Incidental Mutation 'R7038:Mrc2'
| ID |
546876 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mrc2
|
| Ensembl Gene |
ENSMUSG00000020695 |
| Gene Name |
mannose receptor, C type 2 |
| Synonyms |
Endo180, uPARAP, novel lectin |
| MMRRC Submission |
045138-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7038 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
105183469-105241965 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 105223062 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 435
(E435G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000021038
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021038]
[ENSMUST00000100335]
|
| AlphaFold |
Q64449 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000021038
AA Change: E435G
PolyPhen 2
Score 0.456 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000021038
Gene: ENSMUSG00000020695
AA Change: E435G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
30 |
N/A |
INTRINSIC |
|
RICIN
|
40 |
160 |
8.49e-12 |
SMART |
|
FN2
|
179 |
227 |
4.83e-27 |
SMART |
|
CLECT
|
234 |
359 |
1.15e-33 |
SMART |
|
CLECT
|
381 |
504 |
1.47e-40 |
SMART |
|
CLECT
|
520 |
644 |
6.82e-27 |
SMART |
|
CLECT
|
668 |
808 |
2.71e-30 |
SMART |
|
CLECT
|
824 |
950 |
6.77e-31 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000100335
AA Change: E435G
PolyPhen 2
Score 0.202 (Sensitivity: 0.92; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000097909
Gene: ENSMUSG00000020695
AA Change: E435G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
30 |
N/A |
INTRINSIC |
|
RICIN
|
40 |
160 |
8.49e-12 |
SMART |
|
FN2
|
179 |
227 |
4.83e-27 |
SMART |
|
CLECT
|
234 |
359 |
1.15e-33 |
SMART |
|
CLECT
|
381 |
504 |
1.47e-40 |
SMART |
|
CLECT
|
520 |
644 |
6.82e-27 |
SMART |
|
CLECT
|
668 |
808 |
2.71e-30 |
SMART |
|
CLECT
|
824 |
950 |
6.77e-31 |
SMART |
|
CLECT
|
971 |
1107 |
3.91e-36 |
SMART |
|
CLECT
|
1124 |
1243 |
1.04e-17 |
SMART |
|
CLECT
|
1259 |
1392 |
9.08e-23 |
SMART |
|
transmembrane domain
|
1412 |
1434 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
99% (101/102) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
PHENOTYPE: Homozygous mice are visibly normal, viable and have no reproductive defects. Mouse embryonic fibroblasts derived from null mice exhibit decreased migration while bone marrow-derived macrophages exhibit increased migration. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 102 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abl2 |
T |
C |
1: 156,468,979 (GRCm39) |
S748P |
possibly damaging |
Het |
| Alppl2 |
T |
C |
1: 87,016,833 (GRCm39) |
D104G |
probably damaging |
Het |
| Als2 |
C |
A |
1: 59,206,673 (GRCm39) |
W1590L |
possibly damaging |
Het |
| Aopep |
G |
T |
13: 63,338,339 (GRCm39) |
V571F |
possibly damaging |
Het |
| Aplf |
C |
T |
6: 87,630,805 (GRCm39) |
W210* |
probably null |
Het |
| Ash1l |
A |
T |
3: 88,889,978 (GRCm39) |
H619L |
probably benign |
Het |
| Baiap3 |
G |
A |
17: 25,462,814 (GRCm39) |
R1075C |
probably benign |
Het |
| Bpifb1 |
G |
T |
2: 154,044,589 (GRCm39) |
V19F |
probably damaging |
Het |
| Capn1 |
A |
T |
19: 6,064,349 (GRCm39) |
L50Q |
probably benign |
Het |
| Carmil1 |
A |
G |
13: 24,323,318 (GRCm39) |
S245P |
probably damaging |
Het |
| Cavin4 |
A |
G |
4: 48,672,479 (GRCm39) |
H308R |
probably benign |
Het |
| Cd4 |
C |
T |
6: 124,847,217 (GRCm39) |
V316M |
probably damaging |
Het |
| Cdcp1 |
T |
C |
9: 123,002,662 (GRCm39) |
Y803C |
probably damaging |
Het |
| Cep295nl |
A |
G |
11: 118,223,815 (GRCm39) |
I343T |
probably benign |
Het |
| Cgn |
T |
G |
3: 94,670,392 (GRCm39) |
T1021P |
possibly damaging |
Het |
| Cilk1 |
C |
T |
9: 78,016,484 (GRCm39) |
|
probably benign |
Het |
| Col6a5 |
A |
G |
9: 105,822,937 (GRCm39) |
V140A |
unknown |
Het |
| Cops8 |
T |
C |
1: 90,531,320 (GRCm39) |
|
probably benign |
Het |
| Crhbp |
A |
G |
13: 95,580,699 (GRCm39) |
Y54H |
probably damaging |
Het |
| Cyp2c29 |
G |
A |
19: 39,275,571 (GRCm39) |
V4I |
probably benign |
Het |
| Cyp2j6 |
T |
A |
4: 96,423,708 (GRCm39) |
Y220F |
probably benign |
Het |
| D130043K22Rik |
A |
G |
13: 25,077,391 (GRCm39) |
