Mutagenetix > Incidental Mutation

Incidental Mutation 'R7056:Vmn2r111'

547950

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r111

Ensembl Gene

ENSMUSG00000095093

Gene Name

vomeronasal 2, receptor 111

Synonyms

EG210876

MMRRC Submission

045153-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

R7056 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

22766922-22792254 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 22778032 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 549 (N549S)

Ref Sequence

ENSEMBL: ENSMUSP00000090148 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000092491]

AlphaFold

K7N674

Predicted Effect

possibly damaging
Transcript: ENSMUST00000092491
AA Change: N549S

PolyPhen 2 Score 0.502 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000090148
Gene: ENSMUSG00000095093
AA Change: N549S

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	2.5e-29	PFAM
Pfam:NCD3G	512	565	1.1e-20	PFAM
Pfam:7tm_3	595	833	5.6e-54	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.1%

Validation Efficiency

100% (62/62)

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Atr	T	A	9: 95,744,916 (GRCm39)	S78T	probably damaging	Het
B2m	T	C	2: 121,981,465 (GRCm39)	L60P	probably damaging	Het
C1ra	G	A	6: 124,494,684 (GRCm39)	E316K	probably benign	Het
Cep350	A	C	1: 155,724,373 (GRCm39)	I3075S	probably damaging	Het
Cep97	A	G	16: 55,725,935 (GRCm39)	S651P	probably damaging	Het
Chrna5	C	T	9: 54,888,985 (GRCm39)		probably benign	Het
Cog5	T	C	12: 31,715,468 (GRCm39)	V80A	possibly damaging	Het
Col9a2	G	A	4: 120,906,913 (GRCm39)		probably null	Het
Cop1	C	T	1: 159,077,647 (GRCm39)	L161F	probably damaging	Het
Cyp4f17	A	T	17: 32,746,846 (GRCm39)	M383L	possibly damaging	Het
Dennd4a	A	G	9: 64,814,205 (GRCm39)	D1474G	possibly damaging	Het
Dgkb	A	C	12: 38,150,492 (GRCm39)	S100R	probably benign	Het
Dnah17	A	G	11: 118,016,212 (GRCm39)	V309A	probably benign	Het
Dner	C	A	1: 84,558,457 (GRCm39)	R169L	possibly damaging	Het
Dus1l	T	C	11: 120,682,120 (GRCm39)	E362G	probably benign	Het
Eed	A	T	7: 89,619,564 (GRCm39)	S168T	possibly damaging	Het
Eif3a	T	A	19: 60,751,500 (GRCm39)		probably null	Het
Fam234b	A	G	6: 135,205,450 (GRCm39)	S472G	probably benign	Het
Fbn2	T	A	18: 58,209,798 (GRCm39)	T1028S	probably benign	Het
Fbxw16	A	G	9: 109,265,352 (GRCm39)	V393A	possibly damaging	Het
Fig4	A	T	10: 41,096,928 (GRCm39)	L838Q	probably benign	Het
Gm13941	T	G	2: 110,927,147 (GRCm39)	S137R	unknown	Het
Gm9938	T	G	19: 23,701,981 (GRCm39)		probably benign	Het
Igsf10	T	G	3: 59,238,501 (GRCm39)	D560A	probably damaging	Het
Lrrk2	T	A	15: 91,659,198 (GRCm39)	L1870*	probably null	Het
Mep1b	T	A	18: 21,224,247 (GRCm39)	Y347N	probably damaging	Het
Mepce	T	C	5: 137,780,968 (GRCm39)	N613D	probably damaging	Het
Mgat3	T	G	15: 80,096,097 (GRCm39)	L308R	probably damaging	Het
Morc2a	A	G	11: 3,625,925 (GRCm39)	Y175C	probably damaging	Het
Necab2	A	G	8: 120,178,878 (GRCm39)	N98S	probably benign	Het
Net1	T	C	13: 3,934,845 (GRCm39)	M394V	probably benign	Het
Nfat5	G	A	8: 108,094,738 (GRCm39)	G993D	probably damaging	Het
Obscn	C	A	11: 58,887,122 (GRCm39)		probably benign	Het
Olr1	T	C	6: 129,465,904 (GRCm39)	H34R	probably damaging	Het
Or2ab1	A	G	11: 58,489,044 (GRCm39)	Y274C	probably damaging	Het
Or4f60	T	C	2: 111,902,662 (GRCm39)	N89D	probably benign	Het
Pmm2	T	A	16: 8,460,628 (GRCm39)	F27L	probably damaging	Het
Ptpdc1	C	A	13: 48,740,466 (GRCm39)	V261F	possibly damaging	Het
Pyroxd1	G	T	6: 142,304,808 (GRCm39)	R345L	probably benign	Het
Radil	A	T	5: 142,480,109 (GRCm39)	C670*	probably null	Het
Rasgrf2	C	T	13: 92,167,203 (GRCm39)	S290N	probably damaging	Het
Rbm33	T	C	5: 28,599,001 (GRCm39)		probably benign	Het
Rnf111	A	T	9: 70,360,957 (GRCm39)	S501R	possibly damaging	Het
Sel1l2	T	A	2: 140,087,334 (GRCm39)	I446F	probably benign	Het
Sh3pxd2b	T	C	11: 32,372,737 (GRCm39)	S635P	probably benign	Het
Slc30a2	G	A	4: 134,074,726 (GRCm39)	R161Q	probably damaging	Het
Smg1	T	C	7: 117,745,623 (GRCm39)		probably benign	Het
Sorcs2	C	A	5: 36,225,474 (GRCm39)	D132Y	probably damaging	Het
Sox18	T	C	2: 181,313,280 (GRCm39)	D12G	probably damaging	Het
Srsf4	G	T	4: 131,628,004 (GRCm39)		probably benign	Het
Susd4	C	A	1: 182,660,721 (GRCm39)	T81N	probably benign	Het
Tmem256	G	T	11: 69,729,416 (GRCm39)		probably benign	Het
Tor4a	T	C	2: 25,084,853 (GRCm39)	H350R	probably benign	Het
Ugt2a3	T	A	5: 87,484,953 (GRCm39)	S24C	probably damaging	Het
Vmn2r77	C	T	7: 86,451,023 (GRCm39)	T303I	probably benign	Het
Wdr70	T	A	15: 7,913,877 (GRCm39)	I591F	possibly damaging	Het
Wdr93	T	C	7: 79,399,088 (GRCm39)	I74T	probably damaging	Het
Zfp292	A	T	4: 34,809,784 (GRCm39)	C1087S	probably damaging	Het
Zfp592	T	A	7: 80,673,067 (GRCm39)	D10E	probably damaging	Het
Zfp69	A	G	4: 120,788,295 (GRCm39)	V340A	probably benign	Het
Zswim2	C	T	2: 83,751,092 (GRCm39)		probably null	Het

Other mutations in Vmn2r111

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00932:Vmn2r111	APN	17	22,767,734 (GRCm39)	missense	probably benign	0.00
IGL01306:Vmn2r111	APN	17	22,787,965 (GRCm39)	missense	probably damaging	0.99
IGL01309:Vmn2r111	APN	17	22,787,997 (GRCm39)	missense	possibly damaging	0.51
IGL01457:Vmn2r111	APN	17	22,790,966 (GRCm39)	nonsense	probably null
IGL01465:Vmn2r111	APN	17	22,767,718 (GRCm39)	missense	probably benign	0.00
IGL01505:Vmn2r111	APN	17	22,767,553 (GRCm39)	missense	probably benign	0.00
IGL01571:Vmn2r111	APN	17	22,790,373 (GRCm39)	missense	probably damaging	0.99
IGL01715:Vmn2r111	APN	17	22,788,054 (GRCm39)	splice site	probably benign
IGL01962:Vmn2r111	APN	17	22,767,265 (GRCm39)	missense	possibly damaging	0.90
IGL02190:Vmn2r111	APN	17	22,789,754 (GRCm39)	missense	probably benign	0.00
IGL02496:Vmn2r111	APN	17	22,787,837 (GRCm39)	missense	probably benign
IGL02519:Vmn2r111	APN	17	22,767,320 (GRCm39)	missense	possibly damaging	0.80
IGL02616:Vmn2r111	APN	17	22,790,031 (GRCm39)	missense	possibly damaging	0.67
IGL02641:Vmn2r111	APN	17	22,792,205 (GRCm39)	missense	possibly damaging	0.82
IGL02690:Vmn2r111	APN	17	22,778,023 (GRCm39)	critical splice donor site	probably null
IGL02698:Vmn2r111	APN	17	22,790,226 (GRCm39)	missense	probably damaging	1.00
IGL03017:Vmn2r111	APN	17	22,789,839 (GRCm39)	missense	probably damaging	1.00
R0046:Vmn2r111	UTSW	17	22,766,990 (GRCm39)	missense	probably benign
R0064:Vmn2r111	UTSW	17	22,791,053 (GRCm39)	missense	probably benign	0.00
R0519:Vmn2r111	UTSW	17	22,792,102 (GRCm39)	missense	probably benign	0.02
R1439:Vmn2r111	UTSW	17	22,790,097 (GRCm39)	missense	probably benign	0.00
R1467:Vmn2r111	UTSW	17	22,790,028 (GRCm39)	missense	probably damaging	0.99
R1467:Vmn2r111	UTSW	17	22,790,028 (GRCm39)	missense	probably damaging	0.99
R1636:Vmn2r111	UTSW	17	22,790,380 (GRCm39)	missense	probably damaging	1.00
R1647:Vmn2r111	UTSW	17	22,788,042 (GRCm39)	missense	probably benign	0.03
R1648:Vmn2r111	UTSW	17	22,788,042 (GRCm39)	missense	probably benign	0.03
R1697:Vmn2r111	UTSW	17	22,767,041 (GRCm39)	missense	probably benign	0.26
R1996:Vmn2r111	UTSW	17	22,767,062 (GRCm39)	missense	probably benign	0.21
R2040:Vmn2r111	UTSW	17	22,767,395 (GRCm39)	missense	probably damaging	1.00
R2075:Vmn2r111	UTSW	17	22,778,043 (GRCm39)	missense	probably damaging	1.00
R2134:Vmn2r111	UTSW	17	22,792,085 (GRCm39)	missense	possibly damaging	0.68
R2357:Vmn2r111	UTSW	17	22,778,151 (GRCm39)	splice site	probably benign
R3700:Vmn2r111	UTSW	17	22,790,142 (GRCm39)	nonsense	probably null
R3782:Vmn2r111	UTSW	17	22,790,301 (GRCm39)	missense	possibly damaging	0.89
R4085:Vmn2r111	UTSW	17	22,778,096 (GRCm39)	missense	probably benign	0.00
R4323:Vmn2r111	UTSW	17	22,792,159 (GRCm39)	missense	probably benign	0.02
R4900:Vmn2r111	UTSW	17	22,767,637 (GRCm39)	missense	possibly damaging	0.94
R5072:Vmn2r111	UTSW	17	22,767,022 (GRCm39)	missense	probably damaging	0.99
R5123:Vmn2r111	UTSW	17	22,790,124 (GRCm39)	missense	possibly damaging	0.82
R5181:Vmn2r111	UTSW	17	22,790,001 (GRCm39)	missense	possibly damaging	0.56
R5357:Vmn2r111	UTSW	17	22,767,083 (GRCm39)	nonsense	probably null
R5398:Vmn2r111	UTSW	17	22,792,252 (GRCm39)	start codon destroyed	probably null	0.88
R5434:Vmn2r111	UTSW	17	22,767,470 (GRCm39)	missense	probably damaging	0.99
R5462:Vmn2r111	UTSW	17	22,767,238 (GRCm39)	missense	probably damaging	1.00
R6149:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6149:Vmn2r111	UTSW	17	22,767,796 (GRCm39)	missense	probably benign	0.00
R6207:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6281:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6282:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6283:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6307:Vmn2r111	UTSW	17	22,792,070 (GRCm39)	missense	probably benign	0.00
R6323:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6325:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6367:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6368:Vmn2r111	UTSW	17	22,790,889 (GRCm39)	missense	probably benign	0.38
