
R9429:Dusp10 UTSW 1 183,801,091 (GRCm39) missense probably benign 0.01
R9466:Dusp10 UTSW 1 183,769,234 (GRCm39) missense probably damaging 1.00
R9593:Dusp10 UTSW 1 183,806,643 (GRCm39) missense probably damaging 0.99
Z1177:Dusp10 UTSW 1 183,801,189 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GCAGGCCTTTCATGGAGTAC -3'
(R):5'- CTTGGGGTTAGAAGAAGGCTGC -3'

Sequencing Primer
(F):5'- AGGAGCTGTCCACATTAACTG -3'
(R):5'- GGCTGCCACTTGTAAGAGAATCTC -3'
Posted On 2019-05-13