Incidental Mutation 'R7078:Cobl'
| ID |
549361 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cobl
|
| Ensembl Gene |
ENSMUSG00000020173 |
| Gene Name |
cordon-bleu WH2 repeat |
| Synonyms |
C530045F18Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7078 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
12186676-12415022 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 12328271 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Proline
at position 112
(T112P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000045693
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000046755]
[ENSMUST00000109650]
[ENSMUST00000109651]
[ENSMUST00000172919]
[ENSMUST00000172956]
[ENSMUST00000174874]
|
| AlphaFold |
Q5NBX1 |
| PDB Structure |
Actin complex with Gelsolin Segment 1 fused to Cobl segment [X-RAY DIFFRACTION]
Crystal Structure of an Actin Dimer in Complex with the Actin Nucleator Cordon-Bleu [X-RAY DIFFRACTION]
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000046755
AA Change: T112P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000045693
Gene: ENSMUSG00000020173
AA Change: T112P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
14 |
30 |
N/A |
INTRINSIC |
|
Pfam:Cobl
|
144 |
235 |
2.2e-46 |
PFAM |
|
low complexity region
|
328 |
333 |
N/A |
INTRINSIC |
|
low complexity region
|
360 |
376 |
N/A |
INTRINSIC |
|
low complexity region
|
408 |
433 |
N/A |
INTRINSIC |
|
low complexity region
|
468 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
526 |
541 |
N/A |
INTRINSIC |
|
coiled coil region
|
564 |
589 |
N/A |
INTRINSIC |
|
WH2
|
1185 |
1205 |
1.32e0 |
SMART |
|
WH2
|
1225 |
1245 |
6.36e-3 |
SMART |
|
low complexity region
|
1276 |
1296 |
N/A |
INTRINSIC |
|
WH2
|
1313 |
1333 |
3.91e-3 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000109650
AA Change: T112P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000105277
Gene: ENSMUSG00000020173
AA Change: T112P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
14 |
30 |
N/A |
INTRINSIC |
|
Pfam:Cobl
|
182 |
260 |
1.6e-40 |
PFAM |
|
low complexity region
|
303 |
308 |
N/A |
INTRINSIC |
|
low complexity region
|
335 |
351 |
N/A |
INTRINSIC |
|
low complexity region
|
386 |
400 |
N/A |
INTRINSIC |
|
low complexity region
|
444 |
459 |
N/A |
INTRINSIC |
|
coiled coil region
|
482 |
507 |
N/A |
INTRINSIC |
|
WH2
|
1103 |
1123 |
1.32e0 |
SMART |
|
WH2
|
1143 |
1163 |
6.36e-3 |
SMART |
|
low complexity region
|
1194 |
1214 |
N/A |
INTRINSIC |
|
WH2
|
1231 |
1251 |
3.91e-3 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000109651
AA Change: T112P
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000105278
Gene: ENSMUSG00000020173
AA Change: T112P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
14 |
30 |
N/A |
INTRINSIC |
|
Pfam:Cobl
|
182 |
260 |
1.2e-40 |
PFAM |
|
low complexity region
|
303 |
308 |
N/A |
INTRINSIC |
|
low complexity region
|
335 |
351 |
N/A |
INTRINSIC |
|
low complexity region
|
383 |
408 |
N/A |
INTRINSIC |
|
low complexity region
|
443 |
457 |
N/A |
INTRINSIC |
|
low complexity region
|
501 |
516 |
N/A |
INTRINSIC |
|
coiled coil region
|
539 |
564 |
N/A |
INTRINSIC |
|
WH2
|
1160 |
1180 |
1.32e0 |
SMART |
|
WH2
|
1200 |
1220 |
6.36e-3 |
SMART |
|
low complexity region
|
1251 |
1271 |
N/A |
INTRINSIC |
|
WH2
|
1288 |
1308 |
3.91e-3 |
SMART |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000119008
Gene: ENSMUSG00000020173
AA Change: T3P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Cobl
|
35 |
142 |
5e-43 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000172919
AA Change: T112P
PolyPhen 2
Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000133669
Gene: ENSMUSG00000020173
AA Change: T112P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
14 |
30 |
N/A |
INTRINSIC |
|
Pfam:Cobl
|
182 |
260 |
2.6e-41 |
PFAM |
|
low complexity region
|
328 |
333 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000172956
AA Change: T112P
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000134372
Gene: ENSMUSG00000020173
AA Change: T112P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
14 |
30 |
N/A |
INTRINSIC |
|
Pfam:Cobl
|
182 |
260 |
2.4e-41 |
PFAM |
|
low complexity region
|
303 |
308 |
N/A |
INTRINSIC |
|
low complexity region
|
335 |
351 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000174874
AA Change: T105P
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000133470
Gene: ENSMUSG00000020173
AA Change: T105P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
23 |
N/A |
INTRINSIC |
|
Pfam:Cobl
|
175 |
253 |
1.2e-40 |
PFAM |
|
low complexity region
|
321 |
326 |
N/A |
INTRINSIC |
|
low complexity region
|
353 |
369 |
N/A |
INTRINSIC |
|
low complexity region
|
401 |
426 |
N/A |
INTRINSIC |
|
low complexity region
|
461 |
475 |
N/A |
INTRINSIC |
|
low complexity region
|
519 |
534 |
N/A |
INTRINSIC |
|
coiled coil region
|
557 |
582 |
N/A |
INTRINSIC |
|
WH2
|
1178 |
1198 |
1.32e0 |
SMART |
|
WH2
|
1218 |
1238 |
6.36e-3 |
SMART |
|
low complexity region
|
1269 |
1289 |
N/A |
INTRINSIC |
|
WH2
|
1306 |
1326 |
3.91e-3 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that contains WH2 domains (WASP, Wiskott-Aldrich syndrome protein, homology domain-2) that interact with actin. The encoded actin regulator protein is required for growth and assembly of brush border microvilli that play a role in maintaining intestinal homeostasis. A similar protein in mouse functions in midbrain neural tube closure. A pseudogene of this gene is located on chromosome X. [provided by RefSeq, Oct 2016]
PHENOTYPE: Animals homozygous for this mutation do not display a phenotype. However, the allele exacerbates the neural tube defects seen in the loop tail mouse. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 91 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acaca |
G |
A |
11: 84,154,138 (GRCm39) |
R953Q |
possibly damaging |
Het |
| Aldh1a1 |
A |
T |
19: 20,579,434 (GRCm39) |
H20L |
probably benign |
Het |
| Ankrd52 |
T |
A |
10: 128,219,526 (GRCm39) |
C487S |
probably benign |
Het |
| Ap1s3 |
T |
C |
1: 79,602,845 (GRCm39) |
E54G |
probably benign |
Het |
| Arglu1 |
A |
C |
8: 8,717,361 (GRCm39) |
M236R |
probably benign |
Het |
| Baz1b |
T |
A |
5: 135,246,293 (GRCm39) |
F581I |
probably benign |
Het |
| Bbox1 |
T |
G |
2: 110,122,884 (GRCm39) |
D135A |
probably benign |
Het |
| Bcl2l14 |
T |
A |
6: 134,400,786 (GRCm39) |
V69E |
probably damaging |
Het |
| Brinp3 |
C |
T |
1: 146,390,627 (GRCm39) |
Q58* |
probably null |
Het |
| Ccnb1ip1 |
T |
A |
