Incidental Mutation 'R0611:Vmn2r84'
| ID |
54735 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r84
|
| Ensembl Gene |
ENSMUSG00000070601 |
| Gene Name |
vomeronasal 2, receptor 84 |
| Synonyms |
EG625068 |
| MMRRC Submission |
038800-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.070)
|
| Stock # |
R0611 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
130221669-130230110 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 130221991 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Valine
at position 743
(A743V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000092079
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094502]
|
| AlphaFold |
D3YWE3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000094502
AA Change: A743V
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000092079
Gene: ENSMUSG00000070601
AA Change: A743V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
448 |
1.3e-27 |
PFAM |
|
Pfam:NCD3G
|
508 |
561 |
6.9e-21 |
PFAM |
|
Pfam:7tm_3
|
594 |
830 |
4.6e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.9%
- 10x: 97.5%
- 20x: 94.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca14 |
T |
A |
7: 119,851,479 (GRCm39) |
M819K |
possibly damaging |
Het |
| Adamtsl3 |
T |
G |
7: 82,178,120 (GRCm39) |
C528G |
probably damaging |
Het |
| Akap9 |
A |
G |
5: 4,004,870 (GRCm39) |
K148E |
probably benign |
Het |
| Akr1b1 |
A |
T |
6: 34,286,577 (GRCm39) |
D225E |
probably benign |
Het |
| Alms1 |
C |
A |
6: 85,655,653 (GRCm39) |
Q2931K |
possibly damaging |
Het |
| Ano3 |
T |
C |
2: 110,715,346 (GRCm39) |
K31E |
possibly damaging |
Het |
| Cdc37 |
A |
G |
9: 21,053,537 (GRCm39) |
I242T |
probably damaging |
Het |
| Celsr1 |
T |
A |
15: 85,816,524 (GRCm39) |
K1806N |
possibly damaging |
Het |
| Clpb |
T |
A |
7: 101,436,956 (GRCm39) |
I707N |
possibly damaging |
Het |
| Cntnap2 |
A |
T |
6: 47,072,483 (GRCm39) |
Y1017F |
possibly damaging |
Het |
| Creb3l2 |
A |
T |
6: 37,311,416 (GRCm39) |
S458T |
probably benign |
Het |
| Ctnnd2 |
C |
A |
15: 31,009,230 (GRCm39) |
T1109K |
possibly damaging |
Het |
| Dcaf10 |
T |
A |
4: 45,373,011 (GRCm39) |
L425Q |
probably damaging |
Het |
| Dlec1 |
A |
G |
9: 118,941,167 (GRCm39) |
E239G |
probably benign |
Het |
| Dnah2 |
T |
C |
11: 69,390,020 (GRCm39) |
K742E |
probably damaging |
Het |
| Dsp |
A |
T |
13: 38,371,717 (GRCm39) |
R889S |
probably damaging |
Het |
| Dync1h1 |
T |
A |
12: 110,599,222 (GRCm39) |
M1859K |
probably damaging |
Het |
| Efcab7 |
T |
A |
4: 99,758,886 (GRCm39) |
N361K |
probably damaging |
Het |
| Eps8l2 |
T |
C |
7: 140,935,646 (GRCm39) |
V139A |
probably damaging |
Het |
| Fads3 |
T |
G |
19: 10,019,200 (GRCm39) |
H35Q |
probably damaging |
Het |
| Fam163b |
C |
A |
2: 27,003,583 (GRCm39) |
V24F |
probably damaging |
Het |
| Gm14496 |
A |
T |
2: 181,636,904 (GRCm39) |
T121S |
probably benign |
Het |
| Gm4799 |
C |
T |
10: 82,790,563 (GRCm39) |
|
noncoding transcript |
Het |
| Gm7168 |
A |
T |
17: 14,169,797 (GRCm39) |
D388V |
probably benign |
Het |
| Gmeb1 |
A |
T |
4: 131,953,386 (GRCm39) |
L460* |
probably null |
Het |
| Gpc6 |
T |
G |
14: 118,212,430 (GRCm39) |
F534V |
probably null |
Het |
| Hectd3 |
A |
G |
4: 116,853,241 (GRCm39) |
D156G |
possibly damaging |
Het |
| Itga6 |
T |
C |
2: 71,650,404 (GRCm39) |
I150T |
possibly damaging |
Het |
| Kansl1 |
A |
G |
11: 104,229,012 (GRCm39) |
M863T |
probably benign |
Het |
| Kcnb2 |
A |
T |
1: 15,780,664 (GRCm39) |
Y512F |
probably benign |
Het |
| Klhdc2 |
A |
T |
12: 69,347,053 (GRCm39) |
M73L |
probably benign |
Het |
| Ktn1 |
A |
G |
14: 47,932,073 (GRCm39) |
T667A |
probably benign |
Het |
| Lgsn |
A |
C |
1: 31,242,736 (GRCm39) |
I273L |
probably benign |
Het |
