Incidental Mutation 'R7036:Kmt2e'
| ID |
546672 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kmt2e
|
| Ensembl Gene |
ENSMUSG00000029004 |
| Gene Name |
lysine (K)-specific methyltransferase 2E |
| Synonyms |
9530077A04Rik, 1810033J14Rik, D230038D11Rik, Mll5 |
| MMRRC Submission |
045012-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7036 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
23639439-23709233 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 23683741 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 333
(E333G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000110781
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094962]
[ENSMUST00000115128]
[ENSMUST00000196889]
|
| AlphaFold |
Q3UG20 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000094962
AA Change: E333G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000092569
Gene: ENSMUSG00000029004
AA Change: E333G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
38 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
55 |
N/A |
INTRINSIC |
|
low complexity region
|
70 |
81 |
N/A |
INTRINSIC |
|
low complexity region
|
100 |
109 |
N/A |
INTRINSIC |
|
PHD
|
120 |
164 |
4.25e-8 |
SMART |
|
SET
|
328 |
453 |
2.13e-26 |
SMART |
|
low complexity region
|
487 |
503 |
N/A |
INTRINSIC |
|
low complexity region
|
569 |
582 |
N/A |
INTRINSIC |
|
low complexity region
|
854 |
867 |
N/A |
INTRINSIC |
|
low complexity region
|
882 |
908 |
N/A |
INTRINSIC |
|
low complexity region
|
933 |
945 |
N/A |
INTRINSIC |
|
low complexity region
|
951 |
960 |
N/A |
INTRINSIC |
|
low complexity region
|
1184 |
1197 |
N/A |
INTRINSIC |
|
low complexity region
|
1214 |
1237 |
N/A |
INTRINSIC |
|
low complexity region
|
1294 |
1312 |
N/A |
INTRINSIC |
|
low complexity region
|
1348 |
1367 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1434 |
1496 |
6.13e-7 |
PROSPERO |
|
low complexity region
|
1506 |
1518 |
N/A |
INTRINSIC |
|
low complexity region
|
1625 |
1641 |
N/A |
INTRINSIC |
|
low complexity region
|
1677 |
1705 |
N/A |
INTRINSIC |
|
low complexity region
|
1720 |
1731 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1783 |
1842 |
6.13e-7 |
PROSPERO |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000115128
AA Change: E333G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000110781
Gene: ENSMUSG00000029004
AA Change: E333G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
38 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
55 |
N/A |
INTRINSIC |
|
low complexity region
|
70 |
81 |
N/A |
INTRINSIC |
|
low complexity region
|
100 |
109 |
N/A |
INTRINSIC |
|
PHD
|
120 |
164 |
4.25e-8 |
SMART |
|
SET
|
328 |
453 |
2.13e-26 |
SMART |
|
low complexity region
|
487 |
503 |
N/A |
INTRINSIC |
|
low complexity region
|
569 |
582 |
N/A |
INTRINSIC |
|
low complexity region
|
854 |
867 |
N/A |
INTRINSIC |
|
low complexity region
|
882 |
908 |
N/A |
INTRINSIC |
|
low complexity region
|
933 |
945 |
N/A |
INTRINSIC |
|
low complexity region
|
951 |
960 |
N/A |
INTRINSIC |
|
low complexity region
|
1184 |
1197 |
N/A |
INTRINSIC |
|
low complexity region
|
1214 |
1237 |
N/A |
INTRINSIC |
|
low complexity region
|
