Incidental Mutation 'R7060:Cdon'
ID 548194
Institutional Source Beutler Lab
Gene Symbol Cdon
Ensembl Gene ENSMUSG00000038119
Gene Name cell adhesion molecule-related/down-regulated by oncogenes
Synonyms CAM-related/down-regulated by oncogenes, CDO
MMRRC Submission 045157-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.241) question?
Stock # R7060 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 35332836-35418948 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 35398205 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 974 (L974P)
Ref Sequence ENSEMBL: ENSMUSP00000113977 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042842] [ENSMUST00000119129]
AlphaFold Q32MD9
Predicted Effect probably damaging
Transcript: ENSMUST00000042842
AA Change: L974P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000045547
Gene: ENSMUSG00000038119
AA Change: L974P

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
IGc2 40 103 1.35e-9 SMART
IG 125 212 7.25e-1 SMART
IGc2 233 296 1.38e-6 SMART
IGc2 323 386 4.62e-17 SMART
IGc2 416 506 5e-13 SMART
FN3 573 660 2.18e-2 SMART
FN3 717 800 1.89e-11 SMART
FN3 822 909 7.01e-6 SMART
transmembrane domain 962 984 N/A INTRINSIC
low complexity region 1101 1111 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000119129
AA Change: L974P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000113977
Gene: ENSMUSG00000038119
AA Change: L974P

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
IGc2 40 103 1.35e-9 SMART
IG 125 212 7.25e-1 SMART
IGc2 233 296 1.38e-6 SMART
IGc2 323 386 4.62e-17 SMART
IGc2 416 506 5e-13 SMART
FN3 573 660 2.18e-2 SMART
FN3 717 800 1.89e-11 SMART
FN3 822 909 7.01e-6 SMART
transmembrane domain 962 984 N/A INTRINSIC
low complexity region 1101 1111 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 96% (78/81)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011]
PHENOTYPE: Homozygous null mice display facial defects characteristic of microform holoprosencephaly, are runted, and are prone to death prior to weaning. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg4 T A 9: 44,186,425 (GRCm39) T535S probably benign Het
Adamts19 A T 18: 58,970,712 (GRCm39) R99* probably null Het
Alg6 C T 4: 99,650,198 (GRCm39) L473F possibly damaging Het
Ankar A T 1: 72,695,272 (GRCm39) N893K probably benign Het
Ankrd54 G A 15: 78,939,739 (GRCm39) A183V possibly damaging Het
Anpep G T 7: 79,491,542 (GRCm39) T153K probably benign Het
Arap1 A G 7: 101,058,564 (GRCm39) probably null Het
Aspg A T 12: 112,089,387 (GRCm39) T392S probably benign Het
B230307C23Rik A C 16: 97,811,331 (GRCm39) R68S probably benign Het
Bdp1 G C 13: 100,196,002 (GRCm39) N1253K probably damaging Het
Ccrl2 G A 9: 110,884,682 (GRCm39) S272F probably damaging Het
Celsr1 C A 15: 85,916,856 (GRCm39) E372D probably benign Het
Cers1 A T 8: 70,768,555 (GRCm39) M16L possibly damaging Het
Col2a1 G T 15: 97,874,022 (GRCm39) Q1387K unknown Het
Ddx39b G A 17: 35,471,726 (GRCm39) V291M probably damaging Het
Dppa2 T A 16: 48,136,076 (GRCm39) S143T probably benign Het
Dpy19l1 A T 9: 24,334,419 (GRCm39) M583K possibly damaging Het
Eno3 A T 11: 70,552,245 (GRCm39) D299V possibly damaging Het
Epha8 C T 4: 136,658,469 (GRCm39) V969M probably damaging Het
