Incidental Mutation 'R7087:Wnk1'
ID 549953
Institutional Source Beutler Lab
Gene Symbol Wnk1
Ensembl Gene ENSMUSG00000045962
Gene Name WNK lysine deficient protein kinase 1
Synonyms Prkwnk1, 6430573H23Rik, EG406236, Hsn2
MMRRC Submission 045181-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R7087 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 119900930-120015633 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 120014491 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Lysine at position 35 (E35K)
Ref Sequence ENSEMBL: ENSMUSP00000063001 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060043] [ENSMUST00000088644] [ENSMUST00000088646] [ENSMUST00000177761] [ENSMUST00000203030]
AlphaFold P83741
Predicted Effect possibly damaging
Transcript: ENSMUST00000060043
AA Change: E35K

PolyPhen 2 Score 0.938 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000063001
Gene: ENSMUSG00000045962
AA Change: E35K

DomainStartEndE-ValueType
low complexity region 101 115 N/A INTRINSIC
low complexity region 127 141 N/A INTRINSIC
low complexity region 171 193 N/A INTRINSIC
Pfam:Pkinase_Tyr 221 477 1.5e-44 PFAM
Pfam:Pkinase 221 479 4.4e-58 PFAM
Pfam:OSR1_C 500 537 2e-22 PFAM
coiled coil region 563 597 N/A INTRINSIC
low complexity region 734 746 N/A INTRINSIC
low complexity region 865 876 N/A INTRINSIC
low complexity region 1018 1028 N/A INTRINSIC
low complexity region 1042 1058 N/A INTRINSIC
internal_repeat_1 1136 1178 2.15e-5 PROSPERO
low complexity region 1289 1305 N/A INTRINSIC
low complexity region 1345 1357 N/A INTRINSIC
low complexity region 1379 1396 N/A INTRINSIC
low complexity region 1398 1428 N/A INTRINSIC
low complexity region 1429 1454 N/A INTRINSIC
low complexity region 1496 1515 N/A INTRINSIC
low complexity region 1542 1556 N/A INTRINSIC
low complexity region 1586 1609 N/A INTRINSIC
low complexity region 1670 1691 N/A INTRINSIC
low complexity region 1698 1712 N/A INTRINSIC
low complexity region 1738 1764 N/A INTRINSIC
low complexity region 1882 1900 N/A INTRINSIC
coiled coil region 2065 2092 N/A INTRINSIC
low complexity region 2103 2114 N/A INTRINSIC
low complexity region 2116 2140 N/A INTRINSIC
low complexity region 2208 2232 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000088644
AA Change: E35K

PolyPhen 2 Score 0.732 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000086017
Gene: ENSMUSG00000045962
AA Change: E35K

DomainStartEndE-ValueType
low complexity region 101 115 N/A INTRINSIC
low complexity region 127 141 N/A INTRINSIC
low complexity region 171 193 N/A INTRINSIC
Pfam:Pkinase_Tyr 221 477 5.5e-44 PFAM
Pfam:Pkinase 221 479 4.3e-56 PFAM
Pfam:OSR1_C 500 537 1.9e-22 PFAM
coiled coil region 563 597 N/A INTRINSIC
low complexity region 742 753 N/A INTRINSIC
low complexity region 919 935 N/A INTRINSIC
low complexity region 1050 1063 N/A INTRINSIC
low complexity region 1067 1076 N/A INTRINSIC
low complexity region 1146 1158 N/A INTRINSIC
low complexity region 1276 1286 N/A INTRINSIC
low complexity region 1300 1316 N/A INTRINSIC
internal_repeat_1 1394 1436 2.19e-5 PROSPERO
low complexity region 1547 1563 N/A INTRINSIC
low complexity region 1603 1615 N/A INTRINSIC
low complexity region 1637 1654 N/A INTRINSIC
low complexity region 1656 1686 N/A INTRINSIC
low complexity region 1687 1712 N/A INTRINSIC
low complexity region 1754 1773 N/A INTRINSIC
