Incidental Mutation 'R7070:Vmn2r69'
| ID |
548833 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r69
|
| Ensembl Gene |
ENSMUSG00000091006 |
| Gene Name |
vomeronasal 2, receptor 69 |
| Synonyms |
|
| MMRRC Submission |
045166-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.088)
|
| Stock # |
R7070 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
85055584-85064884 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 85060688 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 299
(I299V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132726
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171213]
|
| AlphaFold |
G3XA45 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000171213
AA Change: I299V
PolyPhen 2
Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000132726
Gene: ENSMUSG00000091006
AA Change: I299V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
465 |
1.3e-28 |
PFAM |
|
Pfam:NCD3G
|
507 |
559 |
1.8e-20 |
PFAM |
|
Pfam:7tm_3
|
592 |
827 |
3.2e-54 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 68 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930544G11Rik |
T |
C |
6: 65,930,232 (GRCm39) |
Y156H |
probably damaging |
Het |
| Abca13 |
T |
A |
11: 9,240,701 (GRCm39) |
F855I |
probably benign |
Het |
| Abca2 |
T |
G |
2: 25,333,007 (GRCm39) |
F1569V |
probably benign |
Het |
| Adcy8 |
T |
A |
15: 64,792,404 (GRCm39) |
N184I |
probably damaging |
Het |
| Akap3 |
T |
C |
6: 126,850,987 (GRCm39) |
V835A |
probably damaging |
Het |
| Atg5 |
T |
A |
10: 44,162,150 (GRCm39) |
L22H |
probably damaging |
Het |
| Atp13a5 |
A |
G |
16: 29,152,879 (GRCm39) |
F196L |
possibly damaging |
Het |
| C1qtnf9 |
A |
G |
14: 61,017,232 (GRCm39) |
H254R |
probably damaging |
Het |
| Capza3 |
C |
T |
6: 139,987,646 (GRCm39) |
R82C |
probably damaging |
Het |
| Ccdc126 |
A |
G |
6: 49,316,796 (GRCm39) |
D92G |
probably damaging |
Het |
| Cdh12 |
T |
A |
15: 21,583,915 (GRCm39) |
M585K |
probably benign |
Het |
| Chrnb3 |
A |
T |
8: 27,883,989 (GRCm39) |
Y242F |
probably damaging |
Het |
| Cngb3 |
T |
C |
4: 19,425,593 (GRCm39) |
V467A |
possibly damaging |
Het |
| Cnot8 |
A |
G |
11: 58,008,278 (GRCm39) |
D248G |
probably benign |
Het |
| Cntn1 |
C |
T |
15: 92,151,917 (GRCm39) |
T452M |
probably damaging |
Het |
| Cygb |
C |
A |
11: 116,544,851 (GRCm39) |
|
probably benign |
Het |
| D930020B18Rik |
G |
A |
10: 121,477,879 (GRCm39) |
V35M |
probably damaging |
Het |
| Dcaf17 |
C |
T |
2: 70,918,857 (GRCm39) |
T477M |
probably benign |
Het |
| Dpp3 |
A |
T |
19: 4,968,356 (GRCm39) |
F239I |
probably benign |
Het |
| Dst |
T |
A |
1: 34,314,383 (GRCm39) |
V6442E |
probably damaging |
Het |
| Enpp2 |
T |
A |
15: 54,762,685 (GRCm39) |
I188F |
probably damaging |
Het |
| Galnt5 |
A |
G |
2: 57,888,621 (GRCm39) |
M74V |
probably benign |
Het |
| Grin2a |
T |
C |
16: 9,397,288 (GRCm39) |
D933G |
possibly damaging |
Het |
| Gtf2i |
T |
A |
5: 134,311,657 (GRCm39) |
E223D |
probably damaging |
Het |
| H2-M5 |
C |
A |
17: 37,300,051 (GRCm39) |
G41V |
possibly damaging |
Het |
| Hars2 |
C |
T |
18: 36,924,165 (GRCm39) |
R501* |
probably null |
Het |
| Heatr4 |
A |
G |
12: 84,016,632 (GRCm39) |
V545A |
probably benign |
Het |
| Hsd3b3 |
T |
A |
3: 98,649,787 (GRCm39) |
T179S |
possibly damaging |
Het |
| Ighv5-6 |
A |
G |
12: 113,589,429 (GRCm39) |
V17A |
probably damaging |
Het |
| Jak3 |
A |
