Incidental Mutation 'R7052:Vmn2r112'
ID 547683
Institutional Source Beutler Lab
Gene Symbol Vmn2r112
Ensembl Gene ENSMUSG00000094921
Gene Name vomeronasal 2, receptor 112
Synonyms EG628185
MMRRC Submission 045149-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.105) question?
Stock # R7052 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 22820129-22838114 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 22821507 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 160 (M160K)
Ref Sequence ENSEMBL: ENSMUSP00000094994 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097381]
AlphaFold L7N221
Predicted Effect probably benign
Transcript: ENSMUST00000097381
AA Change: M160K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000094994
Gene: ENSMUSG00000094921
AA Change: M160K

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 73 471 2.8e-32 PFAM
Pfam:NCD3G 512 565 5.8e-21 PFAM
Pfam:7tm_3 598 833 6.5e-54 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 100% (63/63)
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc9 C T 6: 142,604,261 (GRCm39) R658H probably benign Het
Als2cl C T 9: 110,727,151 (GRCm39) R906C probably damaging Het
Asb8 T C 15: 98,034,282 (GRCm39) H91R probably damaging Het
Atp8b3 C T 10: 80,355,858 (GRCm39) E1285K probably benign Het
Bves G A 10: 45,222,386 (GRCm39) R172H possibly damaging Het
C6 A T 15: 4,763,177 (GRCm39) N59I probably damaging Het
Capn15 A T 17: 26,180,724 (GRCm39) V782D probably damaging Het
Ccdc168 T A 1: 44,096,466 (GRCm39) Y1544F possibly damaging Het
Ccdc18 T C 5: 108,309,554 (GRCm39) L383S probably benign Het
Coro6 C A 11: 77,357,056 (GRCm39) N119K probably benign Het
Cps1 T A 1: 67,237,569 (GRCm39) D1023E probably damaging Het
Dctn1 T A 6: 83,172,262 (GRCm39) probably null Het
Ero1a T A 14: 45,544,040 (GRCm39) K55* probably null Het
Fam209 G A 2: 172,314,751 (GRCm39) G80D possibly damaging Het
Fam89b G A 19: 5,779,276 (GRCm39) R94C probably damaging Het
Fut1 A G 7: 45,269,181 (GRCm39) *323W probably null Het
Garin2 C T 12: 78,766,176 (GRCm39) T315I probably benign Het
Gm47985 T A 1: 151,058,890 (GRCm39) F177Y possibly damaging Het
Gstm7 T A 3: 107,838,633 (GRCm39) D37V probably damaging Het
H2-Aa T A 17: 34,503,484 (GRCm39) S38C possibly damaging Het
Ighg2c T C 12: 113,252,343 (GRCm39) T70A Het
Ino80 A G 2: 119,257,068 (GRCm39) probably null Het
Irf8 C T 8: 121,466,581 (GRCm39) R9W probably damaging Het
Kcnt2 A G 1: 140,310,785 (GRCm39) N197S probably damaging Het
Kif11 T A 19: 37,373,040 (GRCm39) C86* probably null Het
Lonp1 A T 17: 56,933,549 (GRCm39) F109I probably benign Het
Mlkl G A 8: 112,046,074 (GRCm39) S312L possibly damaging Het
Mroh9 T A 1: 162,866,525 (GRCm39) Q706L possibly damaging Het
Mtmr7 T C 8: 41,008,874 (GRCm39) H315R possibly damaging Het
Myh7b G C 2: 155,456,053 (GRCm39) R146P probably damaging Het
Naip5 A G 13: 100,358,855 (GRCm39) Y794H probably benign Het
Nup153 A T 13: 46,840,949 (GRCm39) N886K probably benign Het
Nup205 A G 6: 35,192,077 (GRCm39) R1047G possibly damaging Het
Oog3 A T 4: 143,887,027 (GRCm39) L31Q probably damaging Het
Or5b123 T A 19: 13,596,990 (GRCm39) S155T probably benign Het
Or6c38 T C 10: 128,929,744 (GRCm39) Y33C probably damaging Het
Palmd T C 3: 116,717,012 (GRCm39) N495S probably benign Het
Patj A G 4: 98,565,497 (GRCm39) Q1070R probably benign Het
Pax1 G A 2: 147,207,824 (GRCm39) R232H probably damaging Het
Pcdhb1 A G 18: 37,399,582 (GRCm39) N511S probably damaging Het
Pigs C T 11: 78,232,211 (GRCm39) L448F probably damaging Het
Pih1d2 A G 9: 50,533,077 (GRCm39) Y235C probably damaging Het
Pkd2l2 T A 18: 34,558,212 (GRCm39) I297K possibly damaging Het
Pou2f1 C T 1: 165,742,684 (GRCm39) V82I possibly damaging Het
Pramel1 T C 4: 143,123,074 (GRCm39) L17P probably damaging Het
Riok1 C T 13: 38,220,991 (GRCm39) probably benign Het
Scg3 C A 9: 75,568,664 (GRCm39) E358* probably null Het
Siglec15 T C 18: 78,091,946 (GRCm39) E85G probably damaging Het
Snx20 T C 8: 89,356,606 (GRCm39) H70R probably benign Het
Spi1 T A 2: 90,943,685 (GRCm39) S76R probably damaging Het
Stat5a T C 11: 100,770,111 (GRCm39) S463P probably damaging Het
Svs5 A G 2: 164,080,126 (GRCm39) I13T unknown Het
Tmem132e T C 11: 82,328,189 (GRCm39) S406P probably damaging Het
Top1mt T C 15: 75,540,560 (GRCm39) N237S possibly damaging Het
Trav6d-4 G A 14: 52,991,053 (GRCm39) V30M possibly damaging Het
Trp73 A T 4: 154,149,140 (GRCm39) M217K probably damaging Het
Vmn1r58 A G 7: 5,414,134 (GRCm39) I32T probably benign Het
Vmn1r9 T C 6: 57,048,396 (GRCm39) M157T probably benign Het
Vmn2r100 C T 17: 19,751,556 (GRCm39) S533F possibly damaging Het
Vps13d C A 4: 144,889,914 (GRCm39) A597S probably benign Het
Zfp27 AATCCGCTTGTGCA AA 7: 29,594,446 (GRCm39) probably benign Het
Other mutations in Vmn2r112
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00341:Vmn2r112 APN 17 22,837,917 (GRCm39) missense probably benign 0.13
IGL01021:Vmn2r112 APN 17 22,837,885 (GRCm39) missense probably damaging 1.00
IGL01122:Vmn2r112 APN 17 22,821,988 (GRCm39) missense probably benign 0.00
IGL01360:Vmn2r112 APN 17 22,837,603 (GRCm39) missense probably benign 0.03
IGL01536:Vmn2r112 APN 17 22,824,136 (GRCm39) missense probably damaging 1.00
IGL02148:Vmn2r112 APN 17 22,838,013 (GRCm39) missense probably damaging 1.00
IGL02465:Vmn2r112 APN 17 22,833,975 (GRCm39) missense probably damaging 1.00
PIT4576001:Vmn2r112 UTSW 17 22,833,912 (GRCm39) missense probably benign 0.00
R0278:Vmn2r112 UTSW 17 22,821,987 (GRCm39) missense probably benign 0.44
R0328:Vmn2r112 UTSW 17 22,824,251 (GRCm39) missense probably benign 0.01
R0583:Vmn2r112 UTSW 17 22,837,930 (GRCm39) missense probably damaging 1.00
R0831:Vmn2r112 UTSW 17 22,833,980 (GRCm39) missense probably damaging 0.99
R1080:Vmn2r112 UTSW 17 22,837,980 (GRCm39) missense probably damaging 1.00
R1245:Vmn2r112 UTSW 17 22,822,228 (GRCm39) missense probably benign 0.03
R1321:Vmn2r112 UTSW 17 22,837,500 (GRCm39) nonsense probably null
R1381:Vmn2r112 UTSW 17 22,837,467 (GRCm39) missense probably damaging 1.00
R1514:Vmn2r112 UTSW 17 22,821,825 (GRCm39) missense probably benign 0.40
R1519:Vmn2r112 UTSW 17 22,837,884 (GRCm39) missense possibly damaging 0.83
R1572:Vmn2r112 UTSW 17 22,822,125 (GRCm39) missense possibly damaging 0.61
R1590:Vmn2r112 UTSW 17 22,833,989 (GRCm39) critical splice donor site probably null
R1640:Vmn2r112 UTSW 17 22,824,097 (GRCm39) missense probably benign 0.01
R2221:Vmn2r112 UTSW 17 22,820,214 (GRCm39) missense possibly damaging 0.86
R2223:Vmn2r112 UTSW 17 22,820,214 (GRCm39) missense possibly damaging 0.86
R2310:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R2312:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R2337:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R2339:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R2340:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R2341:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R2342:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R2401:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R2860:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R2861:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R2926:Vmn2r112 UTSW 17 22,833,984 (GRCm39) missense possibly damaging 0.90
