Incidental Mutation 'R7075:Mphosph9'
ID 549154
Institutional Source Beutler Lab
Gene Symbol Mphosph9
Ensembl Gene ENSMUSG00000038126
Gene Name M-phase phosphoprotein 9
Synonyms 4930548D04Rik, MPP9, B930097C17Rik, 9630025B04Rik, MPP-9
MMRRC Submission 045170-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7075 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 124389022-124466001 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 124458922 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Glycine at position 83 (W83G)
Ref Sequence ENSEMBL: ENSMUSP00000138982 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031344] [ENSMUST00000130502] [ENSMUST00000141203] [ENSMUST00000147737] [ENSMUST00000184951]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000031344
AA Change: W83G

PolyPhen 2 Score 0.816 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000031344
Gene: ENSMUSG00000038126
AA Change: W83G

DomainStartEndE-ValueType
low complexity region 102 119 N/A INTRINSIC
low complexity region 128 140 N/A INTRINSIC
low complexity region 414 428 N/A INTRINSIC
coiled coil region 574 736 N/A INTRINSIC
low complexity region 879 898 N/A INTRINSIC
low complexity region 957 971 N/A INTRINSIC
coiled coil region 1040 1105 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000130502
SMART Domains Protein: ENSMUSP00000120827
Gene: ENSMUSG00000038126

DomainStartEndE-ValueType
low complexity region 47 74 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000141203
Predicted Effect probably benign
Transcript: ENSMUST00000147737
Predicted Effect probably damaging
Transcript: ENSMUST00000184951
AA Change: W83G

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000138982
Gene: ENSMUSG00000038126
AA Change: W83G

