Incidental Mutation 'R0613:Gpr108'
ID 54917
Institutional Source Beutler Lab
Gene Symbol Gpr108
Ensembl Gene ENSMUSG00000005823
Gene Name G protein-coupled receptor 108
Synonyms 1810015L19Rik
MMRRC Submission 038802-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0613 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 57541635-57555446 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 57545174 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000005975 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000005975]
AlphaFold Q91WD0
Predicted Effect probably benign
Transcript: ENSMUST00000005975
SMART Domains Protein: ENSMUSP00000005975
Gene: ENSMUSG00000005823

DomainStartEndE-ValueType
low complexity region 61 75 N/A INTRINSIC
low complexity region 86 103 N/A INTRINSIC
Pfam:Lung_7-TM_R 240 529 2.3e-98 PFAM
low complexity region 535 547 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.6%
  • 20x: 95.3%
Validation Efficiency 100% (72/72)
Allele List at MGI

All alleles(3) : Targeted, other(2) Gene trapped(1)

Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acd A T 8: 106,427,200 (GRCm39) probably null Het
Adcy9 A G 16: 4,237,403 (GRCm39) S3P probably damaging Het
Adgrl4 T C 3: 151,248,859 (GRCm39) probably benign Het
Aff3 T C 1: 38,249,004 (GRCm39) E700G probably benign Het
Ahctf1 A G 1: 179,596,979 (GRCm39) S56P probably damaging Het
Atp12a T A 14: 56,611,978 (GRCm39) I384N probably damaging Het
Brca1 A T 11: 101,399,036 (GRCm39) S1519T probably benign Het
Ccl25 T C 8: 4,399,850 (GRCm39) V94A probably benign Het
Cep170 T C 1: 176,602,246 (GRCm39) T287A probably benign Het
Ces1a A G 8: 93,752,209 (GRCm39) S383P probably benign Het
Cntnap3 A T 13: 64,906,228 (GRCm39) F793I probably damaging Het
Ctsm T C 13: 61,687,496 (GRCm39) R89G probably damaging Het
Cyp2j12 T G 4: 95,990,316 (GRCm39) T417P probably damaging Het
D430041D05Rik G C 2: 103,998,295 (GRCm39) P1836R probably damaging Het
Edn2 T A 4: 120,019,061 (GRCm39) probably null Het
Emc1 T A 4: 139,102,383 (GRCm39) probably benign Het
Entrep1 T A 19: 23,963,853 (GRCm39) N239Y probably damaging Het
Fras1 T C 5: 96,848,347 (GRCm39) probably benign Het
Fsip2 A T 2: 82,824,139 (GRCm39) D6624V probably damaging Het
Gpr107 A G 2: 31,068,297 (GRCm39) Y253C probably damaging Het
Grik1 A G 16: 87,848,221 (GRCm39) probably null Het
Gtf3c1 G A 7: 125,243,306 (GRCm39) P1766L possibly damaging Het
Gucy2c A T 6: 136,737,721 (GRCm39) N293K probably damaging Het
Hps6 C A 19: 45,992,260 (GRCm39) P66T probably benign Het
Hspa9 A T 18: 35,081,033 (GRCm39) V216E probably damaging Het
Igsf8 T A 1: 172,145,156 (GRCm39) M224K probably benign Het
Igsf9b T C 9: 27,238,216 (GRCm39) V569A probably damaging Het
Itgb4 A T 11: 115,884,168 (GRCm39) I952F probably damaging Het
Kcnh4 C T 11: 100,637,758 (GRCm39) G633E probably benign Het
Khdrbs2 A G 1: 32,696,603 (GRCm39) H344R possibly damaging Het
Kmo C A 1: 175,465,458 (GRCm39) R71S probably damaging Het
Lrrc31 A G 3: 30,739,184 (GRCm39) probably benign Het
Map1b T A 13: 99,578,149 (GRCm39) D168V probably damaging Het
Mfsd6 T C 1: 52,697,855 (GRCm39) probably benign Het
Mgst1 G A 6: 138,133,243 (GRCm39) G186D probably damaging Het
Mrc1 C T 2: 14,299,630 (GRCm39) A740V probably damaging Het
Mroh2a G A 1: 88,171,672 (GRCm39) R770Q probably damaging Het
Mtor T C 4: 148,610,503 (GRCm39) Y1605H possibly damaging Het
Ncoa4 T A 14: 31,898,509 (GRCm39) L443Q probably damaging Het
Nelfa G A 5: 34,060,807 (GRCm39) probably benign Het
Nepn T A 10: 52,277,353 (GRCm39) L363Q probably damaging Het
Nfat5 A G 8: 108,092,927 (GRCm39) T630A possibly damaging Het
Nipal4 A T 11: 46,041,211 (GRCm39) V328E probably benign Het
Or11h4b T A 14: 50,918,861 (GRCm39) I77F probably benign Het
Or2y1e T A 11: 49,218,575 (GRCm39) S112R possibly damaging Het
