Incidental Mutation 'R7088:Nsd3'
| ID |
550010 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nsd3
|
| Ensembl Gene |
ENSMUSG00000054823 |
| Gene Name |
nuclear receptor binding SET domain protein 3 |
| Synonyms |
Whsc1l1, WHISTLE |
| MMRRC Submission |
045182-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.303)
|
| Stock # |
R7088 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
26091617-26209694 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 26156050 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 539
(I539T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000117596
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000084026]
[ENSMUST00000136107]
[ENSMUST00000139966]
[ENSMUST00000142395]
[ENSMUST00000143445]
[ENSMUST00000146919]
[ENSMUST00000155861]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000084026
AA Change: I539T
PolyPhen 2
Score 0.114 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000081040
Gene: ENSMUSG00000054823
AA Change: I539T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
128 |
151 |
N/A |
INTRINSIC |
|
low complexity region
|
193 |
225 |
N/A |
INTRINSIC |
|
PWWP
|
278 |
341 |
1.6e-12 |
SMART |
|
low complexity region
|
680 |
701 |
N/A |
INTRINSIC |
|
PHD
|
713 |
756 |
4.49e-7 |
SMART |
|
PHD
|
761 |
808 |
5.82e-1 |
SMART |
|
PHD
|
809 |
861 |
3.06e0 |
SMART |
|
PHD
|
874 |
963 |
1e-4 |
SMART |
|
PWWP
|
968 |
1030 |
8.62e-18 |
SMART |
|
AWS
|
1103 |
1154 |
2.61e-17 |
SMART |
|
SET
|
1155 |
1278 |
2.17e-41 |
SMART |
|
PostSET
|
1279 |
1295 |
2.63e-3 |
SMART |
|
low complexity region
|
1309 |
1326 |
N/A |
INTRINSIC |
|
PHD
|
1332 |
1375 |
4.32e-9 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000136107
AA Change: I539T
PolyPhen 2
Score 0.329 (Sensitivity: 0.90; Specificity: 0.89)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000139966
AA Change: I539T
PolyPhen 2
Score 0.114 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000122096
Gene: ENSMUSG00000054823
AA Change: I539T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
128 |
151 |
N/A |
INTRINSIC |
|
low complexity region
|
193 |
225 |
N/A |
INTRINSIC |
|
PWWP
|
278 |
341 |
1.6e-12 |
SMART |
|
low complexity region
|
680 |
701 |
N/A |
INTRINSIC |
|
PHD
|
713 |
756 |
4.49e-7 |
SMART |
|
PHD
|
761 |
808 |
5.82e-1 |
SMART |
|
PHD
|
809 |
861 |
3.06e0 |
SMART |
|
PHD
|
874 |
914 |
5.24e-8 |
SMART |
|
PWWP
|
919 |
981 |
8.62e-18 |
SMART |
|
AWS
|
1054 |
1105 |
2.61e-17 |
SMART |
|
SET
|
1106 |
1229 |
2.17e-41 |
SMART |
|
PostSET
|
1230 |
1246 |
2.63e-3 |
SMART |
|
low complexity region
|
1260 |
1277 |
N/A |
INTRINSIC |
|
PHD
|
1283 |
1326 |
4.32e-9 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000142395
AA Change: I539T
PolyPhen 2
Score 0.114 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000117778
Gene: ENSMUSG00000054823
AA Change: I539T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
128 |
151 |
N/A |
INTRINSIC |
|
low complexity region
|
193 |
225 |
N/A |
INTRINSIC |
|
PWWP
|
278 |
341 |
1.6e-12 |
SMART |
|
low complexity region
|
680 |
701 |
N/A |
INTRINSIC |
|
PHD
|
713 |
756 |
4.49e-7 |
SMART |
|
PHD
|
761 |
808 |
5.82e-1 |
SMART |
|
PHD
|
809 |
861 |
3.06e0 |
SMART |
|
PHD
|
874 |
963 |
1e-4 |
SMART |
|
PWWP
|
968 |
1030 |
8.62e-18 |
SMART |
|
AWS
|
1103 |
1154 |
2.61e-17 |
SMART |
|
SET
|
1155 |
1278 |
2.17e-41 |
SMART |
|
PostSET
|
1279 |
1295 |
2.63e-3 |
SMART |
|
low complexity region
|
1309 |
1326 |
N/A |
INTRINSIC |
|
PHD
|
1332 |
1375 |
4.32e-9 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000143445
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000146919
AA Change: I539T
PolyPhen 2
Score 0.397 (Sensitivity: 0.89; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000115470
Gene: ENSMUSG00000054823
AA Change: I539T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
128 |
151 |
N/A |
INTRINSIC |
|
low complexity region
|
193 |
225 |
N/A |
INTRINSIC |
|
Pfam:PWWP
|
278 |
388 |
1.6e-25 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000155861
AA Change: I539T
PolyPhen 2
Score 0.397 (Sensitivity: 0.89; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000117596
Gene: ENSMUSG00000054823
AA Change: I539T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
128 |
151 |
N/A |
INTRINSIC |
|
low complexity region
|
193 |
225 |
N/A |
INTRINSIC |
|
Pfam:PWWP
|
278 |
388 |
1.6e-25 |
PFAM |
|
| Meta Mutation Damage Score |
0.0957 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
99% (77/78) |
| MGI Phenotype |
FUNCTION: This gene encodes a member of the SET domain family of histone lysine N-methyltransferase proteins. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. It acts in opposition to the histone demethylase Jmjd1c. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2015]
|
| Allele List at MGI |
All alleles(5) : Gene trapped(5)
|
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700020L24Rik |
G |
T |
11: 83,331,232 (GRCm39) |
E48* |
probably null |
Het |
| Acaca |
T |
C |
11: 84,169,783 (GRCm39) |
|
probably null |
Het |
| Albfm1 |
T |
A |
5: 90,720,609 (GRCm39) |
L260* |
probably null |
Het |
| Alkbh3 |
A |
G |
2: 93,835,097 (GRCm39) |
S83P |
possibly damaging |
Het |
| Ammecr1l |
T |
C |
18: 31,904,872 (GRCm39) |
S38P |
probably benign |
Het |
| Armc10 |
T |
C |
5: 21,858,390 (GRCm39) |
V145A |
probably damaging |
Het |
| BC048671 |
A |
G |
6: 90,280,222 (GRCm39) |
K46R |
probably null |
Het |
| C2cd3 |
A |
G |
7: 100,065,388 (GRCm39) |
T347A |
|
Het |
| C8b |
G |
T |
4: 104,650,540 (GRCm39) |
E449D |
probably benign |
Het |
| Camk4 |
T |
C |
18: 33,072,584 (GRCm39) |
S46P |
probably benign |
Het |
| Ccdc113 |
G |
A |
8: 96,264,733 (GRCm39) |
R81H |
probably benign |
Het |
| Cd177 |
A |
T |
7: 24,444,558 (GRCm39) |
C674* |
probably null |
Het |
| Cdc6 |
T |
A |
11: 98,810,065 (GRCm39) |
V458D |
probably damaging |
Het |
| Cenpo |
C |
T |
12: 4,265,307 (GRCm39) |
E238K |
probably benign |
Het |
| Ckap2 |
G |
T |
8: 22,659,882 (GRCm39) |
P533Q |
possibly damaging |
Het |
| Cma1 |
T |
A |
14: 56,181,273 (GRCm39) |
H44L |
probably damaging |
Het |
| Cmya5 |
A |
T |
13: 93,228,372 (GRCm39) |
S2239T |
possibly damaging |
Het |
| Cntnap5b |
T |
A |
1: 100,087,802 (GRCm39) |
I141N |
probably damaging |
Het |
| Col6a4 |
T |
A |
9: 105,877,885 (GRCm39) |
T2031S |
possibly damaging |
Het |
| Cplane1 |
C |
T |
15: 8,248,431 (GRCm39) |
T1660M |
probably benign |
Het |
| Cxcr5 |
T |
A |
9: 44,424,683 (GRCm39) |
T325S |
possibly damaging |
Het |
| Dhx32 |
A |
T |
7: 133,344,417 (GRCm39) |
L204Q |
probably damaging |
Het |
| Dse |
A |
G |
10: 34,029,885 (GRCm39) |
Y402H |
probably damaging |
Het |
| Ecpas |
A |
T |
4: 58,849,766 (GRCm39) |
L458I |
possibly damaging |
Het |
| Exoc6 |
G |
T |
19: 37,565,458 (GRCm39) |
C178F |
probably damaging |
Het |
| Fam149a |
A |
G |
8: 45,803,582 (GRCm39) |
V384A |
probably benign |
Het |
| Fcrl5 |
T |
C |
3: 87,365,141 (GRCm39) |
*597Q |
probably null |
Het |
| Fer1l6 |
A |
G |
15: 58,435,899 (GRCm39) |
K431E |
possibly damaging |
Het |
| Fmo3 |
T |
A |
1: 162,796,434 (GRCm39) |
H46L |
probably benign |
Het |
| Gcm2 |
T |
C |
13: 41,256,840 (GRCm39) |
D303G |
probably damaging |
Het |
| Gk2 |
T |
C |
5: 97,603,534 (GRCm39) |
M435V |
probably damaging |
Het |
| Gli1 |
C |
A |
10: 127,171,868 (GRCm39) |
M295I |
probably damaging |
Het |
| Gm11444 |
G |
T |
11: 85,737,862 (GRCm39) |
H109Q |
|
Het |
| Gtpbp1 |
T |
A |
15: 79,603,483 (GRCm39) |
D182E |
|
Het |
| Hnf4g |
A |
T |
3: 3,713,185 (GRCm39) |
|
probably null |
Het |
| Hsf2 |
G |
A |
10: 57,388,188 (GRCm39) |
R483H |
probably damaging |
Het |
| Kcnq4 |
C |
T |
4: 120,561,596 (GRCm39) |
R491H |
probably damaging |
Het |
| Lama3 |
T |
C |
18: 12,715,602 (GRCm39) |
V1686A |
possibly damaging |
Het |
| Larp6 |
A |
G |
9: 60,631,638 (GRCm39) |
K137E |
probably damaging |
Het |
| Mboat1 |
T |
G |
13: 30,379,772 (GRCm39) |
|
probably null |
Het |
| Mdh1 |
T |
C |
11: 21,508,484 (GRCm39) |
Y286C |
probably damaging |
Het |
| Mga |
G |
T |
2: 119,792,417 (GRCm39) |
K2607N |
probably damaging |
Het |
| Morf4l1 |
C |
A |
9: 89,979,433 (GRCm39) |
V183F |
possibly damaging |
Het |
| Mroh4 |
G |
A |
15: 74,497,993 (GRCm39) |
R196W |
probably benign |
Het |
| Muc16 |
C |
A |
9: 18,503,976 (GRCm39) |
M6438I |
probably damaging |
Het |
| Myom3 |
A |
G |
4: 135,530,589 (GRCm39) |
Y1167C |
probably damaging |
Het |
| Neurl3 |
T |
C |
1: 36,308,302 (GRCm39) |
E170G |
possibly damaging |
Het |
| Nup155 |
T |
C |
15: 8,186,177 (GRCm39) |
F1313S |
probably benign |
Het |
| Nxn |
A |
T |
11: 76,153,974 (GRCm39) |
V287E |
possibly damaging |
Het |
| Or4a80 |
G |
A |
2: 89,582,443 (GRCm39) |
T243I |
probably benign |
Het |
| Or7a38 |
A |
C |
10: 78,753,593 (GRCm39) |
L306F |
probably benign |
Het |
| Or8c13 |
C |
A |
9: 38,091,748 (GRCm39) |
V124F |
probably damaging |
Het |
| Pax6 |
A |
G |
2: 105,526,753 (GRCm39) |
N220D |
probably benign |
Het |
| Pcdha11 |
G |
A |
18: 37,138,470 (GRCm39) |
R33H |
probably benign |
Het |
| Pdzd8 |
A |
G |
19: 59,333,389 (GRCm39) |
F211L |
probably damaging |
Het |
| Pear1 |
C |
A |
3: 87,661,945 (GRCm39) |
V477F |
possibly damaging |
Het |
| Pex19 |
GTCTCTTGTCTCCGAAGGTGCTCTTGATGATTTCTCTTGTCTCCGAAGGTGCTCTTGATGATTTC |
GTCTCTTGTCTCCGAAGGTGCTCTTGATGATTTC |
1: 171,956,150 (GRCm39) |
|
probably null |
Het |
| Pidd1 |
A |
T |
7: 141,020,400 (GRCm39) |
V539E |
probably damaging |
Het |
| Ptprg |
A |
T |
14: 12,207,365 (GRCm38) |
I878F |
probably damaging |
Het |
| Rabepk |
T |
C |
2: 34,675,711 (GRCm39) |
T140A |
probably benign |
Het |
| Ranbp2 |
G |
T |
10: 58,299,728 (GRCm39) |
R454L |
probably damaging |
Het |
| Rnf123 |
C |
T |
9: 107,935,735 (GRCm39) |
R943Q |
probably null |
Het |
| Sash1 |
G |
A |
10: 8,605,481 (GRCm39) |
R970* |
probably null |
Het |
| Serpinb2 |
C |
A |
1: 107,452,422 (GRCm39) |
F333L |
probably damaging |
Het |
| Shank3 |
T |
A |
15: 89,387,728 (GRCm39) |
|
probably null |
Het |
| Slc9a2 |
A |
C |
1: 40,765,539 (GRCm39) |
I310L |
probably damaging |
Het |
| Strip2 |
T |
A |
6: 29,920,532 (GRCm39) |
|
probably null |
Het |
| Thoc3 |
T |
C |
13: 54,611,565 (GRCm39) |
T241A |
probably damaging |
Het |
| Tmem139 |
T |
A |
6: 42,240,199 (GRCm39) |
V2E |
probably damaging |
Het |
| Usp24 |
G |
T |
4: 106,244,743 (GRCm39) |
V1233F |
probably damaging |
Het |
| Vnn1 |
A |
G |
10: 23,776,645 (GRCm39) |
Q332R |
probably benign |
Het |
| Wac |
T |
A |
18: 7,921,455 (GRCm39) |
H530Q |
probably damaging |
Het |
| Wdr35 |
T |
A |
12: 9,028,659 (GRCm39) |
N92K |
probably benign |
Het |
| Zbtb18 |
T |
G |
1: 177,274,820 (GRCm39) |
L60R |
probably damaging |
Het |
| Zfp184 |
T |
A |
13: 22,144,162 (GRCm39) |
C623S |
probably damaging |
Het |
| Zfp292 |
A |
G |
4: 34,806,796 (GRCm39) |
Y2088H |
probably damaging |
Het |
| Zfp975 |
G |
T |
7: 42,312,096 (GRCm39) |
S172R |
probably benign |
Het |
| Zswim2 |
G |
A |
2: 83,746,071 (GRCm39) |
Q456* |
probably null |
Het |
|
| Other mutations in Nsd3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00435:Nsd3
|
APN |
8 |
26,166,728 (GRCm39) |
missense |
probably benign |
0.40 |
|
IGL00718:Nsd3
|
APN |
8 |
26,196,562 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL00727:Nsd3
|
APN |
8 |
26,131,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01324:Nsd3
|
APN |
8 |
26,152,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01614:Nsd3
|
APN |
8 |
26,156,095 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL01834:Nsd3
|
APN |
8 |
26,130,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02066:Nsd3
|
APN |
8 |
26,203,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02229:Nsd3
|
APN |
8 |
26,200,775 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02481:Nsd3
|
APN |
8 |
26,181,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02686:Nsd3
|
APN |
8 |
26,156,086 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03394:Nsd3
|
APN |
8 |
26,165,765 (GRCm39) |
splice site |
probably benign |
|
|
Pine
|
UTSW |
8 |
26,169,952 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
D3080:Nsd3
|
UTSW |
8 |
26,203,572 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL02802:Nsd3
|
UTSW |
8 |
26,130,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0136:Nsd3
|
UTSW |
8 |
26,149,870 (GRCm39) |
nonsense |
probably null |
|
|
R0195:Nsd3
|
UTSW |
8 |
26,170,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0207:Nsd3
|
UTSW |
8 |
26,173,273 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0471:Nsd3
|
UTSW |
8 |
26,138,450 (GRCm39) |
splice site |
probably benign |
|
|
R0511:Nsd3
|
UTSW |
8 |
26,168,732 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R0524:Nsd3
|
UTSW |
8 |
26,190,605 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0581:Nsd3
|
UTSW |
8 |
26,200,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0589:Nsd3
|
UTSW |
8 |
26,131,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0645:Nsd3
|
UTSW |
8 |
26,199,096 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0664:Nsd3
|
UTSW |
8 |
26,204,267 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0738:Nsd3
|
UTSW |
8 |
26,168,725 (GRCm39) |
splice site |
probably null |
|
|
R1148:Nsd3
|
UTSW |
8 |
26,203,407 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1148:Nsd3
|
UTSW |
8 |
26,203,407 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1265:Nsd3
|
UTSW |
8 |
26,172,578 (GRCm39) |
missense |
probably benign |
|
|
R1298:Nsd3
|
UTSW |
8 |
26,169,952 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1424:Nsd3
|
UTSW |
8 |
26,190,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1493:Nsd3
|
UTSW |
8 |
26,203,407 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1528:Nsd3
|
UTSW |
8 |
26,188,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2051:Nsd3
|
UTSW |
8 |
26,181,116 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2199:Nsd3
|
UTSW |
8 |
26,156,073 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3414:Nsd3
|
UTSW |
8 |
26,190,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3522:Nsd3
|
UTSW |
8 |
26,196,642 (GRCm39) |
missense |
probably benign |
|
|
R3623:Nsd3
|
UTSW |
8 |
26,152,835 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3624:Nsd3
|
UTSW |
8 |
26,152,835 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3798:Nsd3
|
UTSW |
8 |
26,188,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4345:Nsd3
|
UTSW |
8 |
26,131,333 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4370:Nsd3
|
UTSW |
8 |
26,138,524 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4421:Nsd3
|
UTSW |
8 |
26,131,288 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4583:Nsd3
|
UTSW |
8 |
26,200,703 (GRCm39) |
missense |
probably benign |
0.20 |
|
R4664:Nsd3
|
UTSW |
8 |
26,188,894 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4741:Nsd3
|
UTSW |
8 |
26,163,382 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4876:Nsd3
|
UTSW |
8 |
26,181,161 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4888:Nsd3
|
UTSW |
8 |
26,188,939 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5000:Nsd3
|
UTSW |
8 |
26,172,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5132:Nsd3
|
UTSW |
8 |
26,168,855 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5632:Nsd3
|
UTSW |
8 |
26,169,985 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5760:Nsd3
|
UTSW |
8 |
26,149,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5778:Nsd3
|
UTSW |
8 |
26,149,834 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5779:Nsd3
|
UTSW |
8 |
26,172,685 (GRCm39) |
nonsense |
probably null |
|
|
R5860:Nsd3
|
UTSW |
8 |
26,156,107 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5911:Nsd3
|
UTSW |
8 |
26,156,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6168:Nsd3
|
UTSW |
8 |
26,181,188 (GRCm39) |
missense |
probably null |
1.00 |
|
R6467:Nsd3
|
UTSW |
8 |
26,130,646 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6490:Nsd3
|
UTSW |
8 |
26,204,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6519:Nsd3
|
UTSW |
8 |
26,152,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6554:Nsd3
|
UTSW |
8 |
26,152,891 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7038:Nsd3
|
UTSW |
8 |
26,131,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7244:Nsd3
|
UTSW |
8 |
26,156,055 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7308:Nsd3
|
UTSW |
8 |
26,130,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7678:Nsd3
|
UTSW |
8 |
26,149,833 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7717:Nsd3
|
UTSW |
8 |
26,172,578 (GRCm39) |
missense |
probably benign |
|
|
R8064:Nsd3
|
UTSW |
8 |
26,190,698 (GRCm39) |
nonsense |
probably null |
|
|
R8242:Nsd3
|
UTSW |
8 |
26,196,567 (GRCm39) |
nonsense |
probably null |
|
|
R8312:Nsd3
|
UTSW |
8 |
26,153,268 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8547:Nsd3
|
UTSW |
8 |
26,184,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8954:Nsd3
|
UTSW |
8 |
26,163,394 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8995:Nsd3
|
UTSW |
8 |
26,131,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9026:Nsd3
|
UTSW |
8 |
26,172,576 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9281:Nsd3
|
UTSW |
8 |
26,152,961 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9320:Nsd3
|
UTSW |
8 |
26,199,088 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9563:Nsd3
|
UTSW |
8 |
26,204,230 (GRCm39) |
missense |
|
|
|
R9703:Nsd3
|
UTSW |
8 |
26,131,228 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0026:Nsd3
|
UTSW |
8 |
26,190,621 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Nsd3
|
UTSW |
8 |
26,131,018 (GRCm39) |
small deletion |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TACTTATCACCTGGACTTAAGGC -3'
(R):5'- AGTATGTCATTATGGCCTGCCTTC -3'
Sequencing Primer
(F):5'- GCAAATTACGGTCACGTTA -3'
(R):5'- CAATGAAACTTTCTTAGGAACCCCTG -3'
|
| Posted On |
2019-05-15 |
Incidental Mutation