| Lilra5 |
A |
G |
7: 4,245,232 (GRCm39) |
D292G |
probably benign |
Het |
| Mrps27 |
C |
T |
13: 99,541,582 (GRCm39) |
R229C |
probably damaging |
Het |
| Muc5b |
T |
G |
7: 141,416,173 (GRCm39) |
S3040A |
probably benign |
Het |
| Nat14 |
T |
C |
7: 4,926,275 (GRCm39) |
S7P |
probably damaging |
Het |
| Nfia |
A |
G |
4: 97,671,694 (GRCm39) |
I135V |
possibly damaging |
Het |
| Nkd1 |
G |
A |
8: 89,248,944 (GRCm39) |
A30T |
probably damaging |
Het |
| Nup205 |
A |
G |
6: 35,202,903 (GRCm39) |
D1370G |
probably null |
Het |
| Or1j15 |
C |
G |
2: 36,459,568 (GRCm39) |
|
probably null |
Het |
| Or4k15c |
G |
A |
14: 50,321,310 (GRCm39) |
T276I |
probably damaging |
Het |
| Or51k2 |
T |
C |
7: 103,596,400 (GRCm39) |
L209P |
probably damaging |
Het |
| Or5p79 |
T |
A |
7: 108,221,494 (GRCm39) |
N158K |
possibly damaging |
Het |
| Or8s10 |
T |
C |
15: 98,336,168 (GRCm39) |
S273P |
possibly damaging |
Het |
| Orc1 |
C |
T |
4: 108,459,229 (GRCm39) |
A466V |
probably benign |
Het |
| Otud7a |
T |
A |
7: 63,385,638 (GRCm39) |
D367E |
possibly damaging |
Het |
| Pcdhb4 |
A |
G |
18: 37,441,263 (GRCm39) |
Y191C |
probably damaging |
Het |
| Pclo |
T |
C |
5: 14,762,828 (GRCm39) |
V3767A |
unknown |
Het |
| Pclo |
T |
C |
5: 14,728,789 (GRCm39) |
|
probably benign |
Het |
| Prmt1 |
A |
T |
7: 44,628,225 (GRCm39) |
|
probably null |
Het |
| Ralgapa1 |
A |
G |
12: 55,842,483 (GRCm39) |
F62S |
probably damaging |
Het |
| Rangrf |
T |
C |
11: 68,863,518 (GRCm39) |
S163G |
probably benign |
Het |
| Rgs12 |
C |
A |
5: 35,176,804 (GRCm39) |
A65E |
probably damaging |
Het |
| Rrbp1 |
T |
C |
2: 143,830,436 (GRCm39) |
N577S |
probably damaging |
Het |
| Septin11 |
A |
G |
5: 93,315,393 (GRCm39) |
H374R |
probably damaging |
Het |
| Serpina5 |
T |
G |
12: 104,070,046 (GRCm39) |
N314K |
probably benign |
Het |
| Sgce |
T |
C |
6: 4,689,621 (GRCm39) |
D395G |
probably damaging |
Het |
| Slc26a9 |
A |
T |
1: 131,690,499 (GRCm39) |
N501I |
probably damaging |
Het |
| Slc9c1 |
A |
G |
16: 45,401,965 (GRCm39) |
D784G |
possibly damaging |
Het |
| Snapc2 |
A |
G |
8: 4,305,676 (GRCm39) |
D207G |
probably benign |
Het |
| Stard9 |
G |
T |
2: 120,529,738 (GRCm39) |
M1998I |
probably benign |
Het |
| Stk38 |
A |
C |
17: 29,194,907 (GRCm39) |
F280V |
possibly damaging |
Het |
| Tas2r126 |
A |
G |
6: 42,412,025 (GRCm39) |
K186R |
probably damaging |
Het |
| Tdp1 |
A |
C |
12: 99,875,970 (GRCm39) |
D307A |
probably benign |
Het |
| Tead2 |
A |
G |
7: 44,866,674 (GRCm39) |
D11G |
probably damaging |
Het |
| Tmco4 |
C |
A |
4: 138,747,383 (GRCm39) |
L211I |
probably damaging |
Het |
| Tmem183a |
A |
G |
1: 134,280,115 (GRCm39) |
F255S |
probably damaging |
Het |
| Tmem87a |
C |
T |
2: 120,205,929 (GRCm39) |
G349S |
possibly damaging |
Het |
| Tpte |
G |
A |
8: 22,826,549 (GRCm39) |
E377K |
possibly damaging |
Het |
| Trim32 |
T |
C |
4: 65,531,893 (GRCm39) |
F150S |
possibly damaging |
Het |
| Trpc7 |
T |
A |
13: 57,035,636 (GRCm39) |
K99M |
probably damaging |
Het |
| Ttc22 |
A |
G |
4: 106,491,381 (GRCm39) |
K195E |
probably damaging |
Het |
| Txn2 |
G |
A |
15: 77,811,917 (GRCm39) |
P7S |
probably damaging |
Het |
| Ubxn2a |
G |
A |
12: 4,930,700 (GRCm39) |
T220I |
probably damaging |
Het |
| Ufd1 |
A |
G |
16: 18,633,626 (GRCm39) |
N17S |
possibly damaging |
Het |
| Unc13a |
A |
G |
8: 72,102,509 (GRCm39) |
S958P |
probably damaging |
Het |
| Vmn1r202 |
T |
A |
13: 22,685,824 (GRCm39) |
M198L |
probably damaging |
Het |
| Washc5 |
A |
G |
15: 59,213,007 (GRCm39) |
F891S |
probably damaging |
Het |
| Zfp708 |
T |
C |
13: 67,218,375 (GRCm39) |
T495A |
probably benign |
Het |
| Zfp81 |
A |
G |
17: 33,553,593 (GRCm39) |
I407T |
probably benign |
Het |
| Zswim5 |
T |