G |
8: 72,137,255 (GRCm39) |
D772G |
probably damaging |
Het |
| Jakmip2 |
A |
T |
18: 43,690,393 (GRCm39) |
|
probably null |
Het |
| Kcnj15 |
C |
G |
16: 95,096,690 (GRCm39) |
T104S |
probably damaging |
Het |
| Kndc1 |
A |
G |
7: 139,501,744 (GRCm39) |
E927G |
probably damaging |
Het |
| Larp1b |
G |
T |
3: 40,931,086 (GRCm39) |
G275C |
probably damaging |
Het |
| Lyst |
C |
A |
13: 13,932,029 (GRCm39) |
H3552Q |
probably benign |
Het |
| Mast2 |
A |
T |
4: 116,168,052 (GRCm39) |
I960N |
probably benign |
Het |
| Mcee |
G |
A |
7: 64,050,078 (GRCm39) |
V70I |
possibly damaging |
Het |
| Muc16 |
G |
A |
9: 18,557,219 (GRCm39) |
Q3025* |
probably null |
Het |
| Nrg1 |
T |
A |
8: 32,339,465 (GRCm39) |
T45S |
probably damaging |
Het |
| Nutm1 |
T |
A |
2: 112,079,806 (GRCm39) |
H703L |
probably benign |
Het |
| Or5m10 |
G |
A |
2: 85,718,034 (GRCm39) |
V297I |
probably benign |
Het |
| Or7a38 |
A |
T |
10: 78,753,102 (GRCm39) |
I143L |
probably benign |
Het |
| Pbx1 |
A |
C |
1: 168,023,337 (GRCm39) |
C273G |
probably damaging |
Het |
| Peg10 |
ACATCAGGATCC |
ACATCAGGATCCCCATCAGGATCC |
6: 4,756,454 (GRCm39) |
|
probably benign |
Het |
| Phf1 |
A |
G |
17: 27,153,307 (GRCm39) |
T42A |
possibly damaging |
Het |
| Pigm |
T |
A |
1: 172,205,233 (GRCm39) |
I323N |
probably damaging |
Het |
| Plcg2 |
G |
A |
8: 118,323,045 (GRCm39) |
R700H |
probably benign |
Het |
| Ptx4 |
G |
A |
17: 25,341,971 (GRCm39) |
A149T |
probably benign |
Het |
| Rab6a |
A |
G |
7: 100,279,064 (GRCm39) |
D68G |
probably damaging |
Het |
| Rcan3 |
C |
T |
4: 135,143,898 (GRCm39) |
E185K |
probably damaging |
Het |
| Rnf14 |
A |
G |
18: 38,434,781 (GRCm39) |
N76S |
possibly damaging |
Het |
| Rpf1 |
A |
T |
3: 146,217,939 (GRCm39) |
F192I |
probably damaging |
Het |
| Rps6ka1 |
T |
C |
4: 133,588,759 (GRCm39) |
T285A |
probably benign |
Het |
| Rrp8 |
T |
C |
7: 105,384,083 (GRCm39) |
K94E |
possibly damaging |
Het |
| Rsbn1 |
A |
G |
3: 103,836,299 (GRCm39) |
K122E |
probably damaging |
Het |
| Senp1 |
T |
C |
15: 97,980,187 (GRCm39) |
T53A |
possibly damaging |
Het |
| Slc23a1 |
T |
G |
18: 35,754,834 (GRCm39) |
D519A |
probably damaging |
Het |
| Slfn14 |
T |
G |
11: 83,167,531 (GRCm39) |
R661S |
probably benign |
Het |
| Snta1 |
T |
C |
2: 154,222,979 (GRCm39) |
E248G |
probably benign |
Het |
| Son |
CATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAG |
CATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAG |
16: 91,453,729 (GRCm39) |
|
probably benign |
Het |
| Spmap2l |
G |
T |
5: 77,195,124 (GRCm39) |
|
probably null |
Het |
| Stk11ip |
C |
T |
1: 75,504,259 (GRCm39) |
H297Y |
probably benign |
Het |
| Synpr |
T |
A |
14: 13,493,628 (GRCm38) |
F76I |
probably damaging |
Het |
| Tns2 |
A |
G |
15: 102,012,968 (GRCm39) |
R27G |
possibly damaging |
Het |
| Trav5-4 |
C |
T |
14: 53,941,912 (GRCm39) |
S95F |
possibly damaging |
Het |
| Ttyh1 |
T |
C |
7: 4,136,363 (GRCm39) |
Y330H |
probably damaging |
Het |
| Ugt1a2 |
T |
A |
1: 88,129,224 (GRCm39) |
|
probably null |
Het |
| Vmn2r90 |
T |
A |
17: 17,924,313 (GRCm39) |
D37E |
probably damaging |
Het |
|
| Other mutations in Vmn2r69 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01019:Vmn2r69
|
APN |
7 |
85,055,739 (GRCm39) |
missense |
probably benign |
|
|
IGL01457:Vmn2r69
|
APN |
7 |
85,055,836 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL01760:Vmn2r69
|
APN |