DomainStartEndE-ValueType
coiled coil region 102 130 N/A INTRINSIC
low complexity region 132 149 N/A INTRINSIC
low complexity region 158 170 N/A INTRINSIC
low complexity region 444 458 N/A INTRINSIC
coiled coil region 604 766 N/A INTRINSIC
low complexity region 909 928 N/A INTRINSIC
low complexity region 987 1001 N/A INTRINSIC
coiled coil region 1070 1135 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 95% (60/63)
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acyp1 A T 12: 85,325,782 (GRCm39) H72Q unknown Het
Afmid T A 11: 117,726,531 (GRCm39) D218E probably benign Het
Ankhd1 T C 18: 36,693,042 (GRCm39) V1A Het
Atf7ip T C 6: 136,573,513 (GRCm39) probably null Het
BC024139 C T 15: 76,008,599 (GRCm39) V326I probably benign Het
Bfsp1 T A 2: 143,690,885 (GRCm39) Q159L probably damaging Het
Cct2 A T 10: 116,897,370 (GRCm39) W125R unknown Het
Cnksr3 G T 10: 7,102,931 (GRCm39) T147K probably benign Het
Colq C G 14: 31,274,866 (GRCm39) G101R probably damaging Het
Dlg5 G T 14: 24,227,865 (GRCm39) T352K possibly damaging Het
Dusp9 TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG X: 72,684,217 (GRCm39) probably benign Het
Ebna1bp2 T C 4: 118,479,299 (GRCm39) V119A probably benign Het
Eif2ak4 C T 2: 118,251,291 (GRCm39) Q318* probably null Het
Eif2b1 G A 5: 124,709,314 (GRCm39) T286M probably damaging Het
Fam53b G T 7: 132,361,352 (GRCm39) D225E probably damaging Het
Fh1 A G 1: 175,435,421 (GRCm39) I354T probably benign Het
Fnbp1 T C 2: 30,948,926 (GRCm39) H206R probably benign Het
Gabrg3 A T 7: 56,973,444 (GRCm39) D74E probably damaging Het
Galnt18 A T 7: 111,155,595 (GRCm39) V246E possibly damaging Het
Glt6d1 T C 2: 25,685,292 (GRCm39) R44G probably benign Het
Gm17087 T C 17: 8,785,635 (GRCm39) M23V probably benign Het
Gpr160 A T 3: 30,950,926 (GRCm39) I333L possibly damaging Het
Hars1 T C 18: 36,905,408 (GRCm39) N142S possibly damaging Het
Hmgcll1 T C 9: 75,963,834 (GRCm39) V97A possibly damaging Het
Itih4 T G 14: 30,614,560 (GRCm39) V474G probably damaging Het
Itprid2 T A 2: 79,466,004 (GRCm39) S41T probably damaging Het
Keap1 C T 9: 21,142,552 (GRCm39) V568I probably benign Het
Kifc5b A G 17: 27,144,872 (GRCm39) M633V probably benign Het
Lsm4 A G 8: 71,130,435 (GRCm39) E18G probably damaging Het
Meox1 T A 11: 101,784,569 (GRCm39) Q88L probably damaging Het
Mettl25 T C 10: 105,665,785 (GRCm39) N147S possibly damaging Het
Or1j15 T C 2: 36,459,192 (GRCm39) I194T probably benign Het
Or5ak22 T C 2: 85,230,544 (GRCm39) D111G probably damaging Het
Or7e170 T A 9: 19,795,359 (GRCm39) M81L probably benign Het
Or8b4 T C 9: 37,830,370 (GRCm39) V139A probably benign Het
Or8h8 T G 2: 86,752,990 (GRCm39) K295N possibly damaging Het
Or9g4 T A 2: 85,505,168 (GRCm39) Y109F Het
Otogl G T 10: 107,614,790 (GRCm39) T1954K probably benign Het
Padi2 T C 4: 140,660,528 (GRCm39) V336A probably damaging Het
Phf21a C T 2: 92,190,724 (GRCm39) Q675* probably null Het
Ppip5k1 T C 2: 121,152,231 (GRCm39) E1092G probably damaging Het
Psg21 T C 7: 18,388,786 (GRCm39) N102S probably damaging Het
Ralgapa1 C A 12: 55,867,508 (GRCm39) Q15H possibly damaging Het
Rbm26 A T 14: 105,398,043 (GRCm39) D26E unknown Het
Rbp4 T C 19: 38,112,509 (GRCm39) Y152C probably damaging Het
Recql4 A G 15: 76,590,624 (GRCm39) V646A possibly damaging Het
Rnf220 A T 4: 117,143,079 (GRCm39) M63K probably benign Het
Selenok T C 14: 29,692,024 (GRCm39) S21P probably damaging Het
Senp1 A G 15: 97,956,207 (GRCm39) V404A probably benign Het
Sh3yl1 A G 12: 30,990,165 (GRCm39) probably null Het
Snx32 A G 19: 5,547,018 (GRCm39) L275P probably damaging Het
Stat5a T C 11: 100,770,519 (GRCm39) V519A possibly damaging Het
Tbc1d10b A T 7: 126,802,410 (GRCm39) V388E possibly damaging Het
Tdrd6 A G 17: 43,936,065 (GRCm39) V1661A probably benign Het
Tmem63a T A 1: 180,788,714 (GRCm39) F350L probably damaging Het
Trio A T 15: 27,898,086 (GRCm39) I401K unknown Het
Ttn T C 2: 76,547,173 (GRCm39) E32291G probably damaging Het
Tubgcp5 G T 7: 55,479,155 (GRCm39) V1002L probably benign Het
Vav3 C T 3: 109,433,240 (GRCm39) T410I possibly damaging Het
Vmn1r1 A T 1: 181,985,597 (GRCm39) F23I probably benign Het
Vmn2r84 T A 10: 130,226,941 (GRCm39) Q299L probably damaging Het
Vmn2r85 T A 10: 130,258,557 (GRCm39) E499D probably benign Het
Other mutations in Mphosph9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01363:Mphosph9 APN 5 124,400,084 (GRCm39) missense probably damaging 1.00
IGL01527:Mphosph9 APN 5 124,421,687 (GRCm39) splice site probably benign
IGL01784:Mphosph9 APN 5 124,403,373 (GRCm39) splice site probably benign
IGL01958:Mphosph9 APN 5 124,463,053 (GRCm39) utr 5 prime probably benign
IGL02020:Mphosph9 APN 5 124,397,013 (GRCm39) missense probably damaging 0.99
