Incidental Mutation 'R7043:Gpr85'
ID 547154
Institutional Source Beutler Lab
Gene Symbol Gpr85
Ensembl Gene ENSMUSG00000048216
Gene Name G protein-coupled receptor 85
Synonyms 2900026B03Rik
MMRRC Submission 045142-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.189) question?
Stock # R7043 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 13834457-13839941 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 13835876 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Tyrosine at position 343 (N343Y)
Ref Sequence ENSEMBL: ENSMUSP00000111155 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060442] [ENSMUST00000115491] [ENSMUST00000115492]
AlphaFold P60894
Predicted Effect probably damaging
Transcript: ENSMUST00000060442
AA Change: N343Y

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000053837
Gene: ENSMUSG00000048216
AA Change: N343Y

DomainStartEndE-ValueType
Pfam:7tm_1 37 338 4.1e-38 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000115491
AA Change: N343Y

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000111154
Gene: ENSMUSG00000048216
AA Change: N343Y

DomainStartEndE-ValueType
Pfam:7tm_1 37 338 4.1e-38 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000115492
AA Change: N343Y

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000111155
Gene: ENSMUSG00000048216
AA Change: N343Y

DomainStartEndE-ValueType
Pfam:7tm_1 37 338 1.6e-32 PFAM
Meta Mutation Damage Score 0.4775 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (51/51)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the G protein-coupled receptor (GPCR) family, such as GPR85, have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli, such as neurotransmitters, hormones, or light, induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins (Matsumoto et al., 2000 [PubMed 10833454]).[supplied by OMIM, Aug 2008]
PHENOTYPE: Mice homozygous for a knock-out allele display a significant increase in brain weight and enhanced contextual memory in a fear-conditioning task but no additional behavioral abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 A G 17: 24,484,474 (GRCm39) L1596P probably damaging Het
Actr3b A G 5: 26,054,936 (GRCm39) M329V probably benign Het
Avpr1a C T 10: 122,285,586 (GRCm39) R293C probably damaging Het
Bdp1 A T 13: 100,215,215 (GRCm39) C390S probably benign Het
C2cd2l A T 9: 44,227,848 (GRCm39) M131K probably damaging Het
Ccna2 T C 3: 36,624,302 (GRCm39) probably benign Het
Cd53 T C 3: 106,670,577 (GRCm39) D152G probably damaging Het
Cdpf1 A T 15: 85,692,485 (GRCm39) V66E probably null Het
Chd9 G T 8: 91,760,843 (GRCm39) probably benign Het
Crybg2 A G 4: 133,818,447 (GRCm39) D1710G probably benign Het
Dst A G 1: 34,296,992 (GRCm39) T5794A probably damaging Het
Eif2s1 G T 12: 78,923,882 (GRCm39) R113L probably damaging Het
Eif5 A G 12: 111,511,030 (GRCm39) D423G probably benign Het
Eri1 A C 8: 35,945,792 (GRCm39) D164E probably damaging Het
F7 A T 8: 13,083,997 (GRCm39) R227S probably benign Het
Gm14496 T G 2: 181,642,120 (GRCm39) I597S possibly damaging Het
H2-T23 A T 17: 36,342,803 (GRCm39) S112T probably damaging Het
Itga9 C T 9: 118,598,184 (GRCm39) P573S probably damaging Het