1294 |
1312 |
N/A |
INTRINSIC |
|
low complexity region
|
1348 |
1367 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1434 |
1496 |
6.13e-7 |
PROSPERO |
|
low complexity region
|
1506 |
1518 |
N/A |
INTRINSIC |
|
low complexity region
|
1625 |
1641 |
N/A |
INTRINSIC |
|
low complexity region
|
1677 |
1705 |
N/A |
INTRINSIC |
|
low complexity region
|
1720 |
1731 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1783 |
1842 |
6.13e-7 |
PROSPERO |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000196889
AA Change: E333G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000142568
Gene: ENSMUSG00000029004
AA Change: E333G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
38 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
55 |
N/A |
INTRINSIC |
|
low complexity region
|
70 |
81 |
N/A |
INTRINSIC |
|
low complexity region
|
100 |
109 |
N/A |
INTRINSIC |
|
PHD
|
120 |
164 |
2.7e-10 |
SMART |
|
Blast:SET
|
216 |
327 |
6e-61 |
BLAST |
|
Blast:SET
|
328 |
377 |
3e-26 |
BLAST |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit neonatal and postnatal lethality, reduced fertility and growth, and abnormal lymphopoiesis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700017N19Rik |
T |
A |
10: 100,445,118 (GRCm39) |
|
probably null |
Het |
| Ahnak2 |
A |
G |
12: 112,745,216 (GRCm39) |
|
probably benign |
Het |
| Akt2 |
T |
C |
7: 27,336,437 (GRCm39) |
|
probably null |
Het |
| Aldh1a7 |
A |
T |
19: 20,685,542 (GRCm39) |
L336Q |
possibly damaging |
Het |
| Ank2 |
T |
C |
3: 126,740,041 (GRCm39) |
|
probably benign |
Het |
| Ank3 |
C |
T |
10: 69,835,209 (GRCm39) |
T680M |
probably damaging |
Het |
| Apeh |
T |
C |
9: 107,971,470 (GRCm39) |
E59G |
possibly damaging |
Het |
| Arl8a |
G |
C |
1: 135,082,206 (GRCm39) |
E145Q |
probably benign |
Het |
| Armc8 |
C |
T |
9: 99,366,018 (GRCm39) |
|
probably null |
Het |
| Armh3 |
A |
G |
19: 45,953,688 (GRCm39) |
I195T |
probably damaging |
Het |
| Arsj |
T |
C |
3: 126,158,649 (GRCm39) |
L76P |
probably damaging |
Het |
| Atp2b1 |
C |
T |
10: 98,823,172 (GRCm39) |
T244I |
probably damaging |
Het |
| Bcl6 |
A |
T |
16: 23,793,611 (GRCm39) |
L112Q |
probably damaging |
Het |
| Bfsp1 |
T |
A |
2: 143,668,843 (GRCm39) |
T579S |
possibly damaging |
Het |
| Btaf1 |
C |
A |
19: 36,981,869 (GRCm39) |
T1633K |
probably benign |
Het |
| Cacng8 |
A |
G |
7: 3,463,819 (GRCm39) |
S324G |
probably benign |
Het |
| Cd2ap |
A |
T |
17: 43,109,490 (GRCm39) |
L623Q |
probably damaging |
Het |
| Cerkl |
T |
C |
2: 79,171,722 (GRCm39) |
I379V |
probably benign |
Het |
| Cndp2 |
T |
A |
18: 84,688,070 (GRCm39) |
H307L |
possibly damaging |
Het |
| Derl1 |
A |
G |
15: 57,742,443 (GRCm39) |
|
probably null |
Het |
| Dixdc1 |
T |
A |
9: 50,593,864 (GRCm39) |
R254S |
probably benign |
Het |
| Dop1b |
T |
A |
16: 93,574,378 (GRCm39) |
D30E |
probably benign |
Het |
| Duox2 |
T |
G |
2: 122,110,934 (GRCm39) |
H1513P |
probably damaging |
Het |
| Dyrk1a |
G |
A |
16: 94,487,427 (GRCm39) |
V546I |
probably benign |
Het |
| E130308A19Rik |
A |
C |
4: 59,719,991 (GRCm39) |
K508Q |
probably damaging |
Het |
| Emc8 |
A |
T |
8: 121,385,790 (GRCm39) |
V108E |
probably benign |
Het |
