Incidental Mutation 'R7072:Mettl24'
ID548973
Institutional Source Beutler Lab
Gene Symbol Mettl24
Ensembl Gene ENSMUSG00000045555
Gene Namemethyltransferase like 24
Synonyms9030224M15Rik
MMRRC Submission
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R7072 (G1)
Quality Score202.009
Status Validated
Chromosome10
Chromosomal Location40683282-40811083 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 40683513 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Proline at position 53 (H53P)
Ref Sequence ENSEMBL: ENSMUSP00000049997 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058747] [ENSMUST00000213856]
Predicted Effect probably benign
Transcript: ENSMUST00000058747
AA Change: H53P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000049997
Gene: ENSMUSG00000045555
AA Change: H53P

DomainStartEndE-ValueType
signal peptide 1 32 N/A INTRINSIC
low complexity region 37 51 N/A INTRINSIC
Pfam:Methyltransf_21 131 328 3.8e-8 PFAM
Pfam:Methyltransf_22 139 344 3.7e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213856
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (73/73)
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 T A 3: 122,173,943 L2214Q probably damaging Het
Acbd3 T C 1: 180,726,369 F90L probably benign Het
Ahnak2 T A 12: 112,788,166 Q23L Het
Anpep A T 7: 79,835,379 L620I possibly damaging Het
Bpi T C 2: 158,272,078 S299P probably damaging Het
Bpifa2 A G 2: 154,011,373 D132G probably damaging Het
Brd7 T A 8: 88,346,987 E258D probably benign Het
Btc T C 5: 91,402,937 probably benign Het
Cacna1c A G 6: 118,596,106 V2039A Het
Calm4 T A 13: 3,838,275 V127E probably benign Het
Casp8ap2 T A 4: 32,644,766 S1280T probably damaging Het
Cc2d2b T C 19: 40,760,359 V80A unknown Het
Ccdc33 A G 9: 58,111,984 *279R probably null Het
Cercam T A 2: 29,881,924 H585Q probably benign Het
Cnnm1 A G 19: 43,440,857 D138G probably benign Het
Cox4i2 T C 2: 152,760,653 F89S probably damaging Het
Crb1 G A 1: 139,237,275 T1098I probably damaging Het
Csnk1e C T 15: 79,438,767 probably null Het
Ctsj C A 13: 61,003,083 E187* probably null Het
D730001G18Rik C T 15: 74,772,270 V66M Het
Dagla A T 19: 10,256,295 probably null Het
Dnah7a G A 1: 53,419,753 T3742I probably benign Het
Dnajc6 A C 4: 101,615,615 H381P probably damaging Het
Dyrk3 A T 1: 131,129,728 L236Q probably damaging Het
Edc4 T A 8: 105,888,002 D105E probably damaging Het
Frmd5 A T 2: 121,557,870 L241Q probably damaging Het
Gcc2 A G 10: 58,270,927 T662A probably benign Het
Gins1 C T 2: 150,909,751 probably null Het
Gli3 T A 13: 15,725,695 N1222K possibly damaging Het
Gm15922 C G 7: 3,737,320 A301P probably damaging Het
Gm4302 G T 10: 100,341,659 Q268H unknown Het
Grin2d A T 7: 45,857,498 W518R probably damaging Het
Grm5 A T 7: 88,074,304 I601F probably damaging Het
Gtpbp10 A T 5: 5,546,365 N193K probably benign Het
Igdcc4 T G 9: 65,130,731 V798G probably damaging Het
Igkv8-19 A T 6: 70,341,412 F13I probably benign Het
Kctd11 T A 11: 69,879,795 N139I probably benign Het
Lmo7 G A 14: 101,898,700 probably null Het
Lrrk2 A T 15: 91,801,920 M2155L probably benign Het
Mier2 A G 10: 79,540,299 M264T unknown Het
Mplkip T C 13: 17,695,537 I18T unknown Het
Mtmr2 T C 9: 13,788,620 V101A probably benign Het
Nbeal2 G T 9: 110,626,051 T2593K probably benign Het
Neu3 A T 7: 99,814,197 C106* probably null Het
Nutm1 T C 2: 112,251,847 T295A probably benign Het
Olfr753-ps1 A G 17: 37,170,378 I90T probably benign Het
Pcdhga7 G T 18: 37,717,276 V779L probably benign Het
Pde10a A G 17: 8,943,026 E231G probably benign Het
Plcg2 T A 8: 117,589,835 probably null Het
Pofut2 T C 10: 77,259,429 L36P probably benign Het
Pou6f2 T C 13: 18,125,169 N635S Het
Pramef17 A C 4: 143,994,128 I81R probably damaging Het
Ptpra T C 2: 130,553,430 Y818H probably damaging Het
Rad18 T C 6: 112,681,440 E168G probably benign Het
Rev1 C A 1: 38,067,545 E634* probably null Het
Sec24d A G 3: 123,330,351 D403G probably damaging Het
Sema5a C A 15: 32,574,959 H404Q possibly damaging Het
Shank1 A G 7: 44,344,946 S844G unknown Het
Slc32a1 T A 2: 158,611,496 Y85* probably null Het
Slc39a4 T C 15: 76,613,258 T485A probably damaging Het
Sp5 A C 2: 70,476,730 Q253P probably benign Het
Sspo A T 6: 48,454,979 D709V probably damaging Het
Sucnr1 A G 3: 60,086,183 Y44C probably damaging Het
Taar8b A G 10: 24,091,978 L106P possibly damaging Het
Tbc1d9 A G 8: 83,264,865 D922G probably damaging Het
Tbx6 A T 7: 126,784,740 D322V probably benign Het
Tex15 T A 8: 33,575,431 S1630T possibly damaging Het
Ube2o G A 11: 116,541,501 P880S probably benign Het
Uck1 C T 2: 32,258,166 R182Q probably damaging Het
Utrn T A 10: 12,465,213 H2840L probably damaging Het
Vps8 A G 16: 21,581,579 T1266A probably benign Het
Wnk1 A T 6: 119,937,861 I1909N unknown Het
Zfp352 C T 4: 90,224,424 T267I probably benign Het
Zfp773 A T 7: 7,132,875 C241S probably benign Het
Zfp934 T C 13: 62,520,525 D8G probably damaging Het
Other mutations in Mettl24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00517:Mettl24 APN 10 40810500 missense probably benign 0.05
R0381:Mettl24 UTSW 10 40746390 missense probably damaging 1.00
R0961:Mettl24 UTSW 10 40810619 missense possibly damaging 0.49
R1172:Mettl24 UTSW 10 40737708 missense probably benign 0.01
R1430:Mettl24 UTSW 10 40737795 missense probably damaging 1.00
R1835:Mettl24 UTSW 10 40737816 critical splice donor site probably null
R1940:Mettl24 UTSW 10 40737726 missense probably benign 0.01
R3424:Mettl24 UTSW 10 40683641 nonsense probably null
R4831:Mettl24 UTSW 10 40683417 missense possibly damaging 0.79
R5430:Mettl24 UTSW 10 40737784 missense probably benign 0.07
R5889:Mettl24 UTSW 10 40746490 missense probably benign 0.27
R6893:Mettl24 UTSW 10 40737798 missense probably damaging 1.00
R7177:Mettl24 UTSW 10 40810512 missense probably damaging 1.00
R7309:Mettl24 UTSW 10 40810500 missense probably benign 0.05
X0022:Mettl24 UTSW 10 40746387 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGTTGCCACAGTTGTCAGC -3'
(R):5'- CATGGTTTGCAACTGACCTTC -3'

Sequencing Primer
(F):5'- TGGGAACGCTTCTCTGCAG -3'
(R):5'- AACTGACCTTCCTGCGGAGAAG -3'
Posted On2019-05-15