7 |
85,056,072 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01834:Vmn2r69
|
APN |
7 |
85,061,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02001:Vmn2r69
|
APN |
7 |
85,056,434 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02057:Vmn2r69
|
APN |
7 |
85,060,990 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02289:Vmn2r69
|
APN |
7 |
85,056,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02472:Vmn2r69
|
APN |
7 |
85,058,960 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02478:Vmn2r69
|
APN |
7 |
85,055,889 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02554:Vmn2r69
|
APN |
7 |
85,059,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02723:Vmn2r69
|
APN |
7 |
85,059,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0526:Vmn2r69
|
UTSW |
7 |
85,060,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0560:Vmn2r69
|
UTSW |
7 |
85,058,922 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0909:Vmn2r69
|
UTSW |
7 |
85,055,873 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0976:Vmn2r69
|
UTSW |
7 |
85,056,108 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1158:Vmn2r69
|
UTSW |
7 |
85,059,058 (GRCm39) |
splice site |
probably benign |
|
|
R1459:Vmn2r69
|
UTSW |
7 |
85,055,908 (GRCm39) |
nonsense |
probably null |
|
|
R1482:Vmn2r69
|
UTSW |
7 |
85,056,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1917:Vmn2r69
|
UTSW |
7 |
85,060,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2016:Vmn2r69
|
UTSW |
7 |
85,056,493 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2108:Vmn2r69
|
UTSW |
7 |
85,059,404 (GRCm39) |
missense |
probably benign |
|
|
R2571:Vmn2r69
|
UTSW |
7 |
85,064,764 (GRCm39) |
missense |
probably benign |
|
|
R2910:Vmn2r69
|
UTSW |
7 |
85,055,918 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2920:Vmn2r69
|
UTSW |
7 |
85,060,973 (GRCm39) |
missense |
probably benign |
0.08 |
|
R3708:Vmn2r69
|
UTSW |
7 |
85,061,029 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3710:Vmn2r69
|
UTSW |
7 |
85,055,601 (GRCm39) |
missense |
probably benign |
|
|
R4757:Vmn2r69
|
UTSW |
7 |
85,061,575 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4823:Vmn2r69
|
UTSW |
7 |
85,060,508 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4870:Vmn2r69
|
UTSW |
7 |
85,060,793 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4918:Vmn2r69
|
UTSW |
7 |
85,055,967 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5022:Vmn2r69
|
UTSW |
7 |
85,060,367 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R5174:Vmn2r69
|
UTSW |
7 |
85,064,739 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5200:Vmn2r69
|
UTSW |
7 |
85,055,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5278:Vmn2r69
|
UTSW |
7 |
85,060,991 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5643:Vmn2r69
|
UTSW |
7 |
85,056,404 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5996:Vmn2r69
|
UTSW |
7 |
85,061,117 (GRCm39) |
splice site |
probably null |
|
|
R6083:Vmn2r69
|
UTSW |
7 |
85,055,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6140:Vmn2r69
|
UTSW |
7 |
85,060,657 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6306:Vmn2r69
|
UTSW |
7 |
85,064,799 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6330:Vmn2r69
|
UTSW |
7 |
85,060,835 (GRCm39) |
missense |
probably benign |
|
|
R6380:Vmn2r69
|
UTSW |
7 |
85,061,067 (GRCm39) |
missense |
