Incidental Mutation 'R0612:Hdac5'
| ID |
54834 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Hdac5
|
| Ensembl Gene |
ENSMUSG00000008855 |
| Gene Name |
histone deacetylase 5 |
| Synonyms |
mHDA1 |
| MMRRC Submission |
038801-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0612 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
102085244-102120968 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 102087078 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 1042
(V1042A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000102768
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000008999]
[ENSMUST00000070334]
[ENSMUST00000078975]
[ENSMUST00000107150]
[ENSMUST00000107151]
[ENSMUST00000107152]
[ENSMUST00000124077]
[ENSMUST00000140962]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000008999
AA Change: V1061A
PolyPhen 2
Score 0.727 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000008999
Gene: ENSMUSG00000008855
AA Change: V1061A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
58 |
75 |
N/A |
INTRINSIC |
|
Pfam:HDAC4_Gln
|
86 |
174 |
1e-30 |
PFAM |
|
low complexity region
|
233 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
322 |
337 |
N/A |
INTRINSIC |
|
low complexity region
|
502 |
541 |
N/A |
INTRINSIC |
|
low complexity region
|
560 |
577 |
N/A |
INTRINSIC |
|
coiled coil region
|
583 |
617 |
N/A |
INTRINSIC |
|
Pfam:Hist_deacetyl
|
704 |
1034 |
1.4e-81 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000070334
|
| SMART Domains |
Protein: ENSMUSP00000064276
Gene: ENSMUSG00000034793
| Domain | Start | End | E-Value | Type |
|---|
|
acidPPc
|
53 |
187 |
2.53e-15 |
SMART |
|
transmembrane domain
|
196 |
218 |
N/A |
INTRINSIC |
|
transmembrane domain
|
284 |
302 |
N/A |
INTRINSIC |
|
transmembrane domain
|
317 |
336 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000078975
|
| SMART Domains |
Protein: ENSMUSP00000077995
Gene: ENSMUSG00000034793
| Domain | Start | End | E-Value | Type |
|---|
|
acidPPc
|
53 |
187 |
2.53e-15 |
SMART |
|
transmembrane domain
|
196 |
218 |
N/A |
INTRINSIC |
|
transmembrane domain
|
284 |
302 |
N/A |
INTRINSIC |
|
transmembrane domain
|
317 |
336 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000107150
AA Change: V1042A
PolyPhen 2
Score 0.915 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000102768
Gene: ENSMUSG00000008855
AA Change: V1042A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
39 |
56 |
N/A |
INTRINSIC |
|
Pfam:HDAC4_Gln
|
66 |
155 |
5.1e-37 |
PFAM |
|
low complexity region
|
214 |
228 |
N/A |
INTRINSIC |
|
low complexity region
|
303 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
483 |
522 |
N/A |
INTRINSIC |
|
low complexity region
|
541 |
558 |
N/A |
INTRINSIC |
|
coiled coil region
|
564 |
598 |
N/A |
INTRINSIC |
|
Pfam:Hist_deacetyl
|
685 |
1015 |
9.4e-91 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107151
AA Change: V958A
PolyPhen 2
Score 0.231 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000102769
Gene: ENSMUSG00000008855
AA Change: V958A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
40 |
57 |
N/A |
INTRINSIC |
|
Pfam:HDAC4_Gln
|
67 |
156 |
1.1e-37 |
PFAM |
|
low complexity region
|
215 |
229 |
N/A |
INTRINSIC |
|
low complexity region
|
304 |
319 |
N/A |
INTRINSIC |
|
low complexity region
|
484 |
523 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
559 |
N/A |
INTRINSIC |
|
coiled coil region
|
565 |
599 |
N/A |
INTRINSIC |
|
Pfam:Hist_deacetyl
|
618 |
931 |