D1008G |
probably damaging |
Het |
| Ddx47 |
T |
A |
6: 135,000,336 (GRCm39) |
V444E |
possibly damaging |
Het |
| Dnttip2 |
T |
A |
3: 122,070,181 (GRCm39) |
C465* |
probably null |
Het |
| Dst |
C |
A |
1: 34,221,879 (GRCm39) |
S2561* |
probably null |
Het |
| Dstyk |
T |
C |
1: 132,381,847 (GRCm39) |
S534P |
probably benign |
Het |
| Eif4e |
A |
G |
3: 138,232,943 (GRCm39) |
|
probably benign |
Het |
| Eipr1 |
C |
T |
12: 28,801,817 (GRCm39) |
|
probably benign |
Het |
| Fastkd2 |
T |
A |
1: 63,771,032 (GRCm39) |
D129E |
possibly damaging |
Het |
| Fndc3b |
C |
T |
3: 27,555,618 (GRCm39) |
G312D |
probably benign |
Het |
| Gab2 |
T |
A |
7: 96,952,290 (GRCm39) |
I562N |
probably damaging |
Het |
| Gata5 |
C |
A |
2: 179,975,685 (GRCm39) |
D160Y |
possibly damaging |
Het |
| Gcn1 |
G |
A |
5: 115,749,203 (GRCm39) |
V1912I |
probably damaging |
Het |
| Gdf5 |
C |
A |
2: 155,786,655 (GRCm39) |
Q107H |
probably damaging |
Het |
| Gdpd1 |
A |
G |
11: 86,926,118 (GRCm39) |
Y276H |
probably damaging |
Het |
| Gins1 |
A |
G |
2: 150,759,791 (GRCm39) |
Y81C |
probably damaging |
Het |
| Gm28360 |
T |
C |
1: 117,781,329 (GRCm39) |
C107R |
probably damaging |
Het |
| Hadha |
T |
C |
5: 30,324,998 (GRCm39) |
|
probably null |
Het |
| Hcn4 |
A |
T |
9: 58,730,867 (GRCm39) |
I25F |
unknown |
Het |
| Hectd4 |
A |
G |
5: 121,437,660 (GRCm39) |
Y1095C |
possibly damaging |
Het |
| Hsp90b1 |
A |
T |
10: 86,531,730 (GRCm39) |
L73Q |
probably damaging |
Het |
| Hspa12a |
A |
G |
19: 58,793,132 (GRCm39) |
V351A |
probably damaging |
Het |
| Htr1b |
T |
A |
9: 81,514,296 (GRCm39) |
M104L |
probably benign |
Het |
| Igf2r |
T |
C |
17: 12,917,212 (GRCm39) |
T1563A |
probably benign |
Het |
| Kif13a |
C |
T |
13: 46,905,931 (GRCm39) |
V671M |
possibly damaging |
Het |
| Liph |
A |
T |
16: 21,795,009 (GRCm39) |
V201E |
probably damaging |
Het |
| Ltn1 |
T |
C |
16: 87,221,759 (GRCm39) |
D196G |
probably damaging |
Het |
| Med15 |
C |
T |
16: 17,470,591 (GRCm39) |
D589N |
possibly damaging |
Het |
| Mknk1 |
A |
G |
4: 115,714,307 (GRCm39) |
D26G |
probably damaging |
Het |
| Mpi |
T |
C |
9: 57,452,500 (GRCm39) |
D344G |
probably damaging |
Het |
| Mrps5 |
A |
G |
2: 127,442,786 (GRCm39) |
E285G |
probably damaging |
Het |
| Ms4a20 |
A |
T |
19: 11,087,675 (GRCm39) |
F85L |
probably benign |
Het |
| Muc16 |
T |
A |
9: 18,531,764 (GRCm39) |
M6197L |
probably damaging |
Het |
| Myo3b |
A |
T |
2: 69,925,552 (GRCm39) |
E34D |
probably benign |
Het |
| Nsd3 |
T |
C |
8: 26,131,279 (GRCm39) |
S215P |
probably damaging |
Het |
| Nsmce2 |
T |
A |
15: 59,368,679 (GRCm39) |
|
probably benign |
Het |
| Ntan1 |
T |
C |
16: 13,644,774 (GRCm39) |
S37P |
probably benign |
Het |
| Nup210l |
T |
A |
3: 90,067,254 (GRCm39) |
Y765N |
probably damaging |
Het |
| Or10q12 |
A |
T |
19: 13,745,715 (GRCm39) |
D3V |
probably benign |
Het |
| Or2aa1 |
T |
C |
11: 59,480,408 (GRCm39) |
Y169C |
possibly damaging |
Het |
| Or4s2b |
A |
T |
2: 88,509,085 (GRCm39) |
R288S |
probably damaging |
Het |
| Or7g30 |
A |
C |
9: 19,352,888 (GRCm39) |
L226F |
possibly damaging |
Het |
| Pald1 |
T |
C |
10: 61,175,078 (GRCm39) |
H724R |
probably benign |
Het |
| Pcdhb7 |
A |
T |
18: 37,475,257 (GRCm39) |
D131V |
possibly damaging |
Het |
| Pds5b |
G |
T |
5: 150,724,225 (GRCm39) |
R1269S |
probably benign |
Het |
| Pikfyve |
T |
C |
1: 65,273,520 (GRCm39) |
V645A |
probably damaging |
Het |
| Plag1 |
G |
T |
4: 3,904,676 (GRCm39) |
H172N |
probably damaging |
Het |
| Plch2 |
G |
C |
4: 155,074,489 (GRCm39) |
|
probably null |
Het |
| Plxnb1 |
T |
A |
9: 108,929,453 (GRCm39) |
V103E |
probably damaging |
Het |
| Prpf8 |
T |
A |
11: 75,386,984 (GRCm39) |
M1143K |
probably benign |
Het |
| Ptpn18 |
T |
A |
1: 34,498,906 (GRCm39) |
M1K |
probably null |
Het |
| Rasgrf2 |
G |
A |
13: 92,130,952 (GRCm39) |
T703I |
possibly damaging |
Het |
| Rassf6 |
A |
T |
5: 90,757,584 (GRCm39) |
H125Q |
probably benign |
Het |
| Sdad1 |
A |
G |
5: 92,446,049 (GRCm39) |
|
probably null |
Het |
| Sf3a3 |
T |
A |
4: 124,622,219 (GRCm39) |
F426L |
probably benign |
Het |
| Sgsm3 |
T |
C |
15: 80,892,576 (GRCm39) |
