Mutagenetix > Incidental Mutation

Incidental Mutation 'R7044:Vmn2r97'

547230

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r97

Ensembl Gene

ENSMUSG00000091491

Gene Name

vomeronasal 2, receptor 97

Synonyms

EG627367

MMRRC Submission

045143-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.071) question?

Stock #

R7044 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

19134584-19168333 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 19134629 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Isoleucine at position 16 (F16I)

Ref Sequence

ENSEMBL: ENSMUSP00000156141 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168710] [ENSMUST00000232219]

AlphaFold

K7N6Z2

Predicted Effect

probably benign
Transcript: ENSMUST00000168710
AA Change: F16I

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000129313
Gene: ENSMUSG00000091491
AA Change: F16I

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	82	442	2.9e-36	PFAM
Pfam:NCD3G	513	566	4.9e-21	PFAM
Pfam:7tm_3	599	834	1.7e-52	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000232219
AA Change: F16I

PolyPhen 2 Score 0.047 (Sensitivity: 0.94; Specificity: 0.83)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 98.9%

Validation Efficiency

98% (40/41)

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankrd6	T	A	4: 32,815,260 (GRCm39)	Q448L	possibly damaging	Het
Appl1	A	G	14: 26,650,634 (GRCm39)	S513P	possibly damaging	Het
Cdhr2	A	T	13: 54,881,134 (GRCm39)	K1066*	probably null	Het
Ckap5	T	C	2: 91,407,946 (GRCm39)	I824T	probably benign	Het
Cracdl	C	T	1: 37,651,361 (GRCm39)	D1169N	possibly damaging	Het
Ctbp2	T	C	7: 132,616,831 (GRCm39)	R35G	possibly damaging	Het
Dcdc2c	T	C	12: 28,520,493 (GRCm39)		probably benign	Het
Eya1	T	A	1: 14,301,634 (GRCm39)		probably null	Het
Fat4	G	C	3: 39,064,959 (GRCm39)	A4972P	probably benign	Het
Fat4	C	T	3: 39,064,960 (GRCm39)	A4972V	probably benign	Het
Fbxl8	T	A	8: 105,993,647 (GRCm39)	M1K	probably null	Het
Glyat	T	C	19: 12,627,629 (GRCm39)	S75P	probably benign	Het
Gm3543	T	A	14: 41,802,023 (GRCm39)	I154F	probably damaging	Het
Gm4565	T	A	7: 22,282,795 (GRCm39)	M8L	probably benign	Het
Gpr179	T	C	11: 97,240,616 (GRCm39)	Q269R	probably benign	Het
Hjv	C	A	3: 96,434,790 (GRCm39)	H176Q	possibly damaging	Het
Ikzf2	T	C	1: 69,578,060 (GRCm39)	H483R	possibly damaging	Het
Il25	G	A	14: 55,170,615 (GRCm39)	A63T	probably benign	Het
Krt27	T	A	11: 99,237,640 (GRCm39)	N366I	probably benign	Het
Mfge8	A	G	7: 78,792,268 (GRCm39)	V219A	probably benign	Het
Nrbp1	T	C	5: 31,407,290 (GRCm39)	V373A	probably damaging	Het
Or4c100	A	G	2: 88,356,830 (GRCm39)	N301S	probably benign	Het
Otulinl	A	G	15: 27,657,321 (GRCm39)		probably benign	Het
Pcdh20	A	G	14: 88,706,607 (GRCm39)	I231T	probably damaging	Het
Pfkp	A	G	13: 6,631,603 (GRCm39)	W151R	probably damaging	Het
Pikfyve	T	C	1: 65,286,013 (GRCm39)	I1084T	probably benign	Het
Poteg	T	C	8: 27,939,923 (GRCm39)	C27R	probably damaging	Het
Ptprz1	G	A	6: 23,044,345 (GRCm39)	V1266M	probably damaging	Het
Rpa1	T	C	11: 75,203,628 (GRCm39)	D358G	probably damaging	Het
Slx9	T	C	10: 77,350,226 (GRCm39)	D35G	possibly damaging	Het
Snapc4	A	G	2: 26,259,965 (GRCm39)	S495P	probably damaging	Het
Surf6	A	G	2: 26,789,368 (GRCm39)	I123T	probably damaging	Het
Sybu	A	T	15: 44,541,091 (GRCm39)	S324T	possibly damaging	Het
Trim3	A	T	7: 105,267,421 (GRCm39)	S319R	probably damaging	Het
Trmt11	A	G	10: 30,466,930 (GRCm39)	F72L	probably benign	Het
Tsks	C	T	7: 44,593,216 (GRCm39)	R61W	probably damaging	Het
Ube2k	T	C	5: 65,738,772 (GRCm39)	V36A	possibly damaging	Het
Ube3a	T	C	7: 58,938,161 (GRCm39)	V688A	probably damaging	Het
Vegfc	A	G	8: 54,610,080 (GRCm39)	K79E	possibly damaging	Het
Vmn1r77	G	A	7: 11,775,761 (GRCm39)	R179Q	probably benign	Het
Zfp451	A	T	1: 33,841,248 (GRCm39)		probably benign	Het
Zfp600	C	T	4: 146,131,892 (GRCm39)	Q187*	probably null	Het