1.2e-82 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000107152
AA Change: V1043A
PolyPhen 2
Score 0.899 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000102770
Gene: ENSMUSG00000008855
AA Change: V1043A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
40 |
57 |
N/A |
INTRINSIC |
|
Pfam:HDAC4_Gln
|
67 |
156 |
3.7e-37 |
PFAM |
|
low complexity region
|
215 |
229 |
N/A |
INTRINSIC |
|
low complexity region
|
304 |
319 |
N/A |
INTRINSIC |
|
low complexity region
|
484 |
523 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
559 |
N/A |
INTRINSIC |
|
coiled coil region
|
565 |
599 |
N/A |
INTRINSIC |
|
Pfam:Hist_deacetyl
|
686 |
1016 |
6.4e-91 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000124077
|
| SMART Domains |
Protein: ENSMUSP00000116672
Gene: ENSMUSG00000008855
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
37 |
50 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000140962
AA Change: V34A
PolyPhen 2
Score 0.187 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000115435
Gene: ENSMUSG00000008855
AA Change: V34A
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:2VQQ|B
|
1 |
71 |
3e-21 |
PDB |
|
transmembrane domain
|
118 |
135 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000145540
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000153178
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000150965
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136304
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000124594
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000140481
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000137787
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000131382
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000126453
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000133651
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139995
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000145490
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000149087
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000155065
|
| Meta Mutation Damage Score |
0.6093 |
| Coding Region Coverage |
- 1x: 99.6%
- 3x: 99.0%
- 10x: 97.2%
- 20x: 93.5%
|
| Validation Efficiency |
98% (92/94) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice are viable and display cardiac hypertrophy. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 86 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca15 |
T |
C |
7: 119,936,478 (GRCm39) |
L181P |
probably damaging |
Het |
| Aldh3a1 |
A |
T |
11: 61,105,445 (GRCm39) |
I184F |
probably damaging |
Het |
| Arl6ip4 |
A |
G |
5: 124,254,596 (GRCm39) |
S30G |
probably benign |
Het |
| Atp9b |
T |
C |
18: 80,797,171 (GRCm39) |
E891G |
possibly damaging |
Het |
| Brsk1 |
T |
C |
7: 4,710,425 (GRCm39) |
L478P |
possibly damaging |
Het |
| Btaf1 |
G |
A |
19: 36,946,537 (GRCm39) |
V448I |
probably damaging |
Het |
| Cab39 |
T |
C |
1: 85,746,236 (GRCm39) |
|
probably null |
Het |
| Cacna2d4 |
G |
T |
6: 119,258,679 (GRCm39) |
|
probably benign |
Het |
| Capzb |
C |
T |
4: 139,018,340 (GRCm39) |
S253L |
probably benign |
Het |
| Ccdc174 |
A |
G |
6: 91,867,873 (GRCm39) |
|
probably benign |
Het |
| Ccdc180 |
C |
T |
4: 45,927,969 (GRCm39) |
A1168V |
probably damaging |
Het |
| Cdh19 |
T |
C |
1: 110,820,900 (GRCm39) |
|
probably benign |
Het |
| Cdh8 |
T |
C |
8: 100,127,546 (GRCm39) |
T22A |
probably benign |
Het |
| Cdk10 |
T |
C |
8: 123,957,419 (GRCm39) |
V181A |
probably benign |
