Incidental Mutation 'R7052:Pou2f1'
| ID |
547638 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pou2f1
|
| Ensembl Gene |
ENSMUSG00000026565 |
| Gene Name |
POU domain, class 2, transcription factor 1 |
| Synonyms |
Oct-1z, Oct-1A, Oct-1B, Oct-1C, oct-1, Oct1, 2810482H01Rik, Otf-1, Otf1 |
| MMRRC Submission |
045149-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7052 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
165692723-165830247 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 165742684 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Isoleucine
at position 82
(V82I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000107055
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027850]
[ENSMUST00000069609]
[ENSMUST00000111426]
[ENSMUST00000111427]
[ENSMUST00000111429]
[ENSMUST00000159212]
[ENSMUST00000160260]
[ENSMUST00000160908]
[ENSMUST00000177358]
[ENSMUST00000184643]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
unknown
Transcript: ENSMUST00000027850
AA Change: V93I
|
| SMART Domains |
Protein: ENSMUSP00000027850
Gene: ENSMUSG00000026565
AA Change: V93I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
22 |
N/A |
INTRINSIC |
|
low complexity region
|
94 |
123 |
N/A |
INTRINSIC |
|
low complexity region
|
137 |
152 |
N/A |
INTRINSIC |
|
low complexity region
|
171 |
192 |
N/A |
INTRINSIC |
|
low complexity region
|
199 |
217 |
N/A |
INTRINSIC |
|
POU
|
241 |
315 |
1.55e-52 |
SMART |
|
low complexity region
|
316 |
332 |
N/A |
INTRINSIC |
|
HOX
|
342 |
404 |
2.54e-19 |
SMART |
|
low complexity region
|
422 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
453 |
520 |
N/A |
INTRINSIC |
|
low complexity region
|
529 |
567 |
N/A |
INTRINSIC |
|
low complexity region
|
675 |
685 |
N/A |
INTRINSIC |
|
low complexity region
|
688 |
705 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000069609
AA Change: V82I
|
| SMART Domains |
Protein: ENSMUSP00000064000
Gene: ENSMUSG00000026565
AA Change: V82I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
83 |
112 |
N/A |
INTRINSIC |
|
low complexity region
|
130 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
189 |
204 |
N/A |
INTRINSIC |
|
low complexity region
|
223 |
244 |
N/A |
INTRINSIC |
|
low complexity region
|
251 |
269 |
N/A |
INTRINSIC |
|
POU
|
293 |
367 |
1.55e-52 |
SMART |
|
low complexity region
|
368 |
384 |
N/A |
INTRINSIC |
|
HOX
|
394 |
456 |
2.54e-19 |
SMART |
|
low complexity region
|
474 |
500 |
N/A |
INTRINSIC |
|
low complexity region
|
505 |
572 |
N/A |
INTRINSIC |
|
low complexity region
|
581 |
619 |
N/A |
INTRINSIC |
|
low complexity region
|
727 |
737 |
N/A |
INTRINSIC |
|
low complexity region
|
740 |
757 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000111426
AA Change: V82I
PolyPhen 2
Score 0.594 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000107055
Gene: ENSMUSG00000026565
AA Change: V82I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
83 |
112 |
N/A |
INTRINSIC |
|
low complexity region
|
130 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
189 |
204 |
N/A |
INTRINSIC |
|
low complexity region
|
223 |
244 |
N/A |
INTRINSIC |
|
low complexity region
|
251 |
269 |
N/A |
INTRINSIC |
|
POU
|
293 |
367 |
6.7e-55 |
SMART |
|
low complexity region
|
368 |
384 |
N/A |
INTRINSIC |
|
HOX
|
394 |
456 |
1.3e-21 |
SMART |
|
low complexity region
|
474 |
500 |
N/A |
INTRINSIC |
|
low complexity region
|
531 |
596 |
N/A |
INTRINSIC |
|
low complexity region
|
605 |
643 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000111427
AA Change: V82I
|