C |
4: 116,843,874 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Vmn2r84 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01461:Vmn2r84
|
APN |
10 |
130,227,094 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL01590:Vmn2r84
|
APN |
10 |
130,221,964 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01639:Vmn2r84
|
APN |
10 |
130,225,141 (GRCm39) |
nonsense |
probably null |
|
|
IGL01843:Vmn2r84
|
APN |
10 |
130,222,148 (GRCm39) |
missense |
probably benign |
|
|
IGL01911:Vmn2r84
|
APN |
10 |
130,222,277 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01937:Vmn2r84
|
APN |
10 |
130,221,755 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01977:Vmn2r84
|
APN |
10 |
130,229,935 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02177:Vmn2r84
|
APN |
10 |
130,227,881 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02291:Vmn2r84
|
APN |
10 |
130,226,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02590:Vmn2r84
|
APN |
10 |
130,227,356 (GRCm39) |
splice site |
probably benign |
|
|
IGL02727:Vmn2r84
|
APN |
10 |
130,229,995 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02900:Vmn2r84
|
APN |
10 |
130,223,861 (GRCm39) |
splice site |
probably benign |
|
|
IGL03383:Vmn2r84
|
APN |
10 |
130,222,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4378001:Vmn2r84
|
UTSW |
10 |
130,221,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0076:Vmn2r84
|
UTSW |
10 |
130,230,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0089:Vmn2r84
|
UTSW |
10 |
130,222,588 (GRCm39) |
splice site |
probably benign |
|
|
R0153:Vmn2r84
|
UTSW |
10 |
130,227,877 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0883:Vmn2r84
|
UTSW |
10 |
130,226,984 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1237:Vmn2r84
|
UTSW |
10 |
130,223,725 (GRCm39) |
splice site |
probably null |
|
|
R1295:Vmn2r84
|
UTSW |
10 |
130,225,008 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1401:Vmn2r84
|
UTSW |
10 |
130,227,859 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1521:Vmn2r84
|
UTSW |
10 |
130,225,137 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1590:Vmn2r84
|
UTSW |
10 |
130,227,349 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1710:Vmn2r84
|
UTSW |
10 |
130,226,968 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1891:Vmn2r84
|
UTSW |
10 |
130,221,938 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1956:Vmn2r84
|
UTSW |
10 |
130,226,677 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1957:Vmn2r84
|
UTSW |
10 |
130,226,677 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1962:Vmn2r84
|
UTSW |
10 |
130,226,591 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1994:Vmn2r84
|
UTSW |
10 |
130,221,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2124:Vmn2r84
|
UTSW |
10 |
130,227,100 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2409:Vmn2r84
|
UTSW |
10 |
130,227,940 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2474:Vmn2r84
|
UTSW |
10 |
130,222,392 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2851:Vmn2r84
|
UTSW |
10 |
130,230,036 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3508:Vmn2r84
|
UTSW |
10 |
130,226,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3792:Vmn2r84
|
UTSW |
10 |
130,221,669 (GRCm39) |
makesense |
probably null |
|
|
R4051:Vmn2r84
|
UTSW |
10 |
130,226,767 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4061:Vmn2r84
|
UTSW |
10 |
130,221,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4091:Vmn2r84
|
UTSW |
10 |
130,227,238 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4190:Vmn2r84
|
UTSW |
10 |
130,227,163 (GRCm39) |
nonsense |
probably null |
|
|
R4520:Vmn2r84
|
UTSW |
10 |