low complexity region 1800 1814 N/A INTRINSIC
low complexity region 1844 1867 N/A INTRINSIC
low complexity region 1928 1949 N/A INTRINSIC
low complexity region 1956 1970 N/A INTRINSIC
low complexity region 1996 2022 N/A INTRINSIC
low complexity region 2140 2158 N/A INTRINSIC
coiled coil region 2323 2350 N/A INTRINSIC
low complexity region 2361 2372 N/A INTRINSIC
low complexity region 2374 2398 N/A INTRINSIC
low complexity region 2466 2490 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000088646
AA Change: E35K

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000086019
Gene: ENSMUSG00000045962
AA Change: E35K

DomainStartEndE-ValueType
low complexity region 101 115 N/A INTRINSIC
low complexity region 127 141 N/A INTRINSIC
low complexity region 171 193 N/A INTRINSIC
Pfam:Pkinase_Tyr 221 477 1.3e-44 PFAM
Pfam:Pkinase 221 479 4e-58 PFAM
Pfam:OSR1_C 500 537 1.8e-22 PFAM
coiled coil region 563 597 N/A INTRINSIC
low complexity region 734 746 N/A INTRINSIC
low complexity region 864 874 N/A INTRINSIC
low complexity region 888 904 N/A INTRINSIC
internal_repeat_1 982 1024 7.56e-6 PROSPERO
low complexity region 1135 1151 N/A INTRINSIC
low complexity region 1191 1203 N/A INTRINSIC
low complexity region 1225 1242 N/A INTRINSIC
low complexity region 1244 1274 N/A INTRINSIC
low complexity region 1275 1300 N/A INTRINSIC
low complexity region 1342 1361 N/A INTRINSIC
low complexity region 1388 1402 N/A INTRINSIC
low complexity region 1432 1455 N/A INTRINSIC
low complexity region 1516 1537 N/A INTRINSIC
low complexity region 1544 1558 N/A INTRINSIC
low complexity region 1584 1610 N/A INTRINSIC
low complexity region 1700 1718 N/A INTRINSIC
coiled coil region 1883 1910 N/A INTRINSIC
low complexity region 1921 1932 N/A INTRINSIC
low complexity region 1934 1958 N/A INTRINSIC
low complexity region 2026 2050 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000177761
AA Change: E35K
SMART Domains Protein: ENSMUSP00000136777
Gene: ENSMUSG00000045962
AA Change: E35K

DomainStartEndE-ValueType
low complexity region 101 115 N/A INTRINSIC
low complexity region 127 141 N/A INTRINSIC
low complexity region 171 193 N/A INTRINSIC
Pfam:Pkinase_Tyr 221 477 1.7e-44 PFAM
Pfam:Pkinase 221 479 5.1e-58 PFAM
Pfam:OSR1_C 500 537 2.2e-22 PFAM
coiled coil region 563 597 N/A INTRINSIC
low complexity region 710 722 N/A INTRINSIC
low complexity region 828 839 N/A INTRINSIC
low complexity region 1005 1021 N/A INTRINSIC
low complexity region 1136 1149 N/A INTRINSIC
low complexity region 1153 1162 N/A INTRINSIC
low complexity region 1232 1244 N/A INTRINSIC
low complexity region 1291 1307 N/A INTRINSIC
internal_repeat_1 1385 1427 1.91e-5 PROSPERO
low complexity region 1538 1554 N/A INTRINSIC
low complexity region 1594 1606 N/A INTRINSIC
low complexity region 1628 1645 N/A INTRINSIC
low complexity region 1647 1677 N/A INTRINSIC
low complexity region 1678 1703 N/A INTRINSIC
low complexity region 1745 1764 N/A INTRINSIC
low complexity region 1791 1805 N/A INTRINSIC
low complexity region 1835 1858 N/A INTRINSIC
low complexity region 1919 1940 N/A INTRINSIC
low complexity region 1947 1961 N/A INTRINSIC
low complexity region 1987 2013 N/A INTRINSIC
low complexity region 2131 2149 N/A INTRINSIC
coiled coil region 2314 2341 N/A INTRINSIC
low complexity region 2352 2363 N/A INTRINSIC
low complexity region 2365 2389 N/A INTRINSIC
