Incidental Mutation 'R7075:Vmn2r84'
ID 549172
Institutional Source Beutler Lab
Gene Symbol Vmn2r84
Ensembl Gene ENSMUSG00000070601
Gene Name vomeronasal 2, receptor 84
Synonyms EG625068
MMRRC Submission 045170-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R7075 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 130221669-130230110 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 130226941 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Leucine at position 299 (Q299L)
Ref Sequence ENSEMBL: ENSMUSP00000092079 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094502]
AlphaFold D3YWE3
Predicted Effect probably damaging
Transcript: ENSMUST00000094502
AA Change: Q299L

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000092079
Gene: ENSMUSG00000070601
AA Change: Q299L

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ANF_receptor 77 448 1.3e-27 PFAM
Pfam:NCD3G 508 561 6.9e-21 PFAM
Pfam:7tm_3 594 830 4.6e-55 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 95% (60/63)
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acyp1 A T 12: 85,325,782 (GRCm39) H72Q unknown Het
Afmid T A 11: 117,726,531 (GRCm39) D218E probably benign Het
Ankhd1 T C 18: 36,693,042 (GRCm39) V1A Het
Atf7ip T C 6: 136,573,513 (GRCm39) probably null Het
BC024139 C T 15: 76,008,599 (GRCm39) V326I probably benign Het
Bfsp1 T A 2: 143,690,885 (GRCm39) Q159L probably damaging Het
Cct2 A T 10: 116,897,370 (GRCm39) W125R unknown Het
Cnksr3 G T 10: 7,102,931 (GRCm39) T147K probably benign Het
Colq C G 14: 31,274,866 (GRCm39) G101R probably damaging Het
Dlg5 G T 14: 24,227,865 (GRCm39) T352K possibly damaging Het
Dusp9 TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG X: 72,684,217 (GRCm39) probably benign Het
Ebna1bp2 T C 4: 118,479,299 (GRCm39) V119A probably benign Het
Eif2ak4 C T 2: 118,251,291 (GRCm39) Q318* probably null Het
Eif2b1 G A 5: 124,709,314 (GRCm39) T286M probably damaging Het
Fam53b G T 7: 132,361,352 (GRCm39) D225E probably damaging Het
Fh1 A G 1: 175,435,421 (GRCm39) I354T probably benign Het
Fnbp1 T C 2: 30,948,926 (GRCm39) H206R probably benign Het
Gabrg3 A T 7: 56,973,444 (GRCm39) D74E probably damaging Het
Galnt18 A T 7: 111,155,595 (GRCm39) V246E possibly damaging Het
Glt6d1 T C 2: 25,685,292 (GRCm39) R44G probably benign Het
Gm17087 T C 17: 8,785,635 (GRCm39) M23V probably benign Het
Gpr160 A T 3: 30,950,926 (GRCm39) I333L possibly damaging Het
Hars1 T C 18: 36,905,408 (GRCm39) N142S possibly damaging Het
Hmgcll1 T C 9: 75,963,834 (GRCm39) V97A possibly damaging Het
Itih4 T G 14: 30,614,560 (GRCm39) V474G probably damaging Het
Itprid2 T A 2: 79,466,004 (GRCm39) S41T probably damaging Het
Keap1 C T 9: 21,142,552 (GRCm39) V568I probably benign Het
Kifc5b A G 17: 27,144,872 (GRCm39) M633V probably benign Het
Lsm4 A G 8: 71,130,435 (GRCm39) E18G probably damaging Het
Meox1 T A 11: 101,784,569 (GRCm39) Q88L probably damaging Het
Mettl25 T C 10: 105,665,785 (GRCm39) N147S possibly damaging Het
Mphosph9 A C 5: 124,458,922 (GRCm39) W83G probably damaging Het
Or1j15 T C 2: 36,459,192 (GRCm39) I194T probably benign Het
Or5ak22 T C 2: 85,230,544 (GRCm39) D111G probably damaging Het
Or7e170 T A 9: 19,795,359 (GRCm39) M81L probably benign Het
Or8b4 T C 9: 37,830,370 (GRCm39) V139A probably benign Het
Or8h8 T G 2: 86,752,990 (GRCm39) K295N possibly damaging Het
Or9g4 T A 2: 85,505,168 (GRCm39) Y109F Het
Otogl G T 10: 107,614,790 (GRCm39) T1954K probably benign Het
Padi2 T C 4: 140,660,528 (GRCm39) V336A probably damaging Het
Phf21a C T 2: 92,190,724 (GRCm39) Q675* probably null Het
Ppip5k1 T C 2: 121,152,231 (GRCm39) E1092G probably damaging Het
Psg21 T C 7: 18,388,786 (GRCm39) N102S probably damaging Het
Ralgapa1 C A 12: 55,867,508 (GRCm39) Q15H possibly damaging Het
Rbm26 A T 14: 105,398,043 (GRCm39) D26E unknown Het
Rbp4 T C 19: 38,112,509 (GRCm39) Y152C probably damaging Het
Recql4 A G 15: 76,590,624 (GRCm39) V646A possibly damaging Het
Rnf220 A T 4: 117,143,079 (GRCm39) M63K probably benign Het
Selenok T C 14: 29,692,024 (GRCm39) S21P probably damaging Het
Senp1 A G 15: 97,956,207 (GRCm39) V404A probably benign Het
Sh3yl1 A G 12: 30,990,165 (GRCm39) probably null Het
Snx32 A G 19: 5,547,018 (GRCm39) L275P probably damaging Het
Stat5a T C 11: 100,770,519 (GRCm39) V519A possibly damaging Het
Tbc1d10b A T 7: 126,802,410 (GRCm39) V388E possibly damaging Het
Tdrd6 A G 17: 43,936,065 (GRCm39) V1661A probably benign Het
Tmem63a T A 1: 180,788,714 (GRCm39) F350L probably damaging Het
Trio A T 15: 27,898,086 (GRCm39) I401K unknown Het
Ttn T C 2: 76,547,173 (GRCm39) E32291G probably damaging Het
Tubgcp5 G T 7: 55,479,155 (GRCm39) V1002L probably benign Het
Vav3 C T 3: 109,433,240 (GRCm39) T410I possibly damaging Het
Vmn1r1 A T 1: 181,985,597 (GRCm39) F23I probably benign Het
Vmn2r85 T A 10: 130,258,557 (GRCm39) E499D probably benign Het
Other mutations in Vmn2r84
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01461:Vmn2r84 APN 10 130,227,094 (GRCm39) missense possibly damaging 0.65
IGL01590:Vmn2r84 APN 10 130,221,964 (GRCm39) missense probably damaging 1.00
IGL01639:Vmn2r84 APN 10 130,225,141 (GRCm39) nonsense probably null
IGL01843:Vmn2r84 APN 10 130,222,148 (GRCm39) missense probably benign
IGL01911:Vmn2r84 APN 10 130,222,277 (GRCm39) missense probably damaging 0.99
IGL01937:Vmn2r84 APN 10 130,221,755 (GRCm39) missense probably damaging 1.00
IGL01977:Vmn2r84 APN 10 130,229,935 (GRCm39) missense probably benign 0.11
IGL02177:Vmn2r84 APN 10 130,227,881 (GRCm39) missense probably benign 0.00
IGL02291:Vmn2r84 APN 10 130,226,617 (GRCm39) missense probably damaging 1.00
IGL02590:Vmn2r84 APN 10 130,227,356 (GRCm39) splice site probably benign
IGL02727:Vmn2r84 APN 10 130,229,995 (GRCm39) missense possibly damaging 0.95
IGL02900:Vmn2r84 APN 10 130,223,861 (GRCm39) splice site probably benign
IGL03383:Vmn2r84 APN 10 130,222,556 (GRCm39) missense probably damaging 1.00
PIT4378001:Vmn2r84 UTSW 10 130,221,784 (GRCm39) missense probably damaging 1.00
R0076:Vmn2r84 UTSW 10 130,230,062 (GRCm39) missense probably damaging 1.00
R0089:Vmn2r84 UTSW 10 130,222,588 (GRCm39) splice site probably benign
R0153:Vmn2r84 UTSW 10 130,227,877 (GRCm39) missense probably benign 0.06
R0611:Vmn2r84 UTSW 10 130,221,991 (GRCm39) missense probably damaging 1.00
R0883:Vmn2r84 UTSW 10 130,226,984 (GRCm39) missense probably damaging 0.99
R1237:Vmn2r84 UTSW 10 130,223,725 (GRCm39) splice site probably null
R1295:Vmn2r84 UTSW 10 130,225,008 (GRCm39) missense probably benign 0.12
R1401:Vmn2r84 UTSW 10 130,227,859 (GRCm39) missense possibly damaging 0.89
R1521:Vmn2r84 UTSW 10 130,225,137 (GRCm39) missense probably benign 0.10
R1590:Vmn2r84 UTSW 10 130,227,349 (GRCm39) critical splice acceptor site probably null
R1710:Vmn2r84 UTSW 10 130,226,968 (GRCm39) missense probably benign 0.02
R1891:Vmn2r84 UTSW 10 130,221,938 (GRCm39) missense possibly damaging 0.78
R1956:Vmn2r84 UTSW 10 130,226,677 (GRCm39) missense probably benign 0.01
R1957:Vmn2r84 UTSW 10 130,226,677 (GRCm39) missense probably benign 0.01
R1962:Vmn2r84 UTSW 10 130,226,591 (GRCm39) missense probably damaging 0.99
R1994:Vmn2r84 UTSW 10 130,221,878 (GRCm39) missense probably damaging 1.00
R2124:Vmn2r84 UTSW 10 130,227,100 (GRCm39) missense probably damaging 0.99