Other mutations in Vmn2r97

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00897:Vmn2r97	APN	17	19,167,921 (GRCm39)	missense	probably benign	0.37
IGL00962:Vmn2r97	APN	17	19,149,490 (GRCm39)	missense	probably damaging	1.00
IGL01704:Vmn2r97	APN	17	19,168,073 (GRCm39)	missense	probably damaging	0.99
IGL01888:Vmn2r97	APN	17	19,149,286 (GRCm39)	nonsense	probably null
IGL02429:Vmn2r97	APN	17	19,150,596 (GRCm39)	missense	possibly damaging	0.94
IGL02742:Vmn2r97	APN	17	19,149,432 (GRCm39)	missense	probably damaging	0.97
IGL02934:Vmn2r97	APN	17	19,149,947 (GRCm39)	missense	probably benign	0.00
IGL02978:Vmn2r97	APN	17	19,168,298 (GRCm39)	missense	probably benign	0.01
IGL03230:Vmn2r97	APN	17	19,149,668 (GRCm39)	missense	probably benign	0.10
IGL03241:Vmn2r97	APN	17	19,148,438 (GRCm39)	missense	probably benign	0.11
IGL03050:Vmn2r97	UTSW	17	19,167,900 (GRCm39)	missense	possibly damaging	0.84
PIT4469001:Vmn2r97	UTSW	17	19,149,878 (GRCm39)	missense	probably benign	0.00
R0482:Vmn2r97	UTSW	17	19,167,930 (GRCm39)	missense	probably damaging	1.00
R0514:Vmn2r97	UTSW	17	19,134,734 (GRCm39)	missense	probably benign	0.25
R0944:Vmn2r97	UTSW	17	19,167,665 (GRCm39)	missense	probably benign	0.13
R1061:Vmn2r97	UTSW	17	19,148,440 (GRCm39)	nonsense	probably null
R1546:Vmn2r97	UTSW	17	19,168,110 (GRCm39)	missense	probably damaging	1.00
R1725:Vmn2r97	UTSW	17	19,149,397 (GRCm39)	missense	probably benign	0.43
R1860:Vmn2r97	UTSW	17	19,167,648 (GRCm39)	missense	probably benign	0.01
R1938:Vmn2r97	UTSW	17	19,149,593 (GRCm39)	missense	probably benign	0.01
R1944:Vmn2r97	UTSW	17	19,160,500 (GRCm39)	missense	probably benign	0.00
R2027:Vmn2r97	UTSW	17	19,149,944 (GRCm39)	missense	unknown
R2106:Vmn2r97	UTSW	17	19,168,100 (GRCm39)	missense	probably damaging	1.00
R2151:Vmn2r97	UTSW	17	19,167,584 (GRCm39)	nonsense	probably null
R2153:Vmn2r97	UTSW	17	19,167,584 (GRCm39)	nonsense	probably null
R2154:Vmn2r97	UTSW	17	19,167,584 (GRCm39)	nonsense	probably null
R2516:Vmn2r97	UTSW	17	19,167,814 (GRCm39)	missense	probably benign
R3739:Vmn2r97	UTSW	17	19,148,413 (GRCm39)	missense	probably damaging	1.00
R3744:Vmn2r97	UTSW	17	19,149,890 (GRCm39)	missense	probably benign
R3885:Vmn2r97	UTSW	17	19,148,596 (GRCm39)	missense	possibly damaging	0.90
R3899:Vmn2r97	UTSW	17	19,167,873 (GRCm39)	missense	probably damaging	0.96
R4115:Vmn2r97	UTSW	17	19,148,332 (GRCm39)	missense	probably benign	0.01
R4247:Vmn2r97	UTSW	17	19,167,542 (GRCm39)	missense	possibly damaging	0.83
R4287:Vmn2r97	UTSW	17	19,168,337 (GRCm39)	intron	probably benign
R4439:Vmn2r97	UTSW	17	19,150,616 (GRCm39)	missense	probably benign	0.00
R4523:Vmn2r97	UTSW	17	19,149,333 (GRCm39)	missense	probably benign	0.03
R4783:Vmn2r97	UTSW	17	19,149,550 (GRCm39)	missense	probably benign
R4948:Vmn2r97	UTSW	17	19,167,561 (GRCm39)	missense	possibly damaging	0.95