low complexity region 2457 2481 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000203030
AA Change: E35K
SMART Domains Protein: ENSMUSP00000145304
Gene: ENSMUSG00000045962
AA Change: E35K

DomainStartEndE-ValueType
low complexity region 101 115 N/A INTRINSIC
low complexity region 127 141 N/A INTRINSIC
low complexity region 171 193 N/A INTRINSIC
Pfam:Pkinase_Tyr 221 477 4.1e-44 PFAM
Pfam:Pkinase 221 479 3.2e-56 PFAM
Pfam:OSR1_C 500 537 1.5e-22 PFAM
coiled coil region 563 597 N/A INTRINSIC
low complexity region 734 746 N/A INTRINSIC
low complexity region 793 809 N/A INTRINSIC
internal_repeat_1 887 929 5.8e-6 PROSPERO
low complexity region 1040 1056 N/A INTRINSIC
low complexity region 1096 1108 N/A INTRINSIC
low complexity region 1130 1147 N/A INTRINSIC
low complexity region 1149 1179 N/A INTRINSIC
low complexity region 1180 1205 N/A INTRINSIC
low complexity region 1247 1266 N/A INTRINSIC
low complexity region 1293 1307 N/A INTRINSIC
low complexity region 1337 1360 N/A INTRINSIC
low complexity region 1421 1442 N/A INTRINSIC
low complexity region 1449 1463 N/A INTRINSIC
low complexity region 1489 1515 N/A INTRINSIC
low complexity region 1633 1651 N/A INTRINSIC
coiled coil region 1816 1843 N/A INTRINSIC
low complexity region 1854 1865 N/A INTRINSIC
low complexity region 1867 1891 N/A INTRINSIC
low complexity region 1959 1983 N/A INTRINSIC
Meta Mutation Damage Score 0.0907 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 98% (43/44)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]
PHENOTYPE: Homozygous mutant mice die before birth, whereas heterozygotes survive and exhibit decreased blood pressure. Mice homozygous for an allele that does not produce the kidney isoform exhibit a slight increase in systemic arterial diastolic blood pressure and reduced sensitivity to amiloride. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsm3 T A 7: 119,373,870 (GRCm39) V252D probably damaging Het
Adprhl1 A G 8: 13,271,856 (GRCm39) L1634P probably damaging Het
Arhgef4 A T 1: 34,850,767 (GRCm39) R438W probably damaging Het
Asb3 A C 11: 30,948,321 (GRCm39) K38T probably benign Het
Atp1a4 A T 1: 172,074,269 (GRCm39) L328Q probably damaging Het
BC030500 T A 8: 59,365,388 (GRCm39) I13N unknown Het
Cbarp A G 10: 79,972,242 (GRCm39) S136P probably damaging Het
Ccdc18 T A 5: 108,343,988 (GRCm39) D910E probably benign Het
Cenpo C T 12: 4,265,307 (GRCm39) E238K probably benign Het
Cmya5 A G 13: 93,227,483 (GRCm39) V2535A probably benign Het
Ddx39b C T 17: 35,472,025 (GRCm39) R355C probably damaging Het
Dock10 T C 1: 80,570,543 (GRCm39) T338A probably benign Het
Dpysl3 T C 18: 43,496,595 (GRCm39) D147G probably damaging Het
Eif3i G T 4: 129,486,104 (GRCm39) H284Q probably damaging Het
Erbb4 A T 1: 68,779,650 (GRCm39) L42Q probably null Het
Exoc3l2 A G 7: 19,203,582 (GRCm39) E58G Het
Fgf18 C T 11: 33,074,677 (GRCm39) R98Q probably damaging Het
Gm40460 GCAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAG GCAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAG 7: 141,794,171 (GRCm39) probably benign Het
Gp2 T A 7: 119,049,455 (GRCm39) T361S probably damaging Het
Gtsf1 A T 15: 103,333,876 (GRCm39) H33Q probably damaging Het
Hoxa4 G A 6: 52,168,271 (GRCm39) T133M probably damaging Het
Hspb7 C A 4: 141,149,866 (GRCm39) T84K possibly damaging Het
Kcnq4 C T 4: 120,561,596 (GRCm39) R491H probably damaging Het
Kdm7a C T 6: 39,152,315 (GRCm39) R127H probably benign Het
Lsm10 C T 4: 125,991,952 (GRCm39) R103C probably damaging Het
Mgme1 T C 2: 144,114,101 (GRCm39) S68P probably damaging Het
Nes G T 3: 87,887,065 (GRCm39) V1775L probably benign Het
Nfrkb C T 9: 31,331,228 (GRCm39) Q1250* probably null Het
Or4s2 T C 2: 88,473,197 (GRCm39) F29L probably damaging Het
Phf21b A T 15: 84,676,033 (GRCm39) L338H probably damaging Het
Pira12 G A 7: 3,900,218 (GRCm39) A128V probably benign Het
Ppp2r5b A G 19: 6,282,580 (GRCm39) V190A possibly damaging Het
Prmt1 T C 7: 44,631,007 (GRCm39) probably null Het
Rusc1 A G 3: 88,996,799 (GRCm39) V639A probably damaging Het
Slc24a2 T A 4: 86,909,456 (GRCm39) probably null Het
Slc39a10 T C 1: 46,874,880 (GRCm39) T141A probably damaging Het
Spta1 A T 1: 174,002,076 (GRCm39) M69L probably benign Het
St8sia5 A C 18: 77,342,238 (GRCm39) Q316P possibly damaging Het
Svs3a T C 2: 164,131,717 (GRCm39) I96T possibly damaging Het
Syne1 T A 10: 5,492,024 (GRCm39) probably benign Het
Trappc3 T C 4: 126,166,474 (GRCm39) S16P probably benign Het
Vmn2r44 A T 7: 8,381,366 (GRCm39) F176I probably benign Het
Zfp354c A G 11: 50,706,040 (GRCm39) L345P probably damaging Het
Zfp608 T A 18: 55,032,469 (GRCm39) K490N probably damaging Het
Zfp687 A C 3: 94,917,524 (GRCm39) S709A probably benign Het
Other mutations in Wnk1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00901:Wnk1 APN 6 119,937,669 (GRCm39) missense probably damaging 1.00
IGL01364:Wnk1 APN 6 119,914,372 (GRCm39) missense probably damaging 1.00
IGL01715:Wnk1 APN 6 119,925,358 (GRCm39) missense probably damaging 1.00
IGL01951:Wnk1 APN 6 119,940,446 (GRCm39) missense probably damaging 0.99
IGL02043:Wnk1 APN 6 119,926,039 (GRCm39) unclassified probably benign
IGL02268:Wnk1 APN 6 119,914,334 (GRCm39) nonsense probably null
IGL02348:Wnk1 APN 6 119,940,289 (GRCm39) missense probably damaging 0.98
IGL02425:Wnk1 APN 6 119,940,415 (GRCm39) missense probably damaging 1.00
IGL02850:Wnk1 APN 6 119,914,823 (GRCm39) missense probably benign 0.26
IGL03160:Wnk1 APN 6 119,903,594 (GRCm39) missense probably damaging 1.00
IGL03387:Wnk1 APN 6 119,931,148 (GRCm39) missense possibly damaging 0.76
IGL03405:Wnk1 APN 6 119,930,856 (GRCm39) missense probably benign 0.41
Actor UTSW 6 119,947,939 (GRCm39) missense probably damaging 1.00
Bad UTSW 6 119,942,639 (GRCm39) intron probably benign
Blink UTSW 6 119,979,234 (GRCm39) nonsense probably null
Knock UTSW 6 119,920,839 (GRCm39) splice site probably null
Narrow UTSW 6 119,969,369 (GRCm39) missense probably damaging 1.00
nictitate UTSW 6 119,979,241 (GRCm39) missense possibly damaging 0.88
opportunity UTSW 6 119,928,029 (GRCm39) missense probably damaging 1.00
path UTSW 6 120,014,110 (GRCm39) missense probably damaging 0.99
Stormy UTSW 6 119,969,408 (GRCm39) missense probably damaging 1.00
tear UTSW 6 119,940,431 (GRCm39) missense probably damaging 0.98
Tic UTSW 6 119,927,044 (GRCm39) missense probably damaging 1.00
Unforgiving UTSW 6 119,925,243 (GRCm39) missense probably damaging 1.00
Window UTSW 6 119,969,414 (GRCm39) missense probably damaging 1.00
Woke UTSW 6 119,939,916 (GRCm39) missense probably benign 0.12
IGL03052:Wnk1 UTSW 6 119,921,760 (GRCm39) splice site probably benign
PIT4480001:Wnk1 UTSW 6 119,940,328 (GRCm39) nonsense probably null
R0044:Wnk1 UTSW 6 120,014,110 (GRCm39) missense probably damaging 0.99
R0207:Wnk1 UTSW 6 119,929,694 (GRCm39) missense probably damaging 1.00
R0333:Wnk1 UTSW 6 119,905,124 (GRCm39) intron probably benign
R0453:Wnk1 UTSW 6 119,940,112 (GRCm39) missense probably damaging 0.99
R0457:Wnk1 UTSW 6 119,946,293 (GRCm39) missense probably damaging 1.00
R0501:Wnk1 UTSW 6 119,939,764 (GRCm39) missense probably damaging 1.00
R0525:Wnk1 UTSW 6 119,903,525 (GRCm39) missense probably damaging 1.00
R0526:Wnk1 UTSW 6 119,928,953 (GRCm39) missense probably damaging 0.99
R0606:Wnk1 UTSW 6 119,903,644 (GRCm39) missense probably damaging 1.00
R0658:Wnk1 UTSW 6 119,925,466 (GRCm39) missense probably damaging 0.98
R1148:Wnk1 UTSW 6 119,928,967 (GRCm39) splice site probably benign
R1188:Wnk1 UTSW 6 119,925,670 (GRCm39) nonsense probably null
R1245:Wnk1 UTSW 6 119,925,418 (GRCm39) missense probably benign 0.26
R1449:Wnk1 UTSW 6 119,929,779 (GRCm39) missense probably damaging 1.00
R1469:Wnk1 UTSW 6 119,927,645 (GRCm39) splice site probably benign
R1869:Wnk1 UTSW 6 119,928,050 (GRCm39) missense probably damaging 1.00
R1871:Wnk1 UTSW 6 119,928,050 (GRCm39) missense probably damaging 1.00
R1928:Wnk1 UTSW 6 119,929,884 (GRCm39) missense probably damaging 1.00
R1959:Wnk1 UTSW 6 119,946,208 (GRCm39) missense probably damaging 0.98
R1961:Wnk1 UTSW 6 119,946,208 (GRCm39) missense probably damaging 0.98
R1964:Wnk1 UTSW 6 119,911,343 (GRCm39) missense possibly damaging 0.86
R1983:Wnk1 UTSW 6 119,914,539 (GRCm39) missense probably damaging 1.00
R2062:Wnk1 UTSW 6 119,905,118 (GRCm39) splice site probably null
R2144:Wnk1 UTSW 6 119,925,949 (GRCm39) unclassified probably benign
R2186:Wnk1 UTSW 6 119,925,528 (GRCm39) missense probably benign 0.26
R2281:Wnk1 UTSW 6 119,940,601 (GRCm39) splice site probably null
R2338:Wnk1 UTSW 6 119,946,495 (GRCm39) missense probably benign 0.42
R2420:Wnk1 UTSW 6 119,913,328 (GRCm39) critical splice donor site probably null
R3727:Wnk1 UTSW 6 119,969,414 (GRCm39) missense probably damaging 1.00
R3773:Wnk1 UTSW 6 119,979,241 (GRCm39) missense possibly damaging 0.88
R3836:Wnk1 UTSW 6 119,927,004 (GRCm39) missense probably damaging 1.00
R3837:Wnk1 UTSW 6 119,927,004 (GRCm39) missense probably damaging 1.00
R3847:Wnk1 UTSW 6 119,946,315 (GRCm39) missense possibly damaging 0.70
R3903:Wnk1 UTSW 6 119,926,012 (GRCm39) missense probably damaging 1.00
R4031:Wnk1 UTSW 6 119,928,029 (GRCm39) missense probably damaging 1.00
R4095:Wnk1 UTSW 6 119,925,087 (GRCm39) missense probably damaging 1.00
R4232:Wnk1 UTSW 6 119,926,222 (GRCm39) missense possibly damaging 0.90
R4422:Wnk1 UTSW 6 119,930,856 (GRCm39) missense probably benign 0.41
R4423:Wnk1 UTSW 6 119,903,387 (GRCm39) missense probably damaging 1.00
R4572:Wnk1 UTSW 6 119,928,872 (GRCm39) missense possibly damaging 0.49
R4704:Wnk1 UTSW 6 119,942,705 (GRCm39) missense possibly damaging 0.83
R4755:Wnk1 UTSW 6 119,940,431 (GRCm39) missense probably damaging 0.98
R4812:Wnk1 UTSW 6 119,929,732 (GRCm39) missense probably benign 0.16
R4822:Wnk1 UTSW 6 119,939,399 (GRCm39) missense probably benign 0.02
R4879:Wnk1 UTSW 6 119,926,338 (GRCm39) missense probably damaging 1.00
R4970:Wnk1 UTSW 6 119,942,696 (GRCm39) intron probably benign
R5002:Wnk1 UTSW 6 119,914,924 (GRCm39) missense probably benign 0.13
R5037:Wnk1 UTSW 6 119,942,696 (GRCm39) intron probably benign