R2409:Vmn2r84 UTSW 10 130,227,940 (GRCm39) missense probably damaging 0.99
R2474:Vmn2r84 UTSW 10 130,222,392 (GRCm39) missense possibly damaging 0.50
R2851:Vmn2r84 UTSW 10 130,230,036 (GRCm39) missense probably benign 0.05
R3508:Vmn2r84 UTSW 10 130,226,777 (GRCm39) missense probably damaging 1.00
R3792:Vmn2r84 UTSW 10 130,221,669 (GRCm39) makesense probably null
R4051:Vmn2r84 UTSW 10 130,226,767 (GRCm39) missense probably damaging 1.00
R4061:Vmn2r84 UTSW 10 130,221,898 (GRCm39) missense probably damaging 1.00
R4091:Vmn2r84 UTSW 10 130,227,238 (GRCm39) missense probably damaging 1.00
R4190:Vmn2r84 UTSW 10 130,227,163 (GRCm39) nonsense probably null
R4520:Vmn2r84 UTSW 10 130,222,391 (GRCm39) missense probably damaging 1.00
R4584:Vmn2r84 UTSW 10 130,226,582 (GRCm39) missense probably benign 0.00
R4588:Vmn2r84 UTSW 10 130,221,809 (GRCm39) missense probably damaging 0.98
R4655:Vmn2r84 UTSW 10 130,229,973 (GRCm39) nonsense probably null
R4860:Vmn2r84 UTSW 10 130,221,712 (GRCm39) missense probably damaging 0.99
R4860:Vmn2r84 UTSW 10 130,221,712 (GRCm39) missense probably damaging 0.99
R5022:Vmn2r84 UTSW 10 130,222,417 (GRCm39) missense probably damaging 1.00
R5146:Vmn2r84 UTSW 10 130,221,971 (GRCm39) missense probably damaging 1.00
R5237:Vmn2r84 UTSW 10 130,221,863 (GRCm39) missense probably damaging 0.99
R5695:Vmn2r84 UTSW 10 130,225,064 (GRCm39) missense probably benign 0.12
R5793:Vmn2r84 UTSW 10 130,221,754 (GRCm39) missense probably damaging 0.99
R6210:Vmn2r84 UTSW 10 130,222,114 (GRCm39) missense probably damaging 1.00
R6286:Vmn2r84 UTSW 10 130,226,737 (GRCm39) missense possibly damaging 0.65
R6580:Vmn2r84 UTSW 10 130,225,110 (GRCm39) missense possibly damaging 0.93
R6607:Vmn2r84 UTSW 10 130,226,731 (GRCm39) missense possibly damaging 0.87
R6818:Vmn2r84 UTSW 10 130,222,147 (GRCm39) missense probably benign 0.09
R6956:Vmn2r84 UTSW 10 130,225,136 (GRCm39) missense probably damaging 0.98
R6994:Vmn2r84 UTSW 10 130,226,876 (GRCm39) missense possibly damaging 0.90
R7225:Vmn2r84 UTSW 10 130,222,552 (GRCm39) missense probably damaging 0.99
R7252:Vmn2r84 UTSW 10 130,222,279 (GRCm39) missense probably damaging 1.00
R7263:Vmn2r84 UTSW 10 130,225,077 (GRCm39) missense probably damaging 1.00
R7297:Vmn2r84 UTSW 10 130,227,119 (GRCm39) missense probably benign 0.19
R7439:Vmn2r84 UTSW 10 130,227,982 (GRCm39) missense possibly damaging 0.90
R7441:Vmn2r84 UTSW 10 130,227,982 (GRCm39) missense possibly damaging 0.90
R7857:Vmn2r84 UTSW 10 130,226,738 (GRCm39) missense probably benign 0.00
R8263:Vmn2r84 UTSW 10 130,227,037 (GRCm39) missense probably damaging 1.00
R8555:Vmn2r84 UTSW 10 130,230,100 (GRCm39) missense probably benign 0.28
R8766:Vmn2r84 UTSW 10 130,222,241 (GRCm39) missense probably damaging 0.98
R8821:Vmn2r84 UTSW 10 130,226,968 (GRCm39) missense probably benign 0.02
R8831:Vmn2r84 UTSW 10 130,226,968 (GRCm39) missense probably benign 0.02
R8970:Vmn2r84 UTSW 10 130,222,244 (GRCm39) missense probably damaging 0.98
R9164:Vmn2r84 UTSW 10 130,221,669 (GRCm39) makesense probably null
R9190:Vmn2r84 UTSW 10 130,226,843 (GRCm39) missense probably benign 0.03
R9261:Vmn2r84 UTSW 10 130,229,976 (GRCm39) missense probably benign 0.00
R9310:Vmn2r84 UTSW 10 130,227,993 (GRCm39) missense possibly damaging 0.81
R9434:Vmn2r84 UTSW 10 130,221,745 (GRCm39) missense possibly damaging 0.65
R9613:Vmn2r84 UTSW 10 130,226,591 (GRCm39) missense probably damaging 0.99
Z1177:Vmn2r84 UTSW 10 130,227,771 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGTTTTCGCATGTGAAATGATCC -3'
(R):5'- TGTGATCCCAGAAACCATGAAG -3'

Sequencing Primer
(F):5'- TTAATGCTGTTCTTAGAGACTGAAC -3'
(R):5'- TCCCAGAAACCATGAAGATATACATG -3'
Posted On 2019-05-15