probably benign |
|
|
R6466:Vmn2r69
|
UTSW |
7 |
85,056,378 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6542:Vmn2r69
|
UTSW |
7 |
85,060,413 (GRCm39) |
nonsense |
probably null |
|
|
R6583:Vmn2r69
|
UTSW |
7 |
85,059,017 (GRCm39) |
missense |
probably benign |
|
|
R6623:Vmn2r69
|
UTSW |
7 |
85,056,309 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6709:Vmn2r69
|
UTSW |
7 |
85,061,069 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6732:Vmn2r69
|
UTSW |
7 |
85,060,351 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6741:Vmn2r69
|
UTSW |
7 |
85,061,724 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7234:Vmn2r69
|
UTSW |
7 |
85,056,315 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7323:Vmn2r69
|
UTSW |
7 |
85,060,972 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7427:Vmn2r69
|
UTSW |
7 |
85,060,467 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7428:Vmn2r69
|
UTSW |
7 |
85,060,467 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7453:Vmn2r69
|
UTSW |
7 |
85,060,768 (GRCm39) |
frame shift |
probably null |
|
|
R7532:Vmn2r69
|
UTSW |
7 |
85,059,622 (GRCm39) |
missense |
probably benign |
0.36 |
|
R7556:Vmn2r69
|
UTSW |
7 |
85,060,768 (GRCm39) |
frame shift |
probably null |
|
|
R7562:Vmn2r69
|
UTSW |
7 |
85,056,420 (GRCm39) |
missense |
probably benign |
|
|
R7592:Vmn2r69
|
UTSW |
7 |
85,060,768 (GRCm39) |
frame shift |
probably null |
|
|
R7708:Vmn2r69
|
UTSW |
7 |
85,061,755 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7803:Vmn2r69
|
UTSW |
7 |
85,056,324 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7960:Vmn2r69
|
UTSW |
7 |
85,055,973 (GRCm39) |
missense |
probably benign |
|
|
R7966:Vmn2r69
|
UTSW |
7 |
85,060,762 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8071:Vmn2r69
|
UTSW |
7 |
85,055,713 (GRCm39) |
nonsense |
probably null |
|
|
R8237:Vmn2r69
|
UTSW |
7 |
85,060,340 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8347:Vmn2r69
|
UTSW |
7 |
85,064,838 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8737:Vmn2r69
|
UTSW |
7 |
85,055,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8795:Vmn2r69
|
UTSW |
7 |
85,064,883 (GRCm39) |
start codon destroyed |
probably null |
0.94 |
|
R8831:Vmn2r69
|
UTSW |
7 |
85,059,018 (GRCm39) |
nonsense |
probably null |
|
|
R8856:Vmn2r69
|
UTSW |
7 |
85,061,663 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8998:Vmn2r69
|
UTSW |
7 |
85,060,307 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8999:Vmn2r69
|
UTSW |
7 |
85,060,307 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9161:Vmn2r69
|
UTSW |
7 |
85,056,177 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9228:Vmn2r69
|
UTSW |
7 |
85,064,697 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9494:Vmn2r69
|
UTSW |
7 |
85,060,768 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9494:Vmn2r69
|
UTSW |
7 |
85,056,084 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9541:Vmn2r69
|
UTSW |
7 |
85,056,209 (GRCm39) |
missense |
probably benign |
|
|
R9620:Vmn2r69
|
UTSW |
7 |
85,061,504 (GRCm39) |
missense |
probably benign |
0.10 |
|
Z1176:Vmn2r69
|
UTSW |
7 |
85,055,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGTTTTGGTTGGACAATTCTTCAGC -3'
(R):5'- CCAAACTGAGATGTCCATGGCTC -3'
Sequencing Primer
(F):5'- TTCGATGGTGGCAATGAACATC -3'
(R):5'- CTGAGATGTCCATGGCTCTTAAAG -3'
|
| Posted On |
2019-05-13 |
Incidental Mutation