Het |
| Ceacam15 |
A |
C |
7: 16,407,445 (GRCm39) |
L24* |
probably null |
Het |
| Cftr |
A |
C |
6: 18,198,125 (GRCm39) |
T20P |
probably benign |
Het |
| Cip2a |
C |
T |
16: 48,819,402 (GRCm39) |
A112V |
probably benign |
Het |
| Clstn3 |
T |
C |
6: 124,426,459 (GRCm39) |
T576A |
probably damaging |
Het |
| Col1a2 |
G |
A |
6: 4,516,003 (GRCm39) |
V165I |
unknown |
Het |
| Copg2 |
A |
T |
6: 30,838,404 (GRCm39) |
|
probably null |
Het |
| Cps1 |
A |
G |
1: 67,178,929 (GRCm39) |
H47R |
probably benign |
Het |
| Cytip |
T |
C |
2: 58,024,202 (GRCm39) |
D206G |
possibly damaging |
Het |
| Dcaf8l |
G |
A |
X: 88,448,972 (GRCm39) |
R386* |
probably null |
Het |
| Dnmt1 |
C |
T |
9: 20,829,489 (GRCm39) |
E824K |
probably damaging |
Het |
| Dock7 |
A |
C |
4: 98,877,470 (GRCm39) |
V442G |
probably benign |
Het |
| Dsc1 |
T |
G |
18: 20,247,573 (GRCm39) |
K14T |
probably damaging |
Het |
| Dync1h1 |
C |
T |
12: 110,582,930 (GRCm39) |
P371L |
probably damaging |
Het |
| Enah |
A |
G |
1: 181,734,013 (GRCm39) |
|
probably benign |
Het |
| Entrep2 |
C |
T |
7: 64,411,549 (GRCm39) |
V395M |
probably benign |
Het |
| Fastkd1 |
T |
C |
2: 69,542,727 (GRCm39) |
T27A |
probably benign |
Het |
| Fcho1 |
A |
G |
8: 72,168,168 (GRCm39) |
L248P |
probably damaging |
Het |
| Fezf1 |
A |
T |
6: 23,247,028 (GRCm39) |
V268D |
probably damaging |
Het |
| Fgd2 |
T |
A |
17: 29,597,321 (GRCm39) |
V547E |
probably benign |
Het |
| Flnb |
T |
A |
14: 7,887,682 (GRCm38) |
|
probably benign |
Het |
| Gabrg3 |
A |
G |
7: 56,379,454 (GRCm39) |
M316T |
probably damaging |
Het |
| Gigyf2 |
T |
C |
1: 87,376,802 (GRCm39) |
F1265L |
probably damaging |
Het |
| Git2 |
A |
G |
5: 114,890,342 (GRCm39) |
S271P |
probably damaging |
Het |
| Gorab |
T |
C |
1: 163,224,738 (GRCm39) |
D21G |
possibly damaging |
Het |
| Gpr179 |
T |
A |
11: 97,229,264 (GRCm39) |
T964S |
possibly damaging |
Het |
| Hoxa2 |
T |
A |
6: 52,140,540 (GRCm39) |
T149S |
probably damaging |
Het |
| Igsf8 |
G |
T |
1: 172,146,974 (GRCm39) |
*108L |
probably null |
Het |
| Il1rap |
C |
T |
16: 26,519,855 (GRCm39) |
T307M |
possibly damaging |
Het |
| Itih2 |
T |
C |
2: 10,122,205 (GRCm39) |
D232G |
probably benign |
Het |
| Jak3 |
A |
G |
8: 72,136,021 (GRCm39) |
Y607C |
probably damaging |
Het |
| Kcnh1 |
C |
T |
1: 191,959,361 (GRCm39) |
P305L |
probably damaging |
Het |
| Lrrc7 |
T |
A |
3: 157,869,990 (GRCm39) |
I644F |
probably damaging |
Het |
| Lrrn2 |
T |
C |
1: 132,865,466 (GRCm39) |
L177P |
probably damaging |
Het |
| Lypd8l |
A |
G |
11: 58,502,799 (GRCm39) |
|
probably null |
Het |
| Map4k3 |
C |
A |
17: 80,909,622 (GRCm39) |
K712N |
probably damaging |
Het |
| Med11 |
A |
G |
11: 70,342,910 (GRCm39) |
T36A |
probably benign |
Het |
| Mmp14 |
A |
G |
14: 54,677,891 (GRCm39) |
D504G |
probably damaging |
Het |
| Mob1a |
A |
G |
6: 83,311,140 (GRCm39) |
T120A |
probably benign |
Het |
| Mr1 |
T |
A |
1: 155,013,436 (GRCm39) |
D47V |
probably damaging |
Het |
| Nacad |
G |
T |
11: 6,551,382 (GRCm39) |
A603E |
possibly damaging |
Het |
| Nwd1 |
T |
A |
8: 73,394,308 (GRCm39) |
W524R |
probably damaging |
Het |
| Or11g26 |
A |
T |
14: 50,752,939 (GRCm39) |
T93S |
probably benign |
Het |
| Or13a19 |
T |
A |
7: 139,903,101 (GRCm39) |
M163K |
possibly damaging |
Het |
| Or4e1 |
T |
C |
14: 52,701,008 (GRCm39) |
T153A |
probably benign |
Het |
| Parp14 |
G |
A |
16: 35,677,130 (GRCm39) |
A946V |
probably benign |
Het |
| Pde6c |
T |
A |
19: 38,121,694 (GRCm39) |
C101S |