130,222,391 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4584:Vmn2r84
|
UTSW |
10 |
130,226,582 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4588:Vmn2r84
|
UTSW |
10 |
130,221,809 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4655:Vmn2r84
|
UTSW |
10 |
130,229,973 (GRCm39) |
nonsense |
probably null |
|
|
R4860:Vmn2r84
|
UTSW |
10 |
130,221,712 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4860:Vmn2r84
|
UTSW |
10 |
130,221,712 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5022:Vmn2r84
|
UTSW |
10 |
130,222,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5146:Vmn2r84
|
UTSW |
10 |
130,221,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5237:Vmn2r84
|
UTSW |
10 |
130,221,863 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5695:Vmn2r84
|
UTSW |
10 |
130,225,064 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5793:Vmn2r84
|
UTSW |
10 |
130,221,754 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6210:Vmn2r84
|
UTSW |
10 |
130,222,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6286:Vmn2r84
|
UTSW |
10 |
130,226,737 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R6580:Vmn2r84
|
UTSW |
10 |
130,225,110 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6607:Vmn2r84
|
UTSW |
10 |
130,226,731 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6818:Vmn2r84
|
UTSW |
10 |
130,222,147 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6956:Vmn2r84
|
UTSW |
10 |
130,225,136 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6994:Vmn2r84
|
UTSW |
10 |
130,226,876 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7075:Vmn2r84
|
UTSW |
10 |
130,226,941 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7225:Vmn2r84
|
UTSW |
10 |
130,222,552 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7252:Vmn2r84
|
UTSW |
10 |
130,222,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7263:Vmn2r84
|
UTSW |
10 |
130,225,077 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7297:Vmn2r84
|
UTSW |
10 |
130,227,119 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7439:Vmn2r84
|
UTSW |
10 |
130,227,982 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7441:Vmn2r84
|
UTSW |
10 |
130,227,982 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7857:Vmn2r84
|
UTSW |
10 |
130,226,738 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8263:Vmn2r84
|
UTSW |
10 |
130,227,037 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8555:Vmn2r84
|
UTSW |
10 |
130,230,100 (GRCm39) |
missense |
probably benign |
0.28 |
|
R8766:Vmn2r84
|
UTSW |
10 |
130,222,241 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8821:Vmn2r84
|
UTSW |
10 |
130,226,968 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8831:Vmn2r84
|
UTSW |
10 |
130,226,968 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8970:Vmn2r84
|
UTSW |
10 |
130,222,244 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9164:Vmn2r84
|
UTSW |
10 |
130,221,669 (GRCm39) |
makesense |
probably null |
|
|
R9190:Vmn2r84
|
UTSW |
10 |
130,226,843 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9261:Vmn2r84
|
UTSW |
10 |
130,229,976 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9310:Vmn2r84
|
UTSW |
10 |
130,227,993 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R9434:Vmn2r84
|
UTSW |
10 |
130,221,745 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R9613:Vmn2r84
|
UTSW |
10 |
130,226,591 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Vmn2r84
|
UTSW |
10 |
130,227,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACCCTGCACTAGAAGCCAAGATGG -3'
(R):5'- TCAAGCTCACTACTCCAGGAGGAAG -3'
Sequencing Primer
(F):5'- AGCCAAGATGGAAAAGACCTC -3'
(R):5'- CTACTCCAGGAGGAAGGATGAG -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation