Incidental Mutation 'R7087:Zfp354c'
ID 549967
Institutional Source Beutler Lab
Gene Symbol Zfp354c
Ensembl Gene ENSMUSG00000044807
Gene Name zinc finger protein 354C
Synonyms 5330421P20Rik, Kid3, AJ18
MMRRC Submission 045181-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R7087 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 50701913-50718551 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 50706040 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 345 (L345P)
Ref Sequence ENSEMBL: ENSMUSP00000000632 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000000632] [ENSMUST00000109135]
AlphaFold Q571J5
Predicted Effect probably damaging
Transcript: ENSMUST00000000632
AA Change: L345P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000000632
Gene: ENSMUSG00000044807
AA Change: L345P

DomainStartEndE-ValueType
KRAB 14 74 9.98e-33 SMART
ZnF_C2H2 218 240 5.9e-3 SMART
ZnF_C2H2 246 268 3.74e-5 SMART
ZnF_C2H2 274 296 1.72e-4 SMART
ZnF_C2H2 302 324 7.78e-3 SMART
ZnF_C2H2 330 352 1.92e-2 SMART
ZnF_C2H2 358 380 4.79e-3 SMART
ZnF_C2H2 386 408 1.1e-2 SMART
ZnF_C2H2 414 436 5.67e-5 SMART
ZnF_C2H2 442 464 9.08e-4 SMART
ZnF_C2H2 470 492 5.59e-4 SMART
ZnF_C2H2 498 520 3.39e-3 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000109135
AA Change: L345P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000104763
Gene: ENSMUSG00000044807
AA Change: L345P