probably benign |
Het |
| Pdia3 |
G |
A |
2: 121,262,858 (GRCm39) |
G275S |
probably damaging |
Het |
| Pdlim4 |
G |
A |
11: 53,959,713 (GRCm39) |
R16C |
probably damaging |
Het |
| Pfkp |
A |
G |
13: 6,655,670 (GRCm39) |
|
probably null |
Het |
| Plcg2 |
T |
A |
8: 118,300,104 (GRCm39) |
S225T |
probably benign |
Het |
| Pramel1 |
T |
C |
4: 143,124,101 (GRCm39) |
S259P |
probably damaging |
Het |
| Pramel27 |
G |
T |
4: 143,578,658 (GRCm39) |
|
probably benign |
Het |
| Rc3h2 |
T |
C |
2: 37,301,227 (GRCm39) |
N92D |
possibly damaging |
Het |
| Ric8b |
C |
A |
10: 84,837,745 (GRCm39) |
N517K |
probably damaging |
Het |
| Rnf34 |
G |
A |
5: 123,002,237 (GRCm39) |
R65H |
probably damaging |
Het |
| Rraga |
C |
T |
4: 86,494,564 (GRCm39) |
R137C |
probably damaging |
Het |
| Scube2 |
C |
T |
7: 109,403,971 (GRCm39) |
|
probably benign |
Het |
| Slc28a2b |
T |
C |
2: 122,352,179 (GRCm39) |
M339T |
probably damaging |
Het |
| Spata31d1d |
T |
C |
13: 59,875,787 (GRCm39) |
I583V |
probably benign |
Het |
| Suox |
T |
C |
10: 128,506,525 (GRCm39) |
E501G |
probably benign |
Het |
| Susd1 |
A |
G |
4: 59,390,561 (GRCm39) |
|
probably benign |
Het |
| Tac1 |
T |
C |
6: 7,555,653 (GRCm39) |
S14P |
probably damaging |
Het |
| Tbc1d8 |
T |
C |
1: 39,411,596 (GRCm39) |
E1080G |
possibly damaging |
Het |
| Tll1 |
A |
C |
8: 64,524,344 (GRCm39) |
S447R |
possibly damaging |
Het |
| Tmem132e |
G |
A |
11: 82,334,198 (GRCm39) |
V662M |
probably damaging |
Het |
| Upf2 |
G |
T |
2: 6,038,909 (GRCm39) |
|
probably benign |
Het |
| Uspl1 |
A |
G |
5: 149,151,767 (GRCm39) |
E989G |
probably damaging |
Het |
| Vmn1r58 |
T |
C |
7: 5,413,618 (GRCm39) |
H204R |
probably damaging |
Het |
| Vmn2r25 |
A |
T |
6: 123,816,481 (GRCm39) |
C367S |
probably damaging |
Het |
| Vps13b |
A |
T |
15: 35,623,803 (GRCm39) |
Q1240L |
probably benign |
Het |
| Xrcc1 |
C |
T |
7: 24,269,744 (GRCm39) |
|
probably benign |
Het |
| Yeats2 |
T |
G |
16: 20,005,175 (GRCm39) |
V385G |
probably benign |
Het |
|
| Other mutations in Hdac5 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00815:Hdac5
|
APN |
11 |
102,088,168 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01614:Hdac5
|
APN |
11 |
102,090,854 (GRCm39) |
missense |
probably benign |
0.38 |
|
IGL01799:Hdac5
|
APN |
11 |
102,090,911 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02839:Hdac5
|
APN |
11 |
102,095,734 (GRCm39) |
missense |
probably damaging |
1.00 |
|
E0354:Hdac5
|
UTSW |
11 |
102,092,972 (GRCm39) |
unclassified |
probably benign |
|
|
R0544:Hdac5
|
UTSW |
11 |
102,086,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0632:Hdac5
|
UTSW |
11 |
102,096,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0659:Hdac5
|
UTSW |
11 |
102,086,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0930:Hdac5
|
UTSW |
11 |
102,095,472 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1195:Hdac5
|
UTSW |
11 |
102,096,332 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1195:Hdac5
|
UTSW |
11 |
102,096,332 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1195:Hdac5
|
UTSW |
11 |
102,096,332 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1475:Hdac5
|
UTSW |
11 |
102,093,012 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1491:Hdac5
|
UTSW |
11 |
102,092,079 (GRCm39) |
missense |
probably benign |
|
|
R1596:Hdac5
|
UTSW |
11 |
102,095,482 (GRCm39) |
splice site |
probably null |
|
|
R1673:Hdac5
|
UTSW |
11 |
102,089,631 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1783:Hdac5
|
UTSW |
11 |
102,091,342 (GRCm39) |
missense |
probably benign |
|
|
R1932:Hdac5
|
UTSW |
11 |
102,086,698 (GRCm39) |
splice site |
probably benign |
|
|
R2197:Hdac5
|
UTSW |
11 |
102,095,340 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2348:Hdac5
|
UTSW |
11 |
102,090,840 (GRCm39) |
missense |
probably benign |
0.44 |
|
R2518:Hdac5
|
UTSW |
11 |
102,087,962 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3081:Hdac5
|
UTSW |
11 |
102,096,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3622:Hdac5
|
UTSW |
11 |
102,086,644 (GRCm39) |
missense |
probably benign |
0.34 |
|
R4543:Hdac5
|
UTSW |
11 |
102,104,770 (GRCm39) |
intron |
probably benign |
|
|
R4559:Hdac5
|
UTSW |
11 |
102,089,928 (GRCm39) |
unclassified |
probably benign |
|
|
R4661:Hdac5
|
UTSW |
11 |
102,096,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4682:Hdac5
|
UTSW |
11 |
102,097,456 (GRCm39) |
missense |
probably null |
0.99 |
|
R4708:Hdac5
|
UTSW |
11 |
102,093,019 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4933:Hdac5
|
UTSW |
11 |
102,091,389 (GRCm39) |
unclassified |
probably benign |
|
|
R4957:Hdac5
|
UTSW |
11 |
102,096,082 (GRCm39) |
unclassified |
probably benign |
|
|
R4991:Hdac5
|
UTSW |
11 |
102,096,450 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5090:Hdac5
|
UTSW |
11 |
102,088,539 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5103:Hdac5
|
UTSW |
11 |
102,087,109 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5330:Hdac5
|
UTSW |
11 |
102,088,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5331:Hdac5
|
UTSW |
11 |
102,088,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5386:Hdac5
|
UTSW |
11 |
102,092,967 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5449:Hdac5
|
UTSW |
11 |
102,086,923 (GRCm39) |
nonsense |
probably null |
|
|
R5682:Hdac5
|
UTSW |
11 |
102,104,749 (GRCm39) |
intron |
probably benign |
|
|
R6615:Hdac5
|
UTSW |
11 |
102,087,882 (GRCm39) |
splice site |
probably null |
|
|
R6705:Hdac5
|
UTSW |
11 |
102,092,062 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6875:Hdac5
|
UTSW |
11 |
102,093,102 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6952:Hdac5
|
UTSW |
11 |
102,095,786 (GRCm39) |
missense |
probably benign |
|
|
R7179:Hdac5
|
UTSW |
11 |
102,095,385 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R7368:Hdac5
|
UTSW |
11 |
102,088,207 (GRCm39) |
missense |
probably null |
1.00 |
|
R8140:Hdac5
|
UTSW |
11 |
102,088,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8151:Hdac5
|
UTSW |
11 |
102,097,294 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8684:Hdac5
|
UTSW |
11 |
102,096,147 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8719:Hdac5
|
UTSW |
11 |
102,097,963 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8751:Hdac5
|
UTSW |
11 |
102,109,280 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8893:Hdac5
|
UTSW |
11 |
102,097,512 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9337:Hdac5
|
UTSW |
11 |
102,096,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9516:Hdac5
|
UTSW |
11 |
102,093,522 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9595:Hdac5
|
UTSW |
11 |
102,096,129 (GRCm39) |
missense |
probably benign |
0.06 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTACACAGCTCCAGTGTTTGCC -3'
(R):5'- ACTTGACCGCCATCTGTGATGC -3'
Sequencing Primer
(F):5'- CAGTGTTTGCCTATGGCAAGAAG -3'
(R):5'- GTCAGTAGGGACATCCACTTC -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation