Incidental Mutation 'R7090:Or2n1b'
ID 550180
Institutional Source Beutler Lab
Gene Symbol Or2n1b
Ensembl Gene ENSMUSG00000063240
Gene Name olfactory receptor family 2 subfamily N member 1B
Synonyms GA_x6K02T2PSCP-2597192-2598130, MOR256-6, Olfr133
MMRRC Submission 045184-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.246) question?
Stock # R7090 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 38459481-38460419 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 38460385 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Aspartic acid at position 302 (G302D)
Ref Sequence ENSEMBL: ENSMUSP00000149451 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000113636] [ENSMUST00000173610] [ENSMUST00000215078] [ENSMUST00000215549]
AlphaFold Q8VG94
Predicted Effect probably benign
Transcript: ENSMUST00000113636
AA Change: G302D

PolyPhen 2 Score 0.332 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000109266
Gene: ENSMUSG00000063240
AA Change: G302D

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srv 27 305 3.4e-7 PFAM
Pfam:7tm_4 31 308 6.1e-52 PFAM
Pfam:7tm_1 41 290 1.5e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000173610
SMART Domains Protein: ENSMUSP00000133824
Gene: ENSMUSG00000063240

DomainStartEndE-ValueType
Pfam:7tm_1 55 109 3.3e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215078
AA Change: G302D

PolyPhen 2 Score 0.332 (Sensitivity: 0.90; Specificity: 0.89)
Predicted Effect probably benign
Transcript: ENSMUST00000215549
AA Change: G302D

PolyPhen 2 Score 0.332 (Sensitivity: 0.90; Specificity: 0.89)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (66/66)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Calm3 A T 7: 16,651,004 (GRCm39) Y139* probably null Het
Ccdc27 T C 4: 154,112,523 (GRCm39) N584S probably benign Het
Cdh24 C G 14: 54,876,964 (GRCm39) G13A probably damaging Het
Chd8 T C 14: 52,452,677 (GRCm39) K1281E probably damaging Het
Clasp1 G T 1: 118,409,816 (GRCm39) G4C probably benign Het
Cul9 G T 17: 46,811,765 (GRCm39) P2488T probably damaging Het
Daam2 A G 17: 49,789,973 (GRCm39) V428A probably damaging Het
Dcaf8 A G 1: 172,016,535 (GRCm39) S441G probably damaging Het
Dchs2 A G 3: 83,255,581 (GRCm39) T2426A probably benign Het
Dnai3 C A 3: 145,746,582 (GRCm39) K881N possibly damaging Het
Dpys A G 15: 39,690,279 (GRCm39) V358A probably damaging Het
Efhd1 A G 1: 87,217,219 (GRCm39) D112G probably damaging Het
Exoc1 T C 5: 76,714,800 (GRCm39) S120P unknown Het
Fyco1 A G 9: 123,626,784 (GRCm39) L1309S probably damaging Het
Gm14403 A G 2: 177,201,114 (GRCm39) N111S possibly damaging Het
Gm5901 A G 7: 105,026,555 (GRCm39) T108A probably benign Het
Idh2 TCCCAGG T 7: 79,748,079 (GRCm39) probably benign Het
Itgb5 T G 16: 33,705,464 (GRCm39) D251E probably damaging Het
Kcnk15 T C 2: 163,700,637 (GRCm39) V292A probably benign Het
Kdm2a A T 19: 4,369,169 (GRCm39) Y1149N probably damaging Het
Kdm3a T C 6: 71,572,529 (GRCm39) T1011A possibly damaging Het
Krt35 A T 11: 99,986,498 (GRCm39) probably null Het
Lipn T A 19: 34,049,180 (GRCm39) D115E possibly damaging Het
Lpin3 T G 2: 160,738,672 (GRCm39) L208R probably damaging Het
Ltf C A 9: 110,855,048 (GRCm39) Q354K probably benign Het
Marf1 C A 16: 13,929,566 (GRCm39) C1680F possibly damaging Het
Mtss2 T A 8: 111,456,656 (GRCm39) V242E probably damaging Het
Myo7b T C 18: 32,131,765 (GRCm39) Y477C probably damaging Het
Nbn T A 4: 15,981,350 (GRCm39) S481T probably benign Het
Ncoa2 A G 1: 13,257,062 (GRCm39) Y146H probably damaging Het
Ntng1 A T 3: 109,842,496 (GRCm39) C92* probably null Het
Or10ad1b C T 15: 98,125,083 (GRCm39) V150I probably benign Het
Or8k18 T A 2: 86,085,420 (GRCm39) N206Y probably damaging Het
Or8k31-ps1 T C 2: 86,356,471 (GRCm39) I17V probably benign Het
Os9 A T 10: 126,935,547 (GRCm39) S308T probably benign Het
Otx2 T A 14: 48,896,192 (GRCm39) T289S probably benign Het
Pakap C T 4: 57,648,042 (GRCm39) A60V probably benign Het
Pigg A G 5: 108,484,378 (GRCm39) T675A possibly damaging Het
Pink1 C T 4: 138,042,912 (GRCm39) E461K probably damaging Het
Pip5k1a A G 3: 94,967,809 (GRCm39) S543P possibly damaging Het
Prkaa1 A G 15: 5,206,611 (GRCm39) T454A probably benign Het
Ptk2 G A 15: 73,093,658 (GRCm39) P854S possibly damaging Het
Rab31 C T 17: 66,005,012 (GRCm39) V83I possibly damaging Het
Rabggtb G T 3: 153,615,986 (GRCm39) D117E probably benign Het
Rbl1 T C 2: 156,994,820 (GRCm39) H951R probably benign Het
Sapcd2 A G 2: 25,266,091 (GRCm39) S314G probably benign Het
Septin4 T C 11: 87,475,264 (GRCm39) L164P probably damaging Het
Shroom1 A G 11: 53,356,760 (GRCm39) E541G probably damaging Het
Slc26a7 C A 4: 14,565,460 (GRCm39) G208* probably null Het
Smco2 A G 6: 146,772,711 (GRCm39) I304M probably damaging Het
Spg7 T C 8: 123,818,491 (GRCm39) probably null Het
Spocd1 T C 4: 129,847,691 (GRCm39) F552L Het
St6galnac2 T C 11: 116,568,461 (GRCm39) D334G probably damaging Het
Sub1 A G 15: 11,986,572 (GRCm39) S92P probably benign Het
Syne2 T C 12: 75,989,125 (GRCm39) F1829L probably benign Het
Tdrd1 T C 19: 56,839,833 (GRCm39) V631A probably benign Het
Tdrd9 T C 12: 111,958,904 (GRCm39) S113P probably benign Het
Tgfbrap1 A C 1: 43,110,725 (GRCm39) V260G probably damaging Het
Tyw3 G C 3: 154,299,426 (GRCm39) S94R probably benign Het
Urb2 T C 8: 124,757,338 (GRCm39) V1015A probably benign Het
Usp5 A G 6: 124,806,357 (GRCm39) M1T probably null Het
Utrn T C 10: 12,560,260 (GRCm39) D1343G possibly damaging Het
Vmn2r56 T C 7: 12,449,254 (GRCm39) Y328C probably damaging Het
Vmn2r99 A T 17: 19,613,972 (GRCm39) E564V possibly damaging Het
Zc3h8 T C 2: 128,777,241 (GRCm39) T133A possibly damaging Het
Other mutations in Or2n1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02212:Or2n1b APN 17 38,459,746 (GRCm39) missense probably benign
IGL02486:Or2n1b APN 17 38,460,112 (GRCm39) missense probably damaging 1.00
IGL02574:Or2n1b APN 17 38,460,280 (GRCm39) missense possibly damaging 0.56
PIT4243001:Or2n1b UTSW 17 38,460,394 (GRCm39) missense probably benign 0.06
PIT4504001:Or2n1b UTSW 17 38,460,060 (GRCm39) missense probably benign
R0726:Or2n1b UTSW 17 38,459,515 (GRCm39) missense probably damaging 1.00
R2242:Or2n1b UTSW 17 38,459,613 (GRCm39) missense possibly damaging 0.87
R2496:Or2n1b UTSW 17 38,460,322 (GRCm39) missense possibly damaging 0.91
R4579:Or2n1b UTSW 17 38,460,296 (GRCm39) missense probably damaging 1.00
R5085:Or2n1b UTSW 17 38,460,003 (GRCm39) missense probably damaging 1.00
R6273:Or2n1b UTSW 17 38,459,833 (GRCm39) missense possibly damaging 0.94
R6344:Or2n1b UTSW 17 38,459,611 (GRCm39) missense probably benign 0.01
R7046:Or2n1b UTSW 17 38,459,691 (GRCm39) missense probably benign 0.00
R7213:Or2n1b UTSW 17 38,459,965 (GRCm39) missense probably benign 0.00
R8874:Or2n1b UTSW 17 38,459,623 (GRCm39) missense possibly damaging 0.78
R9185:Or2n1b UTSW 17 38,459,754 (GRCm39) missense probably damaging 1.00
R9334:Or2n1b UTSW 17 38,459,840 (GRCm39) missense probably benign 0.01
R9703:Or2n1b UTSW 17 38,459,856 (GRCm39) missense possibly damaging 0.91
Predicted Primers PCR Primer
(F):5'- AAGGCCTTTGGGACATGTTCC -3'
(R):5'- CTATCCAAGATCAACCATTGCCTAG -3'

Sequencing Primer
(F):5'- GGGACATGTTCCTCTCATCTCATTG -3'
(R):5'- CAACCATTGCCTAGCATAATTAGG -3'
Posted On 2019-05-15