DomainStartEndE-ValueType
KRAB 14 74 9.98e-33 SMART
ZnF_C2H2 218 240 5.9e-3 SMART
ZnF_C2H2 246 268 3.74e-5 SMART
ZnF_C2H2 274 296 1.72e-4 SMART
ZnF_C2H2 302 324 7.78e-3 SMART
ZnF_C2H2 330 352 1.92e-2 SMART
ZnF_C2H2 358 380 4.79e-3 SMART
ZnF_C2H2 386 408 1.1e-2 SMART
ZnF_C2H2 414 436 5.67e-5 SMART
ZnF_C2H2 442 464 9.08e-4 SMART
ZnF_C2H2 470 492 5.59e-4 SMART
ZnF_C2H2 498 520 3.39e-3 SMART
Meta Mutation Damage Score 0.7658 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 98% (43/44)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsm3 T A 7: 119,373,870 (GRCm39) V252D probably damaging Het
Adprhl1 A G 8: 13,271,856 (GRCm39) L1634P probably damaging Het
Arhgef4 A T 1: 34,850,767 (GRCm39) R438W probably damaging Het
Asb3 A C 11: 30,948,321 (GRCm39) K38T probably benign Het
Atp1a4 A T 1: 172,074,269 (GRCm39) L328Q probably damaging Het
BC030500 T A 8: 59,365,388 (GRCm39) I13N unknown Het
Cbarp A G 10: 79,972,242 (GRCm39) S136P probably damaging Het
Ccdc18 T A 5: 108,343,988 (GRCm39) D910E probably benign Het
Cenpo C T 12: 4,265,307 (GRCm39) E238K probably benign Het
Cmya5 A G 13: 93,227,483 (GRCm39) V2535A probably benign Het
Ddx39b C T 17: 35,472,025 (GRCm39) R355C probably damaging Het
Dock10 T C 1: 80,570,543 (GRCm39) T338A probably benign Het
Dpysl3 T C 18: 43,496,595 (GRCm39) D147G probably damaging Het
Eif3i G T 4: 129,486,104 (GRCm39) H284Q probably damaging Het
Erbb4 A T 1: 68,779,650 (GRCm39) L42Q probably null Het
Exoc3l2 A G 7: 19,203,582 (GRCm39) E58G Het
Fgf18 C T 11: 33,074,677 (GRCm39) R98Q probably damaging Het
Gm40460 GCAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAG GCAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAGCAGGGCTTACAGCAGCTGGACTGGCAGCAG 7: 141,794,171 (GRCm39) probably benign Het
Gp2 T A 7: 119,049,455 (GRCm39) T361S probably damaging Het
Gtsf1 A T 15: 103,333,876 (GRCm39) H33Q probably damaging Het
Hoxa4 G A 6: 52,168,271 (GRCm39) T133M probably damaging Het
Hspb7 C A 4: 141,149,866 (GRCm39) T84K possibly damaging Het
Kcnq4 C T 4: 120,561,596 (GRCm39) R491H probably damaging Het
Kdm7a C T 6: 39,152,315 (GRCm39) R127H probably benign Het
Lsm10 C T 4: 125,991,952 (GRCm39) R103C probably damaging Het
Mgme1 T C 2: 144,114,101 (GRCm39) S68P probably damaging Het
Nes G T 3: 87,887,065 (GRCm39) V1775L probably benign Het
Nfrkb C T 9: 31,331,228 (GRCm39) Q1250* probably null Het
Or4s2 T C 2: 88,473,197 (GRCm39) F29L probably damaging Het
Phf21b A T 15: 84,676,033 (GRCm39) L338H probably damaging Het
Pira12 G A 7: 3,900,218 (GRCm39) A128V probably benign Het
Ppp2r5b A G 19: 6,282,580 (GRCm39) V190A possibly damaging Het
Prmt1 T C 7: 44,631,007 (GRCm39) probably null Het
Rusc1 A G 3: 88,996,799 (GRCm39) V639A probably damaging Het
Slc24a2 T A 4: 86,909,456 (GRCm39) probably null Het
Slc39a10 T C 1: 46,874,880 (GRCm39) T141A probably damaging Het
Spta1 A T 1: 174,002,076 (GRCm39) M69L probably benign Het
St8sia5 A C 18: 77,342,238 (GRCm39) Q316P possibly damaging Het
Svs3a T C 2: 164,131,717 (GRCm39) I96T possibly damaging Het
Syne1 T A 10: 5,492,024 (GRCm39) probably benign Het
Trappc3 T C 4: 126,166,474 (GRCm39) S16P probably benign Het
Vmn2r44 A T 7: 8,381,366 (GRCm39) F176I probably benign Het
Wnk1 C T 6: 120,014,491 (GRCm39) E35K possibly damaging Het
Zfp608 T A 18: 55,032,469 (GRCm39) K490N probably damaging Het
Zfp687 A C 3: 94,917,524 (GRCm39) S709A probably benign Het
Other mutations in Zfp354c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00923:Zfp354c APN 11 50,706,440 (GRCm39) missense probably damaging 0.97
IGL01615:Zfp354c APN 11 50,708,732 (GRCm39) missense possibly damaging 0.90
IGL03019:Zfp354c APN 11 50,708,021 (GRCm39) missense probably damaging 1.00
R0546:Zfp354c UTSW 11 50,706,457 (GRCm39) missense probably benign 0.12
R1370:Zfp354c UTSW 11 50,706,667 (GRCm39) missense probably benign
R2109:Zfp354c UTSW 11 50,707,969 (GRCm39) missense probably benign 0.01
R2850:Zfp354c UTSW 11 50,706,158 (GRCm39) nonsense probably null
R4010:Zfp354c UTSW 11 50,705,771 (GRCm39) missense probably damaging 0.98
R5034:Zfp354c UTSW 11 50,705,866 (GRCm39) missense probably benign 0.14
R5430:Zfp354c UTSW 11 50,706,022 (GRCm39) missense probably benign 0.02
R5439:Zfp354c UTSW 11 50,706,597 (GRCm39) missense probably benign 0.01
R5905:Zfp354c UTSW 11 50,706,253 (GRCm39) missense probably damaging 1.00
R6244:Zfp354c UTSW 11 50,705,798 (GRCm39) missense probably benign 0.41
R6264:Zfp354c UTSW 11 50,706,274 (GRCm39) missense probably benign 0.00
R6591:Zfp354c UTSW 11 50,705,602 (GRCm39) missense probably benign 0.41
R6650:Zfp354c UTSW 11 50,705,518 (GRCm39) missense probably damaging 1.00
R6691:Zfp354c UTSW 11 50,705,602 (GRCm39) missense probably benign 0.41
R7313:Zfp354c UTSW 11 50,705,483 (GRCm39) missense probably damaging 1.00
R7467:Zfp354c UTSW 11 50,706,253 (GRCm39) missense probably damaging 1.00
R7619:Zfp354c UTSW 11 50,708,635 (GRCm39) critical splice donor site probably null
R7699:Zfp354c UTSW 11 50,706,067 (GRCm39) small deletion probably benign
R7710:Zfp354c UTSW 11 50,706,067 (GRCm39) small deletion probably benign
R7712:Zfp354c UTSW 11 50,706,067 (GRCm39) small deletion probably benign
R7747:Zfp354c UTSW 11 50,706,067 (GRCm39) small deletion probably benign
R7748:Zfp354c UTSW 11 50,706,067 (GRCm39) small deletion probably benign
R7784:Zfp354c UTSW 11 50,706,067 (GRCm39) small deletion probably benign
R7816:Zfp354c UTSW 11 50,706,067 (GRCm39) small deletion probably benign
R7817:Zfp354c UTSW 11 50,706,067 (GRCm39) small deletion probably benign
R7853:Zfp354c UTSW 11 50,706,067 (GRCm39) small deletion probably benign
R7855:Zfp354c UTSW 11 50,706,067 (GRCm39) small deletion probably benign
R7870:Zfp354c UTSW 11 50,706,065 (GRCm39) small deletion probably benign
R8852:Zfp354c UTSW 11 50,706,019 (GRCm39) missense probably damaging 1.00
R8860:Zfp354c UTSW 11 50,706,019 (GRCm39) missense probably damaging 1.00
R8862:Zfp354c UTSW 11 50,708,718 (GRCm39) missense probably benign 0.15
R9169:Zfp354c UTSW 11 50,706,088 (GRCm39) missense probably damaging 1.00
R9215:Zfp354c UTSW 11 50,706,666 (GRCm39) missense probably benign 0.31
R9273:Zfp354c UTSW 11 50,706,059 (GRCm39) missense probably damaging 1.00
R9762:Zfp354c UTSW 11 50,706,239 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCGATAAGGGTAGACACACGTG -3'
(R):5'- CACTTCAGAGAAAGATTTACCACAG -3'

Sequencing Primer
(F):5'- GTAGACACACGTGTAAAGGTTCTCC -3'
(R):5'- TCTTCTAGAGCACAAGAGGCTTC -3'
Posted On 2019-05-15