IGL02190:Mphosph9 APN 5 124,403,488 (GRCm39) missense possibly damaging 0.92
IGL02261:Mphosph9 APN 5 124,398,150 (GRCm39) missense probably damaging 1.00
IGL02569:Mphosph9 APN 5 124,435,634 (GRCm39) nonsense probably null
IGL02640:Mphosph9 APN 5 124,453,563 (GRCm39) missense possibly damaging 0.66
IGL02702:Mphosph9 APN 5 124,398,052 (GRCm39) missense probably damaging 1.00
IGL02793:Mphosph9 APN 5 124,421,800 (GRCm39) critical splice acceptor site probably null
IGL02813:Mphosph9 APN 5 124,453,691 (GRCm39) missense probably benign 0.37
IGL02875:Mphosph9 APN 5 124,421,800 (GRCm39) critical splice acceptor site probably null
IGL03149:Mphosph9 APN 5 124,401,074 (GRCm39) missense probably damaging 1.00
PIT4445001:Mphosph9 UTSW 5 124,436,853 (GRCm39) missense possibly damaging 0.82
R0304:Mphosph9 UTSW 5 124,436,892 (GRCm39) missense probably benign 0.01
R0437:Mphosph9 UTSW 5 124,453,631 (GRCm39) missense probably benign 0.27
R0483:Mphosph9 UTSW 5 124,445,033 (GRCm39) nonsense probably null
R0811:Mphosph9 UTSW 5 124,436,822 (GRCm39) missense probably damaging 1.00
R0812:Mphosph9 UTSW 5 124,436,822 (GRCm39) missense probably damaging 1.00
R0942:Mphosph9 UTSW 5 124,400,100 (GRCm39) nonsense probably null
R1175:Mphosph9 UTSW 5 124,453,739 (GRCm39) missense possibly damaging 0.94
R1372:Mphosph9 UTSW 5 124,421,808 (GRCm39) splice site probably null
R1442:Mphosph9 UTSW 5 124,403,461 (GRCm39) missense possibly damaging 0.62
R1533:Mphosph9 UTSW 5 124,405,204 (GRCm39) missense probably damaging 1.00
R1959:Mphosph9 UTSW 5 124,453,764 (GRCm39) missense possibly damaging 0.92
R2036:Mphosph9 UTSW 5 124,442,274 (GRCm39) missense probably damaging 0.97
R2256:Mphosph9 UTSW 5 124,421,722 (GRCm39) missense probably benign 0.00
R2919:Mphosph9 UTSW 5 124,399,069 (GRCm39) missense probably benign 0.22
R2920:Mphosph9 UTSW 5 124,399,069 (GRCm39) missense probably benign 0.22
R4064:Mphosph9 UTSW 5 124,428,980 (GRCm39) missense probably damaging 1.00
R4272:Mphosph9 UTSW 5 124,442,266 (GRCm39) missense probably damaging 0.96
R4430:Mphosph9 UTSW 5 124,403,509 (GRCm39) missense possibly damaging 0.83
R4883:Mphosph9 UTSW 5 124,437,108 (GRCm39) missense probably damaging 1.00
R4992:Mphosph9 UTSW 5 124,442,253 (GRCm39) missense probably damaging 1.00
R5815:Mphosph9 UTSW 5 124,453,481 (GRCm39) missense probably damaging 1.00
R5993:Mphosph9 UTSW 5 124,454,161 (GRCm39) missense probably benign 0.40
R6102:Mphosph9 UTSW 5 124,435,772 (GRCm39) missense possibly damaging 0.86
R6295:Mphosph9 UTSW 5 124,458,978 (GRCm39) missense possibly damaging 0.46
R6320:Mphosph9 UTSW 5 124,463,024 (GRCm39) missense probably damaging 0.99
R6628:Mphosph9 UTSW 5 124,436,825 (GRCm39) missense probably damaging 0.98
R6692:Mphosph9 UTSW 5 124,398,179 (GRCm39) missense probably damaging 1.00
R6705:Mphosph9 UTSW 5 124,429,027 (GRCm39) missense possibly damaging 0.83
R6747:Mphosph9 UTSW 5 124,435,762 (GRCm39) missense possibly damaging 0.93
R6787:Mphosph9 UTSW 5 124,399,090 (GRCm39) missense probably damaging 0.99
R6850:Mphosph9 UTSW 5 124,399,019 (GRCm39) missense probably damaging 1.00
R6956:Mphosph9 UTSW 5 124,435,621 (GRCm39) missense probably damaging 1.00
R7604:Mphosph9 UTSW 5 124,454,180 (GRCm39) missense probably benign 0.01
R7789:Mphosph9 UTSW 5 124,453,650 (GRCm39) missense probably damaging 1.00
R7808:Mphosph9 UTSW 5 124,399,009 (GRCm39) missense probably damaging 0.99
R7823:Mphosph9 UTSW 5 124,442,319 (GRCm39) missense probably damaging 0.99
R7891:Mphosph9 UTSW 5 124,428,967 (GRCm39) missense probably damaging 1.00
R8210:Mphosph9 UTSW 5 124,405,174 (GRCm39) missense probably damaging 1.00
R8256:Mphosph9 UTSW 5 124,393,169 (GRCm39) missense probably damaging 1.00
R8385:Mphosph9 UTSW 5 124,450,785 (GRCm39) missense probably benign 0.19
R8438:Mphosph9 UTSW 5 124,430,455 (GRCm39) missense probably benign 0.19
R8692:Mphosph9 UTSW 5 124,450,875 (GRCm39) missense probably damaging 0.99
R8790:Mphosph9 UTSW 5 124,453,736 (GRCm39) missense probably damaging 1.00
R8818:Mphosph9 UTSW 5 124,463,027 (GRCm39) nonsense probably null
R8847:Mphosph9 UTSW 5 124,454,209 (GRCm39) missense possibly damaging 0.91
R9018:Mphosph9 UTSW 5 124,436,713 (GRCm39) missense probably benign 0.12
R9208:Mphosph9 UTSW 5 124,450,854 (GRCm39) missense probably damaging 0.97
R9221:Mphosph9 UTSW 5 124,403,427 (GRCm39) missense probably benign 0.10
R9603:Mphosph9 UTSW 5 124,463,015 (GRCm39) nonsense probably null
R9721:Mphosph9 UTSW 5 124,436,738 (GRCm39) missense possibly damaging 0.87
Predicted Primers PCR Primer
(F):5'- TATTGAGGCCACCACCTTCC -3'
(R):5'- CAACGCTTCAGTCCAATGAGG -3'

Sequencing Primer
(F):5'- TTTCTTGTTCCTTCAGTATCGGTG -3'
(R):5'- CCAATGAGGAAAACCATCTGAATTG -3'
Posted On 2019-05-15