Incidental Mutation 'R7070:Vmn2r90'
ID 548865
Institutional Source Beutler Lab
Gene Symbol Vmn2r90
Ensembl Gene ENSMUSG00000092120
Gene Name vomeronasal 2, receptor 90
Synonyms EG626942
MMRRC Submission 045166-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.139) question?
Stock # R7070 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 17924203-17954429 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 17924313 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 37 (D37E)
Ref Sequence ENSEMBL: ENSMUSP00000155881 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000169805] [ENSMUST00000231659] [ENSMUST00000232078] [ENSMUST00000232113]
AlphaFold E9PXJ8
Predicted Effect probably damaging
Transcript: ENSMUST00000169805
AA Change: D37E

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000126650
Gene: ENSMUSG00000092120
AA Change: D37E

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 471 1.8e-43 PFAM
Pfam:NCD3G 514 567 3e-22 PFAM
Pfam:7tm_3 600 835 9.8e-54 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000231659
AA Change: D37E

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000232078
AA Change: D37E

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000232113
AA Change: D37E

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930544G11Rik T C 6: 65,930,232 (GRCm39) Y156H probably damaging Het
Abca13 T A 11: 9,240,701 (GRCm39) F855I probably benign Het
Abca2 T G 2: 25,333,007 (GRCm39) F1569V probably benign Het
Adcy8 T A 15: 64,792,404 (GRCm39) N184I probably damaging Het
Akap3 T C 6: 126,850,987 (GRCm39) V835A probably damaging Het
Atg5 T A 10: 44,162,150 (GRCm39) L22H probably damaging Het
Atp13a5 A G 16: 29,152,879 (GRCm39) F196L possibly damaging Het
C1qtnf9 A G 14: 61,017,232 (GRCm39) H254R probably damaging Het
Capza3 C T 6: 139,987,646 (GRCm39) R82C probably damaging Het
Ccdc126 A G 6: 49,316,796 (GRCm39) D92G probably damaging Het
Cdh12 T A 15: 21,583,915 (GRCm39) M585K probably benign Het
Chrnb3 A T 8: 27,883,989 (GRCm39) Y242F probably damaging Het
Cngb3 T C 4: 19,425,593 (GRCm39) V467A possibly damaging Het
Cnot8 A G 11: 58,008,278 (GRCm39) D248G probably benign Het
Cntn1 C T 15: 92,151,917 (GRCm39) T452M probably damaging Het
Cygb C A 11: 116,544,851 (GRCm39) probably benign Het
D930020B18Rik G A 10: 121,477,879 (GRCm39) V35M probably damaging Het
Dcaf17 C T 2: 70,918,857 (GRCm39) T477M probably benign Het
Dpp3 A T 19: 4,968,356 (GRCm39) F239I probably benign Het
Dst T A 1: 34,314,383 (GRCm39) V6442E probably damaging Het
Enpp2 T A 15: 54,762,685 (GRCm39) I188F probably damaging Het
Galnt5 A G 2: 57,888,621 (GRCm39) M74V probably benign Het
Grin2a T C 16: 9,397,288 (GRCm39) D933G possibly damaging Het
Gtf2i T A 5: 134,311,657 (GRCm39) E223D probably damaging Het
H2-M5 C A 17: 37,300,051 (GRCm39) G41V possibly damaging Het
Hars2 C T 18: 36,924,165 (GRCm39) R501* probably null Het
Heatr4 A G 12: 84,016,632 (GRCm39) V545A probably benign Het
Hsd3b3 T A 3: 98,649,787 (GRCm39) T179S possibly damaging Het
Ighv5-6 A G 12: 113,589,429 (GRCm39) V17A probably damaging Het
Jak3 A G 8: 72,137,255 (GRCm39) D772G probably damaging Het
Jakmip2 A T 18: 43,690,393 (GRCm39) probably null Het
Kcnj15 C G 16: 95,096,690 (GRCm39) T104S probably damaging Het