F6L |
possibly damaging |
Het |
| Slc14a2 |
A |
T |
18: 78,202,252 (GRCm39) |
I626N |
probably damaging |
Het |
| Slc17a8 |
T |
C |
10: 89,436,083 (GRCm39) |
N165S |
probably benign |
Het |
| Slc41a1 |
C |
A |
1: 131,769,795 (GRCm39) |
A305D |
possibly damaging |
Het |
| Smyd4 |
C |
A |
11: 75,281,340 (GRCm39) |
P271Q |
probably damaging |
Het |
| Spag17 |
C |
A |
3: 99,891,925 (GRCm39) |
H260N |
probably benign |
Het |
| Spata2 |
A |
T |
2: 167,327,283 (GRCm39) |
V38E |
possibly damaging |
Het |
| Sprr2b |
CTGAGCCTTGTCCTCCTCCAAAGTGCCCTGAGCCTTGTCCTCCCCCAGTATGCTGTGAGCCTTGTCCTCCTCCAAAGTGCCCTGAGCCTTGTCCTCCCCCAGTATGCTGTGAGCCTTGTCCTCC |
CTGAGCCTTGTCCTCCTCCAAAGTGCCCTGAGCCTTGTCCTCCCCCAGTATGCTGTGAGCCTTGTCCTCC |
3: 92,224,826 (GRCm39) |
|
probably benign |
Het |
| Syt14 |
T |
A |
1: 192,665,966 (GRCm39) |
|
probably benign |
Het |
| Tbx21 |
A |
G |
11: 96,990,597 (GRCm39) |
S329P |
probably damaging |
Het |
| Tex2 |
A |
T |
11: 106,402,726 (GRCm39) |
|
probably null |
Het |
| Tmem62 |
A |
G |
2: 120,824,058 (GRCm39) |
I244M |
possibly damaging |
Het |
| Tnks |
A |
T |
8: 35,318,790 (GRCm39) |
N830K |
probably damaging |
Het |
| Tox2 |
A |
G |
2: 163,156,264 (GRCm39) |
E145G |
probably damaging |
Het |
| Tpcn1 |
T |
C |
5: 120,723,342 (GRCm39) |
D7G |
probably damaging |
Het |
| Ttc28 |
T |
A |
5: 111,414,445 (GRCm39) |
M1320K |
probably benign |
Het |
| Tubgcp5 |
T |
G |
7: 55,455,114 (GRCm39) |
V270G |
probably damaging |
Het |
| Unc5a |
A |
G |
13: 55,152,297 (GRCm39) |
R62G |
probably damaging |
Het |
| Unc5d |
A |
G |
8: 29,205,749 (GRCm39) |
|
probably null |
Het |
| Utrn |
T |
C |
10: 12,558,082 (GRCm39) |
H1459R |
probably damaging |
Het |
| Vmn2r100 |
T |
A |
17: 19,725,263 (GRCm39) |
L64Q |
possibly damaging |
Het |
| Wdr55 |
T |
G |
18: 36,893,473 (GRCm39) |
L45R |
probably damaging |
Het |
| Zfp292 |
A |
G |
4: 34,816,357 (GRCm39) |
Y306H |
probably damaging |
Het |
| Zfp398 |
G |
T |
6: 47,843,243 (GRCm39) |
D300Y |
probably damaging |
Het |
| Zfp407 |
A |
G |
18: 84,579,982 (GRCm39) |
V377A |
probably damaging |
Het |
| Zfp457 |
G |
A |
13: 67,441,997 (GRCm39) |
H97Y |
probably benign |
Het |
| Zfp467 |
T |
C |
6: 48,415,072 (GRCm39) |
T527A |
probably damaging |
Het |
|
| Other mutations in Mrc2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01105:Mrc2
|
APN |
11 |
105,219,567 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01374:Mrc2
|
APN |
11 |
105,238,469 (GRCm39) |
nonsense |
probably null |
|
|
IGL01751:Mrc2
|
APN |
11 |
105,216,560 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01780:Mrc2
|
APN |
11 |
105,216,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01835:Mrc2
|
APN |
11 |
105,227,503 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02350:Mrc2
|
APN |
11 |
105,216,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02357:Mrc2
|
APN |
11 |
105,216,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02829:Mrc2
|
APN |
11 |
105,227,533 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL02863:Mrc2
|
APN |
11 |
105,224,446 (GRCm39) |
splice site |
probably benign |
|
|
IGL02940:Mrc2
|
APN |
11 |
105,231,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02988:Mrc2
|
UTSW |
11 |
105,216,397 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0254:Mrc2
|
UTSW |
11 |
105,238,692 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0634:Mrc2
|
UTSW |
11 |
105,238,518 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1102:Mrc2
|
UTSW |
11 |
105,231,647 (GRCm39) |
missense |
probably benign |
|
|
R1233:Mrc2
|
UTSW |
11 |
105,239,241 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1244:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R1458:Mrc2
|
UTSW |
11 |
105,228,598 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1500:Mrc2
|
UTSW |
11 |
105,238,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1573:Mrc2
|
UTSW |
11 |
105,227,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1770:Mrc2
|
UTSW |
11 |
105,229,619 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1842:Mrc2
|
UTSW |
11 |
105,228,546 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2156:Mrc2
|
UTSW |
11 |
105,238,682 (GRCm39) |
splice site |
probably null |
|
|
R2165:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2265:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2266:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2267:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2268:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2269:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2270:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2271:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2272:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2296:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2298:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2300:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2326:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2518:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2519:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2520:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2895:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3029:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3030:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3079:Mrc2
|
UTSW |
11 |
105,227,539 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3122:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3149:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3150:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3420:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3422:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3441:Mrc2
|
UTSW |
11 |
105,238,542 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R3726:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3731:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3800:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3820:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3821:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3837:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3838:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3849:Mrc2
|
UTSW |
11 |
105,183,729 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3850:Mrc2
|
UTSW |
11 |
105,183,729 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3914:Mrc2
|
UTSW |
11 |
105,238,058 (GRCm39) |
splice site |
probably benign |
|
|
R3932:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3933:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3971:Mrc2
|
UTSW |
11 |
105,218,857 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4105:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4107:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4113:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4274:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4399:Mrc2
|
UTSW |
11 |
105,227,484 (GRCm39) |
nonsense |
probably null |
|
|
R4477:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4478:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4493:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4494:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4495:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4547:Mrc2
|
UTSW |
11 |
105,227,467 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4600:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4601:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4602:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4603:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4610:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4611:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4637:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4672:Mrc2
|
UTSW |
11 |
105,233,923 (GRCm39) |
missense |
probably benign |
0.22 |
|
R4674:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4675:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4693:Mrc2
|
UTSW |
11 |
105,234,528 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4706:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4707:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4791:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4792:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4888:Mrc2