| Epb41l1 |
A |
G |
2: 156,371,322 (GRCm39) |
T720A |
probably benign |
Het |
| Fcgr4 |
T |
A |
1: 170,847,657 (GRCm39) |
M85K |
probably benign |
Het |
| Fem1b |
T |
A |
9: 62,704,310 (GRCm39) |
I317F |
probably damaging |
Het |
| Focad |
A |
G |
4: 88,042,874 (GRCm39) |
E36G |
probably benign |
Het |
| Fryl |
C |
T |
5: 73,212,951 (GRCm39) |
E2275K |
probably benign |
Het |
| Galnt11 |
T |
C |
5: 25,463,811 (GRCm39) |
I361T |
probably damaging |
Het |
| Garin3 |
G |
A |
11: 46,298,235 (GRCm39) |
S513N |
|
Het |
| Gatad2a |
A |
T |
8: 70,370,644 (GRCm39) |
N114K |
probably damaging |
Het |
| Gcnt2 |
CTAATG |
C |
13: 41,041,032 (GRCm39) |
|
probably null |
Het |
| Gramd1a |
A |
G |
7: 30,832,181 (GRCm39) |
|
probably null |
Het |
| Gsn |
T |
A |
2: 35,182,611 (GRCm39) |
W187R |
probably damaging |
Het |
| Hoxc12 |
G |
A |
15: 102,846,795 (GRCm39) |
G229D |
probably damaging |
Het |
| Hycc2 |
T |
A |
1: 58,574,696 (GRCm39) |
M282L |
probably benign |
Het |
| Ints14 |
T |
C |
9: 64,871,827 (GRCm39) |
V55A |
probably benign |
Het |
| Itga9 |
T |
C |
9: 118,527,433 (GRCm39) |
L528P |
probably benign |
Het |
| Klf1 |
C |
T |
8: 85,629,379 (GRCm39) |
S68F |
possibly damaging |
Het |
| Krt39 |
A |
C |
11: 99,412,062 (GRCm39) |
V8G |
probably benign |
Het |
| Krt71 |
A |
G |
15: 101,646,772 (GRCm39) |
I312T |
probably benign |
Het |
| Lrp1b |
T |
C |
2: 41,002,354 (GRCm39) |
D2001G |
possibly damaging |
Het |
| Lrrc37 |
T |
A |
11: 103,506,638 (GRCm39) |
|
probably benign |
Het |
| Lrrc71 |
T |
C |
3: 87,655,693 (GRCm39) |
T27A |
probably benign |
Het |
| Lrrcc1 |
T |
C |
3: 14,628,069 (GRCm39) |
V958A |
possibly damaging |
Het |
| Med15 |
A |
T |
16: 17,516,019 (GRCm39) |
M1K |
probably null |
Het |
| Mrgpra3 |
G |
T |
7: 47,239,838 (GRCm39) |
N29K |
possibly damaging |
Het |
| Myl1 |
T |
C |
1: 66,969,395 (GRCm39) |
N79S |
probably damaging |
Het |
| Naip2 |
A |
T |
13: 100,291,529 (GRCm39) |
D1136E |
probably benign |
Het |
| Nat10 |
T |
C |
2: 103,584,453 (GRCm39) |
N108S |
probably benign |
Het |
| Ncald |
A |
T |
15: 37,369,122 (GRCm39) |
S178T |
probably benign |
Het |
| Ndufs2 |
T |
C |
1: 171,065,877 (GRCm39) |
D256G |
probably benign |
Het |
| Nek5 |
T |
C |
8: 22,597,739 (GRCm39) |
N280S |
probably benign |
Het |
| Or5ak25 |
A |
G |
2: 85,268,774 (GRCm39) |
S243P |
probably damaging |
Het |
| Or5d39 |
T |
A |
2: 87,979,469 (GRCm39) |
D298V |
probably damaging |
Het |
| Parp1 |
G |
T |
1: 180,425,817 (GRCm39) |
K849N |
possibly damaging |
Het |
| Pcdhb4 |
T |
A |
18: 37,441,835 (GRCm39) |
C382S |
possibly damaging |
Het |
| Plce1 |
A |
G |
19: 38,727,801 (GRCm39) |
N1520S |
probably damaging |
Het |
| Plcg2 |
G |
A |
8: 118,323,045 (GRCm39) |
R700H |
probably benign |
Het |
| Popdc2 |
A |
T |
16: 38,183,173 (GRCm39) |
Y52F |
probably damaging |
Het |
| Prrx1 |
T |
A |
1: 163,075,907 (GRCm39) |
M220L |
probably benign |
Het |
| Pspc1 |
A |
C |
14: 56,996,085 (GRCm39) |
|
probably null |
Het |
| Ptchd1 |
T |
A |
X: 154,357,708 (GRCm39) |
Y499F |
probably damaging |
Het |
| Ptpn20 |
A |
G |
14: 33,336,392 (GRCm39) |
*44W |
probably null |
Het |
| Qars1 |
T |
A |
9: 108,391,976 (GRCm39) |
V83E |
probably damaging |
