Incidental Mutation 'R7066:Or5t7'
ID 548553
Institutional Source Beutler Lab
Gene Symbol Or5t7
Ensembl Gene ENSMUSG00000075175
Gene Name olfactory receptor family 5 subfamily T member 17
Synonyms GA_x6K02T2Q125-48168771-48167839, MOR179-2, Olfr1086
MMRRC Submission 045162-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.292) question?
Stock # R7066 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 86506743-86507683 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 86507570 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 36 (T36S)
Ref Sequence ENSEMBL: ENSMUSP00000150094 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099878] [ENSMUST00000213198]
AlphaFold Q8VFL9
Predicted Effect possibly damaging
Transcript: ENSMUST00000099878
AA Change: T36S

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000097463
Gene: ENSMUSG00000075175
AA Change: T36S

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 3.3e-49 PFAM
Pfam:7tm_1 39 288 1.4e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213198
AA Change: T36S

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 98% (52/53)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A1cf T C 19: 31,904,514 (GRCm39) V175A probably damaging Het
Adamts5 A T 16: 85,659,652 (GRCm39) V880E probably damaging Het
Adgrf1 T A 17: 43,621,151 (GRCm39) F463I probably benign Het
Ano1 T A 7: 144,190,823 (GRCm39) E249D probably benign Het
Aoc1 A G 6: 48,885,553 (GRCm39) D686G probably damaging Het
Cacna1d A T 14: 30,074,935 (GRCm39) probably benign Het
Cdc42ep4 A G 11: 113,620,044 (GRCm39) S116P probably damaging Het
Ces2a T C 8: 105,466,880 (GRCm39) V463A probably damaging Het
Depdc5 A G 5: 33,059,192 (GRCm39) D297G probably benign Het
Fsip2 T A 2: 82,821,235 (GRCm39) V5656E possibly damaging Het
Gbp5 A G 3: 142,213,490 (GRCm39) T469A probably benign Het
Gm21663 C G 5: 26,146,259 (GRCm39) probably null Het
Iqch A G 9: 63,432,027 (GRCm39) V456A probably benign Het
Lpcat1 A C 13: 73,659,500 (GRCm39) I373L probably benign Het
Morc2b C T 17: 33,355,610 (GRCm39) V721I probably benign Het
Mrgprb1 C T 7: 48,097,424 (GRCm39) V163M probably benign Het
Mtfr2 A G 10: 20,229,972 (GRCm39) I142V possibly damaging Het
Muc16 A T 9: 18,569,317 (GRCm39) S1067R unknown Het
Myh14 T C 7: 44,280,179 (GRCm39) S892G possibly damaging Het
Mylk2 C T 2: 152,753,588 (GRCm39) probably null Het
Mzf1 A T 7: 12,777,490 (GRCm39) V638E possibly damaging Het
Ncoa1 C T 12: 4,372,934 (GRCm39) V156I possibly damaging Het
Nf1 A G 11: 79,447,546 (GRCm39) E2450G probably damaging Het
Or14j3 T A 17: 37,901,034 (GRCm39) D70V probably damaging Het
Or1e29 A G 11: 73,668,018 (GRCm39) I45T probably damaging Het
Or4a72 T C 2: 89,406,047 (GRCm39) T8A probably damaging Het
Or4f60 G A 2: 111,902,541 (GRCm39) P129L probably damaging Het
Or6c88 T C 10: 129,407,373 (GRCm39) L283S probably damaging Het
Or8g54 A G 9: 39,707,420 (GRCm39) I250V probably benign Het
Or8k17 T C 2: 86,067,002 (GRCm39) D52G probably damaging Het
P4htm T G 9: 108,474,162 (GRCm39) K125N probably damaging Het
Patj A G 4: 98,301,434 (GRCm39) T240A probably benign Het