| SMART Domains |
Protein: ENSMUSP00000107056
Gene: ENSMUSG00000026565
AA Change: V82I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
83 |
112 |
N/A |
INTRINSIC |
|
low complexity region
|
130 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
189 |
204 |
N/A |
INTRINSIC |
|
low complexity region
|
223 |
244 |
N/A |
INTRINSIC |
|
low complexity region
|
251 |
269 |
N/A |
INTRINSIC |
|
POU
|
293 |
367 |
1.55e-52 |
SMART |
|
low complexity region
|
368 |
384 |
N/A |
INTRINSIC |
|
HOX
|
394 |
456 |
2.54e-19 |
SMART |
|
low complexity region
|
474 |
500 |
N/A |
INTRINSIC |
|
low complexity region
|
531 |
596 |
N/A |
INTRINSIC |
|
low complexity region
|
605 |
643 |
N/A |
INTRINSIC |
|
low complexity region
|
751 |
761 |
N/A |
INTRINSIC |
|
low complexity region
|
764 |
781 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000111429
AA Change: V70I
|
| SMART Domains |
Protein: ENSMUSP00000107057
Gene: ENSMUSG00000026565
AA Change: V70I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
71 |
100 |
N/A |
INTRINSIC |
|
low complexity region
|
118 |
160 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
192 |
N/A |
INTRINSIC |
|
low complexity region
|
211 |
232 |
N/A |
INTRINSIC |
|
low complexity region
|
239 |
257 |
N/A |
INTRINSIC |
|
POU
|
281 |
355 |
6.7e-55 |
SMART |
|
low complexity region
|
356 |
372 |
N/A |
INTRINSIC |
|
HOX
|
382 |
444 |
1.3e-21 |
SMART |
|
low complexity region
|
462 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
493 |
560 |
N/A |
INTRINSIC |
|
low complexity region
|
569 |
607 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159212
|
| SMART Domains |
Protein: ENSMUSP00000125371
Gene: ENSMUSG00000026565
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
71 |
100 |
N/A |
INTRINSIC |
|
low complexity region
|
118 |
160 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
192 |
N/A |
INTRINSIC |
|
low complexity region
|
211 |
232 |
N/A |
INTRINSIC |
|
low complexity region
|
239 |
257 |
N/A |
INTRINSIC |
|
POU
|
281 |
355 |
1.55e-52 |
SMART |
|
low complexity region
|
356 |
372 |
N/A |
INTRINSIC |
|
HOX
|
382 |
444 |
2.54e-19 |
SMART |
|
low complexity region
|
462 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
493 |
560 |
N/A |
INTRINSIC |
|
low complexity region
|
569 |
607 |
N/A |
INTRINSIC |
|
low complexity region
|
715 |
725 |
N/A |
INTRINSIC |
|
low complexity region
|
728 |
745 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000160260
AA Change: V93I
|
| SMART Domains |
Protein: ENSMUSP00000124738
Gene: ENSMUSG00000026565
AA Change: V93I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
22 |
N/A |
INTRINSIC |
|
low complexity region
|
94 |
123 |
N/A |
INTRINSIC |
|
low complexity region
|
141 |
183 |
N/A |
INTRINSIC |
|
low complexity region
|
200 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
234 |
255 |
N/A |
INTRINSIC |
|
low complexity region
|
262 |
280 |
N/A |
INTRINSIC |
|
POU
|
304 |
378 |
1.55e-52 |
SMART |
|
low complexity region
|
379 |
395 |
N/A |
INTRINSIC |
|
HOX
|
405 |
467 |
2.54e-19 |
SMART |
|
low complexity region
|
485 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
607 |
N/A |
INTRINSIC |
|
low complexity region
|
616 |
654 |
N/A |
INTRINSIC |
|
low complexity region
|
762 |
772 |
N/A |
INTRINSIC |
|
low complexity region
|
775 |
792 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000160908
AA Change: V93I
|
| SMART Domains |
Protein: ENSMUSP00000125444
Gene: ENSMUSG00000026565
AA Change: V93I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
22 |
N/A |
INTRINSIC |
|
low complexity region
|
94 |
123 |
N/A |
INTRINSIC |
|
low complexity region
|
141 |
183 |
N/A |
INTRINSIC |
|
low complexity region
|
200 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
234 |
255 |
N/A |
INTRINSIC |
|
low complexity region
|
262 |
280 |
N/A |
INTRINSIC |
|
POU
|
304 |
378 |
1.55e-52 |
SMART |
|
low complexity region
|
379 |
395 |
N/A |
INTRINSIC |
|
HOX
|
405 |
467 |
2.54e-19 |
SMART |
|
low complexity region
|
485 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
516 |
583 |
N/A |
INTRINSIC |
|
low complexity region
|
592 |
630 |
N/A |
INTRINSIC |
|
low complexity region
|
738 |
748 |
N/A |
INTRINSIC |
|
low complexity region
|
751 |
768 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000177358
AA Change: V70I
|
| SMART Domains |
Protein: ENSMUSP00000135565
Gene: ENSMUSG00000026565
AA Change: V70I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
71 |
100 |
N/A |
INTRINSIC |
|
low complexity region
|
118 |
160 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000184643
AA Change: V70I
|
| SMART Domains |
Protein: ENSMUSP00000138962
Gene: ENSMUSG00000026565
AA Change: V70I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
71 |
100 |
N/A |
INTRINSIC |
|
low complexity region
|
118 |
160 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
192 |
N/A |
INTRINSIC |
|
low complexity region
|
211 |
232 |
N/A |
INTRINSIC |
|
low complexity region
|
239 |
257 |
N/A |
INTRINSIC |
|
POU
|
281 |
355 |
6.7e-55 |
SMART |
|
low complexity region
|
356 |
372 |
N/A |
INTRINSIC |
|
HOX
|
382 |
444 |
1.3e-21 |
SMART |
|
low complexity region
|
462 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
493 |
560 |
N/A |
INTRINSIC |
|
low complexity region
|
569 |
607 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0710 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
100% (63/63) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010]
PHENOTYPE: Homozygous mutation of this gene results in prenatal lethality, with earlier lethality on either a 129/Sv or C57BL/6 background than a mixed 129/Sv and C57BL/6 background. Embryos show decreased erythropoiesis and partial penetrance of small lens size. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 61 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc9 |
C |
T |
6: 142,604,261 (GRCm39) |
R658H |
probably benign |
Het |
| Als2cl |
C |
T |
9: 110,727,151 (GRCm39) |
R906C |
probably damaging |
Het |
| Asb8 |
T |
C |
15: 98,034,282 (GRCm39) |
H91R |
probably damaging |
Het |
| Atp8b3 |
C |
T |
10: 80,355,858 (GRCm39) |
E1285K |
probably benign |
Het |
| Bves |
G |
A |
10: 45,222,386 (GRCm39) |
R172H |
possibly damaging |
Het |
| C6 |
A |
T |
15: 4,763,177 (GRCm39) |
N59I |
probably damaging |
Het |
| Capn15 |
A |
T |
17: 26,180,724 (GRCm39) |
V782D |
probably damaging |
Het |
| Ccdc168 |
T |
A |
1: 44,096,466 (GRCm39) |
Y1544F |
possibly damaging |
Het |
| Ccdc18 |
T |
C |
5: 108,309,554 (GRCm39) |
L383S |
probably benign |
Het |
| Coro6 |
C |
A |
11: 77,357,056 (GRCm39) |
N119K |
probably benign |
Het |
| Cps1 |
T |
A |
1: 67,237,569 (GRCm39) |
D1023E |
probably damaging |
Het |
| Dctn1 |
T |
A |
6: 83,172,262 (GRCm39) |
|
probably null |
Het |
| Ero1a |
T |
A |
14: 45,544,040 (GRCm39) |
K55* |
probably null |
Het |
| Fam209 |
G |
A |
2: 172,314,751 (GRCm39) |
G80D |
possibly damaging |
Het |
| Fam89b |
G |
A |
19: 5,779,276 (GRCm39) |
R94C |
probably damaging |
Het |
| Fut1 |
A |
G |
7: 45,269,181 (GRCm39) |
*323W |
probably null |
Het |
| Garin2 |
C |
T |
12: 78,766,176 (GRCm39) |
T315I |
probably benign |
Het |
| Gm47985 |
T |
A |
1: 151,058,890 (GRCm39) |
F177Y |
possibly damaging |
Het |
| Gstm7 |
T |
A |
3: 107,838,633 (GRCm39) |
D37V |
probably damaging |
Het |
| H2-Aa |
T |
A |
17: 34,503,484 (GRCm39) |
S38C |
possibly damaging |
Het |
| Ighg2c |
T |
C |
12: 113,252,343 (GRCm39) |
T70A |
|
Het |
| Ino80 |
A |
G |
2: 119,257,068 (GRCm39) |
|
probably null |
Het |
| Irf8 |
C |
T |
8: 121,466,581 (GRCm39) |
R9W |
probably damaging |
Het |
| Kcnt2 |
A |
G |
1: 140,310,785 (GRCm39) |
N197S |
probably damaging |
Het |
| Kif11 |
T |
A |
19: 37,373,040 (GRCm39) |
C86* |
probably null |
Het |
| Lonp1 |
A |
T |
17: 56,933,549 (GRCm39) |
F109I |
probably benign |
Het |
| Mlkl |
G |
A |
8: 112,046,074 (GRCm39) |
S312L |
possibly damaging |
Het |
| Mroh9 |
T |
A |
1: 162,866,525 (GRCm39) |
Q706L |
possibly damaging |
Het |
| Mtmr7 |
T |
C |
8: 41,008,874 (GRCm39) |
H315R |
possibly damaging |
Het |
| Myh7b |
G |
C |
2: 155,456,053 (GRCm39) |
R146P |
probably damaging |
Het |
| Naip5 |
A |
G |
13: 100,358,855 (GRCm39) |
Y794H |
probably benign |
Het |
| Nup153 |
A |
T |
13: 46,840,949 (GRCm39) |
N886K |
probably benign |
Het |
| Nup205 |
A |
G |
6: 35,192,077 (GRCm39) |
R1047G |
possibly damaging |
Het |
| Oog3 |
A |
T |
4: 143,887,027 (GRCm39) |
L31Q |
probably damaging |
Het |
| Or5b123 |
T |
A |
19: 13,596,990 (GRCm39) |
S155T |
probably benign |
Het |
| Or6c38 |
T |
C |
10: 128,929,744 (GRCm39) |
Y33C |
probably damaging |
Het |
| Palmd |
T |
C |
3: 116,717,012 (GRCm39) |
N495S |
probably benign |
Het |
| Patj |
A |
G |
4: 98,565,497 (GRCm39) |
Q1070R |
probably benign |
Het |
| Pax1 |
G |
A |
2: 147,207,824 (GRCm39) |
R232H |
probably damaging |
Het |
| Pcdhb1 |
A |
G |
18: 37,399,582 (GRCm39) |
N511S |
probably damaging |
Het |
| Pigs |
C |
T |
11: 78,232,211 (GRCm39) |
L448F |
probably damaging |
Het |
| Pih1d2 |
A |
G |
9: 50,533,077 (GRCm39) |
Y235C |
probably damaging |
Het |
| Pkd2l2 |
T |
A |
18: 34,558,212 (GRCm39) |
I297K |
possibly damaging |
Het |
| Pramel1 |
T |
C |
4: 143,123,074 (GRCm39) |
L17P |
probably damaging |
Het |
| Riok1 |
C |
T |
13: 38,220,991 (GRCm39) |
|
probably benign |
Het |
| Scg3 |
C |
A |
9: 75,568,664 (GRCm39) |
E358* |
probably null |
Het |
| Siglec15 |
T |
C |
18: 78,091,946 (GRCm39) |
E85G |
probably damaging |
Het |
| Snx20 |
T |
C |
8: 89,356,606 (GRCm39) |
H70R |
probably benign |
Het |
| Spi1 |
T |
A |
2: 90,943,685 (GRCm39) |
S76R |
probably damaging |
Het |
| Stat5a |
T |
C |
11: 100,770,111 (GRCm39) |
S463P |
probably damaging |
Het |
| Svs5 |
A |
G |
2: 164,080,126 (GRCm39) |
I13T |
unknown |
Het |
| Tmem132e |
T |
C |
11: 82,328,189 (GRCm39) |
S406P |
probably damaging |
Het |
| Top1mt |
T |
C |
15: 75,540,560 (GRCm39) |
N237S |
possibly damaging |
Het |
| Trav6d-4 |
G |
A |
14: 52,991,053 (GRCm39) |
V30M |
possibly damaging |
Het |
| Trp73 |
A |
T |
4: 154,149,140 (GRCm39) |
M217K |
probably damaging |
Het |
| Vmn1r58 |
A |
G |
7: 5,414,134 (GRCm39) |
I32T |
probably benign |
Het |
| Vmn1r9 |
T |
C |
6: 57,048,396 (GRCm39) |
M157T |
probably benign |
Het |
| Vmn2r100 |
C |
T |
17: 19,751,556 (GRCm39) |
S533F |
possibly damaging |
Het |
| Vmn2r112 |
T |
A |
17: 22,821,507 (GRCm39) |
M160K |
probably benign |
Het |
| Vps13d |
C |
A |
4: 144,889,914 (GRCm39) |
A597S |
probably benign |
Het |
| Zfp27 |
AATCCGCTTGTGCA |
AA |
7: 29,594,446 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Pou2f1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00090:Pou2f1
|
APN |
1 |
165,729,867 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00392:Pou2f1
|
APN |
1 |
165,724,159 (GRCm39) |