14: 51,029,724 (GRCm39) |
K113* |
probably null |
Het |
| Cep128 |
T |
C |
12: 91,200,878 (GRCm39) |
I830M |
probably damaging |
Het |
| Ces2f |
C |
T |
8: 105,681,284 (GRCm39) |
T541I |
probably damaging |
Het |
| Chsy3 |
C |
A |
18: 59,309,149 (GRCm39) |
P134Q |
possibly damaging |
Het |
| Cplane2 |
A |
T |
4: 140,947,159 (GRCm39) |
Y180F |
probably benign |
Het |
| Dcc |
T |
A |
18: 71,680,469 (GRCm39) |
K589I |
probably benign |
Het |
| Depdc1b |
T |
A |
13: 108,523,505 (GRCm39) |
I460K |
possibly damaging |
Het |
| Dlst |
T |
C |
12: 85,157,705 (GRCm39) |
F12S |
probably benign |
Het |
| Dnah1 |
G |
C |
14: 31,019,067 (GRCm39) |
F1342L |
probably damaging |
Het |
| Dtnb |
A |
G |
12: 3,798,480 (GRCm39) |
Q438R |
possibly damaging |
Het |
| Dusp4 |
C |
A |
8: 35,275,065 (GRCm39) |
S61R |
probably damaging |
Het |
| E130308A19Rik |
A |
G |
4: 59,737,688 (GRCm39) |
Y433C |
probably damaging |
Het |
| Ebf2 |
T |
C |
14: 67,661,407 (GRCm39) |
S512P |
probably benign |
Het |
| Elapor2 |
A |
G |
5: 9,460,709 (GRCm39) |
N210S |
probably benign |
Het |
| Eya1 |
C |
T |
1: 14,301,636 (GRCm39) |
|
probably null |
Het |
| Fsd1 |
G |
A |
17: 56,300,876 (GRCm39) |
R245H |
probably damaging |
Het |
| Fzr1 |
T |
A |
10: 81,204,463 (GRCm39) |
D379V |
probably damaging |
Het |
| Gk2 |
T |
A |
5: 97,604,195 (GRCm39) |
E214D |
probably benign |
Het |
| Gm10837 |
C |
G |
14: 122,728,142 (GRCm39) |
A6G |
unknown |
Het |
| Gmnc |
A |
T |
16: 26,779,272 (GRCm39) |
V251E |
probably benign |
Het |
| Golga3 |
A |
G |
5: 110,340,953 (GRCm39) |
Q549R |
probably damaging |
Het |
| Gsdmd |
T |
G |
15: 75,736,204 (GRCm39) |
V111G |
probably damaging |
Het |
| Gtf3c1 |
T |
C |
7: 125,244,914 (GRCm39) |
T1707A |
possibly damaging |
Het |
| Gucy2c |
C |
T |
6: 136,674,937 (GRCm39) |
V1049M |
probably benign |
Het |
| Gucy2g |
A |
G |
19: 55,229,583 (GRCm39) |
V29A |
probably damaging |
Het |
| Hecw1 |
A |
T |
13: 14,609,044 (GRCm39) |
M1K |
probably null |
Het |
| Hmcn1 |
T |
C |
1: 150,736,118 (GRCm39) |
D117G |
probably damaging |
Het |
| Ifnab |
T |
A |
4: 88,609,350 (GRCm39) |
T39S |
possibly damaging |
Het |
| Lcorl |
A |
G |
5: 45,904,566 (GRCm39) |
Y171H |
probably damaging |
Het |
| Ly6g6c |
C |
T |
17: 35,288,437 (GRCm39) |
P103L |
probably damaging |
Het |
| Macf1 |
T |
G |
4: 123,325,936 (GRCm39) |
E5189A |
probably damaging |
Het |
| Mapkap1 |
A |
G |
2: 34,453,151 (GRCm39) |
E348G |
probably damaging |
Het |
| Med25 |
G |
T |
7: 44,534,325 (GRCm39) |
A280D |
probably damaging |
Het |
| Mep1b |
C |
A |
18: 21,233,108 (GRCm39) |
A703E |
probably benign |
Het |
| Morn5 |
T |
A |
2: 35,944,990 (GRCm39) |
N71K |
probably benign |
Het |
| Mtmr10 |
T |
A |
7: 63,970,375 (GRCm39) |
Y373N |
possibly damaging |
Het |
| Myo1d |
C |
T |
11: 80,565,460 (GRCm39) |
E426K |
probably damaging |
Het |
| Ncbp1 |
G |
C |
4: 46,155,756 (GRCm39) |
V302L |
probably benign |
Het |
| Notch4 |
A |
G |
17: 34,801,520 (GRCm39) |
T1123A |
possibly damaging |
Het |
| Nudt18 |
T |
A |
14: 70,816,452 (GRCm39) |
M88K |
possibly damaging |
Het |
| Or12k8 |
A |
G |
2: 36,975,608 (GRCm39) |
S51P |
possibly damaging |
Het |
| Or5b100-ps1 |
A |
T |
19: 12,994,097 (GRCm39) |
D170V |
possibly damaging |
Het |
| Or6d12 |
T |
A |
6: 116,493,632 (GRCm39) |
L298Q |
probably damaging |
Het |
| Or8g4 |
A |
T |
9: 39,661,787 (GRCm39) |
Y35F |
possibly damaging |
Het |
| Pdcd6ip |
T |
C |
9: 113,488,953 (GRCm39) |
N694S |
probably benign |
Het |
| Pecam1 |
T |
A |
11: 106,579,773 (GRCm39) |
T430S |
probably benign |
Het |
| Plaa |
T |
G |
4: 94,462,288 (GRCm39) |
T530P |
probably benign |
Het |
| Ppfia3 |
G |
T |
7: 45,010,019 (GRCm39) |
Q95K |
probably damaging |
Het |
| Ppp4r2 |
T |
C |
6: 100,843,274 (GRCm39) |
S331P |
probably benign |
Het |
| Prg4 |
T |
C |
1: 150,334,014 (GRCm39) |
T117A |
possibly damaging |
Het |
| Prrc2b |
A |
T |
2: 32,103,531 (GRCm39) |
D1003V |
probably benign |
Het |
| Ptk2 |
G |
A |
15: 73,093,658 (GRCm39) |
P854S |
possibly damaging |
Het |
| Rasef |
T |
C |
4: 73,698,626 (GRCm39) |
I12V |
probably benign |
Het |
| Robo2 |
T |
G |
16: 74,149,504 (GRCm39) |
Y108S |
probably damaging |
Het |
| Rp1 |
T |
A |
1: 4,277,014 (GRCm39) |
E762V |
unknown |
Het |
| Rsrc1 |
T |
C |
3: 66,901,987 (GRCm39) |
S46P |
unknown |
Het |
| Rttn |
A |
T |
18: 89,027,546 (GRCm39) |
T554S |
probably benign |
Het |
| Sall3 |
C |
T |
18: 81,017,314 (GRCm39) |
V205M |
probably damaging |
Het |
| Scn3a |
C |
A |
2: 65,327,944 (GRCm39) |
V849L |
probably damaging |
Het |
| Sec23a |
A |
G |
12: 59,039,069 (GRCm39) |
C277R |
probably benign |
Het |
| Sf3b3 |
C |
T |
8: 111,539,639 (GRCm39) |
A1075T |
possibly damaging |
Het |
| Sfxn5 |
T |
C |
6: 85,309,366 (GRCm39) |
D113G |
unknown |
Het |
| Slc22a22 |
C |
T |
15: 57,126,876 (GRCm39) |
M64I |
probably benign |
Het |
| Slc5a11 |
C |
T |
7: 122,857,669 (GRCm39) |
P253S |
probably damaging |
Het |
| Smarcd3 |
A |
G |
5: 24,798,067 (GRCm39) |
F449S |
probably damaging |
Het |
| Sspo |
C |
T |
6: 48,437,313 (GRCm39) |
T1357M |
probably damaging |
Het |
| Styx |
C |
T |
14: 45,609,873 (GRCm39) |
T179I |
probably benign |
Het |
| Syt7 |
A |
T |
19: 10,412,963 (GRCm39) |
T297S |
probably benign |
Het |
| Tbx19 |
T |
A |
1: 164,988,135 (GRCm39) |
|
probably benign |
Het |
| Tg |
T |
A |
15: 66,545,392 (GRCm39) |
V149E |
probably damaging |
Het |
| Tgfbr3l |
T |
A |
8: 4,299,238 (GRCm39) |
L35Q |
probably damaging |
Het |
| Tmem161b |
C |
A |
13: 84,370,537 (GRCm39) |
|
probably benign |
Het |
| Tmem219 |
T |
A |
7: 126,490,975 (GRCm39) |
T161S |
probably damaging |
Het |
| Tox2 |
T |
A |
2: 163,162,501 (GRCm39) |
L68H |
|
Het |
| Trim5 |
T |
A |
7: 103,927,681 (GRCm39) |
D153V |
possibly damaging |
Het |
| Ttn |
T |
C |
2: 76,580,651 (GRCm39) |
Y23414C |
probably damaging |
Het |
| Ttn |
A |
T |
2: 76,582,153 (GRCm39) |
N22913K |
probably damaging |
Het |
| Ubr2 |
A |
C |
17: 47,266,779 (GRCm39) |
M1124R |
possibly damaging |
Het |
| Vmn2r75 |
A |
G |
7: 85,815,568 (GRCm39) |
S99P |
probably damaging |
Het |
| Wdr83 |
T |
C |
8: 85,802,680 (GRCm39) |
D219G |
probably damaging |
Het |
| Wdr90 |
C |
T |
17: 26,068,623 (GRCm39) |
V1285M |
probably damaging |
Het |
| Zmynd15 |
A |
T |
11: 70,351,581 (GRCm39) |
L62F |
probably damaging |
Het |
|
| Other mutations in Cobl |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00338:Cobl
|
APN |
11 |
12,325,813 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL00698:Cobl
|
APN |
11 |
12,203,722 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL00772:Cobl
|