R3236:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R3237:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R3977:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R3979:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R4168:Vmn2r112 UTSW 17 22,822,069 (GRCm39) missense probably benign 0.01
R4256:Vmn2r112 UTSW 17 22,837,393 (GRCm39) missense probably damaging 1.00
R4386:Vmn2r112 UTSW 17 22,820,303 (GRCm39) missense probably benign 0.36
R4912:Vmn2r112 UTSW 17 22,822,363 (GRCm39) missense probably damaging 0.99
R4947:Vmn2r112 UTSW 17 22,821,860 (GRCm39) missense probably benign 0.02
R5446:Vmn2r112 UTSW 17 22,837,231 (GRCm39) missense probably damaging 1.00
R5870:Vmn2r112 UTSW 17 22,838,004 (GRCm39) missense probably benign 0.00
R6351:Vmn2r112 UTSW 17 22,820,259 (GRCm39) missense probably benign
R6384:Vmn2r112 UTSW 17 22,824,136 (GRCm39) missense probably damaging 1.00
R6390:Vmn2r112 UTSW 17 22,824,230 (GRCm39) missense probably benign 0.01
R6401:Vmn2r112 UTSW 17 22,822,532 (GRCm39) nonsense probably null
R6405:Vmn2r112 UTSW 17 22,837,216 (GRCm39) missense probably damaging 1.00
R6620:Vmn2r112 UTSW 17 22,822,082 (GRCm39) missense probably benign 0.00
R6648:Vmn2r112 UTSW 17 22,837,467 (GRCm39) missense probably damaging 1.00
R6649:Vmn2r112 UTSW 17 22,820,160 (GRCm39) missense probably null 1.00
R6653:Vmn2r112 UTSW 17 22,820,160 (GRCm39) missense probably null 1.00
R6654:Vmn2r112 UTSW 17 22,822,450 (GRCm39) missense possibly damaging 0.89
R6700:Vmn2r112 UTSW 17 22,822,462 (GRCm39) missense possibly damaging 0.53
R6993:Vmn2r112 UTSW 17 22,822,195 (GRCm39) missense probably benign 0.01
R7454:Vmn2r112 UTSW 17 22,822,288 (GRCm39) missense probably benign 0.00
R7763:Vmn2r112 UTSW 17 22,822,099 (GRCm39) missense probably damaging 1.00
R8032:Vmn2r112 UTSW 17 22,822,375 (GRCm39) missense probably benign 0.21
R8177:Vmn2r112 UTSW 17 22,822,594 (GRCm39) missense possibly damaging 0.47
R8263:Vmn2r112 UTSW 17 22,824,140 (GRCm39) missense probably damaging 1.00
R8395:Vmn2r112 UTSW 17 22,837,587 (GRCm39) missense possibly damaging 0.94
R8492:Vmn2r112 UTSW 17 22,821,470 (GRCm39) missense probably benign 0.03
R8889:Vmn2r112 UTSW 17 22,837,612 (GRCm39) missense probably damaging 1.00
R8892:Vmn2r112 UTSW 17 22,837,612 (GRCm39) missense probably damaging 1.00
R9246:Vmn2r112 UTSW 17 22,824,088 (GRCm39) missense probably benign 0.21
R9269:Vmn2r112 UTSW 17 22,820,213 (GRCm39) missense probably benign
R9273:Vmn2r112 UTSW 17 22,837,721 (GRCm39) missense probably damaging 1.00
R9288:Vmn2r112 UTSW 17 22,822,323 (GRCm39) missense probably damaging 1.00
R9352:Vmn2r112 UTSW 17 22,822,479 (GRCm39) missense probably damaging 0.98
R9406:Vmn2r112 UTSW 17 22,824,223 (GRCm39) nonsense probably null
R9432:Vmn2r112 UTSW 17 22,821,233 (GRCm39) missense
R9728:Vmn2r112 UTSW 17 22,824,108 (GRCm39) missense probably damaging 0.96
Z1088:Vmn2r112 UTSW 17 22,824,059 (GRCm39) missense possibly damaging 0.89
Predicted Primers PCR Primer
(F):5'- CAAATATGCTCTGGCTTTGGC -3'
(R):5'- GAAGCCCCATCAAATGTGTG -3'

Sequencing Primer
(F):5'- GGAACCCTGATCTTTTACCAAATATG -3'
(R):5'- GCCCCATCAAATGTGTGAATAATAC -3'
Posted On 2019-05-13