splice site |
probably benign |
|
|
IGL01627:Pou2f1
|
APN |
1 |
165,708,002 (GRCm39) |
unclassified |
probably benign |
|
|
IGL01707:Pou2f1
|
APN |
1 |
165,742,685 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02735:Pou2f1
|
APN |
1 |
165,703,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02740:Pou2f1
|
APN |
1 |
165,710,685 (GRCm39) |
nonsense |
probably null |
|
|
IGL03117:Pou2f1
|
APN |
1 |
165,762,382 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03272:Pou2f1
|
APN |
1 |
165,724,049 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R0021:Pou2f1
|
UTSW |
1 |
165,703,587 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1437:Pou2f1
|
UTSW |
1 |
165,719,399 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2171:Pou2f1
|
UTSW |
1 |
165,707,925 (GRCm39) |
unclassified |
probably benign |
|
|
R3722:Pou2f1
|
UTSW |
1 |
165,722,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3789:Pou2f1
|
UTSW |
1 |
165,722,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3790:Pou2f1
|
UTSW |
1 |
165,722,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3901:Pou2f1
|
UTSW |
1 |
165,722,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4225:Pou2f1
|
UTSW |
1 |
165,738,889 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4459:Pou2f1
|
UTSW |
1 |
165,722,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4460:Pou2f1
|
UTSW |
1 |
165,722,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4573:Pou2f1
|
UTSW |
1 |
165,740,830 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4820:Pou2f1
|
UTSW |
1 |
165,719,517 (GRCm39) |
intron |
probably benign |
|
|
R4838:Pou2f1
|
UTSW |
1 |
165,744,492 (GRCm39) |
missense |
probably null |
1.00 |
|
R5579:Pou2f1
|
UTSW |
1 |
165,742,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5856:Pou2f1
|
UTSW |
1 |
165,742,699 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5951:Pou2f1
|
UTSW |
1 |
165,710,625 (GRCm39) |
unclassified |
probably benign |
|
|
R6128:Pou2f1
|
UTSW |
1 |
165,703,056 (GRCm39) |
unclassified |
probably benign |
|
|
R6145:Pou2f1
|
UTSW |
1 |
165,703,002 (GRCm39) |
unclassified |
probably benign |
|
|
R6216:Pou2f1
|
UTSW |
1 |
165,707,889 (GRCm39) |
unclassified |
probably benign |
|
|
R6971:Pou2f1
|
UTSW |
1 |
165,759,258 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7403:Pou2f1
|
UTSW |
1 |
165,738,955 (GRCm39) |
missense |
unknown |
|
|
R7404:Pou2f1
|
UTSW |
1 |
165,738,955 (GRCm39) |
missense |
unknown |
|
|
R7741:Pou2f1
|
UTSW |
1 |
165,703,444 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8011:Pou2f1
|
UTSW |
1 |
165,722,472 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8478:Pou2f1
|
UTSW |
1 |
165,759,287 (GRCm39) |
start codon destroyed |
probably null |
|
|
R8804:Pou2f1
|
UTSW |
1 |
165,708,039 (GRCm39) |
missense |
unknown |
|
|
R8892:Pou2f1
|
UTSW |
1 |
165,708,027 (GRCm39) |
missense |
unknown |
|
|
R9126:Pou2f1
|
UTSW |
1 |
165,722,603 (GRCm39) |
missense |
unknown |
|
|
R9151:Pou2f1
|
UTSW |
1 |
165,703,640 (GRCm39) |
intron |
probably benign |
|
|
R9469:Pou2f1
|
UTSW |
1 |
165,740,830 (GRCm39) |
missense |
probably benign |
0.29 |
|
R9665:Pou2f1
|
UTSW |
1 |
165,703,600 (GRCm39) |
missense |
probably damaging |
0.99 |
|
RF012:Pou2f1
|
UTSW |
1 |
165,740,800 (GRCm39) |
missense |
unknown |
|
|
X0022:Pou2f1
|
UTSW |
1 |
165,724,025 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GTCCACCTTTGGCTCACACA -3'
(R):5'- ATGGCATGCTGACTGATGGT -3'
Sequencing Primer
(F):5'- TTTGGCTCACACACACAGCAG -3'
(R):5'- CAAAAGAAGTTCCTGTGGTTTTCAG -3'
|
| Posted On |
2019-05-13 |
Incidental Mutation