Fcgbp A T 7: 27,791,358 (GRCm39) H873L probably benign Het
Fhad1 CGG CG 4: 141,645,602 (GRCm39) probably null Het
Fntb A C 12: 76,934,649 (GRCm39) N173T possibly damaging Het
Gins2 T A 8: 121,308,880 (GRCm39) M125L probably benign Het
Gys1 G A 7: 45,089,437 (GRCm39) A199T probably damaging Het
Herpud1 C A 8: 95,117,391 (GRCm39) H116N probably benign Het
Hoga1 C A 19: 42,048,685 (GRCm39) Y134* probably null Het
Il10ra A G 9: 45,167,522 (GRCm39) I343T probably benign Het
Inava T C 1: 136,147,935 (GRCm39) K339R possibly damaging Het
Inpp5j C T 11: 3,450,133 (GRCm39) probably null Het
Itpkb T C 1: 180,160,695 (GRCm39) S274P probably damaging Het
Kalrn C T 16: 34,177,418 (GRCm39) C249Y probably damaging Het
Klhl35 G C 7: 99,117,665 (GRCm39) A70P possibly damaging Het
Lhx1 A G 11: 84,411,108 (GRCm39) probably null Het
Lmbrd1 T C 1: 24,732,047 (GRCm39) V88A probably benign Het
Macc1 T G 12: 119,411,190 (GRCm39) L653V probably damaging Het
Madd T C 2: 91,007,452 (GRCm39) D220G probably damaging Het
Mllt10 T A 2: 18,164,371 (GRCm39) H300Q possibly damaging Het
Mlxipl G A 5: 135,161,169 (GRCm39) A363T possibly damaging Het
Mus81 G T 19: 5,537,821 (GRCm39) D78E probably benign Het
Mxd1 A T 6: 86,630,141 (GRCm39) L26M probably damaging Het
Nhsl1 C T 10: 18,402,251 (GRCm39) T1159M probably damaging Het
Nos1ap A G 1: 170,165,694 (GRCm39) S190P possibly damaging Het
Nwd1 A C 8: 73,393,322 (GRCm39) D195A probably damaging Het
Or12d13 G T 17: 37,647,352 (GRCm39) T257N probably benign Het
Or6k4 A T 1: 173,964,376 (GRCm39) D22V probably benign Het
Or8c14-ps1 G A 9: 38,101,392 (GRCm39) V124I probably damaging Het
Or8k24 T A 2: 86,216,569 (GRCm39) R64S possibly damaging Het
Otof T C 5: 30,545,700 (GRCm39) D500G possibly damaging Het
Pcgf5 T A 19: 36,420,339 (GRCm39) Y190* probably null Het
Pdcd11 C T 19: 47,099,418 (GRCm39) T839I probably benign Het
Ppard G C 17: 28,517,886 (GRCm39) S318T probably benign Het
Ppfia2 A G 10: 106,597,970 (GRCm39) K178E probably damaging Het
Ppm1n G T 7: 19,013,187 (GRCm39) R255S probably damaging Het
Ppp1r21 A G 17: 88,887,972 (GRCm39) Y693C probably damaging Het
Ppp2r5d A T 17: 46,998,279 (GRCm39) V169E possibly damaging Het
Prc1 A T 7: 79,954,121 (GRCm39) T53S probably benign Het
Pwp2 A C 10: 78,009,084 (GRCm39) probably null Het
Rab5c G A 11: 100,610,789 (GRCm39) R40C probably damaging Het
Ring1 A G 17: 34,242,364 (GRCm39) C48R probably damaging Het
Rpap1 T C 2: 119,604,043 (GRCm39) D496G probably damaging Het
Rspo4 C A 2: 151,714,998 (GRCm39) Q212K unknown Het
Samd9l T A 6: 3,372,716 (GRCm39) D1515V probably damaging Het
Serinc3 T C 2: 163,478,879 (GRCm39) T83A probably benign Het
Setd5 A C 6: 113,094,343 (GRCm39) D420A probably damaging Het
Sidt2 T C 9: 45,864,544 (GRCm39) T62A possibly damaging Het
Smarcal1 T C 1: 72,652,101 (GRCm39) V621A probably damaging Het
Srcin1 A G 11: 97,464,711 (GRCm39) L12P probably damaging Het
Stx18 G A 5: 38,278,599 (GRCm39) D165N possibly damaging Het
Sumf2 A G 5: 129,883,341 (GRCm39) K139E possibly damaging Het
Tdo2 A T 3: 81,876,866 (GRCm39) I102N probably damaging Het
Tdp1 T A 12: 99,877,947 (GRCm39) S410T probably benign Het
Tmem94 A T 11: 115,683,764 (GRCm39) I726F probably damaging Het