R4981:Vmn2r97	UTSW	17	19,160,436 (GRCm39)	nonsense	probably null
R5029:Vmn2r97	UTSW	17	19,168,173 (GRCm39)	missense	probably damaging	1.00
R5200:Vmn2r97	UTSW	17	19,148,615 (GRCm39)	missense	probably damaging	1.00
R5541:Vmn2r97	UTSW	17	19,148,617 (GRCm39)	nonsense	probably null
R5637:Vmn2r97	UTSW	17	19,167,628 (GRCm39)	nonsense	probably null
R5765:Vmn2r97	UTSW	17	19,167,442 (GRCm39)	nonsense	probably null
R5885:Vmn2r97	UTSW	17	19,168,035 (GRCm39)	missense	possibly damaging	0.50
R6272:Vmn2r97	UTSW	17	19,167,861 (GRCm39)	missense	possibly damaging	0.70
R6553:Vmn2r97	UTSW	17	19,150,566 (GRCm39)	nonsense	probably null
R6818:Vmn2r97	UTSW	17	19,168,193 (GRCm39)	missense	possibly damaging	0.95
R6880:Vmn2r97	UTSW	17	19,134,770 (GRCm39)	missense	probably benign	0.00
R7012:Vmn2r97	UTSW	17	19,167,756 (GRCm39)	missense	probably damaging	0.99
R7023:Vmn2r97	UTSW	17	19,134,663 (GRCm39)	missense	probably damaging	1.00
R7191:Vmn2r97	UTSW	17	19,150,548 (GRCm39)	missense	probably damaging	1.00
R7503:Vmn2r97	UTSW	17	19,148,470 (GRCm39)	missense	probably benign
R7862:Vmn2r97	UTSW	17	19,167,416 (GRCm39)	missense	probably damaging	1.00
R7876:Vmn2r97	UTSW	17	19,149,326 (GRCm39)	missense	probably damaging	0.97
R7890:Vmn2r97	UTSW	17	19,149,802 (GRCm39)	missense	probably benign	0.00
R7936:Vmn2r97	UTSW	17	19,150,662 (GRCm39)	missense	probably damaging	1.00
R7978:Vmn2r97	UTSW	17	19,167,854 (GRCm39)	missense	probably damaging	1.00
R8405:Vmn2r97	UTSW	17	19,134,802 (GRCm39)	critical splice donor site	probably null
R8755:Vmn2r97	UTSW	17	19,168,104 (GRCm39)	missense	probably damaging	1.00
R8790:Vmn2r97	UTSW	17	19,160,472 (GRCm39)	missense	probably damaging	1.00
R8850:Vmn2r97	UTSW	17	19,149,607 (GRCm39)	missense	probably benign	0.00
R9060:Vmn2r97	UTSW	17	19,134,585 (GRCm39)	start codon destroyed	probably null	0.94
R9079:Vmn2r97	UTSW	17	19,149,640 (GRCm39)	missense	probably benign
R9252:Vmn2r97	UTSW	17	19,167,849 (GRCm39)	missense	probably benign	0.00
R9278:Vmn2r97	UTSW	17	19,134,762 (GRCm39)	missense	probably benign	0.00
R9342:Vmn2r97	UTSW	17	19,149,368 (GRCm39)	missense	probably benign
R9422:Vmn2r97	UTSW	17	19,149,333 (GRCm39)	missense	probably benign	0.03
R9496:Vmn2r97	UTSW	17	19,149,227 (GRCm39)	missense	probably damaging	1.00
R9571:Vmn2r97	UTSW	17	19,149,919 (GRCm39)	missense	probably benign
R9601:Vmn2r97	UTSW	17	19,134,770 (GRCm39)	missense	probably benign
R9672:Vmn2r97	UTSW	17	19,149,442 (GRCm39)	missense	probably benign	0.00
R9773:Vmn2r97	UTSW	17	19,168,221 (GRCm39)	missense	probably benign	0.01
R9795:Vmn2r97	UTSW	17	19,167,561 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CCTCAGTAGCAGAGTCCATGTG -3'
(R):5'- TGAACTCACTGTATGACATTGTCC -3'

Sequencing Primer
(F):5'- AATCCCTTGGAATAATCAGTGTGGC -3'
(R):5'- CTCACTGTATGACATTGTCCAAATAG -3'

Posted On

2019-05-13