Het |
| Rrh |
T |
C |
3: 129,609,342 (GRCm39) |
E55G |
possibly damaging |
Het |
| Sash1 |
C |
A |
10: 8,605,847 (GRCm39) |
E848* |
probably null |
Het |
| Sds |
A |
T |
5: 120,618,912 (GRCm39) |
K125M |
possibly damaging |
Het |
| Serpinf2 |
A |
T |
11: 75,329,244 (GRCm39) |
|
probably benign |
Het |
| Sh2b2 |
G |
A |
5: 136,247,739 (GRCm39) |
T604I |
probably benign |
Het |
| Smug1 |
A |
G |
15: 103,064,369 (GRCm39) |
L184P |
probably damaging |
Het |
| Spatc1 |
A |
G |
15: 76,168,080 (GRCm39) |
T180A |
probably benign |
Het |
| Ssr1 |
A |
T |
13: 38,178,001 (GRCm39) |
L20Q |
probably null |
Het |
| Supt4a |
A |
G |
11: 87,634,084 (GRCm39) |
E100G |
probably damaging |
Het |
| Tbx1 |
G |
T |
16: 18,405,551 (GRCm39) |
P38T |
unknown |
Het |
| Tcl1 |
T |
C |
12: 105,183,860 (GRCm39) |
|
probably benign |
Het |
| Teddm2 |
T |
C |
1: 153,726,320 (GRCm39) |
I132V |
probably benign |
Het |
| Tmem131 |
C |
T |
1: 36,832,054 (GRCm39) |
G1861E |
possibly damaging |
Het |
| Tpr |
A |
T |
1: 150,299,358 (GRCm39) |
H1186L |
probably benign |
Het |
| Trim34b |
A |
T |
7: 103,978,743 (GRCm39) |
|
probably benign |
Het |
| Trpm2 |
T |
C |
10: 77,748,426 (GRCm39) |
M1415V |
probably benign |
Het |
| Ttll12 |
A |
G |
15: 83,471,086 (GRCm39) |
F264S |
probably benign |
Het |
| Vmn2r59 |
T |
C |
7: 41,695,644 (GRCm39) |
E256G |
probably benign |
Het |
| Vmn2r93 |
A |
T |
17: 18,546,672 (GRCm39) |
H848L |
probably benign |
Het |
| Vps35l |
T |
C |
7: 118,372,315 (GRCm39) |
S290P |
probably damaging |
Het |
| Wdr70 |
T |
C |
15: 7,913,855 (GRCm39) |
D598G |
possibly damaging |
Het |
| Ybey |
T |
C |
10: 76,304,197 (GRCm39) |
S2G |
possibly damaging |
Het |
| Zfp346 |
A |
T |
13: 55,280,200 (GRCm39) |
Q308L |
probably benign |
Het |
| Zfp872 |
C |
T |
9: 22,111,856 (GRCm39) |
P445L |
probably benign |
Het |
|
| Other mutations in Kmt2e |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00783:Kmt2e
|
APN |
5 |
23,697,356 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01330:Kmt2e
|
APN |
5 |
23,702,946 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL01457:Kmt2e
|
APN |
5 |
23,707,017 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
IGL01691:Kmt2e
|
APN |
5 |
23,702,089 (GRCm39) |
missense |
probably benign |
|
|
IGL02274:Kmt2e
|
APN |
5 |
23,705,758 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02934:Kmt2e
|
APN |
5 |
23,702,882 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02964:Kmt2e
|
APN |
5 |
23,672,098 (GRCm39) |
splice site |
probably benign |
|
|
IGL03011:Kmt2e
|
APN |
5 |
23,702,540 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03291:Kmt2e
|
APN |
5 |
23,704,289 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0035:Kmt2e
|
UTSW |
5 |
23,690,619 (GRCm39) |
splice site |
probably benign |
|
|
R0446:Kmt2e
|
UTSW |
5 |
23,702,532 (GRCm39) |
splice site |
probably null |
|
|
R0498:Kmt2e
|
UTSW |
5 |
23,683,970 (GRCm39) |
nonsense |
probably null |
|
|
R0699:Kmt2e
|
UTSW |
5 |
23,678,581 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0701:Kmt2e
|
UTSW |
5 |
23,678,581 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0761:Kmt2e
|
UTSW |
5 |
23,708,032 (GRCm39) |
nonsense |