APN |
11 |
12,216,985 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL00922:Cobl
|
APN |
11 |
12,204,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00985:Cobl
|
APN |
11 |
12,204,843 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01641:Cobl
|
APN |
11 |
12,259,641 (GRCm39) |
nonsense |
probably null |
|
|
IGL01722:Cobl
|
APN |
11 |
12,203,987 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01734:Cobl
|
APN |
11 |
12,204,980 (GRCm39) |
splice site |
probably benign |
|
|
IGL01924:Cobl
|
APN |
11 |
12,204,596 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL02105:Cobl
|
APN |
11 |
12,199,651 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02326:Cobl
|
APN |
11 |
12,336,712 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02342:Cobl
|
APN |
11 |
12,203,672 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL02426:Cobl
|
APN |
11 |
12,204,351 (GRCm39) |
nonsense |
probably null |
|
|
IGL02754:Cobl
|
APN |
11 |
12,204,370 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02754:Cobl
|
APN |
11 |
12,204,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02811:Cobl
|
APN |
11 |
12,203,285 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL02859:Cobl
|
APN |
11 |
12,319,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02999:Cobl
|
APN |
11 |
12,293,869 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL03030:Cobl
|
APN |
11 |
12,204,241 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL03191:Cobl
|
APN |
11 |
12,203,364 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4418001:Cobl
|
UTSW |
11 |
12,206,240 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
PIT4480001:Cobl
|
UTSW |
11 |
12,203,592 (GRCm39) |
missense |
probably benign |
|
|
PIT4495001:Cobl
|
UTSW |
11 |
12,204,596 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0031:Cobl
|
UTSW |
11 |
12,204,945 (GRCm39) |
missense |
probably benign |
0.36 |
|
R0241:Cobl
|
UTSW |
11 |
12,204,524 (GRCm39) |
missense |
probably benign |
0.25 |
|
R0241:Cobl
|
UTSW |
11 |
12,204,524 (GRCm39) |
missense |
probably benign |
0.25 |
|
R0322:Cobl
|
UTSW |
11 |
12,217,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0597:Cobl
|
UTSW |
11 |
12,204,699 (GRCm39) |
missense |
probably benign |
0.24 |
|
R0733:Cobl
|
UTSW |
11 |
12,315,167 (GRCm39) |
missense |
probably benign |
0.31 |
|
R0734:Cobl
|
UTSW |
11 |
12,325,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0784:Cobl
|
UTSW |
11 |
12,216,843 (GRCm39) |
splice site |
probably benign |
|
|
R0884:Cobl
|
UTSW |
11 |
12,325,908 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1065:Cobl
|
UTSW |
11 |
12,204,327 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R1331:Cobl
|
UTSW |
11 |
12,325,853 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1892:Cobl
|
UTSW |
11 |
12,203,258 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2847:Cobl
|
UTSW |
11 |
12,328,342 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2848:Cobl
|
UTSW |
11 |
12,328,342 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3407:Cobl
|
UTSW |
11 |
12,325,830 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4627:Cobl
|
UTSW |
11 |
12,201,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4662:Cobl
|
UTSW |
11 |
12,203,672 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4677:Cobl