|
UTSW |
11 |
105,232,034 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5523:Mrc2
|
UTSW |
11 |
105,234,408 (GRCm39) |
missense |
probably benign |
|
|
R5600:Mrc2
|
UTSW |
11 |
105,224,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5634:Mrc2
|
UTSW |
11 |
105,227,040 (GRCm39) |
nonsense |
probably null |
|
|
R5692:Mrc2
|
UTSW |
11 |
105,227,468 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5706:Mrc2
|
UTSW |
11 |
105,223,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5775:Mrc2
|
UTSW |
11 |
105,228,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6140:Mrc2
|
UTSW |
11 |
105,237,615 (GRCm39) |
missense |
probably benign |
|
|
R6146:Mrc2
|
UTSW |
11 |
105,216,470 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6225:Mrc2
|
UTSW |
11 |
105,237,646 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6437:Mrc2
|
UTSW |
11 |
105,240,669 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6618:Mrc2
|
UTSW |
11 |
105,240,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6675:Mrc2
|
UTSW |
11 |
105,233,906 (GRCm39) |
splice site |
probably null |
|
|
R6680:Mrc2
|
UTSW |
11 |
105,216,579 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6868:Mrc2
|
UTSW |
11 |
105,219,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6979:Mrc2
|
UTSW |
11 |
105,239,461 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7303:Mrc2
|
UTSW |
11 |
105,216,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7320:Mrc2
|
UTSW |
11 |
105,220,061 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7422:Mrc2
|
UTSW |
11 |
105,183,609 (GRCm39) |
start gained |
probably benign |
|
|
R7537:Mrc2
|
UTSW |
11 |
105,183,623 (GRCm39) |
missense |
probably benign |
|
|
R7640:Mrc2
|
UTSW |
11 |
105,223,121 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R7709:Mrc2
|
UTSW |
11 |
105,237,285 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7885:Mrc2
|
UTSW |
11 |
105,223,092 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7976:Mrc2
|
UTSW |
11 |
105,238,829 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8042:Mrc2
|
UTSW |
11 |
105,239,181 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8096:Mrc2
|
UTSW |
11 |
105,234,333 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8353:Mrc2
|
UTSW |
11 |
105,223,137 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8453:Mrc2
|
UTSW |
11 |
105,223,137 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8519:Mrc2
|
UTSW |
11 |
105,238,132 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R8771:Mrc2
|
UTSW |
11 |
105,240,596 (GRCm39) |
missense |
probably benign |
|
|
R8787:Mrc2
|
UTSW |
11 |
105,238,465 (GRCm39) |
missense |
probably benign |
|
|
R8925:Mrc2
|
UTSW |
11 |
105,216,334 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8927:Mrc2
|
UTSW |
11 |
105,216,334 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8991:Mrc2
|
UTSW |
11 |
105,229,740 (GRCm39) |
missense |
probably benign |
|
|
R9017:Mrc2
|
UTSW |
11 |
105,216,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9096:Mrc2
|
UTSW |
11 |
105,231,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9097:Mrc2
|
UTSW |
11 |
105,231,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9223:Mrc2
|
UTSW |
11 |
105,220,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9471:Mrc2
|
UTSW |
11 |
105,234,559 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9531:Mrc2
|
UTSW |
11 |
105,240,731 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
T0970:Mrc2
|
UTSW |
11 |
105,238,453 (GRCm39) |
missense |
probably benign |
0.41 |
|
X0004:Mrc2
|
UTSW |
11 |
105,238,453 (GRCm39) |
missense |
probably benign |
0.41 |
|
X0062:Mrc2
|
UTSW |
11 |
105,238,301 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1176:Mrc2
|
UTSW |
11 |
105,238,186 (GRCm39) |
nonsense |
probably null |
|
|
Z1176:Mrc2
|
UTSW |
11 |
105,232,202 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTCCTTAGCATCCACAGCATG -3'
(R):5'- GGTGCTATTATGAGAAAGGAAAGTCTC -3'
Sequencing Primer
(F):5'- GCTGAGCTGGAGTTCATCAC -3'
(R):5'- AGGAAAGTCTCACCGGCC -3'
|
| Posted On |
2019-05-13 |
Incidental Mutation