probably null |
|
|
R1110:Kmt2e
|
UTSW |
5 |
23,707,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1295:Kmt2e
|
UTSW |
5 |
23,707,402 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1432:Kmt2e
|
UTSW |
5 |
23,655,319 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1495:Kmt2e
|
UTSW |
5 |
23,704,325 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1505:Kmt2e
|
UTSW |
5 |
23,705,533 (GRCm39) |
missense |
probably null |
0.01 |
|
R1623:Kmt2e
|
UTSW |
5 |
23,687,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1675:Kmt2e
|
UTSW |
5 |
23,687,451 (GRCm39) |
nonsense |
probably null |
|
|
R1691:Kmt2e
|
UTSW |
5 |
23,669,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1778:Kmt2e
|
UTSW |
5 |
23,697,362 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1820:Kmt2e
|
UTSW |
5 |
23,678,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1846:Kmt2e
|
UTSW |
5 |
23,704,484 (GRCm39) |
intron |
probably benign |
|
|
R1912:Kmt2e
|
UTSW |
5 |
23,697,393 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2070:Kmt2e
|
UTSW |
5 |
23,706,993 (GRCm39) |
missense |
probably benign |
|
|
R2195:Kmt2e
|
UTSW |
5 |
23,707,194 (GRCm39) |
splice site |
probably null |
|
|
R2571:Kmt2e
|
UTSW |
5 |
23,706,885 (GRCm39) |
missense |
probably benign |
0.08 |
|
R3901:Kmt2e
|
UTSW |
5 |
23,706,640 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3902:Kmt2e
|
UTSW |
5 |
23,706,640 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3905:Kmt2e
|
UTSW |
5 |
23,706,624 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3906:Kmt2e
|
UTSW |
5 |
23,706,624 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3909:Kmt2e
|
UTSW |
5 |
23,706,624 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3956:Kmt2e
|
UTSW |
5 |
23,701,023 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4242:Kmt2e
|
UTSW |
5 |
23,707,820 (GRCm39) |
unclassified |
probably benign |
|
|
R4299:Kmt2e
|
UTSW |
5 |
23,669,912 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4448:Kmt2e
|
UTSW |
5 |
23,669,788 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4528:Kmt2e
|
UTSW |
5 |
23,678,556 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4574:Kmt2e
|
UTSW |
5 |
23,697,405 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R4719:Kmt2e
|
UTSW |
5 |
23,697,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4754:Kmt2e
|
UTSW |
5 |
23,687,439 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4787:Kmt2e
|
UTSW |
5 |
23,668,081 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4812:Kmt2e
|
UTSW |
5 |
23,707,585 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4853:Kmt2e
|
UTSW |
5 |
23,707,339 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5138:Kmt2e
|
UTSW |
5 |
23,707,693 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5306:Kmt2e
|
UTSW |
5 |
23,704,331 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5659:Kmt2e
|
UTSW |
5 |
23,702,805 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5907:Kmt2e
|
UTSW |
5 |
23,669,704 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5920:Kmt2e
|
UTSW |
5 |
23,704,440 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R6280:Kmt2e
|
UTSW |
5 |