R5152:Wnk1 UTSW 6 119,979,241 (GRCm39) missense possibly damaging 0.88
R5257:Wnk1 UTSW 6 120,014,149 (GRCm39) missense probably benign 0.00
R5354:Wnk1 UTSW 6 119,945,484 (GRCm39) missense probably benign 0.01
R5421:Wnk1 UTSW 6 119,929,779 (GRCm39) missense probably damaging 1.00
R5564:Wnk1 UTSW 6 119,925,852 (GRCm39) unclassified probably benign
R5600:Wnk1 UTSW 6 119,926,319 (GRCm39) missense probably damaging 1.00
R5847:Wnk1 UTSW 6 119,969,369 (GRCm39) missense probably damaging 1.00
R6083:Wnk1 UTSW 6 120,014,562 (GRCm39) missense probably damaging 0.99
R6110:Wnk1 UTSW 6 119,949,958 (GRCm39) intron probably benign
R6128:Wnk1 UTSW 6 119,940,747 (GRCm39) splice site probably null
R6237:Wnk1 UTSW 6 119,929,728 (GRCm39) missense probably damaging 1.00
R6341:Wnk1 UTSW 6 119,925,546 (GRCm39) missense probably damaging 1.00
R6467:Wnk1 UTSW 6 119,939,916 (GRCm39) missense probably benign 0.12
R6696:Wnk1 UTSW 6 119,925,243 (GRCm39) missense probably damaging 1.00
R6888:Wnk1 UTSW 6 119,925,742 (GRCm39) missense probably benign 0.26
R6923:Wnk1 UTSW 6 119,942,639 (GRCm39) intron probably benign
R7024:Wnk1 UTSW 6 119,942,687 (GRCm39) intron probably benign
R7072:Wnk1 UTSW 6 119,914,822 (GRCm39) missense unknown
R7102:Wnk1 UTSW 6 119,925,268 (GRCm39) missense unknown
R7134:Wnk1 UTSW 6 119,903,389 (GRCm39) missense unknown
R7137:Wnk1 UTSW 6 120,015,173 (GRCm39) unclassified probably benign
R7142:Wnk1 UTSW 6 119,926,240 (GRCm39) missense probably benign 0.09
R7174:Wnk1 UTSW 6 119,947,939 (GRCm39) missense probably damaging 1.00
R7205:Wnk1 UTSW 6 119,920,839 (GRCm39) splice site probably null
R7218:Wnk1 UTSW 6 119,979,234 (GRCm39) nonsense probably null
R7498:Wnk1 UTSW 6 119,904,157 (GRCm39) missense unknown
R7599:Wnk1 UTSW 6 119,906,789 (GRCm39) missense possibly damaging 0.83
R7615:Wnk1 UTSW 6 119,909,699 (GRCm39) missense probably benign 0.27
R7799:Wnk1 UTSW 6 119,926,137 (GRCm39) missense probably benign 0.04
R7979:Wnk1 UTSW 6 120,014,409 (GRCm39) missense probably damaging 1.00
R8075:Wnk1 UTSW 6 119,909,675 (GRCm39) missense probably damaging 0.99
R8331:Wnk1 UTSW 6 119,930,794 (GRCm39) missense probably benign 0.09
R8343:Wnk1 UTSW 6 119,940,454 (GRCm39) missense probably damaging 0.99
R8348:Wnk1 UTSW 6 119,906,960 (GRCm39) splice site probably null
R8359:Wnk1 UTSW 6 119,969,408 (GRCm39) missense probably damaging 1.00
R8424:Wnk1 UTSW 6 119,911,388 (GRCm39) missense unknown
R8519:Wnk1 UTSW 6 119,927,044 (GRCm39) missense probably damaging 1.00
R8930:Wnk1 UTSW 6 119,940,226 (GRCm39) missense probably damaging 0.99
R8932:Wnk1 UTSW 6 119,940,226 (GRCm39) missense probably damaging 0.99
R8933:Wnk1 UTSW 6 120,013,959 (GRCm39) missense probably damaging 1.00
R9005:Wnk1 UTSW 6 119,939,393 (GRCm39) missense probably damaging 1.00
R9147:Wnk1 UTSW 6 119,925,631 (GRCm39) missense unknown
R9148:Wnk1 UTSW 6 119,925,631 (GRCm39) missense unknown
R9354:Wnk1 UTSW 6 119,942,660 (GRCm39) missense unknown
R9379:Wnk1 UTSW 6 119,928,678 (GRCm39) missense probably damaging 1.00
X0064:Wnk1 UTSW 6 120,013,993 (GRCm39) missense possibly damaging 0.93
Z1177:Wnk1 UTSW 6 119,925,166 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- ACCACTGCAGGTACACTAGG -3'
(R):5'- AGCACTTCTTGGTGGCTTC -3'

Sequencing Primer
(F):5'- ACTGCAGGTACACTAGGTTGCG -3'
(R):5'- TGGCTTCTCCGGGTCAC -3'
Posted On 2019-05-15