Ttc21a A G 9: 119,795,742 (GRCm39) E1192G probably damaging Het
Ttc8 T C 12: 98,909,726 (GRCm39) I52T probably benign Het
Vmn2r99 A T 17: 19,614,826 (GRCm39) R849* probably null Het
Wwc1 T C 11: 35,806,003 (GRCm39) K77E possibly damaging Het
Xirp2 A T 2: 67,345,952 (GRCm39) E2731V probably damaging Het
Zfp1006 A C 8: 129,945,613 (GRCm39) I404R probably benign Het
Zfp423 G A 8: 88,509,507 (GRCm39) T258I probably damaging Het
Other mutations in Cdon
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00832:Cdon APN 9 35,389,412 (GRCm39) missense probably damaging 1.00
IGL01307:Cdon APN 9 35,368,860 (GRCm39) missense probably benign 0.01
IGL01528:Cdon APN 9 35,381,403 (GRCm39) missense possibly damaging 0.95
IGL01663:Cdon APN 9 35,394,510 (GRCm39) missense possibly damaging 0.57
IGL01723:Cdon APN 9 35,414,634 (GRCm39) missense probably benign 0.05
IGL02200:Cdon APN 9 35,394,405 (GRCm39) missense probably benign 0.28
IGL02444:Cdon APN 9 35,384,744 (GRCm39) missense probably benign 0.09
IGL02547:Cdon APN 9 35,389,950 (GRCm39) missense probably damaging 1.00
IGL02620:Cdon APN 9 35,364,095 (GRCm39) missense probably benign 0.00
IGL02861:Cdon APN 9 35,398,253 (GRCm39) missense probably damaging 0.96
IGL02894:Cdon APN 9 35,366,722 (GRCm39) missense probably benign 0.01
IGL03153:Cdon APN 9 35,389,255 (GRCm39) missense probably damaging 1.00
IGL03206:Cdon APN 9 35,414,602 (GRCm39) missense probably benign
IGL03374:Cdon APN 9 35,389,299 (GRCm39) missense possibly damaging 0.46
corleone UTSW 9 35,398,252 (GRCm39) nonsense probably null
indentured UTSW 9 35,363,402 (GRCm39) start codon destroyed probably null 1.00
Molar UTSW 9 35,375,191 (GRCm39) missense probably benign 0.15
Servitude UTSW 9 35,388,244 (GRCm39) missense probably damaging 1.00
PIT4280001:Cdon UTSW 9 35,398,231 (GRCm39) missense probably damaging 1.00
R0045:Cdon UTSW 9 35,398,103 (GRCm39) missense probably benign
R0045:Cdon UTSW 9 35,398,103 (GRCm39) missense probably benign
R0064:Cdon UTSW 9 35,400,523 (GRCm39) missense probably benign 0.03
R0396:Cdon UTSW 9 35,381,426 (GRCm39) missense probably damaging 1.00
R0403:Cdon UTSW 9 35,384,796 (GRCm39) missense probably benign 0.00
R0490:Cdon UTSW 9 35,363,978 (GRCm39) missense probably damaging 1.00
R0547:Cdon UTSW 9 35,368,794 (GRCm39) missense possibly damaging 0.88
R0609:Cdon UTSW 9 35,389,907 (GRCm39) missense probably damaging 1.00
R0645:Cdon UTSW 9 35,388,379 (GRCm39) splice site probably null
R0781:Cdon UTSW 9 35,367,733 (GRCm39) splice site probably benign
R1110:Cdon UTSW 9 35,367,733 (GRCm39) splice site probably benign
R1391:Cdon UTSW 9 35,415,485 (GRCm39) missense possibly damaging 0.51
R1574:Cdon UTSW 9 35,364,233 (GRCm39) splice site probably benign
R1851:Cdon UTSW 9 35,394,454 (GRCm39) missense probably damaging 1.00
R2031:Cdon UTSW 9 35,415,370 (GRCm39) missense probably damaging 0.96
R2230:Cdon UTSW 9 35,403,222 (GRCm39) critical splice donor site probably null
R3683:Cdon UTSW 9 35,400,328 (GRCm39) missense possibly damaging 0.89
R3684:Cdon UTSW 9 35,400,328 (GRCm39) missense possibly damaging 0.89
R3685:Cdon UTSW 9 35,400,328 (GRCm39) missense possibly damaging 0.89
R3941:Cdon UTSW 9 35,375,467 (GRCm39) missense probably benign 0.09
R4030:Cdon UTSW 9 35,403,202 (GRCm39) missense probably damaging 1.00
R4084:Cdon UTSW 9 35,389,427 (GRCm39) missense probably damaging 0.98
R4462:Cdon UTSW 9 35,368,876 (GRCm39) missense probably damaging 0.97
R4569:Cdon UTSW 9 35,388,265 (GRCm39) missense probably damaging 1.00
R4677:Cdon UTSW 9 35,389,901 (GRCm39) missense probably damaging 1.00
R4869:Cdon UTSW 9 35,364,200 (GRCm39) missense possibly damaging 0.71
R5032:Cdon UTSW 9 35,400,330 (GRCm39) missense probably damaging 1.00
R5047:Cdon UTSW 9 35,389,935 (GRCm39) missense probably damaging 1.00
R5214:Cdon UTSW 9 35,394,504 (GRCm39) missense probably damaging 1.00
R5341:Cdon UTSW 9 35,381,431 (GRCm39) missense probably damaging 1.00
R5410:Cdon UTSW 9 35,381,331 (GRCm39) missense probably damaging 0.99
R5581:Cdon UTSW 9 35,415,377 (GRCm39) missense probably benign 0.01
R5696:Cdon UTSW 9 35,403,162 (GRCm39) missense possibly damaging 0.69
R5757:Cdon UTSW 9 35,364,068 (GRCm39) missense probably damaging 0.98
R5802:Cdon UTSW 9 35,365,716 (GRCm39) missense probably damaging 0.99
R5845:Cdon UTSW 9 35,368,762 (GRCm39) missense probably damaging 1.00
R5949:Cdon UTSW 9 35,398,247 (GRCm39) missense probably benign 0.32
R6106:Cdon UTSW 9 35,366,704 (GRCm39) nonsense probably null
R6245:Cdon UTSW 9 35,388,235 (GRCm39) missense probably damaging 1.00
R6845:Cdon UTSW 9 35,398,252 (GRCm39) nonsense probably null
R6896:Cdon UTSW 9 35,363,402 (GRCm39) start codon destroyed probably null 1.00
R7076:Cdon UTSW 9 35,415,446 (GRCm39) missense probably benign 0.00
R7184:Cdon UTSW 9 35,375,191 (GRCm39) missense probably benign 0.15
R7382:Cdon UTSW 9 35,389,944 (GRCm39) missense probably damaging 1.00
R7763:Cdon UTSW 9 35,365,711 (GRCm39) nonsense probably null
R7857:Cdon UTSW 9 35,367,908 (GRCm39) missense possibly damaging 0.79
R7885:Cdon UTSW 9 35,367,818 (GRCm39) missense probably benign 0.01
R7894:Cdon UTSW 9 35,388,244 (GRCm39) missense probably damaging 1.00
R7984:Cdon UTSW 9 35,414,598 (GRCm39) missense probably benign 0.00
R8287:Cdon UTSW 9 35,375,225 (GRCm39) missense probably benign
R8428:Cdon UTSW 9 35,403,163 (GRCm39) missense probably benign 0.21
R8519:Cdon UTSW 9 35,389,950 (GRCm39) missense probably damaging 1.00
R8698:Cdon UTSW 9 35,398,269 (GRCm39) critical splice donor site probably null
R8797:Cdon UTSW 9 35,389,931 (GRCm39) missense probably damaging 1.00
R8995:Cdon UTSW 9 35,398,093 (GRCm39) missense probably damaging 1.00
R9090:Cdon UTSW 9 35,403,175 (GRCm39) missense probably damaging 0.98
R9177:Cdon UTSW 9 35,381,230 (GRCm39) missense probably benign 0.00
R9200:Cdon UTSW 9 35,414,617 (GRCm39) missense probably benign 0.00
R9271:Cdon UTSW 9 35,403,175 (GRCm39) missense probably damaging 0.98
R9330:Cdon UTSW 9 35,400,275 (GRCm39) nonsense probably null
R9477:Cdon UTSW 9 35,403,201 (GRCm39) missense probably damaging 1.00
R9612:Cdon UTSW 9 35,398,201 (GRCm39) missense probably damaging 1.00
R9730:Cdon UTSW 9 35,398,263 (GRCm39) missense probably benign 0.00
Z1177:Cdon UTSW 9 35,403,196 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCCTATTTCGTAAGCTCTGTATCC -3'
(R):5'- ACAGCTTTCATTCCATGGCAC -3'

Sequencing Primer
(F):5'- CGTAAGCTCTGTATCCACTCTAAC -3'
(R):5'- GGCACAAATATGTGAGAGT -3'
Posted On 2019-05-13