Or4c122 A T 2: 89,079,469 (GRCm39) C178S probably damaging Het
Or4d2b A T 11: 87,780,053 (GRCm39) V223E possibly damaging Het
Or6c76 T A 10: 129,612,131 (GRCm39) M116K probably damaging Het
Or8d2 T A 9: 38,759,909 (GRCm39) C166* probably null Het
Otogl A T 10: 107,652,931 (GRCm39) N1140K probably damaging Het
Ppip5k2 A C 1: 97,680,465 (GRCm39) Y236* probably null Het
Prelid1 C T 13: 55,472,156 (GRCm39) R111* probably null Het
Prpf8 T C 11: 75,394,270 (GRCm39) L1771P probably damaging Het
Ptprb A T 10: 116,138,230 (GRCm39) Y378F possibly damaging Het
Ptprb A G 10: 116,138,283 (GRCm39) T396A possibly damaging Het
Rab3il1 T C 19: 10,005,728 (GRCm39) L174P probably damaging Het
Rab4a T C 8: 124,550,574 (GRCm39) V18A possibly damaging Het
Scn3a T A 2: 65,302,628 (GRCm39) M1273L possibly damaging Het
Sdhc A T 1: 170,957,413 (GRCm39) V156E probably benign Het
Slco3a1 T C 7: 73,996,382 (GRCm39) probably benign Het
Syne3 T C 12: 104,924,371 (GRCm39) T343A probably benign Het
Syt11 A G 3: 88,669,776 (GRCm39) C39R probably damaging Het
Tll2 G T 19: 41,093,429 (GRCm39) D462E probably damaging Het
Tmem132e T A 11: 82,329,164 (GRCm39) V481D probably damaging Het
Tmem161b C T 13: 84,399,439 (GRCm39) L17F probably damaging Het
Vmn2r105 T A 17: 20,428,578 (GRCm39) I833F probably damaging Het
Vstm2a A T 11: 16,213,140 (GRCm39) N175I probably damaging Het
Xpnpep1 G T 19: 52,994,784 (GRCm39) D238E probably damaging Het
Zfp112 G A 7: 23,826,453 (GRCm39) G807D probably benign Het
Zfp518b A T 5: 38,830,946 (GRCm39) V353E probably damaging Het
Zfp69 T C 4: 120,791,544 (GRCm39) E39G probably benign Het
Zfp865 A G 7: 5,032,090 (GRCm39) H25R possibly damaging Het
Other mutations in Gpr108
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01982:Gpr108 APN 17 57,544,877 (GRCm39) missense probably damaging 1.00
IGL02486:Gpr108 APN 17 57,542,977 (GRCm39) missense probably damaging 1.00
IGL02810:Gpr108 APN 17 57,549,742 (GRCm39) missense probably benign 0.39
IGL03233:Gpr108 APN 17 57,552,042 (GRCm39) missense probably benign 0.00
1mM(1):Gpr108 UTSW 17 57,552,352 (GRCm39) unclassified probably benign
IGL02799:Gpr108 UTSW 17 57,544,482 (GRCm39) missense probably damaging 1.00
PIT4468001:Gpr108 UTSW 17 57,554,563 (GRCm39) missense probably null 0.09
R0391:Gpr108 UTSW 17 57,550,101 (GRCm39) missense probably benign 0.02
R0469:Gpr108 UTSW 17 57,542,358 (GRCm39) missense possibly damaging 0.65
R0510:Gpr108 UTSW 17 57,542,358 (GRCm39) missense possibly damaging 0.65
R1034:Gpr108 UTSW 17 57,542,995 (GRCm39) missense probably damaging 1.00
R1141:Gpr108 UTSW 17 57,544,219 (GRCm39) missense probably damaging 1.00
R1748:Gpr108 UTSW 17 57,543,217 (GRCm39) missense probably damaging 0.99
R2000:Gpr108 UTSW 17 57,543,712 (GRCm39) missense probably benign 0.03
R3036:Gpr108 UTSW 17 57,552,323 (GRCm39) missense probably benign 0.01
R4087:Gpr108 UTSW 17 57,544,925 (GRCm39) missense probably damaging 1.00
R4089:Gpr108 UTSW 17 57,544,925 (GRCm39) missense probably damaging 1.00
R5071:Gpr108 UTSW 17 57,542,335 (GRCm39) missense probably damaging 1.00
R5566:Gpr108 UTSW 17 57,543,919 (GRCm39) missense probably damaging 1.00
R6889:Gpr108 UTSW 17 57,543,990 (GRCm39) missense probably damaging 1.00
R7352:Gpr108 UTSW 17 57,543,944 (GRCm39) missense probably damaging 1.00
R7587:Gpr108 UTSW 17 57,543,732 (GRCm39) missense probably damaging 1.00
R7642:Gpr108 UTSW 17 57,543,228 (GRCm39) nonsense probably null
R9574:Gpr108 UTSW 17 57,545,039 (GRCm39) missense probably damaging 1.00
Z1177:Gpr108 UTSW 17 57,544,316 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCATGAGCCAGTGGATCTTGAAGAC -3'
(R):5'- GCTGTTCAGAGCCTTCTGGAGATG -3'

Sequencing Primer
(F):5'- CTTGAAGACACTGTATCTGCCAG -3'
(R):5'- ACAGACACTGGGTCATCCTTG -3'
Posted On 2013-07-11