23,704,514 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6353:Kmt2e
|
UTSW |
5 |
23,698,243 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6375:Kmt2e
|
UTSW |
5 |
23,704,517 (GRCm39) |
missense |
probably benign |
|
|
R6553:Kmt2e
|
UTSW |
5 |
23,668,024 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6572:Kmt2e
|
UTSW |
5 |
23,702,579 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R6678:Kmt2e
|
UTSW |
5 |
23,704,293 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R6791:Kmt2e
|
UTSW |
5 |
23,704,474 (GRCm39) |
intron |
probably benign |
|
|
R6792:Kmt2e
|
UTSW |
5 |
23,704,474 (GRCm39) |
intron |
probably benign |
|
|
R6794:Kmt2e
|
UTSW |
5 |
23,704,474 (GRCm39) |
intron |
probably benign |
|
|
R6797:Kmt2e
|
UTSW |
5 |
23,687,505 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6947:Kmt2e
|
UTSW |
5 |
23,702,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7023:Kmt2e
|
UTSW |
5 |
23,705,485 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7173:Kmt2e
|
UTSW |
5 |
23,669,855 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7202:Kmt2e
|
UTSW |
5 |
23,697,292 (GRCm39) |
unclassified |
probably benign |
|
|
R7563:Kmt2e
|
UTSW |
5 |
23,705,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7571:Kmt2e
|
UTSW |
5 |
23,683,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7604:Kmt2e
|
UTSW |
5 |
23,706,763 (GRCm39) |
missense |
not run |
|
|
R7722:Kmt2e
|
UTSW |
5 |
23,702,016 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7758:Kmt2e
|
UTSW |
5 |
23,701,068 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7794:Kmt2e
|
UTSW |
5 |
23,669,714 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8137:Kmt2e
|
UTSW |
5 |
23,706,952 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8341:Kmt2e
|
UTSW |
5 |
23,704,451 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8383:Kmt2e
|
UTSW |
5 |
23,690,539 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8400:Kmt2e
|
UTSW |
5 |
23,702,090 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8546:Kmt2e
|
UTSW |
5 |
23,686,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8750:Kmt2e
|
UTSW |
5 |
23,698,215 (GRCm39) |
missense |
probably benign |
|
|
R8786:Kmt2e
|
UTSW |
5 |
23,669,864 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9211:Kmt2e
|
UTSW |
5 |
23,669,770 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9660:Kmt2e
|
UTSW |
5 |
23,683,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9786:Kmt2e
|
UTSW |
5 |
23,702,982 (GRCm39) |
missense |
probably benign |
0.16 |
|
RF026:Kmt2e
|
UTSW |
5 |
23,683,507 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
RF028:Kmt2e
|
UTSW |
5 |
23,683,507 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
RF040:Kmt2e
|
UTSW |
5 |
23,683,507 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
RF042:Kmt2e
|
UTSW |
5 |
23,683,507 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
Z1177:Kmt2e
|
UTSW |
5 |
23,686,206 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGCACCAGAAATTGATCCTTCATCTG -3'
(R):5'- TGATAAGTGCATCAGGAGGC -3'
Sequencing Primer
(F):5'- TTTGGGAAACAAAAATCAAAGCATG -3'
(R):5'- GCATCAGGAGGCAAGTCTTTG -3'
|
| Posted On |
2019-05-13 |
Incidental Mutation