R6369:Vmn2r111	UTSW	17	22,767,583 (GRCm39)	missense	probably damaging	1.00
R6489:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6490:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6546:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6547:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6557:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6654:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6655:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6657:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6659:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6660:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6664:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6798:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6799:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6801:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6893:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6895:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6897:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6922:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6923:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6944:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R6945:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7017:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7018:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7024:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7031:Vmn2r111	UTSW	17	22,790,226 (GRCm39)	missense	probably damaging	1.00
R7039:Vmn2r111	UTSW	17	22,767,165 (GRCm39)	missense	probably damaging	1.00
R7053:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7054:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7055:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7145:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7146:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7246:Vmn2r111	UTSW	17	22,767,695 (GRCm39)	missense	probably damaging	1.00
R7259:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7260:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7327:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7401:Vmn2r111	UTSW	17	22,790,067 (GRCm39)	missense	possibly damaging	0.93
R7514:Vmn2r111	UTSW	17	22,767,380 (GRCm39)	missense	probably benign	0.05
R7651:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7781:Vmn2r111	UTSW	17	22,789,714 (GRCm39)	missense	probably benign	0.17
R7816:Vmn2r111	UTSW	17	22,792,083 (GRCm39)	missense	probably damaging	0.97
R7821:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R7838:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R8078:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R8080:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R8117:Vmn2r111	UTSW	17	22,790,469 (GRCm39)	missense	probably benign	0.12
R8171:Vmn2r111	UTSW	17	22,792,073 (GRCm39)	missense	probably benign	0.10
R8195:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R8197:Vmn2r111	UTSW	17	22,778,032 (GRCm39)	missense	possibly damaging	0.50
R8411:Vmn2r111	UTSW	17	22,767,562 (GRCm39)	missense	probably benign	0.03
R8539:Vmn2r111	UTSW	17	22,790,274 (GRCm39)	missense	probably benign	0.23
R8540:Vmn2r111	UTSW	17	22,778,024 (GRCm39)	missense	probably damaging	1.00
R8540:Vmn2r111	UTSW	17	22,778,023 (GRCm39)	critical splice donor site	probably null
R8557:Vmn2r111	UTSW	17	22,790,910 (GRCm39)	nonsense	probably null
R8720:Vmn2r111	UTSW	17	22,792,194 (GRCm39)	missense	possibly damaging	0.88
R8729:Vmn2r111	UTSW	17	22,767,239 (GRCm39)	missense	probably damaging	1.00
R8843:Vmn2r111	UTSW	17	22,767,011 (GRCm39)	missense	probably benign	0.00
R9184:Vmn2r111	UTSW	17	22,790,822 (GRCm39)	missense	probably benign
R9374:Vmn2r111	UTSW	17	22,787,859 (GRCm39)	missense	probably benign	0.17
R9452:Vmn2r111	UTSW	17	22,778,132 (GRCm39)	missense	probably damaging	1.00
X0026:Vmn2r111	UTSW	17	22,767,676 (GRCm39)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- AAAGATGCAGCCCAATTTCTAC -3'
(R):5'- ACAGGATGCTATCAGGTTTTCTTC -3'

Sequencing Primer
(F):5'- TGAGTAACTTAGGACAGAGAT -3'
(R):5'- TTCAAGGAGTTGGGAAACAATTC -3'

Posted On

2019-05-13