|
UTSW |
11 |
12,336,665 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4844:Cobl
|
UTSW |
11 |
12,204,740 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4942:Cobl
|
UTSW |
11 |
12,204,185 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5158:Cobl
|
UTSW |
11 |
12,206,198 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5195:Cobl
|
UTSW |
11 |
12,203,565 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5255:Cobl
|
UTSW |
11 |
12,325,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5588:Cobl
|
UTSW |
11 |
12,293,886 (GRCm39) |
nonsense |
probably null |
|
|
R5637:Cobl
|
UTSW |
11 |
12,246,531 (GRCm39) |
intron |
probably benign |
|
|
R5643:Cobl
|
UTSW |
11 |
12,256,948 (GRCm39) |
splice site |
probably benign |
|
|
R5749:Cobl
|
UTSW |
11 |
12,216,965 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5953:Cobl
|
UTSW |
11 |
12,206,220 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6000:Cobl
|
UTSW |
11 |
12,319,684 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6373:Cobl
|
UTSW |
11 |
12,203,118 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7034:Cobl
|
UTSW |
11 |
12,204,177 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7071:Cobl
|
UTSW |
11 |
12,204,795 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7077:Cobl
|
UTSW |
11 |
12,203,441 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7099:Cobl
|
UTSW |
11 |
12,246,540 (GRCm39) |
missense |
|
|
|
R7153:Cobl
|
UTSW |
11 |
12,204,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7448:Cobl
|
UTSW |
11 |
12,206,225 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7519:Cobl
|
UTSW |
11 |
12,203,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7767:Cobl
|
UTSW |
11 |
12,362,117 (GRCm39) |
start gained |
probably benign |
|
|
R7772:Cobl
|
UTSW |
11 |
12,204,488 (GRCm39) |
missense |
probably benign |
0.29 |
|
R7841:Cobl
|
UTSW |
11 |
12,203,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7845:Cobl
|
UTSW |
11 |
12,315,139 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8026:Cobl
|
UTSW |
11 |
12,203,459 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8118:Cobl
|
UTSW |
11 |
12,204,834 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8192:Cobl
|
UTSW |
11 |
12,199,745 (GRCm39) |
missense |
probably benign |
0.07 |
|
R8320:Cobl
|
UTSW |
11 |
12,217,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8338:Cobl
|
UTSW |
11 |
12,203,696 (GRCm39) |
missense |
probably benign |
0.41 |
|
R9319:Cobl
|
UTSW |
11 |
12,203,648 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9497:Cobl
|
UTSW |
11 |
12,203,501 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9501:Cobl
|
UTSW |
11 |
12,328,235 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Z1176:Cobl
|
UTSW |
11 |
12,325,827 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Cobl
|
UTSW |
11 |
12,319,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Cobl
|
UTSW |
11 |
12,203,433 (GRCm39) |
missense |
probably benign |
0.02 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTGCGCACTCATGTACAAATG -3'
(R):5'- CTACATGACCATTTGTTCAGCC -3'
Sequencing Primer
(F):5'- CTGCGCACTCATGTACAAATGTATAG -3'
(R):5'- TTGTTCAGCCTTACTCAGACAGACAG -3'
|
| Posted On |
2019-05-15 |
Incidental Mutation