Kndc1 A G 7: 139,501,744 (GRCm39) E927G probably damaging Het
Larp1b G T 3: 40,931,086 (GRCm39) G275C probably damaging Het
Lyst C A 13: 13,932,029 (GRCm39) H3552Q probably benign Het
Mast2 A T 4: 116,168,052 (GRCm39) I960N probably benign Het
Mcee G A 7: 64,050,078 (GRCm39) V70I possibly damaging Het
Muc16 G A 9: 18,557,219 (GRCm39) Q3025* probably null Het
Nrg1 T A 8: 32,339,465 (GRCm39) T45S probably damaging Het
Nutm1 T A 2: 112,079,806 (GRCm39) H703L probably benign Het
Or5m10 G A 2: 85,718,034 (GRCm39) V297I probably benign Het
Or7a38 A T 10: 78,753,102 (GRCm39) I143L probably benign Het
Pbx1 A C 1: 168,023,337 (GRCm39) C273G probably damaging Het
Peg10 ACATCAGGATCC ACATCAGGATCCCCATCAGGATCC 6: 4,756,454 (GRCm39) probably benign Het
Phf1 A G 17: 27,153,307 (GRCm39) T42A possibly damaging Het
Pigm T A 1: 172,205,233 (GRCm39) I323N probably damaging Het
Plcg2 G A 8: 118,323,045 (GRCm39) R700H probably benign Het
Ptx4 G A 17: 25,341,971 (GRCm39) A149T probably benign Het
Rab6a A G 7: 100,279,064 (GRCm39) D68G probably damaging Het
Rcan3 C T 4: 135,143,898 (GRCm39) E185K probably damaging Het
Rnf14 A G 18: 38,434,781 (GRCm39) N76S possibly damaging Het
Rpf1 A T 3: 146,217,939 (GRCm39) F192I probably damaging Het
Rps6ka1 T C 4: 133,588,759 (GRCm39) T285A probably benign Het
Rrp8 T C 7: 105,384,083 (GRCm39) K94E possibly damaging Het
Rsbn1 A G 3: 103,836,299 (GRCm39) K122E probably damaging Het
Senp1 T C 15: 97,980,187 (GRCm39) T53A possibly damaging Het
Slc23a1 T G 18: 35,754,834 (GRCm39) D519A probably damaging Het
Slfn14 T G 11: 83,167,531 (GRCm39) R661S probably benign Het
Snta1 T C 2: 154,222,979 (GRCm39) E248G probably benign Het
Son CATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAG CATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAG 16: 91,453,729 (GRCm39) probably benign Het
Spmap2l G T 5: 77,195,124 (GRCm39) probably null Het
Stk11ip C T 1: 75,504,259 (GRCm39) H297Y probably benign Het
Synpr T A 14: 13,493,628 (GRCm38) F76I probably damaging Het
Tns2 A G 15: 102,012,968 (GRCm39) R27G possibly damaging Het
Trav5-4 C T 14: 53,941,912 (GRCm39) S95F possibly damaging Het
Ttyh1 T C 7: 4,136,363 (GRCm39) Y330H probably damaging Het
Ugt1a2 T A 1: 88,129,224 (GRCm39) probably null Het
Vmn2r69 T C 7: 85,060,688 (GRCm39) I299V probably damaging Het
Other mutations in Vmn2r90
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00092:Vmn2r90 APN 17 17,953,758 (GRCm39) missense probably benign 0.00
IGL01330:Vmn2r90 APN 17 17,953,542 (GRCm39) missense probably benign 0.00
IGL01989:Vmn2r90 APN 17 17,933,494 (GRCm39) nonsense probably null
IGL02080:Vmn2r90 APN 17 17,933,120 (GRCm39) missense probably damaging 1.00
IGL02112:Vmn2r90 APN 17 17,932,465 (GRCm39) missense probably damaging 0.98
IGL02123:Vmn2r90 APN 17 17,953,744 (GRCm39) missense probably benign 0.01
IGL02749:Vmn2r90 APN 17 17,947,122 (GRCm39) makesense probably null
IGL03114:Vmn2r90 APN 17 17,953,771 (GRCm39) missense probably damaging 1.00
R0131:Vmn2r90 UTSW 17 17,932,511 (GRCm39) missense probably benign 0.00
R0131:Vmn2r90 UTSW 17 17,932,511 (GRCm39) missense probably benign 0.00
R0132:Vmn2r90 UTSW 17 17,932,511 (GRCm39) missense probably benign 0.00
R0184:Vmn2r90 UTSW 17 17,947,139 (GRCm39) nonsense probably null
R0379:Vmn2r90 UTSW 17 17,948,401 (GRCm39) missense probably damaging 1.00
R1022:Vmn2r90 UTSW 17 17,948,400 (GRCm39) missense probably damaging 1.00
R1024:Vmn2r90 UTSW 17 17,948,400 (GRCm39) missense probably damaging 1.00
R1897:Vmn2r90 UTSW 17 17,953,566 (GRCm39) missense probably damaging 1.00
R1993:Vmn2r90 UTSW 17 17,933,525 (GRCm39) missense probably damaging 1.00
R2472:Vmn2r90 UTSW 17 17,948,408 (GRCm39) missense probably damaging 1.00
R2508:Vmn2r90 UTSW 17 17,954,229 (GRCm39) missense probably damaging 1.00
R2679:Vmn2r90 UTSW 17 17,933,131 (GRCm39) missense possibly damaging 0.46
R3409:Vmn2r90 UTSW 17 17,953,638 (GRCm39) missense probably benign 0.00
R4693:Vmn2r90 UTSW 17 17,953,956 (GRCm39) missense possibly damaging 0.91
R4797:Vmn2r90 UTSW 17 17,932,567 (GRCm39) missense probably damaging 1.00
R5258:Vmn2r90 UTSW 17 17,933,114 (GRCm39) missense probably benign 0.12
R5358:Vmn2r90 UTSW 17 17,924,412 (GRCm39) critical splice donor site probably null
R5445:Vmn2r90 UTSW 17 17,954,386 (GRCm39) missense probably benign 0.04
R5446:Vmn2r90 UTSW 17 17,932,464 (GRCm39) missense probably damaging 0.99
R5567:Vmn2r90 UTSW 17 17,932,336 (GRCm39) missense probably damaging 1.00
R5680:Vmn2r90 UTSW 17 17,947,034 (GRCm39) missense possibly damaging 0.93
R5686:Vmn2r90 UTSW 17 17,933,712 (GRCm39) missense probably benign 0.02
R5751:Vmn2r90 UTSW 17 17,954,128 (GRCm39) missense probably damaging 0.96
R6156:Vmn2r90 UTSW 17 17,953,606 (GRCm39) missense probably benign 0.01
R6185:Vmn2r90 UTSW 17 17,953,644 (GRCm39) missense probably damaging 1.00
R6450:Vmn2r90 UTSW 17 17,953,498 (GRCm39) missense possibly damaging 0.47
R6707:Vmn2r90 UTSW 17 17,948,364 (GRCm39) missense probably damaging 1.00
R6802:Vmn2r90 UTSW 17 17,932,351 (GRCm39) missense probably damaging 1.00
R6913:Vmn2r90 UTSW 17 17,924,323 (GRCm39) missense probably damaging 1.00
R7237:Vmn2r90 UTSW 17 17,924,249 (GRCm39) missense possibly damaging 0.92
R7503:Vmn2r90 UTSW 17 17,933,510 (GRCm39) missense not run
R7698:Vmn2r90 UTSW 17 17,953,596 (GRCm39) missense probably benign
R7943:Vmn2r90 UTSW 17 17,932,566 (GRCm39) missense probably damaging 1.00
R8072:Vmn2r90 UTSW 17 17,947,142 (GRCm39) missense probably damaging 1.00
R8128:Vmn2r90 UTSW 17 17,954,155 (GRCm39) missense probably damaging 1.00
R8295:Vmn2r90 UTSW 17 17,948,358 (GRCm39) missense probably benign 0.03
R8345:Vmn2r90 UTSW 17 17,933,127 (GRCm39) nonsense probably null
R8682:Vmn2r90 UTSW 17 17,932,344 (GRCm39) missense possibly damaging 0.95
R8716:Vmn2r90 UTSW 17 17,924,343 (GRCm39) missense probably damaging 0.98
R9041:Vmn2r90 UTSW 17 17,954,286 (GRCm39) missense probably benign 0.00
R9412:Vmn2r90 UTSW 17 17,954,213 (GRCm39) missense probably damaging 1.00
R9607:Vmn2r90 UTSW 17 17,953,638 (GRCm39) missense possibly damaging 0.88
R9705:Vmn2r90 UTSW 17 17,933,039 (GRCm39) missense possibly damaging 0.91
Z1088:Vmn2r90 UTSW 17 17,953,879 (GRCm39) missense probably damaging 1.00
Z1176:Vmn2r90 UTSW 17 17,933,079 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGTGGGACCAGTTAGAACTTG -3'
(R):5'- GAGGGAACGTGGTGAAGTTTTAATC -3'

Sequencing Primer
(F):5'- CTTGAGCTGAACATAGATCTGATG -3'
(R):5'- GAACGTGGTGAAGTTTTAATCCATAC -3'
Posted On 2019-05-13