Kcnb2 A T 1: 15,383,150 (GRCm39) M159L probably benign Het
Kmt5b T A 19: 3,865,220 (GRCm39) S738R possibly damaging Het
Lrp1b T C 2: 40,812,426 (GRCm39) N2393S possibly damaging Het
Mme T A 3: 63,252,638 (GRCm39) Y427* probably null Het
Naip1 A G 13: 100,563,422 (GRCm39) V581A probably damaging Het
Ndel1 A G 11: 68,713,450 (GRCm39) L329P possibly damaging Het
Nthl1 T G 17: 24,857,644 (GRCm39) V281G probably benign Het
Or52ab2 C A 7: 102,970,292 (GRCm39) probably benign Het
Per2 G T 1: 91,347,130 (GRCm39) H1197Q probably benign Het
Phf8-ps T C 17: 33,284,306 (GRCm39) D832G possibly damaging Het
Plec G A 15: 76,093,328 (GRCm39) probably benign Het
Prpf6 A T 2: 181,291,297 (GRCm39) H704L probably benign Het
Recql5 C T 11: 115,821,502 (GRCm39) probably null Het
Rimbp3 G A 16: 17,028,972 (GRCm39) V799M probably damaging Het
Sema3f C T 9: 107,568,599 (GRCm39) A169T possibly damaging Het
Serpinb9f T C 13: 33,509,970 (GRCm39) I54T possibly damaging Het
Skint5 A T 4: 113,574,304 (GRCm39) L749Q unknown Het
Slc35g3 T C 11: 69,652,476 (GRCm39) D12G probably benign Het
Sptbn1 A G 11: 30,053,323 (GRCm39) V2252A probably benign Het
Stab2 T C 10: 86,706,110 (GRCm39) N1750S probably damaging Het
Supt5 C A 7: 28,019,435 (GRCm39) R543L probably benign Het
Syne1 T C 10: 5,022,193 (GRCm39) E7806G possibly damaging Het
Syt12 T A 19: 4,501,049 (GRCm39) M334L probably benign Het
Tk1 A G 11: 117,706,779 (GRCm39) *234R probably null Het
Trp73 T G 4: 154,151,464 (GRCm39) probably null Het
Ttn A G 2: 76,727,477 (GRCm39) probably benign Het
Vmn2r11 T C 5: 109,200,098 (GRCm39) I452V probably benign Het
Wwox G T 8: 115,406,578 (GRCm39) V190L probably damaging Het
Wwp2 A G 8: 108,184,532 (GRCm39) H80R probably benign Het
Zc3h3 A G 15: 75,681,485 (GRCm39) I532T probably damaging Het
Zfp280d A G 9: 72,226,539 (GRCm39) K328E probably damaging Het
Zfp365 A G 10: 67,745,656 (GRCm39) S41P probably damaging Het
Other mutations in Gpr85
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02414:Gpr85 APN 6 13,836,909 (GRCm39) utr 5 prime probably benign
R0784:Gpr85 UTSW 6 13,836,748 (GRCm39) missense probably benign 0.25
R1356:Gpr85 UTSW 6 13,836,146 (GRCm39) missense probably benign 0.42
R2343:Gpr85 UTSW 6 13,836,695 (GRCm39) missense probably damaging 1.00
R3934:Gpr85 UTSW 6 13,836,044 (GRCm39) missense probably benign 0.02
R3935:Gpr85 UTSW 6 13,836,044 (GRCm39) missense probably benign 0.02
R3936:Gpr85 UTSW 6 13,836,044 (GRCm39) missense probably benign 0.02
R4925:Gpr85 UTSW 6 13,835,977 (GRCm39) missense probably benign 0.26
R5313:Gpr85 UTSW 6 13,836,301 (GRCm39) missense probably damaging 1.00
R5586:Gpr85 UTSW 6 13,836,000 (GRCm39) nonsense probably null
R8458:Gpr85 UTSW 6 13,836,848 (GRCm39) missense probably benign
R8468:Gpr85 UTSW 6 13,836,295 (GRCm39) missense probably damaging 1.00
R8503:Gpr85 UTSW 6 13,836,829 (GRCm39) missense probably benign 0.01
R9519:Gpr85 UTSW 6 13,836,998 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- GCCCAAATCCTTGTCACTGC -3'
(R):5'- ATGCGAATACCACAGGCAG -3'

Sequencing Primer
(F):5'- AAATCCTTGTCACTGCTGATTCC -3'
(R):5'- CAGAAGGCGGCTATTGGTC -3'
Posted On 2019-05-13