Pcolce2 T C 9: 95,563,674 (GRCm39) V220A probably benign Het
Pcyox1 A T 6: 86,371,478 (GRCm39) I136N probably damaging Het
Pde4b A G 4: 102,460,003 (GRCm39) S395G probably benign Het
Peg3 C A 7: 6,711,856 (GRCm39) R1122L probably damaging Het
Plekhm1 A G 11: 103,261,814 (GRCm39) V922A possibly damaging Het
Rad51c T C 11: 87,293,502 (GRCm39) N118S possibly damaging Het
Rb1cc1 T A 1: 6,320,229 (GRCm39) V1216D possibly damaging Het
Rictor C T 15: 6,801,635 (GRCm39) S441L probably benign Het
Rlf T C 4: 121,005,984 (GRCm39) M999V probably benign Het
Rsf1 GGCGGCGGC GGCGGCGGCCGCGGCGGC 7: 97,229,125 (GRCm39) probably benign Het
Samd7 G C 3: 30,805,272 (GRCm39) K18N probably benign Het
Sema5b A C 16: 35,471,682 (GRCm39) D425A probably benign Het
Siglecg A G 7: 43,061,166 (GRCm39) E413G probably benign Het
Tcaf1 A T 6: 42,656,111 (GRCm39) N288K probably damaging Het
Tdp1 A G 12: 99,860,991 (GRCm39) D210G probably benign Het
Umps A T 16: 33,782,103 (GRCm39) L273* probably null Het
Vcan A T 13: 89,853,805 (GRCm39) V385D probably damaging Het
Wdr59 T C 8: 112,192,477 (GRCm39) T676A probably benign Het
Zdbf2 A G 1: 63,346,718 (GRCm39) H1699R probably benign Het
Zfp27 AATCCGCTTGTGCA AA 7: 29,594,446 (GRCm39) probably benign Het
Other mutations in Or5t7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01783:Or5t7 APN 2 86,507,425 (GRCm39) missense probably benign 0.00
R0492:Or5t7 UTSW 2 86,506,834 (GRCm39) missense probably damaging 1.00
R0629:Or5t7 UTSW 2 86,506,873 (GRCm39) missense possibly damaging 0.65
R1114:Or5t7 UTSW 2 86,507,629 (GRCm39) missense possibly damaging 0.72
R1341:Or5t7 UTSW 2 86,507,507 (GRCm39) missense possibly damaging 0.86
R1868:Or5t7 UTSW 2 86,507,629 (GRCm39) missense possibly damaging 0.72
R2183:Or5t7 UTSW 2 86,507,380 (GRCm39) missense probably benign 0.21
R3159:Or5t7 UTSW 2 86,506,855 (GRCm39) missense probably benign 0.03
R4061:Or5t7 UTSW 2 86,507,162 (GRCm39) missense probably damaging 1.00
R4420:Or5t7 UTSW 2 86,507,263 (GRCm39) missense possibly damaging 0.95
R5514:Or5t7 UTSW 2 86,507,225 (GRCm39) missense probably benign 0.03
R7077:Or5t7 UTSW 2 86,507,236 (GRCm39) missense possibly damaging 0.78
R7246:Or5t7 UTSW 2 86,507,633 (GRCm39) missense probably benign 0.11
R7383:Or5t7 UTSW 2 86,507,263 (GRCm39) missense possibly damaging 0.95
R8062:Or5t7 UTSW 2 86,507,410 (GRCm39) missense probably benign 0.01
R8271:Or5t7 UTSW 2 86,507,218 (GRCm39) missense probably benign 0.12
R8417:Or5t7 UTSW 2 86,507,149 (GRCm39) missense probably damaging 1.00
R8927:Or5t7 UTSW 2 86,507,630 (GRCm39) missense probably benign 0.31
R8928:Or5t7 UTSW 2 86,507,630 (GRCm39) missense probably benign 0.31
R9029:Or5t7 UTSW 2 86,506,831 (GRCm39) missense probably damaging 1.00
R9342:Or5t7 UTSW 2 86,507,494 (GRCm39) missense probably damaging 1.00
R9384:Or5t7 UTSW 2 86,507,357 (GRCm39) missense probably benign 0.21
X0064:Or5t7 UTSW 2 86,507,543 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AGCCAGAAACATCTGTGTGGC -3'
(R):5'- GCACAGCTCACCTCATTCAGAG -3'

Sequencing Primer
(F):5'- CACAGCCAATGAATGAAATGACTTTC -3'
(R):5'- TCACCTCATTCAGAGCAAAAATACTG -3'
Posted On 2019-05-13